Article
Biochemistry & Molecular Biology
Carol Dangelmaier, Benjamin Mauri, Akruti Patel, Satya P. Kunapuli, John C. Kostyak
Summary: Platelet functional disorder associated with P2Y12 receptor mutation was identified in a human subject. Knock-in mouse model confirmed the essential role of aspartic acid residue in P2Y12 function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Angela Dziedzic, Elzbieta Miller, Joanna Saluk-Bijak, Marta Niwald, Michal Bijak
Summary: Epidemiological studies confirm a high risk of ischemic events in secondary-progressive multiple sclerosis (SP MS) patients, which is directly associated with an increased level of pro-thrombotic activity of platelets. The study demonstrated enhanced platelet reactivity in response to adenosine diphosphate (ADP) in SP MS patients compared to controls, suggesting a potential molecular basis for the elevated risk of thromboembolism in MS. Identifying the molecular abnormalities of the platelet P2Y(12) receptor expression and functionality could contribute to the development of prevention and targeted treatment strategies for cardiovascular disorders in MS patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Belal O. O. Al-Najjar, Manal A. A. Abbas, Obada A. A. Sibai, Fadi G. G. Saqallah, Aya Y. Y. Al-Kabariti
Summary: P2Y(12) plays a key role in platelet aggregation and thrombus formation. P2Y(12) antagonists have become of great interest in antithrombotic therapy. In this study, a structure-based pharmacophore model of P2Y(12) was explored, and a predictive QSAR equation was created using genetic algorithm and multiple linear regression analyses. The equation was validated and used to screen compounds from a database, resulting in promising hits.
RSC MEDICINAL CHEMISTRY
(2023)
Article
Hematology
Christina C. Rolling, Marcin A. Sowa, Tricia T. T. Wang, MacIntosh Cornwell, Khrystyna Myndzar, Tamar Schwartz, Hanane El Bannoudi, Jill Buyon, Tessa J. Barrett, Jeffrey S. Berger
Summary: Monocyte-platelet aggregates (MPAs) play a role in the intersection of thrombosis and inflammation, and targeting this axis could suppress thromboinflammation. The effect of platelets on monocyte activation and the impact of antiplatelet therapy (APT) on MPA and platelet-induced monocyte activation were analyzed.
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Multidisciplinary Sciences
Jeffrey Chidester, Daniel Bennett, Chris Mathew, Tiffany Denkins, Rebecca Vigen, Tayo Addo, Sandeep Das
Summary: A telephone-based reminder system was developed to improve DAPT adherence post-PCI, leading to directed interventions in nearly 1 in 10 patients contacted. However, the system did not significantly improve PDC levels compared to a contemporary sample, highlighting the ongoing difficulty in detecting barriers to adherence.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Chih-Chin Shih, Melissa Chan, Nicholas S. Kirkby, Ivana Vojnovic, Jane A. Mitchell, Paul C. Armstrong, Timothy D. Warner
Summary: The study demonstrates a synergistic relationship between P2Y(12) receptor antagonists and adenosine signaling, with their efficacy partly dependent on the presence of endogenous adenosine. Despite reported differences in their effects upon adenosine reuptake, both prasugrel and ticagrelor show similar synergistic effects on platelet inhibition in the presence of adenosine or NECA.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Immunology
Paula Alvarenga Borges, Ingrid Waclawiak, Janaina Lima Georgii, Vanderlei da Silva Fraga-Junior, Janaina Figueiredo Barros, Felipe Simoes Lemos, Thais Russo-Abrahao, Elvira Maria Saraiva, Christina M. Takiya, Robson Coutinho-Silva, Carmen Penido, Claudia Mermelstein, Jose Roberto Meyer-Fernandes, Fabio B. Canto, Josiane Sabbadini Neves, Paulo A. Melo, Claudio Canetti, Claudia Farias Benjamim
Summary: The study investigated the role of ADP in wound healing in diabetic patients, showing that ADP accelerated wound healing, improved new tissue formation, reduced ROS production, and increased the count of specific cell types in the wound. The effects of ADP were mainly mediated by P2Y(12) receptor activation, with the involvement of P2Y(1) receptor in the early stages of the repair process.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Yasushi Ueki, Thomas Zanchin, Sylvain Losdat, Alexios Karagiannis, Tatsuhiko Otsuka, George C. M. Siontis, Jonas Haener, Stefan Stortecky, Thomas Pilgrim, Marco Valgimigli, Stephan Windecker, Lorenz Raeber
Summary: The study aimed to evaluate the prevalence of non-adherence to P2Y12 inhibitors in cardiovascular clinical trials and its impact on clinical outcomes. Findings showed that non-adherence was observed in nearly one-fifth of patients, associated with worse clinical outcomes, and risk related to underlying contexts.
