Proteolytic Remodeling of Perineuronal Nets: Effects on Synaptic Plasticity and Neuronal Population Dynamics

Increased metalloproteinase activity in the hippocampus following status epilepticus

(2017) Deepti Dubey et al.   EPILEPSY RESEARCH

Disruption of perineuronal nets increases the frequency of sharp wave ripple events

(2017) Zhi Yong Sun et al.   HIPPOCAMPUS

Erratum: Genetic Otx2 mis-localization delays critical period plasticity across brain regions

(2017) H H C Lee et al.   MOLECULAR PSYCHIATRY

Activity-Dependent Gating of Parvalbumin Interneuron Function by the Perineuronal Net Protein Brevican

(2017) Emilia Favuzzi et al.   NEURON

TGFβ signaling is associated with changes in inflammatory gene expression and perineuronal net degradation around inhibitory neurons following various neurological insults

(2017) Soo Young Kim et al.   Scientific Reports

Gamma oscillation in functional brain networks is involved in the spontaneous remission of depressive behavior induced by chronic restraint stress in mice

(2016) Arshi Khalid et al.   BMC NEUROSCIENCE

Trajectory of Parvalbumin Cell Impairment and Loss of Cortical Inhibition in Traumatic Brain Injury

(2016) Tsung-Hsun Hsieh et al.   CEREBRAL CORTEX

Dopamine increases NMDA-stimulated calcium flux in striatopallidal neurons through a matrix metalloproteinase-dependent mechanism

(2016) Yan Li et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Casting a Wide Net: Role of Perineuronal Nets in Neural Plasticity

(2016) Barbara A. Sorg et al.   JOURNAL OF NEUROSCIENCE

Perineuronal Nets Suppress Plasticity of Excitatory Synapses on CA2 Pyramidal Neurons

(2016) K. E. Carstens et al.   JOURNAL OF NEUROSCIENCE

Removal of Perineuronal Nets Unlocks Juvenile Plasticity Through Network Mechanisms of Decreased Inhibition and Increased Gamma Activity

(2016) Kristian Kinden Lensjø et al.   JOURNAL OF NEUROSCIENCE

HIV-1 Tat causes cognitive deficits and selective loss of parvalbumin, somatostatin, and neuronal nitric oxide synthase expressing hippocampal CA1 interneuron subpopulations

(2016) William D. Marks et al.   JOURNAL OF NEUROVIROLOGY

Reorganization of Synaptic Connections and Perineuronal Nets in the Deep Cerebellar Nuclei ofPurkinje Cell DegenerationMutant Mice

(2016) M. Blosa et al.   NEURAL PLASTICITY

Chondroitin 6-Sulfation Regulates Perineuronal Net Formation by Controlling the Stability of Aggrecan

(2016) Shinji Miyata et al.   NEURAL PLASTICITY

Caught in the Net: Perineuronal Nets and Addiction

(2016) Megan Slaker et al.   NEURAL PLASTICITY

In Sickness and in Health: Perineuronal Nets and Synaptic Plasticity in Psychiatric Disorders

(2016) Harry Pantazopoulos et al.   NEURAL PLASTICITY

The tetrapartite synapse: Extracellular matrix remodeling contributes to corticoaccumbens plasticity underlying drug addiction

(2015) Alexander C.W. Smith et al.   BRAIN RESEARCH

Perineuronal net degradation in epilepsy

(2015) Elyse K. Rankin-Gee et al.   EPILEPSIA

Hippocampal sharp wave-ripple: A cognitive biomarker for episodic memory and planning

(2015) György Buzsáki   HIPPOCAMPUS

Distinct effects of perinatal exposure to fluoxetine or methylmercury on parvalbumin and perineuronal nets, the markers of critical periods in brain development

(2015) Juzoh Umemori et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Removal of Perineuronal Nets in the Medial Prefrontal Cortex Impairs the Acquisition and Reconsolidation of a Cocaine-Induced Conditioned Place Preference Memory

(2015) M. Slaker et al.   JOURNAL OF NEUROSCIENCE

Disinhibition, a Circuit Mechanism for Associative Learning and Memory

(2015) Johannes J. Letzkus et al.   NEURON

A bout of treadmill exercise increases matrix metalloproteinase-9 activity in the rat hippocampus

(2015) Takeshi Nishijima et al.   NEUROSCIENCE LETTERS

Losing the sugar coating: Potential impact of perineuronal net abnormalities on interneurons in schizophrenia

(2015) Sabina Berretta et al.   SCHIZOPHRENIA RESEARCH

An excitatory synapse hypothesis of depression

(2015) Scott M. Thompson et al.   TRENDS IN NEUROSCIENCES

Activity dependent CAM cleavage and neurotransmission

(2015) Katherine Conant et al.   Frontiers in Cellular Neuroscience

Ion exchanger in the brain: Quantitative analysis of perineuronally fixed anionic binding sites suggests diffusion barriers with ion sorting properties

