Article
Cardiac & Cardiovascular Systems
Sheila M. M. Manemann, Suzette J. J. Bielinski, Ethan D. D. Moser, Jennifer L. L. St Sauver, Paul Y. Y. Takahashi, Veronique L. Roger, Janet E. E. Olson, Alanna M. M. Chamberlain, Alan T. T. Remaley, Paul A. A. Decker, Jill M. M. Killian, Nicholas B. B. Larson
Summary: This study found that variability in lipid levels is associated with increased risk of cardiovascular disease (CVD) in a large electronic health record-based population cohort. High variability in total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol is independently associated with an increased risk of CVD.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Clinical Neurology
Zhirong Yang, Duncan Edwards, Stephen Burgess, Carol Brayne, Jonathan Mant
Summary: This study investigated the potential associations between blood LDL-C, HDL-C, and triglycerides and post-stroke dementia. The results showed that higher LDL-C levels were associated with an increased risk of dementia, while lower triglyceride levels were associated with a decreased risk. There was no association between HDL-C levels and dementia.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Medical Laboratory Technology
Christina Tsigalou, Maria Panopoulou, Charalambos Papadopoulos, Alexandros Karvelas, Dimitrios Tsairidis, Konstantinos Anagnostopoulos
Summary: This study demonstrated that machine learning methods outperformed traditional equations in determining LDL, but classification accuracy still needs improvement. Direct determination of LDL values is the preferred method, with machine learning as a good alternative when direct determination is not available.
CLINICA CHIMICA ACTA
(2021)
Review
Biochemistry & Molecular Biology
Saeed Aslani, Bahman Razi, Danyal Imani, Keyhan Mohammadi, Tannaz Jamialahmadi, Zeljko Reiner, Amirhossein Sahebkar
Summary: A systematic review and meta-analysis showed that statin therapy effectively lowered levels of total cholesterol, LDL-C, and TG, and increased levels of HDL-C in patients with different CVDs.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Medicine, General & Internal
Vignesh Chidambaram, Amudha Kumar, Marie Gilbert Majella, Bhavna Seth, Ranjith Kumar Sivakumar, Dinesh Voruganti, Mahesh Bavineni, Ahmad Baghal, Kim Gates, Annu Kumari, Subhi J. Al'Aref, Panagis Galiatsatos, Petros C. Karakousis, Jawahar L. Mehta
Summary: This study found that individuals with higher antecedent serum high-density lipoprotein cholesterol (HDL-C) levels had a lower risk of SARS-CoV-2 infection. However, low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglyceride (TG) levels were not independently associated with infection risk. In COVID-19 patients, serum HDL-C and LDL-C levels transiently decreased at the time of infection.
Article
Oncology
Pik-Fang Kho, Frederic Amant, Daniela Annibali, Katie Ashton, John Attia, Paul L. Auer, Matthias W. Beckmann, Amanda Black, Louise Brinton, Daniel D. Buchanan, Stephen J. Chanock, Chu Chen, Maxine M. Chen, Timothy H. T. Cheng, Linda S. Cook, Marta Crous-Bous, Kamila Czene, Immaculata De Vivo, Joe Dennis, Thilo Doerk, Sean C. Dowdy, Alison M. Dunning, Matthias Duerst, Douglas F. Easton, Arif B. Ekici, Peter A. Fasching, Brooke L. Fridley, Christine M. Friedenreich, Montserrat Garcia-Closas, Mia M. Gaudet, Graham G. Giles, Ellen L. Goode, Maggie Gorman, Christopher A. Haiman, Per Hall, Susan E. Hankinson, Alexander Hein, Peter Hillemanns, Shirley Hodgson, Erling A. Hoivik, Elizabeth G. Holliday, David J. Hunter, Angela Jones, Peter Kraft, Camilla Krakstad, Diether Lambrechts, Loic Le Marchand, Xiaolin Liang, Annika Lindblom, Jolanta Lissowska, Jirong Long, Lingeng Lu, Anthony M. Magliocco, Lynn Martin, Mark McEvoy, Roger L. Milne, Miriam Mints, Rami Nassir, Geoffrey Otton, Claire Palles, Loreall Pooler, Tony Proietto, Timothy R. Rebbeck, Stefan P. Renner, Harvey A. Risch, Matthias Ruebner, Ingo Runnebaum, Carlotta Sacerdote, Gloria E. Sarto, Fredrick Schumacher, Rodney J. Scott, V. Wendy Setiawan, Mitul Shah, Xin Sheng, Xiao-Ou Shu, Melissa C. Southey, Emma Tham, Ian Tomlinson, Jone Trovik, Constance Turman, Jonathan P. Tyrer, David van den Berg, Zhaoming Wang, Nicolas Wentzensen, Lucy Xia, Yong-Bing Xiang, Hannah P. Yang, Herbert Yu, Wei Zheng, Penelope M. Webb, Deborah J. Thompson, Amanda B. Spurdle, Dylan M. Glubb, Tracy A. O'Mara
