Article
Geriatrics & Gerontology
Jason Fanning, Barbara J. Nicklas, W. Jack Rejeski
Summary: Engaging in sufficient levels of physical activity is crucial for maintaining health and quality of life across all ages. Recent research has shifted focus from intense structured exercise to the negative impacts of prolonged sitting, and more recently on interventions targeting individual activity profiles.
EXPERIMENTAL GERONTOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Guilherme Lima de Oliveira, Andressa C. S. Sobrinho, Cicero Jonas R. Benjamim, Guilherme da Silva Rodrigues, Karine Pereira Rodrigues, Carlos Henrique Fernandes, Adriano Bruno Correa, Tamara Nascimento Felicio, Grace Angelica de Oliveira Gomes, Carlos Roberto Bueno Junior
Summary: This study investigates the bidirectional relationship between PAL and SB, and their impact on health variables in women aged 60 to 70 years. It was found that PAL and SB are related to health variables, and NAF can enhance CS. This dependency between variables may affect the quality of health when denied.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Geriatrics & Gerontology
Megan Hetherington-Rauth, Joao P. Magalhaes, Pedro B. Judice, Ignacio Ara, Gil B. Rosa, Ines R. Correia, Asier Manas, Luis B. Sardinha
Summary: The study found that higher sedentary time (ST) was associated with lower composite physical function (CPF) score, while higher moderate-to-vigorous physical activity (MVPA) was associated with better CPF score. Breaks in sedentary time (BST) were not related to physical independence after accounting for MVPA and ST. MVPA was found to moderate the relationship between ST and physical independence.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Review
Geriatrics & Gerontology
Audrey M. Collins, Cristina Molina-Hidalgo, Sarah L. Aghjayan, Jason Fanning, Emily D. Erlenbach, Neha P. Gothe, Daniel Velazquez-Diaz, Kirk I. Erickson
Summary: Public health messaging calls for individuals to be more physically active and less sedentary. However, the influence of sedentary behavior (SB) on brain health in late adulthood remains unclear. Existing literature on this topic is mixed and inconclusive, mainly due to the use of different measurement techniques and the lack of accounting for the role of physical activity (PA). Future research should focus on prospective longitudinal studies and randomized clinical trials to better understand the relationship between SB and the brain in late adulthood.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Geriatrics & Gerontology
Mengying Han, Jiaxin Fang, Yixin Zhang, Xingxu Song, Lina Jin, Yanan Ma
Summary: Sleeping, sedentary behavior, and physical activity are associated with aging among adults, and the competitive nature between sedentary behavior and physical activity has been neglected in previous studies. This study found that spending 30 minutes per day on sedentary behavior was positively associated with aging, while 30 minutes per day of leisure-time moderate-to-vigorous physical activity (MVPA) was negatively associated with aging. Replacing sedentary behavior with MVPA or walking/bicycling was negatively associated with aging, while substituting walking/bicycling for leisure-time MVPA was positively associated with aging.
Article
Geriatrics & Gerontology
Rod L. Walker, Mikael Anne Greenwood-Hickman, John Bellettiere, Andrea Z. LaCroix, David Wing, Michael Higgins, KatieRose Richmire, Eric B. Larson, Paul K. Crane, Dori E. Rosenberg
Summary: This study found associations between physical function and activity metrics other than MVPA among older adults, with steps showing a significant relationship with physical function in adults aged 75+. The study also found that worse function was more pronounced in participants with the lowest levels of MVPA. These findings support research on broader activity patterns for improving function in older adults.
Article
Psychology, Multidisciplinary
Vinko Zovko, Sasa Djuric, Vedrana Sember, Gregor Jurak
Summary: There is a familial association between physical activity and sedentary behavior, with mothers playing an important role in influencing children's activity levels. Grandparents have less significant impact on children's activity, while grandfathers' sedentary behavior is a predictor of children's sedentary behavior.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Sport Sciences
Susan C. Gilchrist, Aleena Bennett, Suzanne E. Judd, Tomi Akinyemiju, Virginia J. Howard, Steven P. Hooker, Mary Cushman, Keith M. Diaz
Summary: Sedentary behavior is associated with poor physical function in older adults, but moderate to vigorous intensity physical activity (MVPA) can improve physical functioning. Reallocating sedentary time to light-intensity physical activity or MVPA can improve physical functioning. High sedentary time combined with low MVPA is associated with poorer physical function.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Clinical Neurology
Wan-Chi Huang, Chia-Shuan Chang, Chien-Yu Lin, Ting-Fu Lai, Ming-Chun Hsueh, Yung Liao, Jong-Hwan Park
Summary: The study found that sleep timing was negatively associated with moderate-to-vigorous physical activity and daily steps in older women, suggesting that sleep timing should be taken into consideration when designing physical activity strategies or interventions for older women.