Article
Multidisciplinary Sciences
Yohei Sotomi, Yuki Matsuoka, Shungo Hikoso, Daisaku Nakatani, Katsuki Okada, Tomoharu Dohi, Hirota Kida, Bolrathanak Oeun, Akihiro Sunaga, Taiki Sato, Tetsuhisa Kitamura, Yasushi Sakata
Summary: This study evaluated the effectiveness of P2Y12 inhibitor monotherapy compared to conventional dual antiplatelet therapy in patients undergoing complex and non-complex percutaneous coronary intervention (PCI). The results showed that P2Y12 inhibitor monotherapy was associated with a lower risk of adverse clinical events in patients undergoing complex PCI, and a trend towards lowering the risk in patients undergoing non-complex PCI.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Brenden S. Ingraham, Michael E. Farkouh, Ryan J. Lennon, Derek So, Shaun G. Goodman, Nancy Geller, Jang-Ho Bae, Myung Ho Jeong, Linnea M. Baudhuin, Verghese Mathew, Malcolm R. Bell, Amir Lerman, Yi-Ping Fu, Ahmed Hasan, Erin Iturriaga, Jean-Francois Tanguay, Robert C. Welsh, Yves Rosenberg, Kent Bailey, Charanjit Rihal, Naveen L. Pereira
Summary: Genetic-guided P2Y12 inhibitor selection can reduce the risk of ischemic events in CYP2C19 LOF carriers treated with clopidogrel after PCI. A prespecified analysis of the TAILOR-PCI study evaluated the effect of genetic-guided P2Y12 inhibitor therapy on cumulative ischemic and bleeding events.
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Agriculture, Multidisciplinary
Yijie Yang, Bo Li
Summary: Collagen peptide DEGP was found to inhibit platelet aggregation and thrombus formation, and regulate phosphorylation processes by antagonizing TP and P2Y12 receptors. Among them, DEGI exhibited the strongest inhibitory activity against platelet aggregation and antithrombotic activity.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Cardiac & Cardiovascular Systems
Ricky D. Turgeon, Sheri L. Koshman, Yuan Dong, Michelle M. Graham
Summary: This study evaluated P2Y(12) inhibitor adherence trajectories among ACS patients treated with PCI and found five distinct trajectories. Rapid decline and delayed initiation were associated with higher MACE risk overall, while early consistent non-adherence was only associated with higher MACE risk in patients with stents.
EUROPEAN HEART JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Larisa H. H. Cavallari, Nita A. A. Limdi, Amber L. L. Beitelshees, James C. C. Lee, Julio D. D. Duarte, Francesco Franchi, Sony Tuteja, Jay Giri, Philip E. E. Empey, Rolf P. P. Kreutz, Todd C. C. Skaar, John M. M. Allen, James C. C. Coons, Yan Gong, Caitrin W. W. McDonough, James M. M. Stevenson, Cameron D. D. Thomas, Julie A. A. Johnson, George A. A. Stouffer, Dominick J. J. Angiolillo, Craig R. Lee
Summary: Black patients and White patients have similar rates of P2Y(12) inhibitor prescribing after genotype-guided antiplatelet therapy selection following percutaneous coronary intervention (PCI).
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Pharmacology & Pharmacy
Arun Kumar, Pamela L. Lutsey, Wendy L. St. Peter, Jon C. Schommer, Jeremy R. Van't Hof, Abhijeet Rajpurohit, Joel F. Farley
Summary: In acute coronary syndrome following percutaneous coronary intervention, newer P2Y12 inhibitors (ticagrelor and prasugrel) reduce cardiovascular outcomes compared to clopidogrel, but have a higher bleeding risk. This study examines the safety of each inhibitor in a real-world population.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Hematology
Jinxiang Piao, Chaeyoung Yoo, SunYoung Kim, Youn-Wha Whang, Sehyun Shin, Cheol Ung Choi
Summary: This study compared the performance of the Anysis-P2Y12 assay system with VerifyNow-P2Y12 in cardiac patients, revealing that Anysis-P2Y12 showed similar sensitivity and specificity to VerifyNow-P2Y12 but had a noticeable difference in the low-response rate to P2Y12.