Summary: This study used Mendelian randomization analysis to investigate the relationship between blood lipids and endometrial cancer risk. Genetically elevated LDL cholesterol levels were associated with reduced risk of endometrial cancer, while higher predicted HDL cholesterol levels were linked to increased risk of non-endometrioid endometrial cancer. Obesity may influence these associations, but triglycerides showed no evidence of involvement in endometrial cancer development.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Obstetrics & Gynecology
Maria C. Adank, Anja K. Johansen, Laura Benschop, Sophia P. Van Streun, Anna M. Smak Gregoor, Linn K. L. Oyri, Monique T. Mulder, Eric A. P. Steegers, Kirsten B. Holven, Jeanine E. Roeters van Lennep
Summary: Maternal lipid levels in early pregnancy are positively associated with childhood lipid levels in offspring, independent of maternal BMI and diet. This suggests that gestational lipid levels can be used as an early predictor of children's long-term health.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Public, Environmental & Occupational Health
Susana Cararo Confortin, Liliana Yanet Gomez Aristizabal, Elma Izze da Silva Magalhaes, Aline Rodrigues Barbosa, Cecilia Claudia Costa Ribeiro, Rosangela Fernandes Lucena Batista, Antonio Augusto Moura da Silva
Summary: There is no association between sleep duration and cardiometabolic risk factors in adolescents.
Article
Geriatrics & Gerontology
Sylvia E. Badon, Kelley Pettee Gabriel, Carrie Karvonen-Gutierrez, Barbara Sternfeld, Ellen B. Gold, L. Elaine Waetjen, Catherine Lee, Lyndsay A. Avalos, Samar R. El Khoudary, Monique M. Hedderson
Summary: Most women in midlife exhibited low trajectories of physical activity and blood lipid levels. Although no clear association was found between long-term trajectories of physical activity and blood lipids in this study, the importance of promoting regular and sustained physical activity for midlife women to achieve cardiovascular and metabolic benefits was highlighted.
Review
Nutrition & Dietetics
Yixue Yang, Shoumeng Yan, Nan Yao, Yinpei Guo, Han Wang, Mengzi Sun, Wenyu Hu, Xiaotong Li, Ling Wang, Bo Li
Summary: This meta-analysis examined the impact of vitamin D supplementation on blood lipid levels in prediabetic individuals. The results showed that vitamin D intervention significantly reduced triglyceride levels, especially among obese individuals, males, and studies with intervention durations longer than 1 year. Both low and high doses of vitamin D supplementation were effective in reducing triglyceride levels, and this effect was observed in both Northern Europe and Asian countries. However, no significant effects were found on total cholesterol, HDL cholesterol, and LDL cholesterol levels.
FRONTIERS IN NUTRITION
(2023)
Article
Medicine, General & Internal
Meleeka Akbarpour, Divya Devineni, Yufan Gong, Nathan D. Wong
Summary: This study examined lipid levels and treatment status in patients with diabetes mellitus (DM), finding a lack of guideline-recommended use of high-intensity statins and inadequately controlled LDL-C among high-risk DM patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Changyu Lv, Wencui Zhang, Xia Tan, Xianping Shang, Mihnea-Alexandru Gaman, Hany Salem, Ahmed Abu-Zaid, Xiaohong Wang
Summary: Tibolone treatment decreases total cholesterol, high-density lipoprotein cholesterol, and triglyceride levels, with a significant reduction in low-density lipoprotein cholesterol observed when administered for <= 26 weeks. The decrease in triglyceride and total cholesterol concentrations is more pronounced in patients with a BMI >= 25 kg/m(2).
PHARMACOLOGICAL RESEARCH
(2021)
Article
Medicine, General & Internal
Hayato Tada, Hidehiro Kaneko, Yuta Suzuki, Akira Okada, Norifumi Takeda, Katsuhito Fujiu, Hiroyuki Morita, Junya Ako, Koichi Node, Yasuaki Takeji, Masayuki Takamura, Hideo Yasunaga, Issei Komuro
Summary: This study found a prevalence of 0.29% for FH in the general population. In addition to being associated with composite outcomes of cardiovascular disease, FH was also significantly associated with heart failure and atrial fibrillation.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Nutrition & Dietetics
Vittoria Carmela Danese, Jessica Pepe, Federica Ferrone, Luciano Colangelo, Viviana De Martino, Luciano Nieddu, Giancarlo Ferrazza, Enrico Panzini, Roberto Pascone, Frank Blocki, Salvatore Minisola, Cristiana Cipriani
Summary: The study investigates the relationship between bone, glucose, and lipid metabolism. Hypovitaminosis D leads to worsening lipid profiles through PTH, while higher PTH levels are associated with elevated glucose and LDL-C levels.
