Article
Biochemistry & Molecular Biology
Shanshan Chen, Yu Song, Huimin Wu, Honglin Ge, Wenzhang Qi, Yue Xi, Jiayi Wu, Yuxiang Ji, Kexin Chen, Xingjian Lin, Jiu Chen
Summary: In patients with amnestic mild cognitive impairment (aMCI), anosognosia is associated with increased tau accumulation in specific brain regions, disrupted functional connectivity, and accelerates progression to Alzheimer's disease dementia.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Medicine, General & Internal
Yu-Kai Lin, Chih-Sung Liang, Chia-Kuang Tsai, Chia-Lin Tsai, Jiunn-Tay Lee, Yueh-Feng Sung, Chung-Hsing Chou, Hung-Sheng Shang, Bing-Heng Yang, Guan-Yu Lin, Ming-Wei Su, Fu-Chi Yang
Summary: This study assessed the potential of 36 trace elements in predicting cognitive decline in patients with amnestic mild cognitive impairment (aMCI) or Alzheimer's disease (AD). The study found that disease severity was linked to lower plasma levels of certain trace elements, and baseline levels of certain trace elements were associated with the rate of cognitive decline.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Geriatrics & Gerontology
Eun Jin Yoon, Jun-Young Lee, Seyul Kwak, Yu Kyeong Kim
Summary: Mild behavioral impairment (MBI) is a neurobehavioral syndrome associated with a higher risk of progression to Alzheimer's disease (AD) in individuals with amnestic mild cognitive impairment (MCI). The presence of multiple MBI domains is also associated with cortical thinning in specific brain regions.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Cell Biology
Ying-Ren Chen, Chih-Sung Liang, Hsin Chu, Joachim Voss, Xiao Linda Kang, Grant O'Connell, Hsiu-Ju Jen, Doresses Liu, Shu-Tai Shen Hsiao, Kuei-Ru Chou
Summary: Blood-based biomarkers have shown high diagnostic accuracy for detecting Alzheimer's disease, with plasma A beta 42, A beta oligomer, and plasma tau demonstrating good sensitivity and specificity. However, evidence for detecting amnestic mild cognitive impairment using blood-based biomarkers is still limited. Ultra-high sensitive technology can help explain the heterogeneity in diagnostic performance.
AGEING RESEARCH REVIEWS
(2021)
Article
Clinical Neurology
Yuting Nie, Changbiao Chu, Qi Qin, Huixin Shen, Lulu Wen, Yi Tang, Miao Qu
Summary: This study identified significant differences in lipid metabolism between Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI) patients compared to normal controls (NC). Three sphingomyelin (SPH) biomarkers were found to effectively distinguish AD and aMCI patients from NC. Additionally, AD patients exhibited elevated oxidative stress, and there were complex interactions between lipid metabolites and oxidative stress.
Article
Neurosciences
Sandra Cardoso, Dina Silva, Luisa Alves, Manuela Guerreiro, Alexandre de Mendonca
Summary: Amyloid-negative aMCI is a heterogeneous condition, with some patients remaining stable for long periods of time while others may later develop psychiatric conditions or other neurodegenerative disorders.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Immunology
Wenjuan Rui, Hong Xiao, Yi Fan, Zhongxuan Ma, Ming Xiao, Sheng Li, Jingping Shi
Summary: The study revealed that canonical inflammasome signaling and GSDMD-induced pyroptosis were activated in PBMCs of aMCI and AD patients. Additionally, the proinflammatory cytokine IL-1 beta was strongly associated with the pathophysiology of aMCI and AD.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Neurosciences
Kentaro Hirao, Fumio Yamashita, Akito Tsugawa, Rieko Haime, Raita Fukasawa, Tomohiko Sato, Hidekazu Kanetaka, Takahiko Umahara, Hirofumi Sakurai, Haruo Hanyu, Soichiro Shimizu
Summary: The study investigated the association between WMH progression and cognitive decline in amnestic MCI patients. Results showed that an increase in DWMH volume was significantly correlated with a decline in frontal lobe function and semantic memory, suggesting that WMH progression might affect some AD pathophysiologies in amnestic MCI patients.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Clinical Neurology
Alessandro Galgani, Francesco Lombardo, Nicola Martini, Andrea Vergallo, Luca Bastiani, Harald Hampel, Hana Hlavata, Filippo Baldacci, Gloria Tognoni, Daniele De Marchi, Irene Ghicopulos, Sara De Cori, Francesca Biagioni, Carla Letizia Busceti, Roberto Ceravolo, Ubaldo Bonuccelli, Dante Chiappino, Gabriele Siciliano, Francesco Fornai, Nicola Pavese, Filippo Sean Giorgi