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
(2021)
Review
Cardiac & Cardiovascular Systems
Kriyana P. P. Reddy, Peter W. W. Groeneveld, Jay Giri, Alexander C. C. Fanaroff, Ashwin S. S. Nathan
Summary: TAVR has significantly improved the treatment of aortic stenosis in the United States, but the high costs and unequal resource allocation have resulted in limited access for certain patient populations, particularly people of color and those who are socioeconomically disadvantaged.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2022)
Letter
Cardiac & Cardiovascular Systems
Timothy M. Markman, Emily Folse, Lin Yang, Peter W. Groeneveld, David S. Frankel
Article
Cardiac & Cardiovascular Systems
Sameed Ahmed M. Khatana, Rachel M. Werner, Peter W. Groeneveld
Summary: Extreme-heat events are associated with higher cardiovascular mortality rates among adults in the United States, with a greater impact on men, non-Hispanic Black individuals, and the elderly.
Article
Anesthesiology
Emily J. MacKay, Bo Zhang, Mark D. Neuman, John G. Augoustides, Nimesh D. Desai, Peter W. Groeneveld
Summary: This study aims to identify and quantify the predictors of intraoperative transesophageal echocardiography (TEE) use in cardiac valve or isolated coronary artery bypass graft (CABG) surgery. The results show that the hospital where the surgery occurs and TEE staffing are important factors influencing the use of TEE.
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2022)
Article
Cardiac & Cardiovascular Systems
Lauren A. Eberly, Howard Julien, Eugenia C. South, Atheendar Venkataraman, Ashwin S. Nathan, Emeka C. Anyawu, Elias Dayoub, Peter W. Groeneveld, Sameed Ahmed M. Khatana
Summary: The study revealed that a decrease in violent crime rates at the community level in Chicago was associated with a decrease in cardiovascular and coronary artery disease mortality rates, suggesting a potential impact of violent crime exposure on cardiovascular health.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Chase R. Brown, Alexandra E. Sperry, William G. Cohen, Jason J. Han, Fabliha Khurshan, Peter Groeneveld, Nimesh Desai
Summary: Guidelines have conflicting opinions on whether or not to use vitamin K antagonists (VKA) after mitral valve repair (MVr) to reduce the risk of cerebral embolic events. An observational study found that VKA does not decrease the risk of cerebral embolic events after MVr, but is associated with an increased risk of major bleeding events.
ANNALS OF THORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Austin S. Kilaru, Nicholas Illenberger, Zachary F. Meisel, Peter W. Groeneveld, Manqing Liu, Angira Mondal, Nandita Mitra, Raina M. Merchant
Summary: Few patients obtain timely outpatient follow-up after being discharged from the emergency department for acute heart failure, and nearly 20% require hospitalization within 30 days. Improving transitions following discharge may present an opportunity to improve outcomes for patients with acute heart failure.
CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES
(2022)
Article
Cardiac & Cardiovascular Systems
Joshua B. Goldberg, Jay Giri, Taisei Kobayashi, Marc Ruel, Alexander J. C. Mittnacht, Belinda Rivera-Lebron, Abe DeAnda, John M. Moriarty, Thomas E. MacGillivray
Summary: Acute pulmonary embolism is a major cause of cardiovascular death, especially when it leads to acute right ventricular failure. Current guideline-directed therapy for hemodynamically compromised patients with pulmonary embolism has limited effectiveness in reducing mortality. Surgical embolectomy, once considered a last resort, has shown promising outcomes in treating acute pulmonary embolism, particularly in patients with hemodynamic instability. This document aims to describe modern surgical techniques, strategies, and outcomes, as well as suggest ways to further explore the role of surgery in the management of pulmonary embolisms.
