Article
Multidisciplinary Sciences
Houssni Lamkaddam, Josef Dommen, Ananth Ranjithkumar, Hamish Gordon, Gunther Wehrle, Jordan Krechmer, Francesca Majluf, Daniil Salionov, Julia Schmale, Sasa Bjelic, Kenneth S. Carslaw, Imad El Haddad, Urs Baltensperger
Summary: The study reveals that processing isoprene oxidation products in cloud droplets can produce a significant amount of secondary organic aerosol, which may have a substantial impact on the global aerosol burden.
Article
Environmental Sciences
Duseong S. Jo, Alma Hodzic, Louisa K. Emmons, Simone Tilmes, Rebecca H. Schwantes, Michael J. Mills, Pedro Campuzano-Jost, Weiwei Hu, Rahul A. Zaveri, Richard C. Easter, Balwinder Singh, Zheng Lu, Christiane Schulz, Johannes Schneider, John E. Shilling, Armin Wisthaler, Jose L. Jimenez
Summary: Secondary organic aerosol (SOA) is a significant contributor to fine particulate matter in the atmosphere, with volatility-based SOA parameterizations showing reasonable performance but potential errors when applied to future climatic conditions. Explicit mechanism predictions suggest variability in isoprene epoxydiols (IEPOX SOA) concentrations across different scenarios, highlighting the importance of capturing key physicochemical drivers for accurate SOA concentration predictions in climate studies.
ATMOSPHERIC CHEMISTRY AND PHYSICS
(2021)
Article
Engineering, Environmental
Fobang Liu, Tianchang Xu, Nga Lee Ng, Hang Lu
Summary: This study reveals that oxidative stress may be a mechanism through which ambient fine particulate matter exerts adverse biological effects. It also demonstrates the association between cellular health and ROS levels upon exposure to secondary organic aerosols, emphasizing the role of oxidative stress in the biological effects of SOA exposure.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Environmental Sciences
Dagen D. Hughes, Megan B. Christiansen, Alissa Milani, Michael P. Vermeuel, Gordon A. Novak, Hariprasad D. Alwe, Angela F. Dickens, R. Bradley Pierce, Dylan B. Millet, Timothy H. Bertram, Charles O. Stanier, Elizabeth A. Stone
Summary: The Lake Michigan Ozone Study conducted in 2017 aimed to understand the sources contributing to ozone and fine particles along the Lake Michigan coast. The study found that different weather patterns during high ozone periods affected the regional characteristics of PM2.5. The research also highlighted the importance of anthropogenic sulfate emissions and aerosol acidity on secondary organic aerosol (SOA) formation.
ATMOSPHERIC ENVIRONMENT
(2021)
Article
Pathology
Robson Seriani, Carla Peres de Paula, Anderson Ferreira da Cunha, Marcos Antonio de Oliveira, Paloma Gava Krempel, Daniela Perroni Frias, Elnara Marcia Negri, Thais Mauad, Mariangela Macchione
Summary: Exposure to diesel exhaust particles may decrease the gene expression patterns of the PRDX family in bronchial epithelial airway cells, leading to an increase in oxidative stress levels.
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2021)
Article
Nutrition & Dietetics
Shu-Ju Wu, Wen-Chung Huang, Ching-Yi Cheng, Meng-Chun Wang, Shu-Chen Cheng, Chian-Jiun Liou
Summary: The study shows that fisetin can reduce the inflammatory response and oxidative stress in bronchial epithelial cells, and improve airway hyperresponsiveness in asthmatic mice. Fisetin decreases the levels of inflammatory cytokines and chemokines, as well as intercellular adhesion molecule-1 expression. It also suppresses monocyte adhesion and reduces eosinophil numbers. Moreover, fisetin promotes glutathione levels and decreases malondialdehyde levels in the lungs.