(2015) Markus Morawski et al.   Scientific Reports

Brain extracellular matrix retains connectivity in neuronal networks

(2015) Arthur Bikbaev et al.   Scientific Reports

Aggrecan and chondroitin-6-sulfate abnormalities in schizophrenia and bipolar disorder: a postmortem study on the amygdala

(2015) H Pantazopoulos et al.   Translational Psychiatry

Hippocampal administration of chondroitinase ABC increases plaque-adjacent synaptic marker and diminishes amyloid burden in aged APPswe/PS1dE9 mice

(2015) Matthew D. Howell et al.   Acta Neuropathologica Communications

Chronic fluoxetine treatment alters the structure, connectivity and plasticity of cortical interneurons

(2014) Ramon Guirado et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Mechanisms for modulation of neural plasticity and axon regeneration by chondroitin sulphate

(2014) S. Miyata et al.   JOURNAL OF BIOCHEMISTRY

Cell-specific and developmental expression of lectican-cleaving proteases in mouse hippocampus and neocortex

(2014) C. Levy et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Metalloproteinase inhibition prevents inhibitory synapse reorganization and seizure genesis

(2014) Emily Pollock et al.   NEUROBIOLOGY OF DISEASE

Enriched Housing Enhances Recovery of Limb Placement Ability and Reduces Aggrecan-Containing Perineuronal Nets in the Rat Somatosensory Cortex after Experimental Stroke

(2014) Alexandre Madinier et al.   PLoS One

Transcriptional Evidence for the Role of Chronic Venlafaxine Treatment in Neurotrophic Signaling and Neuroplasticity Including also Glutatmatergic- and Insulin-Mediated Neuronal Processes

(2014) Viola Tamási et al.   PLoS One

Enhanced cognitive flexibility in reversal learning induced by removal of the extracellular matrix in auditory cortex

(2014) M. F. K. Happel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activity-controlled proteolytic cleavage at the synapse

(2014) Peter Sonderegger et al.   TRENDS IN NEUROSCIENCES

ADAMTS4 and ADAMTS5 Knockout Mice Are Protected from Versican but Not Aggrecan or Brevican Proteolysis during Spinal Cord Injury

(2014) Kadir Demircan et al.   Biomed Research International

Reducing hippocampal extracellular matrix reverses early memory deficits in a mouse model of Alzheimer’s disease

(2014) Marlene J Végh et al.   Acta Neuropathologica Communications

Chondroitinase Enhances Cortical Map Plasticity and Increases Functionally Active Sprouting Axons after Brain Injury

(2013) Neil G. Harris et al.   JOURNAL OF NEUROTRAUMA

Experience-dependent development of perineuronal nets and chondroitin sulfate proteoglycan receptors in mouse visual cortex

(2013) Qian Ye et al.   MATRIX BIOLOGY

Parvalbumin-expressing basket-cell network plasticity induced by experience regulates adult learning

(2013) Flavio Donato et al.   NATURE

Pathophysiology of the brain extracellular matrix: a new target for remyelination

(2013) Lorraine W. Lau et al.   NATURE REVIEWS NEUROSCIENCE

Seizure-like activity in hyaluronidase-treated dissociated hippocampal cultures

(2013) Maria Vedunova et al.   Frontiers in Cellular Neuroscience

Extracellular matrix inhibits structural and functional plasticity of dendritic spines in the adult visual cortex

(2013) L. de Vivo et al.   Nature Communications

Choroid-Plexus-Derived Otx2 Homeoprotein Constrains Adult Cortical Plasticity

(2013) Julien Spatazza et al.   Cell Reports

Chronic fluoxetine treatment reduces parvalbumin expression and perineuronal nets in gamma-aminobutyric acidergic interneurons of the frontal cortex in adult mice

(2013) Koji Ohira et al.   Molecular Brain

Studies in Humans and Mice Implicate Neurocan in the Etiology of Mania

(2012) Xavier Miró et al.   AMERICAN JOURNAL OF PSYCHIATRY

Persistent decrease in multiple components of the perineuronal net following status epilepticus

(2012) Paulette A. McRae et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Neuronal toxicity in HIV CNS disease

(2012) Jane Kovalevich et al.   Future Virology

Otx2 Binding to Perineuronal Nets Persistently Regulates Plasticity in the Mature Visual Cortex

(2012) M. Beurdeley et al.   JOURNAL OF NEUROSCIENCE

Persistent cortical plasticity by upregulation of chondroitin 6-sulfation

(2012) Shinji Miyata et al.   NATURE NEUROSCIENCE

Synaptic circuit remodelling by matrix metalloproteinases in health and disease

(2012) George W. Huntley   NATURE REVIEWS NEUROSCIENCE

Lectican proteoglycans, their cleaving metalloproteinases, and plasticity in the central nervous system extracellular microenvironment

(2012) M.D. Howell et al.   NEUROSCIENCE

Deconstructing the perineuronal net: Cellular contributions and molecular composition of the neuronal extracellular matrix

