Review
Plant Sciences
Siqi Wu, Zhe Sun, Zehuai Guo, Peiqin Li, Qianqian Mao, Yang Tang, Hongyu Chen, Huiting Peng, Sisi Wang, Yang Cao
Summary: Blood-activating and stasis-transforming traditional Chinese medicines (BAST) have been proven to improve hemodynamics and micro-flow, prevent thrombosis, and inhibit the invasion and metastasis of lung cancer. This review summarizes the research progress of BAST on lung cancer and explores the underlying molecular mechanisms.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Medicine, Research & Experimental
PeiYu Liu, QingYang Zhao, Yang Xu, JiaXue Ye, JingRui Tan, Jie Hou, YaZhuo Wang, JianWei Li, WeiZhen Cui, ShiYuan Wang, XueZhen Wang
Summary: With the development of modern medical technology, lung cancer treatment is mainly based on surgery and radiotherapy, supplemented by gene, targeted drugs and immunotherapy; the application of traditional Chinese medicine in the treatment of lung cancer is gradually gaining attention, and Qianjin Weijin Decoction, as a classic traditional Chinese medicine formula, has certain efficacy in lung cancer treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Zhang Wan-Tong, Zhu Bao-Chen, Liu Zhao, Wang Xu-Jie, Gao Rui, Xiao Ning, Tang Wei, Wu Yu-Fei, Phoebe Miles, Weng Wei-Liang, Lin Hao-Xiang, Li Qiu-Yan
Summary: The study showed promising outcomes of treating symptomatic bradyarrhythmia with Yuanjiang decoction, without serious adverse events. However, factors such as completing at least 8 weeks of treatment, presence of atrioventricular block, smoking status, and recent syncope may affect treatment outcomes.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Environmental Sciences
Hiba Muwafaq Saleem, Pushpamala Ramaiah, Jitendra Gupta, Abduladheem Turki Jalil, Noor Abdulaala Kadhim, Fahad Alsaikhan, Andres Alexis Ramirez-Coronel, Nahla A. Tayyib, Qingdong Guo
Summary: Lung cancer is a leading cause of death, and traditional treatments have not been effective in improving prognosis. Gene therapy and targeting molecular pathways have gained attention to combat lung cancer. Nanoparticles have emerged as an important tool in lung cancer treatment, enabling targeted drug and gene delivery and protecting against unwanted interactions. They also induce phototherapy and suppress metastasis and EMT to improve drug sensitivity. Understanding EMT in lung cancer is crucial due to its promotion of invasion, drug resistance, and radio-resistance. Non-coding RNAs and pharmacological compounds can regulate EMT, and EMT-TFs, like Twist and Slug, are discussed as important modulators in this review.
ENVIRONMENTAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Lijuan Guo, Wanjun Zhang, Xue Zhang, Jun Wang, Jiaqi Nie, Xiaomeng Jin, Ying Ma, Shi Wang, Xinhong Zhou, Yilei Zhang, Yan Xu, Yoshimasa Tanaka, Jingping Yuan, Xing-Hua Liao, Yiping Gong, Li Su
Summary: In this study, SIPA1 was found to function as a transcription factor that regulates the expression of genes involved in cell growth, differentiation, and response to environmental factors. Importin β1 was identified as an interacting partner of SIPA1 during fibronectin treatment. SIPA1's DNA-binding region (DBR) recognized and bound to a TGAGTCAB motif, and its transcriptional regulation was shown to be necessary for the migration and invasion of triple-negative breast cancer cells.
Article
Oncology
Shi-Lin Lv, Xu Zhou, Yuan-jun Li, Ling-yu Luo, De-Qiang Huang
Summary: RBMS3 plays an important role in inhibiting lung cancer cell proliferation, invasion, and migration. It is associated with poor prognosis and acts as a mediator in the AMPK-induced inhibition of lung cancer invasion and metastasis.