NATURE AND SCIENCE OF SLEEP
(2021)
Article
Public, Environmental & Occupational Health
Michele Mattle, Ursina Meyer, Wei Lang, Noemi Mantegazza, Michael Gagesch, Richard Mansky, Reto W. Kressig, Andreas Egli, E. John Orav, Heike A. Bischoff-Ferrari
Summary: The study investigated activity profiles regarding physical activity and sedentary behavior among generally healthy European older adults. It found that some older adults did not meet physical activity recommendations and spent a long time in sedentary behavior. Male, younger age, and lower BMI individuals were more likely to meet the physical activity recommendations, while higher BMI and higher cognitive function scores were associated with more sedentary behavior.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Sport Sciences
Anna Kankaanpaa, Asko Tolvanen, Sailalitha Bollepalli, Tuija Leskinen, Urho M. Kujala, Jaakko Kaprio, Miina Ollikainen, Elina Sillanpaa
Summary: The study found that greater leisure-time physical activity was associated with slower epigenetic aging, while occupational physical activity was linked to faster epigenetic aging. However, these associations were attenuated after adjusting for smoking status.
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2021)
Article
Multidisciplinary Sciences
Yanwei You, Yuquan Chen, Xiaoxin Wang, Mengxian Wei, Qi Zhang, Qiang Cao
Summary: Prolonged sitting accelerates aging, while optimal physical activity patterns delay the process. This study investigated the association between sensor-based physical activity and phenotypic age using a nationwide population from the NHANES in the US. The results showed that prolonged sitting was positively associated with phenotypic age, while increasing LPA and MVPA was associated with younger phenotypic age. Substituting sedentary behavior with LPA or MVPA was found to reduce phenotypic age.
Article
Clinical Neurology
Luis E. A. Malheiros, Bruno G. G. da Costa, Marcus V. V. Lopes, Kelly S. Silva
Summary: This study found that the school shift attended by high school students is associated with their sleep behaviors, but not with other lifestyle behaviors.
Article
Health Care Sciences & Services
Chieh-Chen Wu, Chih-Wei Huang, Yao-Chin Wang, Md. Mohaimenul Islam, Woon-Man Kung, Yung-Ching Weng, Chun-Hsien Su
Summary: This study provides a dynamic and longitudinal bibliometric analysis of recent research trends in mHealth technologies for weight loss, physical activity, and sedentary behavior. The findings reveal an exponential growth in the number of publications in these fields, with the United States being the leading contributor. The study highlights the potential of mobile apps and technologies in reducing weight, increasing physical activity, and changing sedentary behavior.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Christine Krogsgaard Schroder, Lisa Urup Tonning, Marianne Tjur, Pia Kjaer Kristensen, Inger Mechlenburg
Summary: This study aimed to provide reference values for accelerometer-based data on physical activity in a background population. A population-based cross-sectional study was conducted on randomly selected individuals aged 18-80 years, using accelerometer-based data and self-reported demographics and health information. The results showed that participants took an average of 6095 daily steps, had an average cadence of 98.5, spent 3.7 hours standing, 1.4 hours walking, 3.8 minutes cycling, 7.0 hours in sedentary activities, and had 43 sit to stand transfers. The findings are important for clinical practice and research as they provide sex- and age-specific reference values for comparing daily physical activity levels.
APPLIED SCIENCES-BASEL
(2023)
Article
Psychology, Clinical
M. J. Bosma, S. R. Cox, T. Ziermans, C. R. Buchanan, X. Shen, E. M. Tucker-Drob, M. J. Adams, H. C. Whalley, S. M. Lawrie
Summary: This study reveals that lower global white matter microstructure is associated with having PLEs in combination with distress, suggesting a direction of future research. Additionally, it replicates the finding that processing speed mediates the relationship between white matter microstructure and g-factor.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Clinical Neurology
J. M. Blodgett, J. J. Mitchell, E. Stamatakis, S. Chastin, M. Hamer
Summary: This study found that spending more time on moderate to vigorous physical activity (MVPA) relative to sedentary behavior (SB), sleep, or light-intensity physical activity (LIPA) is associated with a lower risk of depression. Replacing sleep, SB, or LIPA with MVPA time was strongly associated with lower depression risk. Reallocating time between SB, sleep, or LIPA had minimal to no effect on depression risk.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Public, Environmental & Occupational Health
John J. Mitchell, Joanna M. Blodgett, Sebastien F. M. Chastin, Barbara J. Jefferis, S. Goya Wannamethee, Mark Hamer
Summary: This study examines the associations between movement behaviours (sedentary behaviour, moderate and vigorous physical activity, light intensity physical activity, and sleep) and cognition. It finds that higher levels of moderate and vigorous physical activity and sedentary behaviour are associated with better cognitive scores. Of all the movement behaviours, reducing time spent in moderate and vigorous physical activity has the most detrimental effect on cognition.