Article
Engineering, Environmental
Ziying Lei, Yuzhi Chen, Yue Zhang, Madeline E. Cooke, Isabel R. Ledsky, N. Cazimir Armstrong, Nicole E. Olson, Zhenfa Zhang, Avram Gold, Jason D. Surratt, Andrew P. Ault
Summary: The study demonstrates that initial aerosol acidity plays a significant role in shaping the physicochemical properties of SOA formed from IEPDX, with higher acidity resulting in more organosulfate formation and a tendency for the organic phase to transition to a semi-solid or solid state. These findings can be used to improve model parameterizations of SOA formation and properties from IEPDX to better align predictions with atmospheric observations.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Engineering, Environmental
Min Yao, Ziyue Li, Chenxi Li, Huayun Xiao, Shunyao Wang, Arthur W. H. Chan, Yue Zhao
Summary: Organic peroxides play a crucial role in the formation, evolution, and health impacts of atmospheric aerosols. This study identified a range of peroxide monomers and dimers in secondary organic aerosols formed from the ozonolysis of alpha-pinene. The peroxides undergo rapid chemical transformation in the particle phase, with individual peroxides decomposing on different timescales. The reactivity of the peroxides is influenced by aerosol water content, with a greater impact at lower relative humidity. These findings are important for understanding the fate and impacts of organic peroxides on aerosol chemistry and health effects.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Chemistry, Analytical
Wen Zhang, Haofei Zhang
Summary: Iodide-adduct chemical ionization mass spectrometry (I-CIMS) is widely used in atmospheric chemistry to detect oxygenated volatile organic compounds (OVOCs) in real time. The study reports secondary ion chemistry from interactions between strong oxygen donors and acidic OVOCs in I-CIMS, which can lead to misinterpretations of gas-phase products' compositions and distributions. However, the varying degrees of signal change in response to secondary ion chemistry may provide clues to OVOCs' functionalities.
ANALYTICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Edward R. Pennington, Syed Masood, Steven O. Simmons, Lisa Dailey, Philip A. Bromberg, Rebecca L. Rice, Avram Gold, Zhenfa Zhang, Weidong Wu, Yi Yang, James M. Samet
Summary: This study investigates the effects of air pollutants on intracellular redox homeostasis in human airway cells. The results show that isoprene hydroxy hydroperoxide (ISOPOOH), an atmospheric oxidation product, can disrupt the redox balance in cells, but this imbalance can be restored by glucose. Additionally, glucose-6-phosphate dehydrogenase (G6PD) plays a regulatory role in this process.
Article
Environmental Sciences
Linlin Liang, Guenter Engling, Wanyun Xu, Qianli Ma, Weili Lin, Xuyan Liu, Chang Liu, Gen Zhang
Summary: Laboratory experiments suggest acid-catalyzed aqueous-phase production can promote the formation of isoprene SOA, i.e., 2-methyltetrols. In this study, ambient observations and chemical measurements were used to investigate the importance of environmental factors in the formation of isoprene epoxydiols (IEPDX) SOA under atmospheric humidity conditions. The results show that photochemical processes dominate the formation of 2-methyltetrols in humid environments, and aerosol acidity has a limited influence on their formation. Additionally, high liquid water content reduces aerosol droplet acidity, thereby diminishing the enhancement of SOA formation.
Article
Biochemistry & Molecular Biology
Jiyoung Jang, Sun Park, In-Hong Choi
Summary: This study identified and distinguished the responses of endothelial and epithelial cells to silver nanoparticles, showing toxicity was affected by NP size and dose. There was a noticeable increase in IL-11 gene expression, indicating specific intracellular gene responses to the NPs.