Article
Nutrition & Dietetics
Andreas Rydell, Mikael Hellsten, Martin Lindow, David Iggman
Summary: The study found that providing food-based written advice could help reduce LDL cholesterol in the short term, while reducing carbohydrate intake could lower triglycerides. The intervention had little effect on blood lipids for most individuals.
Article
Cardiac & Cardiovascular Systems
Xin Li, Li-Zhu Guo, Nian Liu, Xin Du, Rong Bai, Jian-Zeng Dong, Chang-Sheng Ma
Summary: This study investigated the relationship between common variants associated with arrhythmia or ECG and heart rhythm parameters in a Chinese population. The T66A variant of the CASQ2 gene was found to be significantly associated with PR interval prolongation, particularly in females. Additionally, the rs3822714 variant in the HAND1 locus may be linked to QRS duration. Further exploration of these associations is warranted to understand their impact on cardiac electrophysiology.
Article
Cardiac & Cardiovascular Systems
Yu Pan, Qi Qiu, Wei-hong Ren, Xian-peng Yu, Liu Zesen, Jian-zeng Dong
Summary: For patients with unprotected left main coronary artery disease and left ventricular systolic dysfunction, there was no significant difference in efficacy and safety between drug-eluting stents and coronary artery bypass grafting. Treatment with drug-eluting stents was found to be an acceptable alternative to CABG.
Correction
Cardiac & Cardiovascular Systems
Yu Pan, Qi Qiu, Wei-hong Ren, Xian-peng Yu, Ze-sen Liu, Jian-zeng Dong
Summary: The article mistakenly switched the first and last names of the fifth author as Ze-sen Liu, when it should be Liu Ze-sen. The publisher apologizes for the error.
Article
Cardiac & Cardiovascular Systems
Wei Wei, Caihua Sang, Sulin Zheng, Roderick Tung, Xunzhang Wang, Yumei Xue, Yuanhong Liang, Shangming Song, Tongbao Liu, Deyong Long, Yang Liu, Jianzeng Dong, Changsheng Ma, Shulin Wu
Summary: Concealed NV fibers can either mediate orthodromic reentrant tachycardia or be a bystander of AVNRT. V-A dissociation usually occurs during such SVTs. Entrainment of right ventricular apex can help differentiate AVNRT from NVRT.
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Changyi Li, Jingrui Zhang, Songnan Li, Caihua Sang, Nian Liu, Xin Du, Jianzeng Dong, Changsheng Ma
Summary: This study demonstrates that the 2D2G technique is safe, feasible, and time-saving for difficult TSP in atrial fibrillation patients. Successful LA access, total TSP time, and ablation time were significantly improved with the 2D2G technique compared to the conventional approach. No major complications occurred in either group, and all patients successfully underwent CPVI.
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Zhen Huang, Pan Huang, Binbin Du, Lingyao Kong, Wenyuan Zhang, Yanzhou Zhang, Jianzeng Dong
Summary: The prevalence of cardiac injury is significantly increased in COVID-19 patients, particularly in those with severe disease and non-survivors. Cardiac injury is associated with a significant increase in the risk of poor outcomes, including severe disease, admission to ICU, and mortality.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Cardiac & Cardiovascular Systems
Caihua Sang, Yiwei Lai, Deyong Long, Mengmeng Li, Rong Bai, Chenxi Jiang, Wei Wang, Songnan Li, Ribo Tang, Xueyuan Guo, Nian Liu, Xin Zhao, Song Zuo, Songnan Wen, Man Ning, Jiahui Wu, Xin Du, Jianzeng Dong, Changsheng Ma
Summary: The study demonstrates that ethanol infusion into the vein of Marshall is feasible and effective for the treatment of perimitral atrial tachycardia, particularly in patients with Marshall bundle-related tachycardia. It was found that patients with Marshall bundle-related tachycardia were more responsive to the treatment.
