Review
Biochemistry & Molecular Biology
Yoon-Seok Seo, Jung-Min Park, Jae-Hyeong Kim, Moo-Yeol Lee
Summary: Smoking is a significant risk factor for various diseases due to the production of excessive reactive oxygen species (ROS). This review focuses on how cigarette smoke promotes the formation of ROS and provides key mechanisms involved.
Article
Biochemistry & Molecular Biology
Ziting Guo, Jinjin Zhao, Meiping Wang, Song Song, Zongliang Xia
Summary: Recent studies have shown that sulfur dioxide (SO2) plays a positive role in stress defense responses in plants, especially in seed germination. SO2 treatment can significantly promote seed germination and vigor in maize by increasing reactive oxygen species levels and NADPH oxidase activities, leading to elevated alpha-amylase activity and transcripts. These findings suggest that SO2 may function as a signaling molecule in plant growth and development, specifically in seed germination control.
Article
Pharmacology & Pharmacy
Sergejs Zavadskis, Adelheid Weidinger, Dominik Hanetseder, Asmita Banerjee, Cornelia Schneider, Susanne Wolbank, Darja Marolt Presen, Andrey Kozlov
Summary: The study found that the inhibitor DPI has different effects on ROS metabolism and mitochondrial function in various types of cells, such as stem cells and differentiated cells, depending on the cell's energy metabolism. Undifferentiated cells may be a better target for DPI compared to differentiated parenchymal cells.
Article
Biochemistry & Molecular Biology
Hironori Mizutani, Yoshifumi Sato, Masaya Yamazaki, Tatsuya Yoshizawa, Yukio Ando, Mitsuharu Ueda, Kazuya Yamagata
Summary: This study found that the expression of SIRT7 is increased in the brain of Alzheimer's disease patients. Treatment with A beta(42) increased the expression of NOX4, leading to the production of reactive oxygen species (ROS) and apoptosis. Knockdown of SIRT7 inhibited A beta(42)-induced ROS production and apoptosis by suppressing the upregulation of NOX4. These findings suggest that inhibiting SIRT7 may be beneficial in the pathogenesis of AD by regulating ROS production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Jong Hee Choi, Jinhee Oh, Min Jung Lee, Hyunsu Bae, Seong-Gyu Ko, Seung-Yeol Nah, Ik-Hyun Cho
Summary: The study revealed that LPARs play a crucial role in multiple sclerosis and could be potential therapeutic targets. While LPAR1-3 antagonist worsened symptoms, LPAR1/2 agonist showed improvement in the animal model.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Biochemistry & Molecular Biology
Marta Massari, Callum R. Nicoll, Sara Marchese, Andrea Mattevi, Maria Laura Mascotti
Summary: This article investigates the phylogenetic analysis of the NADPH oxidase family in eukaryotes and finds that all known members share a common ancestor. Calcium-dependency is identified as the earliest form of NOX regulation, while the protein-protein mode of regulation is a more recent event generated by gene duplication.