Article
Pharmacology & Pharmacy
Huang-Chi Chen, Hsin-Ying Clair Chiou, Mei-Lan Tsai, Szu-Chia Chen, Ming-Hong Lin, Tzu-Chun Chuang, Chih-Hsing Hung, Chao-Hung Kuo
Summary: This study demonstrates that montelukast is effective at reducing arsenic-induced epithelial-mesenchymal transition (EMT) in human bronchial epithelial cells. By inhibiting arsenic-induced reactive oxygen species (ROS) generation and NF-kB activation, montelukast can suppress arsenic-induced cell migration and the expression of extracellular matrix proteins and EMT-regulating transcription factors. Combination treatment with fluticasone and montelukast can reverse the inhibitory effect of montelukast on arsenic-induced EMT.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Engineering, Environmental
Shunyao Wang, Peter J. Gallimore, Carolyn Liu-Kang, Kirsten Yeung, Steven J. Campbell, Battist Utinger, Tengyu Liu, Hui Peng, Markus Kalberer, Arthur W. H. Chan, Jonathan P. D. Abbatt
Summary: This study reports the unique chemical and toxicological metrics of biomass burning organic aerosols (BBOA) from pine wood smoldering during multiphase aging by gas-phase hydroxyl radicals (OH). Both the fresh and OH-aged BBOA show activity relevant to adverse health outcomes. Short-term aging initiated by OH radicals can produce biomass burning particles with a higher particle-bound reactive oxygen species (ROS) generation capacity, posing a greater exposure hazard for residents in large population centers close to wildfire regions than previously studied fresh biomass burning emissions.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Environmental
Fabian Mahrt, Elli Newman, Yuanzhou Huang, Markus Ammann, Allan K. Bertram
Summary: The research found that internal mixtures of POA and SOA in the atmosphere almost always formed two phases when the O/C ratio of the POA was less than 0.11. When the O/C ratio of the POA was between 0.11 and 0.29, the mixtures mostly resulted in particles with one liquid phase. However, depending on the types of SOA and POA surrogates, two liquid phases were also observed in some cases, and an increase in phase-separated particles was observed when increasing the relative humidity within this O/C range.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Review
Pediatrics
T. Michael O'Shea, Monica McGrath, Judy L. Aschner, Barry Lester, Hudson P. Santos, Carmen Marsit, Annemarie Stroustrup, Crisma Emmanuel, Mark Hudak, Elisabeth McGowan, Simran Patel, Rebecca C. Fry
Summary: The National Institutes of Health's ECHO Program conducts research on the links between children's environment and health, with a focus on very preterm infants. The program utilizes data from three cohorts to study the effects of environmental factors on the health outcomes of preterm infants.
PEDIATRIC RESEARCH
(2023)
Article
Pediatrics
Traci A. Bekelman, Emily A. Knapp, Yanan Dong, Dana Dabelea, Tracy M. Bastain, Carrie Breton, Kecia N. Carroll, Carlos A. Camargo, Ann M. Davis, Anne L. Dunlop, Amy J. Elliott, Assiamira Ferrara, Rebecca C. Fry, Jody M. Ganiban, Diane Gilbert-Diamond, Frank D. Gilliland, Monique M. Hedderson, Alison E. Hipwell, Christine W. Hockett, Kathi C. Huddleston, Margaret R. Karagas, Nichole Kelly, Jin-Shei Lai, Barry M. Lester, Maristella Lucchini, Melissa M. Melough, Nicole L. Mihalopoulos, T. Michael O'Shea, Andrew G. Rundle, Joseph B. Stanford, Sara VanBronkhorst, Rosalind J. Wright, Qi Zhao, Katherine A. Sauder
Summary: Societal changes during the COVID-19 pandemic may affect children's health behaviors. Parents experiencing financial strain may need additional support to promote healthy behaviors. Changing work schedules to care for children can lead to shorter screen time and longer sleep duration.
Article
Behavioral Sciences
Robert M. Joseph, Emily R. Lai, Somer Bishop, Joe Yi, Margaret L. Bauman, Jean A. Frazier Jr, Hudson P. Santos, Laurie M. Douglas, Karl K. C. Kuban, Rebecca C. Fry, T. Michael O'Shea
Summary: Children born preterm have different ASD core symptoms and associated characteristics compared to children born at term. This study compared extremely preterm (EP) and term-born children with ASD using the Autism Diagnostic Interview-Revised (ADI-R) and the Autism Diagnostic Observation Schedule (ADOS). The results showed that the EP group had less severe symptom scores on verbal communication, particularly stereotyped language, and restricted, repetitive behaviors. Additionally, the EP group had higher rates of language delays and lower physical growth parameters.
