Article
Clinical Neurology
Sinan Yasaroglu, Joachim Liepert
Summary: This study aimed to characterize the changes in motor excitability and motor performance induced by a single session of anodal and cathodal transcranial direct current stimulation (tDCS) in stroke patients. The results showed that anodal tDCS significantly reduced short interval intracortical inhibition (SICI) without affecting intracortical facilitation (ICF) or long interval intracortical inhibition (LICI). Cathodal tDCS did not change motor excitability. Both types of tDCS did not alter motor performance. The SICI in the affected hemisphere was lower than in the unaffected hemisphere even before anodal tDCS, and it was correlated with changes in motor performance after anodal tDCS.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kevin Pacheco-Barrios, Danielle Carolina Pimenta, Anne Victorio Pessotto, Felipe Fregni
Summary: The clinical correlates of transcranial magnetic stimulation (TMS) measures, such as resting motor threshold (MT), motor-evoked potential (MEP), short intracortical inhibition (SICI), and intracortical facilitation (ICF), in fibromyalgia syndrome (FMS) patients were investigated. It was found that SICI was associated with sleepiness, comorbidities, disease duration, and anxiety, while ICF showed a positive correlation with pain levels and a negative correlation with body mass index (BMI). These findings suggest that SICI and ICF metrics may serve as potential phenotyping biomarkers in FMS.
Article
Behavioral Sciences
Maximilian A. Friehs, Christian Frings, Gesa Hartwigsen
Summary: tDCS is commonly used to investigate the involvement of different cortical regions in response inhibition. Studies have shown that its effects depend on polarity, time, and stimulation sites. There is variability in methodology and heterogeneous effects of tDCS on performance, with the most consistent result being performance enhancement with anodal tDCS over the right prefrontal cortex.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Neurosciences
Zhihua Guo, Yue Gong, Hongliang Lu, Rui Qiu, Xinlu Wang, Xia Zhu, Xuqun You
Summary: The study found that multitarget tDCS stimulation significantly reduced stop-signal reaction time (SSRT), whereas single-target stimulation did not show significant effects. Multitarget stimulation significantly decreased SSRT in both high-performance and low-performance subgroups. Only multitarget stimulation significantly improved neural efficiency post-stimulation.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Jiayue Cheng, Puyu Li, Yingying Tang, Chen Zhang, Liangjun Lin, Jian Gao, Zhen Wang
Summary: The study showed that high-definition tDCS treatment in OCD patients can significantly improve symptoms, and the treatment can lead to improvements in GABAB receptor function.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Medicine, General & Internal
Seong Hoon Bae, Seo Jin Moon, Jeong Gum Lee, Yun Kyung Yim, Hee So Oh, Dong Hee Han, In Seok Moon
Summary: The study compared the effects of rTMS and tDCS treatments for chronic tinnitus, showing comparable results in reducing tinnitus symptoms, with tDCS possibly being more cost-effective.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Neurosciences
Simranjit K. Sidhu
Summary: This study found that atDCS applied over the unexercised muscle M1 representation can enhance cycling exercise performance, possibly mediated by reducing the excitability of global GABA(A) inhibitory interneurons.
EXPERIMENTAL BRAIN RESEARCH
(2021)
Review
Clinical Neurology
B. Gonzalez-Rodriguez, N. Serradell-Ribe, R. Viejo-Sobera, J. P. Romero-Munoz, Elena M. Marron
Summary: This systematic review evaluated the effectiveness of transcranial direct current stimulation (tDCS) in the rehabilitation of hemispatial neglect after stroke. The findings indicate that tDCS can effectively improve neglect recovery, particularly when combined with other interventions. However, due to the limited number of studies and certain design risks, categorical conclusions cannot be drawn at this time. Further research is needed to determine the advantages of tDCS in stroke patients.
JOURNAL OF NEUROLOGY
(2022)
Review
Psychiatry
Parmis Fatih, M. Utku Kucuker, Jennifer L. Vande Voort, Deniz Doruk Camsari, Faranak Farzan, Paul E. Croarkin
Summary: Based on 113 articles, it is suggested that LICI may serve as a biomarker of GABA(B) functioning, but more rigorous research is required. The existing LICI literature shows methodological heterogeneity and inconsistencies in findings, which are also non-specific to diseases. Future studies should address these weaknesses and focus on high-quality test-retest reliability.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study found that transcranial direct current stimulation (tDCS) intervention on the right intraparietal sulcus (rIPS) can improve response inhibition function, and the effect of stimulation depends on the participant's response inhibition function prior to intervention.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Health Care Sciences & Services
Rajan Kashyap, Sagarika Bhattacharjee, Ramaswamy Arumugam, Rose Dawn Bharath, Kaviraja Udupa, Kenichi Oishi, John E. Desmond, S. H. Annabel Chen, Cuntai Guan
Summary: The study introduced a dose-target determination index (DTDI) to quantify the focality of tDCS and found that individuals of different ages and genders show varying changes in focality when the current dose is increased. The nonlinear relationship between the injected tDCS current and the distribution of current density in the target ROI is predominant in older adults, with males exhibiting a stronger decline in focality. Higher current doses in older age can enhance the focality of stimulation.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Neurosciences
Arturo Nuara, Maria Chiara Bazzini, Pasquale Cardellicchio, Emilia Scalona, Doriana De Marco, Giacomo Rizzolatti, Maddalena Fabbri-Destro, Pietro Avanzini
Summary: Observation of others' actions is crucial for motor skill acquisition and can induce changes in motor cortex excitability. Action Observation Training (AOT) improves motor performance, and the extent of improvement is predicted by the modulation of corticospinal excitability and intracortical inhibition during action observation.
