期刊
FRONTIERS IN MICROBIOLOGY
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2018.01242
关键词
fecal microbiota transplant; Clostridium difficile infection; short chain fatty acids; bile acids; sialic acids; antimicrobial peptides; bacteriocins; bacteriophages
类别
资金
- Leiden University Medical Center
- VIDI fellowship VIDI of the Netherlands Organisation for Scientific Research [864.13.003]
- Vedanta Biosciences Inc.
- Netherlands Organisation for Health Research and Development (ZonMW) [1708810011]
Fecal microbiota transplantation has proven to be an effective treatment for infections with the gram-positive enteropathogen Clostridium difficile. Despite its effectiveness, the exact mechanisms that underlie its success are largely unclear. In this review, we highlight the pleiotropic effectors that are transferred during fecal microbiota transfer and relate this to the C. difficile lifecycle. In doing so, we show that it is likely that multiple factors contribute to the elimination of symptoms of C. difficile infections after fecal microbiota transplantation.
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