Review
Medicine, Research & Experimental
Yawei Bi, Xiao Lei, Ningli Chai, Enqiang Linghu
Summary: NOX4 is upregulated in pancreatic cancer and primarily produces hydrogen peroxide, exhibiting different properties from other NOX family subtypes. Recent studies suggest that NOX4 promotes pancreatic cancer occurrence and development, making it a potential therapeutic target in pancreatic cancer.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Andrew J. Robinson, Sara Davies, Richard L. Darley, Alex Tonks
Summary: In AML patients, over 60% exhibit constitutive activation of NOX2 and increased ROS production. This leads to increased glucose uptake and proliferation in AML cells, as well as changes in carbohydrate metabolism. Metabolomic profiling revealed significant ROS-specific metabolic alterations in sphingolipid metabolism, fatty acid oxidation, purine metabolism, amino acid homeostasis, and glycolysis, providing further evidence of ROS rewiring metabolism in AML.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ildiko Szanto
Summary: Cancer cells can adapt to hypoxic environments through metabolic rewiring and synthesis of antioxidant molecules. NOX4, a member of the NOX family enzymes, plays a key role in the oncogenic metabolic adaptation of cancer cells by regulating diverse metabolic processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yutong Jin, Brian Dixon, Lyndon Jones, Maud Gorbet
Summary: Tear polymorphonuclear neutrophils (PMNs) invade the ocular surface during sleep, contributing to homeostasis and possessing an arsenal of inflammatory mediators. This study found that tear PMNs exhibit high constitutive ROS production and differential responses to stimuli like PMA, LPS, and fMLP, suggesting their potential role in ocular inflammatory complications involving oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Hong Ki Min, Se Hee Kim, Ji-Yeon Lee, Sang-Heon Lee, Hae-Rim Kim
Summary: In this study, the effect of DJ-1 on helper T cell differentiation, fibroblast-like synoviocyte (FLS) activation, and osteoclastogenesis in rheumatoid arthritis was investigated. The results demonstrated that DJ-1 inhibits the production of pro-inflammatory cytokines and activation of RA-FLS, as well as osteoclast formation. Therefore, DJ-1 holds potential importance in the treatment of rheumatoid arthritis.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Misbah Hussain, Wajiha Ikram, Usama Ikram
Summary: Oxidative stress affects the redox state of various target proteins, including tyrosine kinases, mitogen-activated protein kinases, and tyrosine phosphatases. c-Src is a non-receptor tyrosine kinase that can activate NADPH oxidases in response to different stimuli. The interaction between c-Src and Noxs is influenced by cell type and primary messengers. Additionally, c-Src and ROS have a bidirectional relationship in the pathobiology of cardiac fibrosis.
MOLECULAR GENETICS AND GENOMICS
(2023)
Article
Medicine, Research & Experimental
Hui Wang, Haowei Lu, Yige Wu
Summary: The study showed that expression of DUOX1 was highest in slow-healing tissues. Knockdown of DUOX1 benefitted cell proliferation and inhibited ROS production, likely through regulation of oxidative stress via NF-kappa B pathway activation.
MEDICAL SCIENCE MONITOR
(2021)
Article
Pharmacology & Pharmacy
Eunice E. To, Jonathan R. Erlich, Felicia Liong, Stella Liong, Raymond Luong, Osezua Oseghale, Mark A. Miles, Paris C. Papagianis, Kylie M. Quinn, Steven Bozinovski, Ross Vlahos, Robert D. Brooks, John J. O'Leary, Doug A. Brooks, Stavros Selemidis
Summary: The combination of an endosome-targeted NOX2 oxidase inhibitor and a mitochondrial ROS scavenger is more effective than monotherapy in reducing inflammation and improving lung pathology in influenza A virus (IAV) infection. This approach also enhances Type I interferon expression and increases IAV-specific CD8(+) T cells in the lungs.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Flavia Rezende, Pedro Felipe Malacarne, Niklas Mueller, Birgit Rathkolb, Martin Hrabe de Angelis, Katrin Schroeder, Ralf P. Brandes
Summary: The study found that Nox4 knockout mice exhibited similar weight loss and sodium sparing function under a low sodium diet, but showed reduced systolic blood pressure, heart-rate ratio, and heart to body weight ratio compared to wild-type mice, indicating that Nox4 plays a role in blood pressure regulation induced by low sodium diets.
