Article
Anatomy & Morphology
Oyvind Wilsgard Simonsen, Rafal Czajkowski, Menno P. Witter
Summary: The medial entorhinal cortex (MEC) and the retrosplenial cortex (RSC) are both involved in spatial processing, and this study reveals that RSC projections synapse onto MEC layer V neurons, which also receive input from the hippocampal formation. These findings suggest that convergent information from RSC and the subiculum contributes to the signal sent from superficial layers of the MEC to the hippocampal formation.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Cell Biology
Emily A. Aery Jones, Antara Rao, Misha Zilberter, Biljana Djukic, Jason S. Bant, Anna K. Gillespie, Nicole Koutsodendris, Maxine Nelson, Seo Yeon Yoon, Ky Huang, Heidi Yuan, Theodore M. Gill, Yadong Huang, Loren M. Frank
Summary: PV+ and SST+ interneurons in the hippocampus play distinct roles in regulating the flow of information through the hippocampal circuit.
Article
Neurosciences
Chelsea Hook, Adam. C. C. Puche
Summary: The circuit operations of the olfactory bulb are modulated by higher order projections from multiple regions, including glutamatergic and GABAergic projections. The GABAergic neurons in the bulb show remarkable specificity in targeting other primary olfactory cortical regions, suggesting their role in modulating synaptic processing and associational processing of olfactory information.
JOURNAL OF COMPARATIVE NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Virginie Bottero, Dallen Powers, Ashna Yalamanchi, James P. Quinn, Judith A. Potashkin
Summary: Alzheimer's disease is a chronic neurodegenerative brain disorder affecting millions of Americans, with increasing incidence expected due to the expanding aging population. Study identified 72 key switch genes differentially expressed in AD patients, along with potential regulators and a therapeutic agent to prevent disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Behavioral Sciences
Ilya D. Ionov, Irina I. Pushinskaya, Nicholas P. Gorev, Larissa A. Shpilevaya, David D. Frenkel, Nicholas N. Severtsev
Summary: A decreased H1 receptor activity in the anterior cingulate cortex (aCgCx) may lead to behavior changes related to depression. Blocking of H1 receptors in the aCgCx and lateral entorhinal cortex significantly reduces sucrose preference in rats, indicating a potential therapeutic target in depressive disorders.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Geriatrics & Gerontology
Yujiro Kose, Yoichi Hatamoto, Rie Takae, Yuki Tomiga, Jun Yasukata, Takaaki Komiyama, Yasuki Higaki
Summary: While overall olfaction was not correlated with physical performance, cognitive function, or brain atrophy, the inability to identify the Japanese orange odor was independently associated with mild medial temporal atrophy in community-dwelling older adults.
Article
Multidisciplinary Sciences
R. C. Feord, A. Gomoliszewska, A. Pienaar, J. W. Mouland, T. M. Brown
Summary: This study establishes a new method for studying cone function in mice and reveals the widespread presence of cone-opponent processing in the mouse visual system. This research provides new insights into the functional characteristics of color processing pathways in mice.
SCIENTIFIC REPORTS
(2023)
Article
Biology
Sau Yee Tsoi, Merve oencuel, Ella Svahn, Mark Robertson, Zuzanna Bogdanowicz, Christina McClure, Guelsen Suermeli
Summary: Complementary actions of the neocortex and the hippocampus facilitate the encoding and storage of experience dependent memories. This study reveals that deep layer neurons in the medial entorhinal cortex project to both the hippocampus and neocortex, suggesting a simultaneous influence on these two brain regions.
Article
Multidisciplinary Sciences
Oswaldo Perez, Sergio Delle Monache, Francesco Lacquaniti, Gianfranco Bosco, Hugo Merchant
Summary: This study investigated whether natural visual motion or its kinematics could provide a synchronization advantage over flashing metronomes. The results showed that motion kinematics was the predominant factor determining rhythm synchronization.
Article
Multidisciplinary Sciences
Alan J. Emanuel, Brendan P. Lehnert, Stefano Panzeri, Christopher D. Harvey, David D. Ginty
Summary: Research shows that signals from physiologically distinct mechanoreceptor subtypes are extensively integrated and transformed within the subcortical somatosensory system to generate cortical representations of touch.