Article
Oncology
Mackenzie L. Davenport, John B. Echols, Austin D. Silva, Joshua C. Anderson, Philip Owens, Clayton Yates, Qing Wei, Shuko Harada, Douglas R. Hurst, Mick D. Edmonds
Summary: miR-31 demonstrates oncogenic properties in specific subtypes of lung cancer, highlighting its potential as a therapeutic target in these subtypes.
Article
Oncology
Favour A. Akinjiyan, Ritu M. Dave, Emily Alpert, Gregory D. Longmore, Katherine C. Fuh
Summary: Ovarian cancer is the most fatal gynecological disease, and the research discovered that the interaction between DDR2 receptor and periostin in cancer-associated fibroblasts promotes tumor metastasis. This study is crucial for understanding the molecular mechanisms underlying ovarian cancer metastasis.
Review
Engineering, Biomedical
Ozlem Sen, Melis Emanet, Gianni Ciofani
Summary: This review examines the use of nanomaterials in the detection and treatment of cancer metastasis, focusing on the impact of nanostructures on cell migration, invasion, and angiogenesis in the tumor microenvironment.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Biochemical Research Methods
Junho Lee, Donggu Lee, Sean Lawler, Yangjin Kim
Summary: This study investigates the mutual interactions between tumor cells and neutrophils in facilitating tumor invasion through a mathematical model. The model shows that tumor-associated neutrophils can enhance tumor cell invasion by secreting neutrophil elastase, reproducing major experimental observations and making important predictions for future experiments.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Agata Dutkowska, Bartosz Szmyd, Marcin Kaszkowiak, Daria Domanska-Senderowska, Dorota Pastuszak-Lewandoska, Ewa Brzezianska-Lasota, Jacek Kordiak, Adam Antczak
Summary: Tumours have the ability to avoid immune destruction and exhibit cancer-associated inflammation. The upregulation of interleukins IL-1 beta and IL-6 in non-small cell lung cancer (NSCLC) tissues suggests that inflammatory processes play a role in NSCLC, with a strong influence of smoking history on inflammation in tumourigenesis.
SCIENTIFIC REPORTS
(2021)
Review
Oncology
Chao Ma, Kang Hu, Irfan Ullah, Qing-Kang Zheng, Nan Zhang, Zhi-Gang Sun
Summary: This article reviews the underlying molecular mechanisms of the hedgehog signaling pathway in promoting malignant biological behaviors in lung cancer, and explores the potential of inhibitors or natural compounds in clinical applications for lung cancer therapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Jing Chen, Jingjing Sun, Qunfeng Wang, Yanze Du, Jie Cheng, Juan Yi, Bei Xie, Suya Jin, Gang Chen, Lina Wang, Xiaoyuan Wang, Hulai Wei
Summary: Functional loss or deletion of the tumor suppressor gene PTEN significantly enhances the proliferation, invasion, and metastasis of breast cancer cells. Inhibition of PTEN in the overall microenvironment also promotes the proliferation and metastasis of breast cancer cells. These findings suggest that PTEN mediates the proliferation, invasion, and metastasis of mouse breast cancer cells by regulating the PI3K-Akt signaling pathway.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Paiwan Buachan, Maneekarn Namsa-Aid, Hye Kyoung Sung, Chun Peng, Gary Sweeney, Wanlaya Tanechpongtamb
Summary: The study found that terrein has significant cytotoxic effects on human lung cancer cells, and can inhibit adhesion, migration, and invasion of lung cancer cells, as well as suppress the angiogenic processes. These effects may be mediated by reducing protein levels and inhibiting the metastatic processes of human lung cancer cells.
Article
Biotechnology & Applied Microbiology
Jun Li, Yongjuan Zhao, Jing Wang
Summary: This study investigated how miR-221-3p-containing extracellular vesicles regulate the functions of lung cancer cells through targeting HMBOX1, leading to enhanced proliferation, migration, and drug resistance. The findings suggest that miR-221-3p released by drug-resistant lung cancer cells can potentially activate the Akt/mTOR signaling pathway by inhibiting HMBOX1, promoting the progression of lung cancer.
