Article
Multidisciplinary Sciences
Nauru Idalia Vargas-Maya, Vianey Olmedo-Monfil, Jorge Humberto Ramirez-Prado, Ruth Reyes-Cortes, Felipe Padilla-Vaca, Bernardo Franco
Summary: Successful pathogenic fungal infection relies on the ability to evade the immune response, with little attention given to the physiological resistance of fungi to the host immune system. Research suggests that fungi thrive in both saprophytic and pathogenic lifestyles by utilizing antioxidant defenses to combat oxidative stress, emphasizing the importance of studying fungal catalases and their role in pathogenesis.
Article
Immunology
David L. Bauer, Louay Bachnak, Vanessa M. Limbert, Rebecca M. Horowitz, Robin L. Baudier, Shaina J. D'Souza, Victoria E. Immethun, Jonathan R. Kurtz, Samuel B. Grant, James B. McLachlan
Summary: Adjuvants are important additions to vaccines that enhance immune responses. Combining adjuvants can increase the efficacy of vaccines. In this study, the combination of dmLT and MPL-A showed enhanced immune responses and activation of dendritic cells.
JOURNAL OF IMMUNOLOGY
(2023)
Article
Immunology
Robert Krause, Christian M. Warren, Joshua D. Simmons, Peter F. Rebeiro, Fernanda Maruri, Farina Karim, Timothy R. Sterling, John R. Koethe, Al Leslie, Yuri F. van der Heijden
Summary: Patients with stable/increased HbA1c during TB treatment exhibited an increased pro-inflammatory state and elevated T cell activity. These changes were associated with unresolved dysglycemia and may indicate failure to fully resolve infection.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Jessica Braverman, Ian R. Monk, Chenghao Ge, Glen P. Westall, Timothy P. Stinear, Linda M. Wakim
Summary: Staphylococcus aureus pneumonia severity can be attenuated by lodging specific immune cells in the lungs, which are not naturally generated during infection. This finding also applies to humans. Therefore, developing vaccines that target these specific cells has the potential to prevent S. aureus pneumonia.
MUCOSAL IMMUNOLOGY
(2022)
Article
Microbiology
Araceli Paredes-Rojas, Alejandro Palma-Ramos, Laura Estela Castrillon-Rivera, Felipe Mendoza-Perez, Maria del Carmen Navarro-Gonzalez, Roberto Arenas-Guzman, Jorge Ismael Castaneda-Sanchez, Julieta Luna-Herrera
Summary: Sporotrichosis is a fungal infection that primarily affects the skin. This study found that infection with Sporothrix schenckii induces changes in the cytoskeleton and an inflammatory response in human keratinocyte cells.
Article
Multidisciplinary Sciences
Sung-Wook Hong, Peter D. Krueger, Kevin C. Osum, Thamotharampillai Dileepan, Adam Herman, Daniel L. Mueller, Marc K. Jenkins
Summary: Exposure to food antigens leads to the formation of various noncanonical T helper cell subsets by naive CD4(+) T cells, which lack inflammatory functions but have the potential to produce regulatory T cells that may suppress gut pathology.
Article
Immunology
Lulu Xu, Fei Hao, Jingjing Wang, Zhixin Feng, Lei Zhang, Ting Yuan, Rong Chen, Zhenzhen Zhang, Guoqing Shao, Qiyan Xiong, Johnson Lin, Xing Xie, Yongjie Liu
Summary: In this study, we evaluated the immune responses and immune efficacy of NFOR and NOX in mice vaccinated via different routes. Our findings showed that IM + IN vaccination induced strong systemic and local mucosal immune responses, and Mhp NFOR and NOX could activate local mucosal immune responses via the intranasal route. These findings lay a foundation for more effective prevention of Mhp and the development of new subunit vaccines for Mhp.
MICROBIAL PATHOGENESIS
(2022)
Article
Multidisciplinary Sciences
Kazutaka Terahara, Takashi Sato, Yu Adachi, Keisuke Tonouchi, Taishi Onodera, Saya Moriyama, Lin Sun, Tomohiro Takano, Ayae Nishiyama, Ai Kawana-Tachikawa, Tetsuro Matano, Takayuki Matsumura, Masaharu Shinkai, Masanori Isogawa, Yoshimasa Takahashi
Summary: The determinants of memory T cell longevity following SARS-CoV-2 infection are still unknown. This study found that the half-lives of CD4(+) and CD8(+) T cells were longer than antibody titers. Th17-like subset of CD4(+) T cells showed the longest half-life, indicating its close association with T cell longevity. In contrast, Th2 and Tfh-like T cells were more closely correlated with antibody levels.
Article
Immunology
Inta Gribonika, Anneli Stromberg, Cristina Lebrero-Fernandez, Karin Schon, James Moon, Mats Bemark, Nils Lycke
Summary: This study found that T(H)17 cells in the intestinal immune system are responsive to both pathogenic and commensal bacteria, but their plasticity to convert into T-FH cells is not a major contributor to gut IgA responses. Two mouse models of T(H)17 deficiency confirmed that gut IgA responses to oral immunization do not require T(H)17 cells.
