CRISPR, cancer, and p53

A path to efficient gene editing

(2018) Fyodor D. Urnov   NATURE MEDICINE

p53 inhibits CRISPR–Cas9 engineering in human pluripotent stem cells

(2018) Robert J. Ihry et al.   NATURE MEDICINE

CRISPR–Cas9 genome editing induces a p53-mediated DNA damage response

(2018) Emma Haapaniemi et al.   NATURE MEDICINE

Restoring the p53 ‘Guardian’ Phenotype in p53-Deficient Tumor Cells with CRISPR/Cas9

(2018) Sergiu Chira et al.   TRENDS IN BIOTECHNOLOGY

p53 dynamics in response to DNA damage vary across cell lines and are shaped by efficiency of DNA repair and activity of the kinase ATM

(2017) Jacob Stewart-Ornstein et al.   Science Signaling

p53 dynamics in response to DNA damage vary across cell lines and are shaped by efficiency of DNA repair and activity of the kinase ATM

(2017) Jacob Stewart-Ornstein et al.   Science Signaling