CANCER GENE THERAPY
(2021)
Article
Plant Sciences
Guo-Sheng Liu, Zhao-Xin Zhang, Guo-zhu Su, Shang-Yi Wang, Cheng-Shuo Yang, Hai-Bo Yu, Ya-Nan Wang, Yong Li
Summary: Two new diterpenoids, dauricumins A and B, along with two known aromatic meroterpenoids, were isolated from the stems of Rhododendron dauricum using HPLC-MS-SPE-NMR combination strategy. The absolute configurations of the new compounds were determined through ECD calculations and CD spectrum analysis. One of the compounds showed an agonistic effect on the GABA(A) receptor in a membrane potential FLIPR assay.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2022)
Article
Plant Sciences
Yu-Zhuo Wu, Gui-Yang Xia, Huan Xia, Ling-Yan Wang, Ya-Nan Wang, Li Li, Hong-Cai Shang, Sheng Lin
Summary: In this study, the Seco and nor-seco isodhilarane-type meroterpenoids (SIMs and NSIMs) with highly congested polycyclic skeletons and broad bioactivities were investigated. The configuration revisions of some compounds were made through isolation, analysis, and empirical method based on C-13 NMR chemical shifts. Furthermore, a re-evaluation of the reported SIMs and NSIMs provided insights into determining the C-9 relative configuration. Biological assays showed that some compounds exhibited cytotoxic and hepatoprotective activities.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Biochemistry & Molecular Biology
Gui-Yang Xia, Dong-Jie Fang, Ling-Yan Wang, Huan Xia, Ya-Nan Wang, Hong-Cai Shang, Sheng Lin
Summary: Six new protoberberine derivatives, including yanhusanines H-L with a unique 13,13a-seco skeleton, were isolated from Corydalis yanhusuo tubers. Among them, yanhusanine J showed potent inhibitory effect against nitric oxide production and anti-inflammatory activity by suppressing NF-kappa B pathway. Molecular docking analysis suggested strong interaction of yanhusanine J with iNOS protein.
Editorial Material
Psychiatry
Zeng Jie Ye
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychology, Multidisciplinary
Xiao Xiao Mei, Hui Yuan Wang, Xiao Na Wu, Jie Yi Wu, Ying Zi Lu, Zeng Jie Ye
Summary: This study aimed to examine the associations between self-efficacy and professional identity. The findings from a survey of 1,051 freshmen nursing students suggested that self-efficacy, resilience, and role models may be three important factors influencing professional identity in this group. Further validation is needed through longitudinal or interventional studies.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Oncology
Liang Mu Zi, Tang Ying, M. Tish Knobf, Alex Molassiotis, Chen Peng, Hu Guang Yun, Sun Zhe, Yu Yuan Liang, Ye Zeng Jie
Summary: This study aimed to develop a new prediction model for estimating the probability of decreased quality of life in breast cancer patients. The results showed that the Resilience Index (RI) improved the prediction accuracy above conventional risk factors. The new model demonstrated good calibration ability in both internal and external cohorts.
JOURNAL OF CANCER SURVIVORSHIP
(2023)
Article
Plant Sciences
Zhenjie Zhuang, Dan Huang, Zhou Rui Sheng, Haimei Jiang, Zeng Jie Ye, Yi Yuan, Binyu Qin, Yan Zhao, Hua-Feng Pan, Ying Tang
Summary: The present study aimed to investigate the pharmacological mechanisms involved in treating non-small cell lung cancer (NSCLC) with Xihuang Pill (XHP), a representative anticancer Chinese patented medicine. XHP was found to suppress cancer cell growth in NSCLC by regulating pathways associated with cell proliferation and immunity. In addition, XHP may increase the expression of CACNA1C to suppress immune cell infiltration and regulate the expression of checkpoint-related genes, thereby improving the overall survival of NSCLC patients.