Summary: This study used LC-MRI to investigate the involvement of the pontine nucleus Locus Coeruleus (LC) in Alzheimer's disease progression and its association with prognosis and cognitive performance in amnestic Mild Cognitive Impairment. The findings suggest that reductions in LC-MRI parameters may be predictive of clinical progression in Mild Cognitive Impairment and support the role of LC degeneration in the continuum of Alzheimer's disease.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Immunology
Erin E. Sundermann, Mark W. Bondi, Laura M. Campbell, Ben Gouaux, Raeanne C. Moore, Virawudh Soontornniyomkij, David J. Moore
Summary: This study aimed to distinguish aMCI from HAND in PWH using a neuropsychological method, finding a higher prevalence of high aMCI risk in the HAND group, with beta-amyloid pathology being associated with high aMCI risk, while phospho-Tau pathology did not differ by aMCI classification.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Min Young Chun, Geon Ha Kim, Hee Kyung Park, Dong Won Yang, SangYun Kim, Seong Hye Choi, Jee Hyang Jeong
Summary: This study aimed to develop a new predictive scale for amyloid positron emission tomography (PET) positivity using easily accessible tools. The results showed that verbal and visual memory tests, medial temporal lobe atrophy, apolipoprotein E (APOE) genotype, and age were significant predictors of A beta deposition. The new predictive scale performed well in the validation cohort.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Geriatrics & Gerontology
Nena Lejko, Shankar Tumati, Esther M. Opmeer, Jan-Bernard C. Marsman, Fransje E. Reesink, Peter P. De Deyn, Andre Aleman, Branislava Curcic-Blake
Summary: The impaired planning ability in individuals with amnestic mild cognitive impairment (aMCI) is associated with lower activation in a diffuse cortico-thalamic network. Higher planning-related activity is related to better memory performance.
EXPERIMENTAL GERONTOLOGY
(2022)
Article
Neurosciences
Hyejin Ahn, Dahyun Yi, Kyungjin Chu, Haejung Joung, Younghwa Lee, Gijung Jung, Kiyoung Sung, Dongkyun Han, Jun Ho Lee, Min Soo Byun, Dong Young Lee
Summary: This study investigated the neural correlates of semantic verbal fluency test (SVFT) scores in subjects with mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia using FDG-PET. The results showed that the total score (TS) of SVFT was positively correlated with cerebral glucose metabolism in various brain regions. However, the strategy scores of switching (SW) and cluster switching (CSW) were found to be better indicators of specific language and executive functions. Furthermore, the associations between strategy scores and regional glucose metabolism varied based on the severity of the disease.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Clinical Neurology
Giacomo Tondo, Giulia Carli, Roberto Santangelo, Maria Vittoria Mattoli, Luca Presotto, Massimo Filippi, Giuseppe Magnani, Sandro Iannaccone, Chiara Cerami, Daniela Perani
Summary: In a large cohort of aMCI subjects, using in vivo biomarkers such as cerebrospinal fluid measures and [F-18]fluorodeoxyglucose (FDG)-positron emission tomography (PET) imaging can accurately predict the prognosis of patients. The specific [F-18]FDG-PET limbic-predominant hypometabolism pattern is associated with clinical stability and low likelihood of progression to Alzheimer's disease, providing important implications for prognosis and clinical trial planning.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Geriatrics & Gerontology
Martina Laczo, Ondrej Lerch, Lukas Martinkovic, Jana Kalinova, Hana Markova, Martin Vyhnalek, Jakub Hort, Jan Laczo
Summary: This study found that older adults with AD aMCI had poorer spatial pattern separation performance compared to non-AD aMCI and CN groups. The decreased volume of BF Ch1-2 nuclei indirectly influenced performance by reducing hippocampal and EC subregions volumes.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Clinical Neurology
Christian Sandoe Musaeus, Louise Baruel Johansen, Steen Hasselbalch, Nina Beyer, Peter Hogh, Hartwig Roman Siebner, Kristian Steen Frederiksen
Summary: This study aimed to investigate the effect of aerobic exercise on functional connectivity in the default mode network (DMN) in patients with Alzheimer's disease (AD). The results showed that 16 weeks of aerobic exercise did not modify functional connectivity in the posterior cingulate cortex (PCC)/precuneus region of patients with AD. Longer intervention may be needed to demonstrate the effect of exercise on brain connectivity.