Article
Neurosciences
Bo Zhang, Fan Wang, Qi Zhang, Yuji Naya
Summary: Our mental representation of egocentric space is influenced by the disproportionate sensory perception of the body. Previous studies have focused on the neural architecture for egocentric representations within the visual field. However, the space representation underlying the body is still unclear. This study used fMRI and MEG to investigate the spatial representation of targets relative to the body and found that the frontoparietal network is more involved in representing left/right targets, while the MTL-parietal network is more involved in retrieving targets behind the participant. MEG data also showed an earlier activation of the MTL-parietal network during target retrieval.
Article
Neurosciences
Mohammad Amani, Julie C. Lauterborn, Aliza A. Le, Brittney M. Cox, Weisheng Wang, Julian Quintanilla, Conor D. Cox, Christine M. Gall, Gary Lynch
Summary: The deterioration of layers II/III of the entorhinal cortex in the early stages of Alzheimer's disease may be due to impaired presynaptic long-term potentiation, reduced endocannabinoid signaling, and decreased TrkB receptor levels. These changes suggest that synaptic plasticity in EC projections related to memory is particularly sensitive to aging, leading to potential pathogenesis later in life.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Ece Boran, Peter Hilfiker, Lennart Stieglitz, Johannes Sarnthein, Peter Klaver
Summary: The involvement of the medial temporal lobe (MTL) in working memory is controversial, but recent research has found that persistent neural firing in the hippocampus during maintenance is related to workload. This study recorded single neuron firing in 13 epilepsy patients while they performed a visual working memory task. The results showed that performance was almost perfect for low workload and dropped at high workload, suggesting that high workload exceeded working memory capacity. Maintenance neurons in the MTL were identified, and more of them were found in the hippocampus for trials with correct performance compared to incorrect performance. Maintenance neurons showed increased firing in the hippocampus and entorhinal cortex for high workload. Population firing in the entorhinal cortex and hippocampus accurately predicted workload during the maintenance period. The data suggest that persistent neural firing in the MTL supports performance and workload of multiple items in working memory, beyond working memory capacity.
Article
Biology
Shinya Ohara, Stefan Blankvoort, Rajeevkumar Raveendran Nair, Maximiliano J. Nigro, Eirik S. Nilssen, Clifford Kentros, Menno P. Witter
Summary: Research indicates the presence of different operational principles in the connections from layer Vb to Va in the entorhinal cortex, with these connections being stronger in dorsal LEC compared to dorsal MEC. This suggests a potential difference in how LEC and MEC mediate episodic memory consolidation in the brain.
Article
Neurosciences
Nichole R. Bouffard, Ali Golestani, Iva K. Brunec, Buddhika Bellana, Jun Young Park, Morgan D. Barense, Morris Moscovitch
Summary: During navigation, there exist temporal dynamics gradients in the hippocampus and entorhinal cortex. The granularity of information represented in the hippocampus increases along its long axis. Signal stability in the anterior-medial hippocampus is modulated by navigational difficulty and is relevant to behavior.
