Article
Oncology
Yi-Jun Hua, Yan-Feng Ou-Yang, Xiong Zou, Le Xia, Dong-Hua Luo, Ming-Yuan Chen
Summary: Radiotherapy is crucial for nasopharyngeal carcinoma patients, with a typical treatment duration of six to six and a half weeks. Prolonged radiotherapy duration is associated with higher risk of distant metastasis and death, highlighting the importance of avoiding prolonged treatment to improve outcomes.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Xinmao Song, Shengzi Wang, Ji Li, Li Yan, Fu Chen, Jie Wang
Summary: The study found that the combination of nimotuzumab with chemoradiotherapy is effective for the treatment of nasopharyngeal carcinoma, especially when used in combination with induction chemotherapy and concurrent chemoradiotherapy. The addition of nimotuzumab did not result in a significant increase in toxicities.
ARCHIVES OF MEDICAL SCIENCE
(2021)
Article
Oncology
Zhining Yang, Zeman Cai, Qingxin Cai, Yingji Hong, Cuidai Zhang, Kaichun Huang, Zhixiong Lin, Mei Li
Summary: The study compared the efficacy and safety of induction chemotherapy followed by intensity-modulated radiotherapy versus concurrent chemotherapy in patients with locoregionally advanced nasopharyngeal carcinoma. The results showed similar outcomes in terms of PFS, OS, LRRFS, and DMFS between the two treatment arms, but the IC plus IMRT arm had lower incidences of leukopenia and anemia.
Article
Medicine, General & Internal
Jing-Jing Yuan, Jian-Wu Ding, Jin-Wei Li, Rong-Huan Hu, Dan Gong, Jia-Li Hu, Kai-Bin Zhu, Yan Liu, Yu-Hai Ding, Jia-Wang Wei, Jian-Lun Zeng, Zhi-Bing Lu, Wei-Hua Yin, Su-Fen Ai, Guo-Hua Zha, Zhi-Lin Zhang, Rui Zou, Lei Zeng
Summary: This study aims to explore individualized treatment strategies for patients with different ICT efficacy, in order to increase treatment intensity for patients with poor efficacy and reduce treatment toxicity for patients with favorable efficacy.
Article
Otorhinolaryngology
Yan He, Zhihao Zhao, Ying Wang, Jialing He, Jiamin Chai, Zhigong Wei, Hui Guan, Jingjing Wang, Zheran Liu, Ruidan Li, Xiaoli Mu, Ling He, Xingchen Peng
Summary: The study compared the efficacy and toxicities of induction chemotherapy followed by intensity-modulated radiotherapy (IC-RT) versus concurrent chemoradiotherapy (CCRT) in treating nasopharyngeal carcinoma (NPC) patients. Results showed no significant difference in overall survival, progression-free survival, distance metastasis-free survival, and locoregional relapse-free survival between IC-RT and CCRT groups. Tumor and lymph node stages were predictive of higher overall survival, while EBV-DNA levels were associated with locoregional relapse-free survival.
CLINICAL OTOLARYNGOLOGY
(2021)
Article
Oncology
Liya Zhou, Jie Lin, Jiawei Chen, Shuai Zhang
Summary: The study aimed to assess the safety and feasibility of induction chemotherapy with nab-paclitaxel plus cisplatin, combined with nimotuzumab and IMRT for N3M0 nasopharyngeal carcinoma. The results showed that this treatment regimen led to excellent survival benefits with manageable toxicities, particularly in terms of locoregional control, overall survival, distant metastasis-free survival, and progression-free survival rates.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2021)
Article
Oncology
Mengshan Ni, Lijun Geng, Fangfang Kong, Chengrun Du, Ruiping Zhai, Yingchen Lyu, Chaosu Hu, Hongmei Ying
Summary: The study analyzed the therapeutic effect and prognostic factors of NPC patients with distant metastases at initial diagnosis receiving induction chemotherapy with IMRT. The results showed that platinum-containing induction chemotherapy combined with IMRT could prolong survival for some patients, but factors like pre-treatment SLDH, number of chemotherapy cycles, and M1 subcategories were associated with poor overall survival. Prospective clinical trials are needed to confirm these findings.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
YuLin Lai, ChengTao Wang, XingLi Yang, ShaSha He, Yan Wang, Yong Chen
Summary: The efficacy of induction chemotherapy (IC) plus concurrent chemoradiotherapy (CCRT) in stage II nasopharyngeal carcinoma (NPC) treated with intensity-modulated radiotherapy (IMRT) was explored. The results showed that adding IC to CCRT or IMRT alone decreased progression-free survival (PFS) and distant metastasis-free survival (DMFS), indicating that IC should not be recommended in stage II NPC patients. There were no significant differences observed in overall survival (OS) and locoregional relapse-free survival (LRRFS) in stage II disease. In addition, high neutrophil-to-lymphocyte ratio was negatively associated with OS, PFS, and DMFS.