SCIENCE IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Yanyu Zhang, Song Gao, Shifei Yao, Danlin Weng, Yan Wang, Qi Huang, Xuemei Zhang, Hong Wang, Wenchun Xu
Summary: The study found that the SPY1 vaccine increased the expression of IL-27 and its specific receptor (WSX-1), promoting vaccine protection through activation of the STAT3 and NF-κB signaling pathways and production of memory CD4(+)T cells to enhance Th17 cell polarization. Additionally, the immune protection of the vaccine was independent of aerobic glycolysis.
Article
Oncology
Isis Benoit-Lizon, Elise Jacquin, Thaiz Rivera Vargas, Corentin Richard, Aurelie Roussey, Ludivine Dal Zuffo, Tiffany Martin, Andrea Melis, Daria Vinokurova, Sayyed Hamed Shahoei, Alvaro Baeza Garcia, Cassandre Pignol, Stephane Giorgiutti, Raphael Carapito, Romain Boidot, Frederique Vegran, Richard A. Flavell, Bernhard Ryffel, Eric R. Nelson, Pauline Soulas-Sprauel, Toby Lawrence, Lionel Apetoh
Summary: Activation of STING signaling enhances the differentiation and antitumor functions of T(H)1 and T(H)9 cells by increasing their production of IFN-gamma and interleukin-9, respectively. IRF3 and IFNARs are required for the enhancement of T(H)1 cell differentiation, while mTOR signaling is implicated in T(H)9 cell differentiation in response to STING activation. STING activation boosts the antitumor activity of T(H)1 and T(H)9 cells through their cytokine production, and enhances the efficacy of T(H)9 cells in adoptive transfer against melanoma.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Immunology
Peng Peng, Yue Lou, Junjun Wang, Shicheng Wang, Ping Liu, Lisa X. Xu
Summary: Recent studies have shown the effectiveness of highly activated, polyfunctional CD4(+) T cells in strengthening overall host antitumor immunity. Cryo-thermal therapy, which remodels the tumor microenvironment and induces antigen-specific CD4(+) T-cell responses, has been found to enhance antitumor immunity in vivo.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Hai Li, Hu Ren, Yan Zhang, Lei Cao, Wenbo Xu
Summary: In this study, intranasal immunization with the recombinant protein CTA1-DD-RBF in mice effectively stimulated specific immune responses and generated protective immunity without inducing lung immunopathology. Compared to other proteins, CTA1-DD-RBF exhibited superior immune protection.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Monika Majewska-Szczepanik, Anna Strzepa, Katarzyna Marcinska, Marian Szczepanik
Summary: The contact hypersensitivity response (CHS) is a mouse model that mimics allergic contact dermatitis in humans. Experiments in mice showed that applying a protein antigen to the skin before inducing CHS effectively reduces the inflammatory response. Epicutaneous immunization also suppresses inflammatory response in various mouse models of autoimmune diseases. This suggests that EC immunization could be a therapeutic approach for T cell-mediated diseases in humans.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Erin E. West, Nicolas S. Merle, Marcin M. Kaminski, Gustavo Palacios, Dhaneshwar Kumar, Luopin Wang, Jack A. Bibby, Kirsten Overdahl, Alan K. Jarmusch, Simon Freeley, Duck-Yeon Lee, J. Will Thompson, Zu-Xi Yu, Naomi Taylor, Marc Sitbon, Douglas R. Green, Andrea Bohrer, Katrin D. Mayer-Barber, Behdad Afzali, Majid Kazemian, Sabine Scholl-Buergi, Daniela Karall, Martina Huemer, Claudia Kemper
Summary: Induction of Arg1 expression in lung CD4+ T cells during mouse in vivo influenza infection accelerates the resolution of virus-specific Th1 effector responses, leading to efficient viral clearance and reduced lung pathology.
Article
Immunology
Laura Antonio-Herrera, Oscar Badillo-Godinez, Oscar Medina-Contreras, Araceli Tepale-Segura, Alberto Garcia-Lozano, Lourdes Gutierrez-Xicotencatl, Gloria Soldevila, Fernando R. Esquivel-Guadarrama, Juliana Idoyaga, Laura C. Bonifaz
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Microbiology
Luis Ontiveros-Padilla, Alberto Garcia-Lozano, Araceli Tepale-Segura, Tania Rivera-Hernandez, Rodolfo Pastelin-Palacios, Armando Isibasi, Lourdes A. Arriaga-Pizano, Laura C. Bonifaz, Constantino Lopez-Macias
Summary: Vaccination with Salmonella enterica serovar Typhi porins induces skin T cell responses, with IFN-gamma- and IL-17-producing cells, and contributes to protection against S. Typhi. The study highlights the importance of circulating memory T cell responses in the optimal protection provided by porins, showcasing a mechanism that could aid in vaccine development.