CURRENT ALZHEIMER RESEARCH
(2022)
Review
Neurosciences
Mariana Vargas-Caballero, Hannah Warming, Robert Walker, Clive Holmes, Garth Cruickshank, Bipin Patel
Summary: Cognitive dysfunction in Alzheimer's disease is caused by disturbances in neuronal circuits and can be improved by vagal nerve stimulation, which enhances synaptic plasticity and reduces inflammatory signaling. Non-invasive VNS shows promise as a therapy for early AD, but further research is needed to determine its effectiveness and compare it with invasive VNS.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Daniele Altomare, Lyduine Collij, Camilla Caprioglio, Philip Scheltens, Bart N. M. van Berckel, Isadora Lopes Alves, Johannes Berkhof, Yvonne de Gier, Valentina Garibotto, Christian Moro, Lea Poitrine, Julien Delrieu, Pierre Payoux, Laure Saint-Aubert, Jose Luis Molinuevo, Oriol Grau-Rivera, Juan-Domingo Gispert, Carolina Minguillon, Karine Fauria, Marta Felez Sanchez, Andreea Radoi, Alexander Drzezga, Frank Jessen, Claus Escher, Philip Zeyen, Agneta Nordberg, Irina Savitcheva, Vesna Jelic, Zuzana Walker, Ho-Yun Lee, Lean Lee, Jean-Francois Demonet, Sonia Plaza Wuthrich, Rossella Gismondi, Gill Farrar, Frederik Barkhof, Andrew W. Stephens, Giovanni B. Frisoni
Summary: The AMYPAD Diagnostic and Patient Management Study aims to investigate the clinical utility and cost-effectiveness of amyloid-PET in Europe. Participants with subjective cognitive decline, mild cognitive impairment, or dementia were recruited in eight European memory clinics and randomized into three study arms. The baseline features of the participants were representative of a memory clinic population, ensuring the generalizability of the study results.
ALZHEIMERS & DEMENTIA
(2023)
Article
Medicine, Research & Experimental
Karen Hoang, Hilary Watt, Mara Golemme, Richard J. Perry, Craig Ritchie, Danielle Wilson, James Pickett, Chris Fox, Robert Howard, Paresh A. Malhotra
Summary: The NorAD trial aims to evaluate the effects of guanfacine in combination with cholinesterase inhibitors on cognition, attention, and other cognitive measures, neuropsychiatric symptoms, caregiver burden, and activities of daily living in individuals with mild to moderate Alzheimer's disease.
Editorial Material
Gastroenterology & Hepatology
Andrea Cherubini, James E. East
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Medical Laboratory Technology
Camilla Steen Jensen, Helena Sophia Gleerup, Christian Sandoe Musaeus, Steen Gregers Hasselbalch, Peter Hogh, Gunhild Waldemar, Anja Hviid Simonsen
Summary: This study examined the levels of glucose in the cerebrospinal fluid (CSF) and plasma, as well as the CSF/plasma glucose ratio, in a large cohort from a mixed memory clinic population. The results showed that these measures were not able to differentiate between healthy controls and patients with different types of dementia disorders.
