Review
Oncology
Xianyuan Wei, Meng Du, Zhiyi Chen, Zhen Yuan
Summary: Bacteria play a significant role in cancer treatment and prevention, particularly in bacteria-based cancer immunotherapy. Compared to traditional cancer treatments, bacteria have versatile capabilities for suppressing cancer due to their preferential accumulation and proliferation within tumors. Genetically engineered bacteria and bacteria-based nanoparticles have shown promising results in efficient antitumor treatments. The design of bacteria with detoxification and specificity is crucial for the efficacy of bacteria-based cancer therapeutics.
Article
Immunology
Kajal H. Gupta, Christina Nowicki, Eileena F. Giurini, Amanda L. Marzo, Andrew Zloza
Summary: Cancer currently ranks as the sixth leading cause of death globally, with immunotherapy showing significant advancements in combating cancer. The use of bacteria and bacterial products as cancer therapy has promising potential to address ongoing challenges in cancer treatment.
Review
Medicine, Research & Experimental
Jiawen Chen, Ting Li, Jianhao Liang, Qiqi Huang, Jian-Dong Huang, Yiquan Ke, Haitao Sun
Summary: Research on the relationship between microbiome and cancer has advanced significantly, revealing the impact of gut microbiome and intratumoral bacteria on tumour biology. Studies have shown that intratumoral bacteria play a role in tumour initiation, progression, and response to treatment, presenting a potential avenue for cancer therapy. Despite the progress, challenges remain in utilizing genetically engineered bacteria for cancer treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biotechnology & Applied Microbiology
Shuya Liang, Chao Wang, Yingchun Shao, Yanhong Wang, Dongming Xing, Zhongmin Geng
Summary: Cancer is a leading cause of death worldwide, and conventional therapies often fail to completely eliminate cancer cells due to the unique characteristics of the tumor microenvironment. Bacteria have emerged as a promising platform for cancer therapy, offering specific tumor-targeting ability and serving as carriers for genes or drugs. Engineered bacteria and the use of nanomaterials have shown potential in improving the efficacy of cancer treatments.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Engineering, Biomedical
Haotian Bai, Wei He, Joe H. C. Chau, Zheng Zheng, Ryan T. K. Kwok, Jacky W. Y. Lam, Ben Zhong Tang
Summary: The emergence of antibiotic-resistant microbes poses a serious threat to human health, highlighting the urgent need for research and development of new antimicrobial systems and strategies. AIEgen-based biofunctional materials and systems offer rapid microbial detection, bacterial classification, and pathogen discrimination, aiding in the scientific study of antibiotic resistance mechanisms.
Article
Oncology
Muhammad Jameel Mughal, Hang Fai Kwok
Summary: The role of bacteria in oncogenesis has long been debated, but recent studies have uncovered their mechanisms in cancer development, such as inflammation, immune evasion, pro-carcinogenic metabolite production, DNA damage, and genomic instability. Bioengineered live bacteria have shown therapeutic potential in cancer treatment and detection, with high specificity, cytotoxicity to cancer cells, responsiveness to external signals, and control after ingestion, making them an ideal approach for overcoming challenges faced by conventional therapies.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Microbiology
Marcell Costa de Medeiros, Stephanie The, Emily Bellile, Nickole Russo, Ligia Schmitd, Erika Danella, Priyanka Singh, Rajat Banerjee, Christine Bassis, George R. Murphy, Maureen A. Sartor, Isabelle Lombaert, Thomas M. Schmidt, Avi Eisbruch, Carol Anne Murdoch-Kinch, Laura Rozek, Gregory T. Wolf, Gen Li, Grace Y. Chen, Nisha J. D'Silva
Summary: Treatment of oral squamous cell carcinoma (SCC) leads to changes in the oral microbiome, including alterations in bacterial richness and diversity, as well as the community structure. These microbiome changes are associated with the expression of the anti-microbial protein DMBT1 in saliva. Increased levels of salivary DMBT1 after treatment correlate with an increase in specific bacterial genera.