Article
Cardiac & Cardiovascular Systems
Ashwin S. Nathan, Kriyana P. Reddy, Lin Yang, Lauren A. Eberly, Elias J. Dayoub, Sameed A. M. Khatana, Howard M. Julien, Nimesh D. Desai, Wilson Y. Szeto, Howard C. Herrmann, Taisei J. Kobayashi, Paul Fiorilli, Wayne B. Batchelor, Roxana Mehran, Mohamad Adnan Alkhouli, Jay Giri, Peter W. Groeneveld, Alexander C. Fanaroff
Summary: Racial and ethnic minority and socioeconomically disadvantaged patients are underrepresented in clinical trials. Efforts to enhance inclusion of minority groups have focused on participating sites, but there may be differences in patient populations.
Article
Cardiac & Cardiovascular Systems
Howard M. Julien, Yongfei Wang, Jeptha P. Curtis, Hillary Johnston-Cox, Lauren A. Eberly, Grace J. Wang, Ashwin S. Nathan, Alexander C. Fanaroff, Sameed Ahmed M. Khatana, Peter W. Groeneveld, Eric A. Secemsky, Nwamaka D. Eneanya, Amit N. Vora, Taisei Kobayashi, Carlos Barbery, Godefroy Chery, Maureen Kohi, Lee Kirksey, Ehrin J. Armstrong, Michael R. Jaff, Jay Giri
Summary: This study evaluates the impact of race on device use and outcomes among patients undergoing lower extremity peripheral arterial intervention. The results show that Black patients are younger, have higher comorbidity rates, and lower socioeconomic status, with lower rates of surgical treatment and repeat revascularization compared to White patients after the index procedure.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Kriyana P. Reddy, Lauren A. Eberly, Rim Halaby, Howard Julien, Sameed Ahmed M. Khatana, Elias J. Dayoub, Megan Coylewright, Mohamad Alkhouli, Paul N. Fiorilli, Taisei J. Kobayashi, David M. Goldberg, Pasquale Santangeli, Howard C. Herrmann, Jay Giri, Peter W. Groeneveld, Alexander C. Fanaroff, Ashwin S. Nathan
Summary: This study examined the characteristics of US hospitals that established left atrial appendage occlusion (LAAO) programs and the patient populations they served. It also investigated the associations between zip code-level racial, ethnic, and socioeconomic composition and rates of LAAO among Medicare beneficiaries in metropolitan areas. The study found that LAAO programs were concentrated in metropolitan areas and treated wealthier patient populations. Additionally, zip codes with higher proportions of Black and Hispanic patients and more patients experiencing socioeconomic disadvantage had lower rates of LAAO.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Sameed Ahmed M. Khatana, Peter W. Groeneveld
Article
Cardiac & Cardiovascular Systems
Sameed Ahmed M. Khatana, Lauren A. Eberly, Ashwin S. Nathan, Peter W. Groeneveld
Summary: This study examines the association between extreme heat and cardiovascular deaths in the United States and projects a significant increase in excess deaths due to extreme heat by midcentury. Elderly adults and non-Hispanic Black adults are projected to be particularly at risk.
Article
Cardiac & Cardiovascular Systems
Ravi Gupta, Lin Yang, Jennifer Lewey, Amol S. Navathe, Peter W. Groeneveld, Sameed Ahmed M. Khatana
Summary: This longitudinal study analyzed 57,690 privately insured patients with chronic cardiovascular disease and found that switching to an HDHP was not associated with changes in healthcare use, but it resulted in increased out-of-pocket costs for patients.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Ashwin S. Nathan, Zhi Geng, Lauren A. Eberly, Nwamaka Eneanya, Elias J. Dayoub, Sameed Ahmed M. Khatana, Daniel M. Kolansky, Taisei J. Kobayashi, Sony Tuteja, Alexander C. Fanaroff, Jay Giri, Peter W. Groeneveld
Summary: This study assessed the association of racial, ethnic, and socioeconomic factors with the use and adherence to novel P2Y(12) inhibitors in a commercially insured population. The results showed that Hispanic patients were more likely to use clopidogrel instead of novel P2Y(12) inhibitors in comparison to ACS patients. Additionally, Black race, Hispanic ethnicity, and lower household income were associated with reduced adherence to P2Y(12) inhibitors.
JOURNAL OF INVASIVE CARDIOLOGY
(2022)