Article
Chemistry, Medicinal
Alexa Canchola, Siri Langmo, Ruth Meletz, Michael Lum, Ying-Hsuan Lin
Summary: Despite previous studies indicating the thermal stability of vitamin E acetate (VEA) at low temperatures, VEA readily decomposes into various degradation products at vaping temperatures of <200 degrees C. The presence of molecular oxygen and transition metals such as Cu-Ni greatly enhance VEA degradation, resulting in the formation of numerous degradation products. The results highlight the importance of oxidation pathways in VEA thermal degradation and aid in the prediction of degradation products from e-liquids.
CHEMICAL RESEARCH IN TOXICOLOGY
(2023)
Article
Environmental Sciences
Lauren A. Eaves, Catherine M. Bulka, Julia E. Rager, Amaree J. Gardner, Aubrey L. Galusha, Patrick J. Parsons, T. Michael O'Shea, Rebecca C. Fry
Summary: Prenatal exposure to toxic metals is associated with adverse birth and later-in-life outcomes. This study aimed to investigate the relationship between metal concentrations in the umbilical cord and altered gene expression networks in placental tissue. The results showed that certain metals, such as lead and cadmium, were associated with changes in gene expression and the dysregulation of important pathways in the placenta. These findings provide insights into the potential mechanisms underlying metal-induced diseases.
Review
Public, Environmental & Occupational Health
Emily Oken, Theresa M. Bastain, Nicole Bornkamp, Carrie Breton, Rebecca C. Fry, Diane R. Gold, Marie-France Hivert, Steve Howland, Daniel J. Jackson, Christine C. Johnson, Kyra Jones, MollyAn Killingbeck, T. Michael O'Shea, Marleny Ortega, Dennis Ownby, Frederica Perera, Julie Rollins, Julie B. Herbstman
Summary: High-quality evidence from prospective longitudinal studies in humans is essential for understanding the developmental origins of health and disease. This paper discusses the challenges faced by birth cohort studies and provides recommendations for long-term funding, maintaining contact with participants, maximizing engagement, and addressing sensitive topics. Successful longitudinal follow-up requires flexibility, adaptability, and appropriate incentives.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2023)
Article
Chemistry, Physical
Bo Chen, Jessica A. Mirrielees, Yuzhi Chen, Timothy B. Onasch, Zhenfa Zhang, Avram Gold, Jason D. Surratt, Yue Zhang, Sarah D. Brooks
Summary: We measured the Tg of IEPOX-derived SOA components using broadband dielectric spectroscopy and found that the Tg of mixtures depends on their composition. The Kwei equation provides a good fit for the Tg-composition relationship of complex mixtures. We demonstrate that the non-linear deviation of Tg as a function of composition may be caused by changes in the extent of hydrogen bonding in the mixture using Raman spectroscopy and density functional theory.
JOURNAL OF PHYSICAL CHEMISTRY A
(2023)
Article
Environmental Sciences
Lauren A. Eaves, Paul Lanier, Adam E. Enggasser, Gerard Chung, Toby Turla, Julia E. Rager, Rebecca C. Fry
Summary: Due to structural racism and income inequality, exposure to environmental chemicals is closely linked to socioeconomic factors. Additionally, exposure to psychosocial stressors and limited resources can increase susceptibility to environmentally induced disease. However, studies in social science and environmental science are often conducted separately, limiting comprehensive risk estimates. To address this gap, the Chemical and Social Stressors Integration Technique (CASS-IT) was developed to integrate environmental chemical and social stressor datasets. CASS-IT provides a framework to identify geographic areas based on environmental chemical exposure, social vulnerability, and access to resources.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Correction
Chemistry, Multidisciplinary
David O. De Haan, Lelia N. Hawkins, Praveen D. Wickremasinghe, Alyssa D. Andretta, Juliette R. Dignum, Audrey C. De Haan, Hannah G. Welsh, Elyse A. Pennington, Tianqu Cui, Jason D. Surratt, Mathieu Cazaunau, Edouard Pangui, Jean-Francois Doussin
ACS EARTH AND SPACE CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
David O. De Haan, Lelia N. Hawkins, Praveen D. Wickremasinghe, Alyssa D. Andretta, Juliette R. Dignum, Audrey C. De Haan, Hannah G. Welsh, Elyse A. Pennington, Tianqu Cui, Jason D. Surratt, Mathieu Cazaunau, Edouard Pangui, Jean-Francois Doussin
Summary: Aqueous-phase dark reactions during the co oxidation of glyoxal and S(IV) were found to be a potential source of brown carbon (BrC), which occurs more slowly in sunlit, sulfite containing solutions. Detectable amounts of BrC in aerosol require an OH radical source and occur most rapidly after a cloud event. Radical-initiated reactions and redox mechanisms play a role in this process. However, the BrC produced is about ten times less light-absorbing than wood smoke BrC at 365 nm.