Article
Clinical Neurology
Forouzan Farahani, Greg Kronberg, Mohamad FallahRad, Hysell V. Oviedo, Lucas C. Parra
Summary: This study found that transcranial direct current stimulation (DCS) enhances synaptic plasticity by increasing postsynaptic somatic spiking, but also discovered that an increase in network activity may both boost and limit this enhancement.
Article
Clinical Neurology
Xiaoyun Li, Junjie Yao, Wenyun Zhang, Shengxiong Chen, Weiwei Peng
Summary: This study aimed to assess the robustness of tDCS effects on experimental pain perception among healthy populations. The results showed a significant tDCS effect on attenuating pain intensity ratings to suprathreshold noxious stimuli, while effects on pain threshold and tolerance were not significant. Moderator analysis suggested that stimulation parameters and experimental pain modality moderated the effectiveness of tDCS in reducing pain intensity ratings.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Behavioral Sciences
Qian Ding, Huiting Cai, Manfeng Wu, Guiyuan Cai, Hongying Chen, Wanqi Li, Tuo Lin, Yinghua Jing, Tifei Yuan, Guangqing Xu, Yue Lan
Summary: This study systematically investigated the relationship between resting-state intracortical inhibition or facilitation and inhibitory control, finding a positive correlation between short intracortical facilitation and poorer inhibitory control. This suggests that short intracortical facilitation may serve as a potential physiological biomarker for motor-inhibitory control and have clinical implications for disorders associated with inhibitory control deficits.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Neurosciences
Ronan A. Mooney, James P. Coxon, John Cirillo, Helen Glenny, Nicholas Gant, Winston D. Byblow
EXPERIMENTAL BRAIN RESEARCH
(2016)
Article
Neurosciences
Ronan A. Mooney, John Cirillo, Winston D. Byblow
JOURNAL OF NEUROPHYSIOLOGY
(2017)
Article
Neurosciences
John Cirillo, Jonathan B. Finch, J. Greg Anson
NEUROSCIENCE LETTERS
(2017)
Editorial Material
Geriatrics & Gerontology
George M. Opie, John Cirillo
FRONTIERS IN AGING NEUROSCIENCE
(2017)
Article
Clinical Neurology
John Cirillo, John G. Semmler, Ronan A. Mooney, Winston D. Byblow
Article
Neurosciences
John Cirillo, Matthew J. Cowie, Hayley J. MacDonald, Winston D. Byblow
JOURNAL OF NEUROPHYSIOLOGY
(2018)
Article
Neurosciences
George M. Opie, John Cirillo, John G. Semmler
JOURNAL OF PHYSIOLOGY-LONDON
(2018)
Article
Neurosciences
Ronan A. Mooney, John Cirillo, Winston D. Byblow
EUROPEAN JOURNAL OF NEUROSCIENCE
(2018)
Article
Clinical Neurology
Anita Trudgen, John Cirillo, Winston D. Byblow
Article
Neurosciences
John Cirillo, John G. Semmier, Ronan A. Mooney, Winston D. Byblow
EXPERIMENTAL BRAIN RESEARCH
(2020)
Review
Neurosciences
John Cirillo
Summary: Engaging in physical activity benefits brain health and function, with older adults experiencing potentially lower plasticity in areas responsible for controlling movement. Motor complications with aging may contribute to reduced physical activity in older adults.
EXPERIMENTAL BRAIN RESEARCH
(2021)
Article
Neurosciences
Corey G. Wadsley, John Cirillo, Arne Nieuwenhuys, Winston D. Byblow
Summary: This study provides a freely available Selective Stopping Toolbox (SeleST) to investigate selective stopping using either anticipatory or stop-signal task variants. The results suggest that selective stopping can be successfully investigated with either anticipatory or stop-signal paradigms in SeleST. The anticipatory paradigm should be used when strict control of response times is desired, while the stop-signal paradigm should be used when it is desired to estimate stop-signal reaction time with the independent race model.
EXPERIMENTAL BRAIN RESEARCH
(2023)
Article
Neurosciences
Corey G. Wadsley, John Cirillo, Arne Nieuwenhuys, Winston D. Byblow
Summary: This study aimed to determine whether nonselective response inhibition during selective stopping is the result of a global pause process or a nonselective cancel process. In a bimanual anticipatory response inhibition paradigm, participants showed delayed responses in the non-signaled hand during selective ignore and stop trials, indicating that stopping-interference cannot solely be attributed to attentional capture. Furthermore, a stimulus-nonselective increase in frontocentral beta-bursts occurred during stop and ignore trials. These findings suggest that nonselective response inhibition primarily arises from a nonselective pause process, but does not fully explain the stopping-interference effect.
Article
Clinical Neurology
Ronan A. Mooney, Suzanne J. Ackerley, Deshan K. Rajeswaran, John Cirillo, P. Alan Barber, Cathy M. Stinear, Winston D. Byblow
NEUROREHABILITATION AND NEURAL REPAIR
(2019)