Article
Biochemistry & Molecular Biology
Yuree Lee, Taek Han Yoon, Jiyoun Lee, So Yeon Jeon, Jae Ho Lee, Mi Kyoung Lee, Huize Chen, Ju Yun, Se Yun Oh, Xiaohong Wen, Hui Kyung Cho, Hyunggon Mang, June M. Kwak
Article
Plant Sciences
Chuanli Ju, Dongdong Kong, Yuree Lee, Gege Ge, Yanan Song, Jiawen Liu, June M. Kwak
JOURNAL OF EXPERIMENTAL BOTANY
(2020)
Review
Plant Sciences
Yuree Lee
CURRENT OPINION IN PLANT BIOLOGY
(2019)
Article
Multidisciplinary Sciences
Jiali Zhu, Ji-Hwan Park, Seulbee Lee, Jae Ho Lee, Daehee Hwang, June M. Kwak, Yun Ju Kim
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Plant Sciences
Seulbee Lee, Myung-Hee Kim, Jae Ho Lee, Jieun Jeon, June M. Kwak, Yun Ju Kim
FRONTIERS IN PLANT SCIENCE
(2020)
Review
Plant Sciences
Yesol Shin, Andrea Chane, Minjung Jung, Yuree Lee
Summary: Pectin, as an abundant cell wall polysaccharide, plays essential roles in cell wall remodeling with specificity and plasticity across different cell types and environmental conditions. Recent studies have revealed that pectin modifications are not only final products of internal pathways, but also critical components of intercellular communication.
Review
Plant Sciences
Soon-Ki Han, June M. Kwak, Xingyun Qi
Summary: Stomatal development plays a critical role in plant survival and growth under varying environmental conditions, with signaling cascades, transcriptional networks, and environmental cues all influencing proper stomatal patterning, density, and polarity. Recent findings highlight the complexity of the developmental program governing stomatal lineage cells, providing insights for improving crop plant photosynthesis and water-stress resilience in the face of climate change.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Plant Sciences
Bae Young Choi, Donghwan Shim, Fantao Kong, Pascaline Auroy, Yuree Lee, Yonghua Li-Beisson, Youngsook Lee, Yasuyo Yamaoka
Summary: This study identified MYB1 as a key regulator of lipid metabolism in microalgae under stress conditions. MYB1 promotes lipid accumulation by facilitating fatty acid transport from the chloroplast to the endoplasmic reticulum.
Article
Biochemistry & Molecular Biology
Huize Chen, Jinsu Lee, Jung-Min Lee, Minsoo Han, Aurelia Emonet, Jiyoun Lee, Xingtian Jia, Yuree Lee
Summary: Reactive oxygen species (ROS) play essential roles in plant physiological processes and can have both beneficial and harmful effects. This study identified a putative manganese SOD, MSD2, which is secreted and regulates ROS metabolism in the roots, thereby influencing root growth and development.
Article
Plant Sciences
Jinsu Lee, Huize Chen, Gisuk Lee, Aurelia Emonet, Sang-Gyu Kim, Donghwan Shim, Yuree Lee
Summary: This study reveals the role of reactive oxygen species (ROS) in regulating the timing of floral organ abscission in plants. The results show that MSD2-dependent ROS metabolism acts upstream of IDA-HAE signaling pathway and interacts with abscisic acid and nitric oxide to facilitate abscission. This finding provides further insights into the molecular mechanism of floral organ abscission.
Review
Biochemistry & Molecular Biology
Jinsu Lee, Minsoo Han, Yesol Shin, Jung-Min Lee, Geon Heo, Yuree Lee
Summary: Reactive oxygen species (ROS), primarily generated by NADPH oxidases (RBOHs), serve as secondary messengers in developmental and signal transduction processes. However, the types and locations of ROS produced by RBOHs differ from those involved in intracellular signaling. Recent studies have revealed mechanisms underlying extracellular ROS (eROS) action, including perception in the apoplast, crosstalk with reactive nitrogen species, and contributions of intracellular organelles. This review summarizes these advances and provides an overview of the routes by which eROS-induced changes reach the intracellular space.
MOLECULES AND CELLS
(2023)
Article
Multidisciplinary Sciences
Nelson Rojas-Murcia, Kian Hematy, Yuree Lee, Aurelia Emonet, Robertas Ursache, Satoshi Fujita, Damien De Bellis, Niko Geldner
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Plant Sciences
Myung-Hee Kim, Jieun Jeon, Seulbee Lee, Jae Ho Lee, Lei Gao, Byung-Hoon Lee, Jeong Mee Park, Yun Ju Kim, June M. Kwak