Article
Anatomy & Morphology
Gunes Unal, Michael G. Crump, Tim J. Viney, Timea Eltes, Linda Katona, Thomas Klausberger, Peter Somogyi
BRAIN STRUCTURE & FUNCTION
(2018)
Article
Neurosciences
Minas Salib, Abhilasha Joshi, Linda Katona, Michael Howarth, Benjamin R. Micklem, Peter Somogyi, Tim J. Viney
JOURNAL OF NEUROSCIENCE
(2019)
Article
Multidisciplinary Sciences
Michael Segel, Bjorn Neumann, Myfanwy F. E. Hill, Isabell P. Weber, Carlo Viscomi, Chao Zhao, Adam Young, Chibeza C. Agley, Amelia J. Thompson, Ginez A. Gonzalez, Amar Sharma, Staffan Holmqvist, David H. Rowitch, Kristian Franze, Robin J. M. Franklin, Kevin J. Chalut
Correction
Multidisciplinary Sciences
Michael Segel, Bjorn Neumann, Myfanwy F. E. Hill, Isabell P. Weber, Carlo Viscomi, Chao Zhao, Adam Young, Chibeza C. Agley, Amelia J. Thompson, Ginez A. Gonzalez, Amar Sharma, Staffan Holmqvist, David H. Rowitch, Kristian Franze, Robin J. M. Franklin, Kevin J. Chalut
Article
Anatomy & Morphology
Linda Katona, Katja Hartwich, Ryohei Tomioka, Jozsef Somogyi, J. David B. Roberts, Kristina Wagner, Abhilasha Joshi, Thomas Klausberger, Kathleen S. Rockland, Peter Somogyi
BRAIN STRUCTURE & FUNCTION
(2020)
Article
Anatomy & Morphology
Abhilasha Joshi, Peter Somogyi
BRAIN STRUCTURE & FUNCTION
(2020)
Review
Neurosciences
Khalil S. Rawji, Ginez A. Gonzalez Martinez, Amar Sharma, Robin J. M. Franklin
TRENDS IN NEUROSCIENCES
(2020)
Article
Neurosciences
Manuel Valero, Tim J. Viney, Robert Machold, Sara Mederos, Ipshita Zutshi, Benjamin Schuman, Yuta Senzai, Bernardo Rudy, Gyorgy Buzsaki
Summary: A unique neuron type called down state-active (DSA) neurons has been identified in mice and rats, which show anti-correlated spiking activity with principal cells and interneurons during non-REM sleep, especially during the down state. Despite their sparsity, DSA neurons play critical roles in physiological functions, shaping the firing sequence of neurons during down-up transitions and interfering with memory consolidation during NREM sleep.
NATURE NEUROSCIENCE
(2021)
Article
Cell Biology
Tim J. Viney, Barbara Sarkany, A. Tugrul Ozdemir, Katja Hartwich, Judith Schweimer, David Bannerman, Peter Somogyi
Summary: This study investigates the impact of hyperphosphorylated Tau (pTau) on cellular and network activity in the hippocampal formation of tauopathy model mice. The accumulation of pTau in deep-layer pyramidal neurons and its spread to oligodendrocytes lead to neurodegeneration. Despite reduced short-term familiarity, spatial working and reference memory remain normal in transgenic mice. It is hypothesized that preserved subcortical network mechanisms maintain cortical neuronal coordination and counteract the effects of pTau aggregation and neurodegeneration.
Article
Multidisciplinary Sciences
Abhilasha Joshi, Eric L. Denovellis, Abhijith Mankili, Yagiz Meneksedag, Thomas J. Davidson, Anna K. Gillespie, Jennifer A. Guidera, Demetris Roumis, Loren M. Frank
Summary: The hippocampus expresses spatial representations and is crucial for navigation, while the details of locomotor processes are primarily computed and represented in subcortical circuits. This study found a coordination between hippocampal spatial representations and the forelimb stepping cycle in freely behaving rats, with precise timing during spatial decisions.
Article
Multidisciplinary Sciences
Balint Kiraly, Andor Domonkos, Marta Jelitai, Vitor Lopes-dos-Santos, Sergio Martinez-Bellver, Barnabas Kocsis, Daniel Schlingloff, Abhilasha Joshi, Minas Salib, Richard Fiath, Peter Bartho, Istvan Ulbert, Tamas F. Freund, Tim J. Viney, David Dupret, Viktor Varga, Balazs Hangya
Summary: The medial septum orchestrates hippocampal network activity at multiple temporal scales likely mediating memory encoding and retrieval.
NATURE COMMUNICATIONS
(2023)
Article
Cell Biology
Bjorn Neumann, Michael Segel, Tanay Ghosh, Chao Zhao, Panagiotis Tourlomousis, Adam Young, Sarah Forster, Amar Sharma, Civia Zi-Yu Chen, Juan F. Cubillos, Khalil S. Rawji, Kevin J. Chalut, Robin J. M. Franklin
Summary: Research indicates that during aging, the functionality of oligodendrocyte progenitor cells is impaired, but the expression of c-Myc can drive their functional rejuvenation, providing important insights for regeneration.