Article
Chemistry, Analytical
Xiying Chen, Xiaomin Wang, Yuan Fang, Liule Zhang, Minyang Zhao, Yaqing Liu
Summary: In this study, a chemiluminescence system with long, persistent, and intensive intensity was constructed using CuSe nanoprobes functionalized with 4-mercaptophenylboronic acid. By integrating a smartphone as an analyzer, this system achieved high sensitivity and efficient elimination of bacteria.
ANALYTICAL CHEMISTRY
(2022)
Article
Materials Science, Multidisciplinary
Tianzhong Li, Lingfeng Gao, Bin Zhang, Guohui Nie, Zhongjian Xie, Han Zhang, Hans Agren
Summary: Bacterial fabrication plays a crucial role in cancer therapy, offering advantages such as specific hypoxia tropism, high motility, and rapid self replication. Through biomineralization, bacteria can be modified by nanomaterials for precise cancer imaging and targeted drug delivery, enhancing therapeutic efficacy.
APPLIED MATERIALS TODAY
(2021)
Review
Biochemistry & Molecular Biology
Christian R. Pangilinan, Che-Hsin Lee
Summary: Bacteria-mediated cancer therapy shows promise in activating the host immune system to eradicate tumors, particularly through the use of Salmonella. The study highlights the immunomodulatory effects of Salmonella on both innate and adaptive immune responses, as well as discusses potential modifications to enhance tumor-specific immune responses. Pre-clinical research and early-phase clinical trials have shown convincing results, indicating the potential of Salmonella-based therapy as a mainstream intervention for cancer treatment.
Review
Oncology
Jun Ying Fan, Yuan Huang, Yi Li, Tobias Achu Muluh, Shao Zhi Fu, Jing Bo Wu
Summary: Tumors pose a significant threat to human life and health. Conventional therapies such as radiotherapy and chemotherapy have limitations in their effectiveness, including high toxicity to normal cells and the risk of drug resistance. Bacterial anti-tumor immunotherapy has emerged as a promising alternative, utilizing bacteria to target and colonize tumor tissues, triggering anti-tumor immune responses to effectively eliminate tumor cells.
Review
Biotechnology & Applied Microbiology
Yuye Wu, Dheerendranath Battalapalli, Mohammed J. Hakeem, Venkatarao Selamneni, Pengfei Zhang, Mohamed S. Draz, Zhi Ruan
Summary: Antibiotic resistance is rapidly spreading worldwide, hindering efforts to control microbial infections. The CRISPR-Cas system offers promising opportunities for precise targeting and editing of nucleic acids, potentially reversing bacterial resistance to antibiotics. Engineered CRISPR-Cas systems have the potential to detect bacteria and their resistance to antibiotics with great significance.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Larisa N. Ikryannikova, Neonila V. Gorokhovets, Darya A. Belykh, Leonid K. Kurbatov, Andrey A. Zamyatnin Jr
Summary: This article introduces the research on the relationship between bacteria and human tumors, including the efforts and achievements of ancient and modern scientists, as well as the challenges and achievements of 21st century science in using bacteria for cancer treatment. It also discusses the future possibilities of bacterial cancer therapy, including the creation of bacterial microrobots or bacteriobots.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biotechnology & Applied Microbiology
Anna Grenda, Pawel Krawczyk
Summary: Bacteria imbalance in the intestines can contribute to cancer, but using beneficial bacteria and their metabolites can restore the natural microbiome and enhance the effectiveness of cancer treatment.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Filipa A. L. S. Silva, Hui-Ping Chang, Jean Anne C. Incorvia, Maria J. Oliveira, Bruno Sarmento, Susana G. Santos, Fernao D. Magalhaes, Artur M. Pinto
Summary: Photothermal therapy (PTT) and magnetic hyperthermia therapy (MHT) using 2D nanomaterials (2DnMat) show promising potential for alternative cancer and bacterial infection treatments. The unique properties of 2DnMat, including high surface area, near-infrared absorption, responsiveness to external stimuli, and surface functionalization possibilities, make them ideal platforms for PTT and MHT. Although significant progress has been made in in vitro and in vivo studies, challenges such as improving drug conjugation, understanding in vivo biodegradation, and refining evaluation criteria still need to be addressed.