Article
Oncology
Wei-Jie Luo, Wen-Qing Zou, Shao-Bo Liang, Lei Chen, Guan-Qun Zhou, Hao Peng, Wen-Fei Li, Xu Liu, Ying Sun, Ai-Hua Lin, Jun Ma, Yan-Ping Mao
Summary: In this study, the role of concurrent chemoradiotherapy (CCRT) after induction chemotherapy (IC) in locoregionally advanced nasopharyngeal carcinoma (LANPC) patients was investigated. Results showed that favorable responders to IC benefited from IC + CCRT with superior 5-year disease-free survival and overall survival compared to IC + IMRT. High-risk patients benefited from CCRT after IC regarding disease-free survival, overall survival, and distant metastasis-free survival.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Medicine, General & Internal
Danxian Jiang, Jinxin Cao, Linying Guo, Yonghua Chen, Ge Yuan, Jing Huang
Summary: This retrospective real-world study evaluated the efficacy and safety of curative sequential approach with induction chemotherapy followed by concurrent chemoradiation + nimotuzumab as first-line therapy in advanced nasopharyngeal carcinoma. The observation group showed significantly higher complete response rate, objective response rate, and 5-year progression-free survival rate compared to the control group. The results indicate that nimotuzumab combined with concurrent chemoradiotherapy as first-line therapy in advanced nasopharyngeal carcinoma can improve efficacy and survival with good safety profile.
Article
Medicine, General & Internal
Peirong Wang, Feng Dong, Chuanshu Cai, Chunlin Ke
Summary: The study evaluated the efficacy of a combinatorial treatment strategy involving IC, IMRT, and AC for locoregionally advanced NPC. Results showed that a total of 4 cycles of IC and AC were more beneficial compared to 3 cycles, as well as a total of 6 chemotherapy cycles compared to 4 in terms of DFFR and PFS.
Article
Oncology
Rui Zou, Jing-Jing Yuan, Qiang Li, Jian-Wu Ding, Bing Liao, Zi-Wei Tu, Rong-Huan Hu, Dan Gong, Jia-Li Hu, Lei Zeng
Summary: The study analyzed the outcomes and toxicities of ICT followed by CCRT plus ACT in LA-NPC patients, and found that this treatment approach did not significantly improve DFS and OS compared to adding ICT to CCRT, with more acute adverse events. Longer-term clinical studies are needed to evaluate treatment outcomes and late toxicities.
FRONTIERS IN ONCOLOGY
(2021)
Review
Otorhinolaryngology
Yongyuan Xue, Guoping Li, Tao Xie, Hongyang Xu, Tianrui Xu, Zhengfei Li, Lixiu Zhu, Xin Li, Zhiyao Li, Wei Xiong
Summary: This study systematically reviewed the significance of concurrent chemoradiotherapy for stage II nasopharyngeal cancer. The results showed that in the era of intensity-modulated radiotherapy, concurrent chemoradiotherapy and radiotherapy alone have the same survival benefits and concurrent chemoradiotherapy increases acute hematological toxicity. Subgroup analysis showed that for people with N1 nasopharyngeal cancer at risk of distant metastases, concurrent chemoradiotherapy and radiotherapy alone also had equal survival benefits.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Oncology
Hao-Yun Tao, Hui Liu, Fang He, Cai-Xian He, Ran Li, Kun-Peng Du, Ya-Wei Yuan, Rong-Hui Zheng
Summary: This study showed that for N2-3 positive LANC, ACT following ICT plus CCRT can reduce distant metastasis and improve overall survival and disease-free survival.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Pei-Jing Li, Yu-Lin Lai, Fang He, Yuan-Yuan Chen, Zhuo-Sheng Gu, Wei Luo, Qun Zhang
Summary: This study compared the treatment outcomes of concurrent chemoradiotherapy (CCRT) versus radiotherapy (RT) alone in stage II nasopharyngeal carcinoma (NPC) patients. The findings showed no significant difference in survival rates and various survival indicators between the CCRT and RT groups. In the era of 2DRT, concurrent chemotherapy significantly improved some survival rates, but it had no significant effect in the era of intensity-modulated radiotherapy (IMRT).
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Fisheries
Liaoyi Xu, Xiefei Zhou, Peichen Wang, Qian Jin, Tingyao Zhu, Ming Chen, Haisheng Xu
Summary: A novel Lmpt protein was identified in the oriental river prawn, and its role in the immune response was investigated. Results suggest that MnLmpt may play a crucial role in the innate immune response in prawns, paving the way for a better understanding of the immune system in crustacean species.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Oncology
Xialin Chen, Rong Ji, Jianjiang Liu, Xueying Jin, Hong Zhu, Jianfang Wang, Ming Chen
Summary: This study revealed the crucial role of DNA polymerase zeta in lung cancer cell radioresistance. Overexpression of polymerase zeta decreased radiosensitivity and inhibited cell apoptosis, while knockdown of polymerase zeta had the opposite effects. Additionally, polymerase zeta knockdown in xenograft animal models decreased tumor size and induced oxidative stress of tumor tissues after irradiation.
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2022)
Article
Oncology
Ying Jin, Yamei Chen, Huarong Tang, Xiao Hu, Shawna M. Hubert, Qian Li, Dan Su, Haimiao Xu, Yun Fan, Xinmin Yu, Qixun Chen, Jinshi Liu, Wei Hong, Yujin Xu, Huan Deng, Dapeng Zhu, Pansong Li, Yuhua Gong, Xuefeng Xia, Carl M. Gay, Jianjun Zhang, Ming Chen
Summary: This study investigates treatment resistance mechanisms in small cell lung cancer (SCLC) by comparing the genotype and phenotype in tumor samples of treatment-resistant and treatment-sensitive SCLC. The results suggest that activation of the PI3K/AKT pathway may be a potential mechanism underlying therapeutic resistance of SCLC, and provides a possible approach to reverse resistance to chemo/radiotherapy.
CLINICAL CANCER RESEARCH
(2022)
Article
Fisheries
Tingyao Zhu, Liaoyi Xu, Jiacheng Peng, Ming Chen, Haisheng Xu
Summary: In this study, the UCHL3 gene from Macrobrachium nipponense was cloned and its expression profile analyzed. The results suggest that UCHL3 may play a role in the innate immune response to bacterial infection by regulating the synthesis of antimicrobial peptides (AMPs).
FISH & SHELLFISH IMMUNOLOGY
(2022)
Review
Oncology
Yamei Chen, Ying Jin, Xiao Hu, Ming Chen
Summary: Immune checkpoint inhibitors have brought new hope for the treatment of SCLC, but the limited response rate is mainly due to the lack of infiltrating T cells in the tumor microenvironment. To fully unleash the potential of ICIs, the trafficking and infiltration of T cells need to be regulated, as the highly immunosuppressive tumor microenvironment weakens the infiltration and function of T cells.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Kaili Cen, Ming Chen, Mengye He, Zhenhao Li, Yinjing Song, Pu Liu, Qi Jiang, Suzhen Xu, Yunlu Jia, Peng Shen
Summary: This study found that combining sporoderm-broken spores of Ganoderma lucidum (SBSGL) with cisplatin can inhibit the growth of ovarian cancer and alleviate cisplatin-induced intestinal injury and myelosuppression. Ganoderic acid D (GAD) can enhance the therapeutic effect of cisplatin by increasing intracellular reactive oxygen species (ROS). Mechanistically, it was proven that ROS-mediated ERK signaling inhibition plays an important role in the chemo-sensitization effect of GAD on cisplatin in ovarian cancer.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Engineering, Biomedical
Yiwei Yang, Rui Huang, Guofeng Lv, Zhiqiang Hu, Guoping Shan, Jie Zhang, Xue Bai, Peng Liu, Hongsheng Li, Ming Chen
Summary: The study introduces a novel structure-contextual representations approach based on 3D high-resolution network for segmentation of OARs and CTV of rectal cancer, showing superior performance. By designing a structure-contextual representation module, the accuracy of segmentation is significantly improved.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2022)
Article
Oncology
Ying Jin, Chen Lin, Xun Shi, Qiong He, Junrong Yan, Xinmin Yu, Ming Chen
Summary: This study found that clinical and molecular features can serve as predictive biomarkers to stratify patients with EGFR T790M-mutant NSCLC receiving second-line Osimertinib treatment.
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaojun Sun, Zhengbo Song, Hongyang Jiang, Yanqing Ma, Ming Chen
Summary: This study conducted dynamic observation of computed tomography (CT) images in lung cancer patients to explore the relationship between immune checkpoint inhibitor-related pneumonia (ICIP) and clinical information. The study found that pre-existing lung lesions could be one of the predisposing factors for ICIP and suggested monitoring them as a target for the onset and progression of ICIP in clinical practice.
Article
Oncology
Meng-Yuan Chen, Yongling Ji, Xiao Hu, Ming Chen
Summary: This study evaluated the risk factors of brain metastasis (BM) in LS-SCLC patients after PCI and found that patients with tumors >5 cm may have a higher risk of developing BM after PCI.
CANCER MANAGEMENT AND RESEARCH
(2022)
Article
Oncology
Qi Li, Mengran Cao, Guosheng Yuan, Xiao Cheng, Mengya Zang, Ming Chen, Xiaoyun Hu, Jing Huang, Rong Li, Yabing Guo, Jian Ruan, Jinzhang Chen
Summary: First-line lenvatinib plus camrelizumab combination therapy showed better effectiveness than lenvatinib monotherapy in patients with unresectable HCC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Chang Xu, Meng Li, Xuwei Cai, Shuanghu Yuan, Jianzhong Cao, Shuchai Zhu, Ming Chen, Nan Bi, Xiao Hu, Jiancheng Li, Wei Zhou, Ping Wang, Lujun Zhao, Ningbo Liu
Summary: There is substantial variation in how Chinese oncologists approach TRT dosing and fractionation for LS-SCLC, with most preferring TRT QD and common doses being 60 Gy QD and 45 Gy BID.
FRONTIERS IN ONCOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Qinglei Hui, Chunlin Wang, Junwei Weng, Ming Chen, Dexing Kong
Summary: Bone age assessment is crucial for investigating endocrine, genetic, and growth disorders in children. Existing methods rely on experience and manual labor, and lack consistency. In this paper, a novel global-local feature fusion convolutional neural network is proposed to improve the accuracy of bone age estimation by integrating global and local information.
APPLIED SCIENCES-BASEL
(2022)
Article
Oncology
Hong Yang, Lin Wang, Guoliang Shao, Baiqiang Dong, Fang Wang, Yuguo Wei, Pu Li, Haiyan Chen, Wujie Chen, Yao Zheng, Yiwei He, Yankun Zhao, Xianghui Du, Xiaojiang Sun, Zhun Wang, Yuezhen Wang, Xia Zhou, Xiaojing Lai, Wei Feng, Liming Shen, Guoqing Qiu, Yongling Ji, Jianxiang Chen, Youhua Jiang, Jinshi Liu, Jian Zeng, Changchun Wang, Qiang Zhao, Xun Yang, Xiao Hu, Honglian Ma, Qixun Chen, Ming Chen, Haitao Jiang, Yujin Xu
Summary: A combined predictive model based on pre-treatment CT radiomics features and clinical factors was established to accurately assess disease progression after Stereotactic Ablative Radiotherapy (SABR) of early-stage Non-Small Cell Lung Cancer (NSCLC). The model showed good prediction efficiency in both the training and validation cohorts, providing valuable information for individualized follow-up plans and treatment strategies.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Jie He, Yilong Wu, Shugeng Gao, Jie Wang, Zhijie Wang, Jun Wang, Zhehai Wang, Lvhua Wang, Hui Tian, Nan Bi, Lunxu Liu, Lin Xu, Hecheng Li, Ning Wu, Jianxing He, Jianming Ying, Qibin Song, Li Zhang, Lanjun Zhang, Shun Lu, Ming Chen, Haiquan Chen, Yun Fan, Caicun Zhou, Lujun Zhao, Yushun Gao, Yunchao Huang, Cheng Huang, Hong Ge, Ying Cheng, Xiaolong Fu, Fengwei Tan, Qi Xue
CHINESE JOURNAL OF CANCER RESEARCH
(2022)