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Guanxing Pan, Lin Chang, Jianjun Zhang, Yangyang Liu, Liang Hu, Si Zhang, Jian Zhang, Jianlin Qiao, Ziga Jakopin, Hu Hu, Jianzeng Dong, Zhongren Ding
Summary: The study found that as a NOD2 antagonist, GSK669 not only has anti-inflammatory effects, but also acts as an efficient and safe antiplatelet agent by targeting GPVI, with antioxidant properties. The drug is also able to effectively inhibit thrombus formation, showing potential therapeutic advantages in treating atherothrombosis.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Xin Du, Lizhu Guo, Shijun Xia, Jing Du, Craig Anderson, Hisatomi Arima, Mark Huffman, Yiqiang Yuan, Yang Zheng, Shulin Wu, Xuefeng Guang, Xianhui Zhou, Hongbo Lin, Xiaoshu Cheng, Jianzeng Dong, Changsheng Ma
Summary: The study found a higher prevalence of atrial fibrillation in China than previously reported, with low awareness and large treatment gaps. Awareness of atrial fibrillation was lower among men and urban residents, and only a small percentage of high-risk patients received anticoagulant therapy.
Article
Clinical Neurology
Zhaoxu Jia, Xin Du, Jing Du, Shijun Xia, Lizhu Guo, Xin Su, Zhaojie Dong, Yiqiang Yuan, Yang Zheng, Shulin Wu, Xuefeng Guang, Xianhui Zhou, Hongbo Lin, Xiaoshu Cheng, Jianzeng Dong, Changsheng Ma
Summary: The study found that the prevalence of depressive and anxiety symptoms in patients with cardiovascular disease in China is relatively low, but significantly increased in females with heart failure and stroke. In addition to gender and age, being unmarried, having a low income, and having a history of certain cardiovascular diseases are also associated with the occurrence of depressive and anxiety symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Cardiac & Cardiovascular Systems
Zhuanzhuan Wu, Chao Jiang, Jingye Li, Jing Du, Yu Bai, Xueyuan Guo, Wei Wang, Songnan Li, Chenxi Jiang, Nian Liu, Ribo Tang, Rong Bai, Caihua Sang, Deyong Long, Xin Du, Changsheng Ma, Jianzeng Dong
Summary: Family history of atrial fibrillation is a risk factor for postablation atrial tachyarrhythmia recurrence, especially in patients diagnosed with atrial fibrillation at age 50 or younger.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2021)
Article
Cell & Tissue Engineering
Xiaowei Li, Wanrong Fu, Guangli Guo, Mengduan Liu, Wenting Du, Jing Zhao, Yangyang Liu, Lu Wang, Jianzeng Dong, Xiaoyan Zhao
Summary: The study generated a human induced pluripotent stem cell line from peripheral blood cells of a female HCM patient with a MYH7 mutation, which expressed pluripotency markers and had a normal female karyotype, capable of differentiating into all three germ layers in vitro.
STEM CELL RESEARCH
(2021)
Article
Cell & Tissue Engineering
Mengduan Liu, Xiaowei Li, Wanrong Fu, Mengyu Wang, Yangyang Liu, Lu Wang, Liang Hu, Xiaoyan Zhao, Jianzeng Dong
Summary: Induced pluripotent stem cells (iPSCs) are a valuable tool for studying drug and disease mechanisms, capable of generating different types of somatic cells. Reprogramming peripheral blood mononuclear cells can yield iPSCs with stable pluripotency, able to differentiate into three germ layers in vitro.
STEM CELL RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Zhaojie Dong, Xin Du, Shangxin Lu, Chao Jiang, Shijun Xia, Liu He, Xin Su, Zhaoxu Jia, Deyong Long, Caihua Sang, Ribo Tang, Nian Liu, Rong Bai, Ronghui Yu, Jianzeng Dong, Changsheng Ma
Summary: More than one-third of atrial fibrillation (AF) patients in this study were hospitalized at least once during a follow-up of over 3 years. Patients aged 65 years or older were mainly hospitalized for non-cardiovascular diseases rather than AF. Patients with comorbidities such as heart failure, coronary artery disease, ischemic stroke/transient ischemic attack, diabetes, chronic obstructive pulmonary disease, gastrointestinal disorder, and renal dysfunction had higher risks of hospitalization.
BMC CARDIOVASCULAR DISORDERS
(2021)
Editorial Material
Medicine, General & Internal
Chao Liu, Li-Li Xiao, Lu Wang, Fu-Qiang Sun, Xing-Xing Yao, Yan-Zhou Zhang, Xiao-Yan Zhao, Ling Li, Xiao-Fang Wang, Jian-Zeng Dong
CHINESE MEDICAL JOURNAL
(2021)