(2012) K.A. Giamanco et al.   NEUROSCIENCE

Perineuronal Nets Play a Role in Regulating Striatal Function in the Mouse

(2012) Hyunchul Lee et al.   PLoS One

Involvement of Perineuronal and Perisynaptic Extracellular Matrix in Alzheimer's Disease Neuropathology

(2011) Markus Morawski et al.   BRAIN PATHOLOGY

Extracellular matrix molecules, their receptors, and secreted proteases in synaptic plasticity

(2011) Jakub Wlodarczyk et al.   Developmental Neurobiology

Extracellular matrix and perineuronal nets in CNS repair

(2011) Jessica C.F. Kwok et al.   Developmental Neurobiology

Disturbance of perineuronal nets in the perilesional area after photothrombosis is not associated with neuronal death

(2011) Magdalena Karetko-Sysa et al.   EXPERIMENTAL NEUROLOGY

6-Sulphated Chondroitins Have a Positive Influence on Axonal Regeneration

(2011) Rachel Lin et al.   PLoS One

Animals lacking link protein have attenuated perineuronal nets and persistent plasticity

(2010) Daniela Carulli et al.   BRAIN

Improved Reversal Learning and Working Memory and Enhanced Reactivity to Novelty in Mice with Enhanced GABAergic Innervation in the Dentate Gyrus

(2010) Fabio Morellini et al.   CEREBRAL CORTEX

Converting juvenile into adult plasticity: a role for the brain’s extracellular matrix

(2010) Eckart D. Gundelfinger et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Pericontusion Axon Sprouting Is Spatially and Temporally Consistent With a Growth-Permissive Environment After Traumatic Brain Injury

(2010) Neil G. Harris et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

MMPs are less efficient than ADAMTS5 in cleaving aggrecan core protein

(2010) Michaela Durigova et al.   MATRIX BIOLOGY

The dual role of the extracellular matrix in synaptic plasticity and homeostasis

(2010) Alexander Dityatev et al.   NATURE REVIEWS NEUROSCIENCE

Aggrecan expression, a component of the inhibitory interneuron perineuronal net, is altered following an early-life seizure

(2010) Paulette A. McRae et al.   NEUROBIOLOGY OF DISEASE

NMDA Receptor Ablation on Parvalbumin-Positive Interneurons Impairs Hippocampal Synchrony, Spatial Representations, and Working Memory

(2010) Tatiana Korotkova et al.   NEURON

Neurons associated with aggrecan-based perineuronal nets are protected against tau pathology in subcortical regions in Alzheimer's disease

(2010) M. Morawski et al.   NEUROSCIENCE

Disruption of ripple-associated hippocampal activity during rest impairs spatial learning in the rat

(2009) Valérie Ego-Stengel et al.   HIPPOCAMPUS

Augmented Hippocampal Ripple Oscillations in Mice with Reduced Fast Excitation onto Parvalbumin-Positive Cells

(2009) A. Racz et al.   JOURNAL OF NEUROSCIENCE

Serum matrix metalloproteinase levels correlate with brain injury in human immunodeficiency virus infection

(2009) Ann B Ragin et al.   JOURNAL OF NEUROVIROLOGY

Brain extracellular matrix affects AMPA receptor lateral mobility and short-term synaptic plasticity

(2009) Renato Frischknecht et al.   NATURE NEUROSCIENCE

Enrichment from Birth Accelerates the Functional and Cellular Development of a Motor Control Area in the Mouse

(2009) Teresa Simonetti et al.   PLoS One

Perineuronal Nets Protect Fear Memories from Erasure

(2009) N. Gogolla et al.   SCIENCE

Discordant localization of WFA reactivity and brevican/ADAMTS-derived fragment in rodent brain

(2008) Joanne M Ajmo et al.   BMC NEUROSCIENCE

Experience-Dependent Transfer of Otx2 Homeoprotein into the Visual Cortex Activates Postnatal Plasticity

(2008) Sayaka Sugiyama et al.   CELL

Important role of matrix metalloproteinase 9 in epileptogenesis

(2008) Grzegorz M. Wilczynski et al.   JOURNAL OF CELL BIOLOGY

Chondroitin-4-sulfation negatively regulates axonal guidance and growth

(2008) H. Wang et al.   JOURNAL OF CELL SCIENCE

Sustained increase in hippocampal sharp-wave ripple activity during slow-wave sleep after learning

(2008) O. Eschenko et al.   LEARNING & MEMORY

A role for a lithium-inhibited Golgi nucleotidase in skeletal development and sulfation

(2008) J. P. Frederick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuronal Diversity and Temporal Dynamics: The Unity of Hippocampal Circuit Operations

(2008) T. Klausberger et al.   SCIENCE

Roles of matrix metalloproteinase-9 and tissue inhibitors of metalloproteinases 1 in acute encephalopathy following prolonged febrile seizures

(2007) Naoko Suenaga et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES