Review
Biochemical Research Methods
Yiwen Wu, Xiaoyan Yang, Zhizhong Xie, Haihong Hu, Xiaoyong Lei, Dun Niu, Shiyan Li, Lu Tuo
Summary: This review systematically summarizes the molecular mechanisms of ncRNAs associated with MDR in gastric cancer, and suggests that ncRNAs may serve as novel therapeutic targets for reversing MDR in gastric cancer.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2022)
Review
Pathology
Mohammad Taheri, Hamed Shoorei, Farhad Tondro Anamag, Soudeh Ghafouri-Fard, Marcel E. Dinger
Summary: Cisplatin is widely used in chemotherapy for various cancers, but chemoresistance can impede its effectiveness. Recent research has highlighted the role of lncRNAs and miRNAs in the development of resistance to cisplatin, affecting overall survival of cancer patients.
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Shahla Chaichian, Sepideh Arbabi Bidgoli, Banafsheh Nikfar, Bahram Moazzami
Summary: Ovarian cancer is the 3rd common gynecologic cancer and understanding the molecular processes involved can improve prevention, diagnosis, and treatment. Long non-coding RNAs (LncRNAs) may play a role in controlling cellular signaling mechanisms, but their involvement in ovarian cancer is still limited.
CURRENT MEDICINAL CHEMISTRY
(2023)
Review
Pharmacology & Pharmacy
Milad Ashrafizaden, Navid Rabiee, Alan Prem Kumar, Gautam Sethi, Ali Zarrabi, Yuzhuo Wang
Summary: Long noncoding RNAs (lncRNAs) play a role in gene regulation in pancreatic cancer cells, affecting apoptosis, autophagy, proliferation, metastasis, and drug resistance.
DRUG DISCOVERY TODAY
(2022)
Review
Biochemistry & Molecular Biology
Dan Wang, Fengjiao Chen, Tao Zeng, Qingxia Tang, Bing Chen, Ling Chen, Yan Dong, Xiaosong Li
Summary: Long non-coding RNAs (lncRNAs) play a significant role in various types of human cancers, especially hepatocellular carcinoma (HCC). With further research and the emergence of new molecular targeted therapies, the diagnosis, treatment, and prognosis of HCC can be considerably improved.
Article
Agronomy
Mao Yin, Yingjie Wen, Juge Liu, Yonghua Jiang, Fachao Shi, Jiezhen Chen, Changhe Cai, Liangxi Ou, Qian Yan, Hailun Liu
Summary: Lychee downy blight (LDB) is a disease that affects lychee fruits and leaves, causing economic losses. This study investigated the role of non-coding RNAs in lychee's response to LDB, providing insights into the molecular mechanisms involved in plant disease resistance.
Review
Medicine, Research & Experimental
Negin Raei, Reza Safaralizadeh, Mohammadali Hesseinpourfeizi, Abbas Yazdanbod, Farhad Pourfarzi, Saeid Latifi-Navid
Summary: Gastrointestinal cancers are commonly affected by dysregulation of lncRNAs through epigenetic alterations, affecting processes such as cell division, migration, invasion, and drug resistance. Multi-drug resistance is a major challenge in chemotherapy for gastrointestinal cancers, impacting patient prognosis and diagnosis.
Review
Biochemistry & Molecular Biology
Mihaela Raluca Radu, Alina Pradatu, Florentina Duica, Romeo Micu, Sanda Maria Cretoiu, Nicolae Suciu, Dragos Cretoiu, Valentin Nicolae Varlas, Viorica Elena Radoi
Summary: Ovarian cancer is a common cause of death in women, with early diagnosis being crucial. Genomic instability is a hallmark of the cancer, and there is diversity within different subtypes. Early detection leads to a favorable prognosis.
Article
Pathology
Xian-Zi Yang, Lei Ma, Shu-Xian Fang, Ye Song, Si-Yu Zhu, Chuan Jin, Wei Liu, Qin Lu, Li-Si Zeng, Shu-Zhong Cui
Summary: This study comprehensively analyzed the expression profile of noncoding RNAs in cisplatin-resistant gastric cancer cells and constructed a ceRNA network and potential regulatory axes related to chemoresistance. The findings provide insights into the mechanisms of chemoresistance in gastric cancer and identify potential therapeutic targets and biomarkers.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Immunology
Chen Liu, Yuhan Huang, Yaoyuan Cui, Jun Zhou, Xu Qin, Li Zhang, Xi Li, Yuan Li, Ensong Guo, Bin Yang, Junpeng Fan, Xiong Li, Yu Fu, Si Liu, Dianxing Hu, Rourou Xiao, Zizhuo Wang, Yingyu Dou, Wei Wang, Wenting Li, Xiaohang Yang, Jingbo Liu, Wenju Peng, Tianyu Qin, Lixin You, Funian Lu, Chaoyang Sun
Summary: "CDK4/6 plays a crucial role in the immune microenvironment of ovarian cancer and is associated with patient prognosis. Inhibiting CDK4/6 leads to an increase in interferon-gamma secretion and activation of immunity in ovarian cancer, while the LRRC75A-AS1-hsa-miR-330-5p axis can inhibit the immune response by upregulating CDK4/6 and leading to a poor prognosis."
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, Research & Experimental
Behnaz Bouzari, Shabahang Mohammadi, Dmitry Olegovich Bokov, Ivan Ivanovich Krasnyuk, Seyed Reza Hosseini-Fard, Marzieh Hajibaba, Rasoul Mirzaei, Sajad Karampoor
Summary: Glioblastoma is an aggressive cancer associated with angiogenesis. Recent research has discovered the critical role of microRNAs and exosomal miRNAs in the angiogenesis process of glioblastoma. This knowledge can lead to the development of potential new treatments.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Leila Jahangiri, Tala Ishola
Summary: Breast cancer is the most common cancer in women, and its targeted treatment depends on the expression of growth factors and hormone receptors by cancer cells. However, approximately 30% of patients may experience relapse due to residual disseminated tumor cells that can either colonize a secondary site or enter a dormant state. Understanding the microenvironmental cues, metabolic and molecular properties, as well as the role of autophagy, lncRNAs, miRNAs, and exosomes, could improve the treatment of breast cancer and enhance patient prognosis and survival.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Maria Teresa Di Martino, Caterina Riillo, Francesca Scionti, Katia Grillone, Nicoletta Polera, Daniele Caracciolo, Mariamena Arbitrio, Pierosandro Tagliaferri, Pierfrancesco Tassone
Summary: Cancer onset and progression are influenced by immune system dysregulation, with noncoding RNAs playing a role in cancer cell immune escape and modulation of the tumor microenvironment. While immunotherapy holds promise for cancer treatment, efforts are needed to achieve cure for immune-refractory tumors.
Review
Oncology
Soudeh Ghafouri-Fard, Amin Aghabalazade, Hamed Shoorei, Jamal Majidpoor, Mohammad Taheri, Majid Mokhtari
Summary: Apoptosis is a coordinated cellular process that occurs in several physiological situations, and dysregulation of apoptosis has been documented in numerous pathological situations, particularly cancer. Non-coding RNAs regulate apoptosis via different mechanisms, and in lung cancer, these RNAs interact with important cancer-related pathways to influence cell fate. Over-expression of apoptosis-blocking non-coding RNAs has been associated with poor prognosis in patients, while apoptosis-promoting ones have the opposite effect.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biology
Nicole Natarelli, Aleena Boby, Shaliz Aflatooni, Jasmine Thuy Tran, Michael Joseph Diaz, Kamil Taneja, Mahtab Forouzandeh
Summary: Non-coding RNAs (ncRNAs), including lncRNAs and miRNAs, play significant regulatory roles in skin cancer pathogenesis, impacting key signaling pathways and gene expression. Dysregulation of miRNAs affects cell cycle regulation, cellular differentiation, and immunological responses in skin cancer. In addition, ncRNAs have potential as diagnostic biomarkers and prognostic indicators, and unraveling their regulatory networks offers groundbreaking opportunities for targeted therapies in dermatologic care.
Editorial Material
Biochemistry & Molecular Biology
Bingjie Zhang, Zhongliang Ma, Xue Li, Caiyan Zhang, Yang Shao, Zhenguo Liu, Yanli Li, Youxin Jin
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2016)
Article
Oncology
Yang Shao, Yu-Qing Shen, Yan-Li Li, Chen Liang, Bing-Jie Zhang, Sheng-Di Lu, Yan-Yun He, Ping Wang, Qiang-Ling Sun, You-Xin Jin, Zhong-Liang Ma
Article
Oncology
Ping Wang, Xiaomin Liu, Yang Shao, Huimin Wang, Chen Liang, Baohui Han, Zhongliang Ma
Article
Oncology
Y-L Li, X-M Liu, C-Y Zhang, J-B Zhou, Y. Shao, C. Liang, H-M Wang, Z-Y Hua, S-D Lu, Z-L Ma
Article
Biotechnology & Applied Microbiology
Yang Shao, Xiaomin Liu, Jiao Meng, Xiaofei Zhang, Zhongliang Ma, Gong Yang
Article
Biochemistry & Molecular Biology
Zhongliang Ma, Jinbao Zhou, Yang Shao, Fatemah A. Jafari, Pengfei Qi, Yanli Li
JOURNAL OF CELLULAR BIOCHEMISTRY
(2020)
Article
Cell Biology
Jiao Meng, Kaiyi Liu, Yang Shao, Xu Feng, Zhaodong Ji, Bin Chang, Yan Wang, Ling Xu, Gong Yang
CELL DEATH & DISEASE
(2020)
Review
Medicine, Research & Experimental
Xiaomin Liu, Yang Shao, Jinbao Zhou, Guangren Qian, Zhongliang Ma
MOLECULAR THERAPY-NUCLEIC ACIDS
(2020)
Article
Biochemistry & Molecular Biology
Yong Wu, Qinhao Guo, Xingzhu Ju, Zhixiang Hu, Lingfang Xia, Yu Deng, Ping Zhao, Meng Zhang, Yang Shao, Shenglin Huang, Xianghuo He, Hao Wen, Xiaohua Wu
Summary: This study identified an oncogenic lincRNA, LINC00662, in ovarian cancer, which is associated with malignant features and serves as a prognostic indicator. LINC00662 promotes OC cell proliferation and metastasis through interaction with GRP78 and activation of the p38 MAPK signaling pathway.
Review
Cell & Tissue Engineering
Yue Kong, Yang Shao, Chunxia Ren, Gong Yang
Summary: Endometrial stem/progenitor cells play crucial roles in cell therapy, immune regulation, and endometriosis, with MenSCs being ideal candidates for their abundant sources and autotransplantation capabilities. Limited BMDSCs in blood circulation can lead to the establishment of deep invasive endometriosis.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Medicine, Research & Experimental
Yang Shao, Xian-yi Wang, Xiang Qiu, Li-li Niu, Zhong-liang Ma
Summary: The objective was to isolate and purify a new Bacillus strain, and determine the effects of its metabolites on bacteria and cancer cells. The results showed that metabolites from Bacillus subtilis NC16 have both antimicrobial and anti-cancer activities.
CURRENT MEDICAL SCIENCE
(2021)
Article
Oncology
Yanli Li, Detao Wang, Xue Li, Yang Shao, Yanyun He, Huansha Yu, Zhongliang Ma
Article
Biochemistry & Molecular Biology
Yang Shao, Qiangling Sun, Xiaomin Liu, Ping Wang, Renqi Wu, Zhongliang Ma
CHEMICAL BIOLOGY & DRUG DESIGN
(2017)