Article
Chemistry, Medicinal
Peng Chen, Ning-yu Huang, Bo Pang, Zeng-jie Ye, Rui-xi Luo, Chang Liu, Qian Gong, Chen Wang, Long Wang
Summary: In this study, the mechanisms underlying the pain-relief effects of emodin in the cerebral cortex were investigated using proteomic and metabolomic approaches. The results showed that emodin treatment could reverse chronic constriction injury-induced hyperalgesia and alleviate neuropathic pain mainly through regulating the GABAergic pathway and PI3K/AKT/NF-kappa B pathway.
PHYTOTHERAPY RESEARCH
(2023)
Article
Nursing
Muzi Liang, Peng Chen, Alex Molassiotis, Sangchoon Jeon, Ying Tang, Guangyun Hu, Yunfei Zhu, Zhe Sun, Yuanling Yu, Tish M. Knobf, Zengjie Ye
Summary: This study examined the measurement invariance of the 10-Item Resilience Scale (RS-SC-10) in American and Chinese cancer patients using propensity score-based multidimensional item response theory analysis. The results identified partial measurement invariance between the two groups, but the RS-SC-10 remains a critical indicator for emotional distress in cancer care.
ASIA-PACIFIC JOURNAL OF ONCOLOGY NURSING
(2023)
Article
Nursing
Shuhan Li, Yuan Liao, Xiaona Wu, Xiaoxiao Mei, Yihao Zeng, Jiahua Wu, Zengjie Ye
Summary: The study aimed to investigate the mediation role of perceived stress between nonrestorative sleep and emotional distress, as well as the moderation role of resilience among these factors in university students. The results revealed that perceived stress significantly mediated the relationship between nonrestorative sleep and emotional distress, while resilience did not significantly moderate the associations among these factors.
PERSPECTIVES IN PSYCHIATRIC CARE
(2023)
Article
Geriatrics & Gerontology
Minyu Liang, Xiyan Xie, Yichao Pan, Andy S. K. Cheng, Zengjie Ye
Summary: This study aimed to gain a deeper comprehension of how caregivers preserve patients' dignity by analyzing qualitative evidence from the perspective of caregivers. The findings revealed that dignity has both inherent and external dimensions, and caregiver-patient relationships play a crucial role in linking the inherent dimension of dignity with its external dimension.
Editorial Material
Psychiatry
Zeng Jie Ye
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychiatry
Mu Zi Liang, Peng Chen, M. Tish Knobf, Alex Molassiotis, Ying Tang, Guang Yun Hu, Zhe Sun, Yuan Liang Yu, Zeng Jie Ye
Summary: This study aimed to measure resilience using advanced Cognitive Diagnosis Models (CDMs) and predict the 6-month Quality of Life (QoL) in breast cancer patients. The results showed that cognitive diagnostic probabilities (CDPs) improved the accuracy of predicting 6-month QoL compared to conventional total score. CDMs can help optimize Patient Reported Outcomes (PROs) measurement in breast cancer.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Oncology
Mu Zi Liang, Mei Ling Liu, Ying Tang, Alex Molassiotis, M. Tish Knobf, Peng Chen, Guang Yun Hu, Zhe Sun, Yuan Liang Yu, Zeng Jie Ye
Summary: This study aimed to explore the impact of a new cancer diagnosis on patients' resilience and whether resilience patterns could predict Quality of Life (QoL) in the first year. Results showed five discrete resilience trajectories with two growing trends, and advanced stage, colorectal cancer, and receiving surgery therapy were significant predictors of negative resilience trajectories.
EUROPEAN JOURNAL OF ONCOLOGY NURSING
(2023)
Article
Nursing
Yingxuan Gu, Fenggui Bie, Meixia Hu, Linfeng Huang, Jiaping Chen, Xiaohui Hu, Caixia Luo, Zengjie Ye
Summary: This study investigated the association between social support and resilience, coping style, and posttraumatic growth in breast cancer patients. The findings revealed the existence of three subtypes of social support in breast cancer patients, and social support, resilience, and coping style were positively correlated with posttraumatic growth. Resilience played a significant mediating role in the association between social support and posttraumatic growth, while coping style did not significantly moderate the association between resilience and posttraumatic growth.
PERSPECTIVES IN PSYCHIATRIC CARE
(2023)