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2023)
Article
Biochemistry & Molecular Biology
Janie Corley, Federica Conte, Sarah E. E. Harris, Adele M. M. Taylor, Paul Redmond, Tom C. C. Russ, Ian J. J. Deary, Simon R. R. Cox
Summary: Understanding why some people experience greater cognitive decline than others is a major challenge in the field of cognitive ageing research. A study conducted on a group of 1091 men and women from the longitudinal Lothian Birth Cohort 1936 revealed that addressing multiple risk factors throughout a person's life may be the most effective strategy. The study also found that APOE e4 carrier status is an important factor in identifying individuals at higher risk for accelerated cognitive ageing.
MOLECULAR PSYCHIATRY
(2023)
Editorial Material
Genetics & Heredity
Riccardo E. Marioni
Summary: The article discusses how the publication of Horvath's epigenetic clock has impacted research on aging, rejuvenation, and epigenetic epidemiology.
NATURE REVIEWS GENETICS
(2023)
Article
Neurosciences
Tyler Saunders, Ciaran Gunn, Kaj Blennow, Hlin Kvartsberg, Henrik Zetterberg, Susan D. Shenkin, Simon R. Cox, Ian J. Deary, Colin Smith, Declan King, Tara Spires-Jones
Summary: Neurogranin (Ng), a post-synaptic protein, has been investigated as a biomarker for Alzheimer's disease (AD) and aging in cerebrospinal fluid (CSF). Our study examined Ng abundance in post-mortem human brain tissue in AD, healthy aging (HA), and mid-life (ML) cohorts. Ng levels were quantified using immunohistochemistry in brain regions associated with cognitive change. The results showed significantly reduced Ng levels in AD compared to HA and ML cases, indicating loss of neurogranin in the brain. Our findings support the use of CSF Ng as a biomarker for AD and cognitive decline in healthy aging.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Psychiatry
Donncha S. Mullin, Lucy E. Stirland, Emily Buchanan, Catherine-Anne Convery, Simon R. Cox, Ian J. Deary, Cinzia Giuntoli, Holly Greer, Danielle Page, Elizabeth Robertson, Susan D. Shenkin, Anna Szalek, Adele Taylor, Georgina Weatherdon, Tim Wilkinson, Tom C. Russ
Summary: This study presents a systematic framework for identifying dementia in cohort studies and reports the incidence and prevalence of all-cause dementia and dementia subtypes in the LBC1936. The study found that self-reported dementia diagnoses only accounted for 17.8% of ascertained dementia diagnoses. Through clinician assessments and consensus diagnostic review, the prevalence of all-cause dementia was found to be 13.6%, increasing with age. Women had higher prevalence rates in almost all age groups. The most common subtype was dementia due to Alzheimer disease (49.2%), followed by mixed Alzheimer and cerebrovascular disease (17.0%), dementia of unknown or unspecified cause (16.1%), and dementia due to vascular disease (8.5%).
Article
Neurosciences
Anna E. Furtjes, Ryan Arathimos, Jonathan R. I. Coleman, James H. Cole, Simon R. Cox, Ian J. Deary, Javier de la Fuente, James W. Madole, Elliot M. Tucker-Drob, Stuart J. Ritchie
Summary: Understanding the neurodegenerative mechanisms of cognitive decline can help detect health issues in late life. This study explores the genetic links between brain morphometry, aging, and cognitive ability using Genomic Principal Components Analysis. The analysis reveals moderate shared genetic etiology between brain-wide morphometry and cognitive aging, suggesting a potential genetic basis for age-related cognitive decline.