ACS EARTH AND SPACE CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Faria Khan, Yuzhi Chen, Hadley J. Hartwell, Jin Yan, Ying-Hsuan Lin, Anastasia Freedman, Zhenfa Zhang, Yue Zhang, Andrew T. Lambe, Barbara J. Turpin, Avram Gold, Andrew P. Ault, Rafal Szmigielski, Rebecca C. Fry, Jason D. Surratt
Summary: This study demonstrates that atmospheric chemical aging of particulate 2-MTSs induces toxic effects in human lung cells, leading to changes in the expression of genes related to oxidative stress and inflammation.
CHEMICAL RESEARCH IN TOXICOLOGY
(2023)
Article
Engineering, Environmental
Clara M. A. Eichler, Naomi Y. Chang, Elaine A. Cohen Hubal, Daniel E. Amparo, Jiaqi Zhou, Jason D. Surratt, Glenn C. Morrison, Barbara J. Turpin
Summary: During the Indoor PFAS Assessment (IPA) Campaign, concentrations of nine neutral PFAS were measured in air and cotton cloth in 11 homes in North Carolina. The study found that fluorotelomer alcohols were the dominant species in indoor air, while perfluorooctane sulfonamidoethanols accumulated most significantly in cloth. Cloth-air partition coefficients were derived for different PFAS and were positively correlated with the octanol-air partition coefficient. Temperature was found to have the greatest effect on PFAS accumulation.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Environmental
Bosen Jin, Yiwen Zhu, Weiyang Zhao, Zekun Liu, Shun Che, Kunpeng Chen, Ying-Hsuan Lin, Jinyong Liu, Yujie Men
Summary: This study investigated the structure-biodegradability relationship for different ether PFAS in activated sludge communities. Only polyfluorinated ethers with specific molecular structures underwent biotransformation, leading to the formation of unstable fluoroalcohol intermediates subject to spontaneous defluorination. The findings suggest that aerobic biotransformation/defluorination can complement advanced reduction processes for cost-effective treatment of PFAS.
ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
(2023)
Article
Chemistry, Analytical
Marc Webb, Liyong Cui, Glenn Morrison, Karsten Baumann, Jason D. Surratt, Zhenfa Zhang, Joanna Atkin, Barbara J. Turpin
Summary: Humidity affects the removal and concentrations of indoor pollutants, especially in humid homes. Research on a model organic peroxide showed that the relative humidity has a greater effect on the removal rate and reaction probability on soiled surfaces compared to clean surfaces. These findings are important for predicting indoor concentrations of organic peroxides.
ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS
(2023)
Article
Engineering, Environmental
Kunpeng Chen, Raphael Mayorga, Caitlin Hamilton, Roya Bahreini, Haofei Zhang, Ying-Hsuan Lin
Summary: Carbonyl chromophores derived from nighttime oxidation of furan and pyrrole derivatives significantly contribute to light absorption in secondary BrC. The quantified N-containing carbonyl chromophores contribute to over 40% of total light absorption at specific wavelengths, highlighting their divergent importance in different spectral regions.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
