期刊
ELIFE
卷 7, 期 -, 页码 -出版社
eLIFE SCIENCES PUBL LTD
DOI: 10.7554/elife.33034
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资金
- Fundacao para a Ciencia e a Tecnologia [PTDC/AGR-ALI/112802/2009, UID/Multi/04378/2013, SFRH/BD/89489/2012, SFRH/BPD/102803/2014]
- National Science Foundation [IOS-1401682, DEB-1253634, DEB-1442148, DEB-1442113]
- National Institute of Food and Agriculture [1003258]
- Wisconsin Alumni Research Foundation
- DOE Great Lakes Bioenergy Research Center [BER DE-FC02-07ER64494]
- Pew Charitable Trusts
- European Regional Development Fund [POCI-01-0145-FEDER-007728]
- H2020 Marie Sklodowska-Curie Actions [747775]
- Division Of Environmental Biology
- Direct For Biological Sciences [1253634] Funding Source: National Science Foundation
- Fundação para a Ciência e a Tecnologia [PTDC/AGR-ALI/112802/2009, SFRH/BD/89489/2012] Funding Source: FCT
Fructophily is a rare trait that consists of the preference for fructose over other carbon sources. Here, we show that in a yeast lineage (the Wickerhamiella/Starmerella, W/S Glade) comprised of fructophilic species thriving in the high-sugar floral niche, the acquisition of fructophily is concurrent with a wider remodeling of central carbon metabolism. Coupling comparative genomics with biochemical and genetic approaches, we gathered ample evidence for the loss of alcoholic fermentation in an ancestor of the W/S Glade and subsequent reinstatement through either horizontal acquisition of homologous bacterial genes or modification of a preexisting yeast gene. An enzyme required for sucrose assimilation was also acquired from bacteria, suggesting that the genetic novelties identified in the W/S Glade may be related to adaptation to the high-sugar environment. This work shows how even central carbon metabolism can be remodeled by a surge of HGT events.
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