HUMAN BRAIN MAPPING
(2023)
Article
Biochemistry & Molecular Biology
V. Kartik Chundru, Riccardo E. Marioni, James G. D. Prendergast, Tian Lin, Allan J. Beveridge, Nicholas G. Martin, Grant W. Montgomery, David A. Hume, Ian J. Deary, Peter M. Visscher, Naomi R. Wray, Allan F. McRae
Summary: Testing the effect of rare variants on phenotypic variation is challenging due to the need for large cohorts. This study investigates the effect of rare genetic variants on DNA methylation (DNAm) and demonstrates their role in phenotypic variation. The study also shows that extreme levels of DNAm have functional consequences on gene expression.
HUMAN MOLECULAR GENETICS
(2023)
Article
Geriatrics & Gerontology
Ashleigh C. Duthie, Jean Hannah, G. David Batty, Ian J. Deary, John M. Starr, Daniel J. Smith, Tom C. Russ
Summary: This study investigated the association between lithium levels in drinking water and the rate of dementia using data from the Scottish Mental Survey 1932. The results showed that lithium levels in drinking water are very low in Scotland, and extremely low levels of lithium are not associated with an increased risk of dementia. However, there was a slight trend towards increased risk in females at lithium levels below 2.1 mu g/L.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Article
Sport Sciences
Le Wei, Matthew N. Ahmadi, Hsiu-Wen Chan, Sebastien Chastin, Mark Hamer, Gita D. Mishra, Emmanuel Stamatakis
Summary: This study aimed to examine the associations between different types and contexts of stepping behaviors and cardiometabolic risk. The results showed that all stepping behaviors were beneficial to cardiometabolic health, with higher stair steps and peak 30-min walking intensity associated with a steep decline of adiposity biomarkers. Purposeful steps showed more consistent associations with cardiometabolic biomarkers than incidental steps.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
Article
Psychology
Miriam Molas-Tuneu, Javier Jerez-Roig, Eduard Minobes-Molina, Laura Coll-Planas, Anna Escriba-Salvans, Pau Farres-Godayol, Meltem Yildirim, Sandra Rierola-Fochs, Ester Goutan-Roura, Dyego Leandro Bezerra De Souza, Dawn A. Skelton, Jordi Naudo-Molist
Summary: This study analyzed the loneliness and its associated factors in 65 residents of 5 nursing homes in Central Catalonia, Spain. The prevalence of overall loneliness among the residents was almost 71%. Overall loneliness was associated with lower perceived quality of life and state subsidized nursing homes, social loneliness was associated with having 0-1 children, and emotional loneliness was associated with depression and urinary incontinence.
ANALES DE PSICOLOGIA
(2023)
Review
Endocrinology & Metabolism
Thomas Z. Schlacht, Inaya Haque, Dawn A. Skelton
Summary: The objective of this review was to determine the effects of exercise on high-resolution peripheral quantitative computed tomography (HR-pQCT) derived trabecular microarchitecture parameters in older adults. Seven studies (397 participants) were included. Exercise was not found to have significant effects on trabecular microarchitecture in postmenopausal women over the age of 50. These findings should be interpreted with caution due to the small number of studies investigating few modes of exercise, their weak to moderate quality, and risk of bias.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Review
Public, Environmental & Occupational Health
Julius Cesar Alejandre, Sebastien Chastin, Katherine N. Irvine, Michail Georgiou, Preeti Khanna, Zoe Tieges, Niamh Smith, Yong-Yee Chong, Frances Claire Onagan, Lesley Price, Sharon Pfleger, Rachel Helliwell, Judith Singleton, Samuel Curran, Allan Estandarte, Emily Sophia Smith, Karin Helwig
Summary: Nature-based social prescribing, such as blue prescription, can improve public health and the health of individuals with chronic conditions. However, there is limited evidence on the implementation of blue prescription programs in healthcare settings. We conducted a review and identified contextual factors and program theories that influence the outcomes of blue prescription programs. After participating in these programs, service users showed improvements in physical, mental, and social health. Consideration of contextual factors and program theories is crucial for the design and evaluation of blue prescription programs.
HEALTH & SOCIAL CARE IN THE COMMUNITY
(2023)
Article
Geriatrics & Gerontology
Pau Farres-Godayol, Miguel angel Ruiz-Diaz, Philippa Dall, Dawn A. Skelton, Eduard Minobes-Molina, Javier Jerez-Roig, Maria Gine-Garriga
Summary: This study aimed to determine the minimum number of valid days required for accurately estimating sedentary behavior (SB) and awake-time movement behaviors (ATMB) in nursing home residents using the activPAL3 device. It also investigated how the starting point of a day impacted reliability.
EUROPEAN REVIEW OF AGING AND PHYSICAL ACTIVITY
(2023)