CLINICAL BIOCHEMISTRY
(2023)
Article
Clinical Neurology
Kasper Jorgensen, Thomas Rune Nielsen, Ann Nielsen, Frans Boch Waldorff, Peter Hogh, Hanne Gottrup, Karsten Vestergaard, Anne-Britt Oxboll, Gunhild Waldemar
Summary: The psychometric properties of the Brief Assessment of Impaired Cognition (BASIC) case-finding instrument were examined in clinical settings. The study found that BASIC has high test-retest reliability and discriminative validity for identification of Alzheimer disease (AD) dementia and non-AD dementia. BASIC performance is significantly associated with cognitive impairment and may be superior to Mini-Mental State Examination (MMSE) for staging of impairment.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Neurosciences
Kristian Steen Frederiksen, Camilla Steen Jensen, Peter Hogh, Robert Gergelyffy, Gunhild Waldemar, Birgitte Bo Andersen, Hanne Gottrup, Karsten Vestergaard, Lene Wermuth, Helle Bach Sondergaard, Finn Sellebjerg, Steen Gregers Hasselbalch, Anja Hviid Simonsen
Summary: This study aimed to investigate whether a 16-week aerobic exercise program could reduce serum NfL in patients with mild Alzheimer's disease. The results showed that the exercise intervention did not have a significant effect on neurodegeneration. Further studies are needed to explore other types and durations of exercise as well as other measures of neurodegeneration.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Mikkel Pejstrup Agger, Else Rubaek Danielsen, Marcus Schultz Carstensen, N. Mai Nguyen, Maibritt Horning, Mark Alexander Henney, Christopher Boe Ravn Jensen, Anders Ohlhues Baandrup, Troels Wesenberg Kjaer, Kristoffer Hougaard Madsen, Kamilla Miskowiak, Paul Michael Petersen, Peter Hogh
Summary: This study investigated the potential therapeutic effect of 40 Hz neural activity on Alzheimer's disease. The results showed that treatment with 40 Hz Invisible Spectral Flicker (ISF) had no significant safety or adherence concerns, and there was a tendency towards improvement in cognition. However, further large-scale clinical trials are needed to validate the effect on hippocampal and ventricular volume.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Review
Biotechnology & Applied Microbiology
Andrea Cherubini, Nhan Ngo Dinh
Summary: Artificial intelligence has the potential to improve decision making in endoscopy by assisting in the process and avoiding inconsistent judgments. The performance assessment of AI-powered medical devices, such as GI Genius, involves a combination of bench tests, controlled trials, and studies on the interaction between physicians and AI. The transparency of the algorithm architecture and the data used for training the AI device contributes to its potential impact on clinical practice by providing a clear understanding of its capabilities.
BIOENGINEERING-BASEL
(2023)
Article
Clinical Neurology
Steen Gregers Hasselbalch, Jonathan Frederik Carlsen, Mohamed Moussa Alaouie, Tina Norgaard Munch, Anders Vedel Holst, Sarah Taudorf, Christina Rorvig-Loppentien, Marianne Juhler, Gunhild Waldemar
Summary: This study aimed to investigate the predictive power of prognostic tests and biomarkers in idiopathic normal pressure hydrocephalus (iNPH). A total of 127 iNPH patients were included and evaluated using clinical, neuroimaging, and lumbar infusion test parameters. The results showed that 82% of the patients had a positive response during follow-up, and gait impairment was more severe in responders. Although infusion test parameters performed modestly, pulse amplitude measures showed promising results that require further exploration.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Neurosciences
Christian Sandoe Musaeus, Kristian Steen Frederiksen, Birgitte Bo Andersen, Peter Hogh, Preben Kidmose, Martin Fabricius, Melita Cacic Hribljan, Martin Christian Hemmsen, Mike Lind Rank, Gunhild Waldemar, Troels Wesenberg Kjaer
Summary: In this study, it was found that most patients with Alzheimer's disease (AD) had epileptiform discharges, with a three-fold higher frequency compared to healthy elderly controls (HC), which most likely originated from the temporal lobes. This result suggests that elevated spike frequency should be considered a marker of hyperexcitability in AD.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Geriatrics & Gerontology
Mikkel Pejstrup Agger, Maibritt Horning, Marcus Schultz Carstensen, Else Rubaek Danielsen, Anders Olhues Baandrup, Mai Nguyen, Peter Hogh, Kamilla Miskowiak, Paul Michael Petersen, Kristoffer Hougaard Madsen, Troels Wesenberg Kjaer
Summary: This article introduces a novel treatment method for patients with Alzheimer's disease (AD) - light-based 40 Hz brain stimulation. The clinical trial aims to evaluate the efficacy and safety of this treatment and measure the effect through a comprehensive assessment battery.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Clinical Neurology
Kasper Jorgensen, Thomas Rune Nielsen, Ann Nielsen, Frans Boch Waldorff, Peter Hogh, Hanne Gottrup, Karsten Vestergaard, Anne-Britt Oxboll, Gunhild Waldemar
Summary: This study validates the reliability and validity of the Brief Assessment of Impaired Cognition (BASIC) in clinical settings, showing significant association with the degree of cognitive impairment and superiority over MMSE for staging impairment.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Neurosciences
Helena Sophia Gleerup, Anja Hviid Simonsen, Peter Hogh
Summary: The added value of CSF NfL does not improve the accuracy of etiological diagnoses, but enhances diagnostic certainty for neurology specialists.
JOURNAL OF ALZHEIMERS DISEASE REPORTS
(2022)