Article
Orthopedics
Domenico Andrea Campanacci, Roberto Scanferla, Matteo Innocenti, Francesco Muratori, Serena Puccini, Guido Scoccianti, Giovanni Beltrami, Rodolfo Capanna, Marco Innocenti
Summary: This retrospective study analyzed the results of intercalary resection of the humeral diaphysis and vascularized fibula graft (VFG) in 127 patients with primary bone tumors. The study found that VFG is an effective reconstructive option after humeral intercalary resection, providing long-term, durable reconstruction with excellent functional results. However, mechanical complications after surgery were relatively high and should be managed by an experienced surgical team.
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
(2023)
Article
Oncology
Vincent Crenn, Yonis Quinette, Charlie Bouthors, Gilles Missenard, Brice Viard, Philippe Anract, Stephane Boisgard, Eric Mascard, Francois Gouin
Summary: The study suggests that using a vascularised fibula graft (VFG) in femoral reconstructions can promote bone union and reduce mid- to long-term revision risks. However, irradiated allografts increase the risk of revisions. Therefore, in cases of tumors, it is recommended to choose VFG+ from fresh-frozen allografts.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Orthopedics
Travis J. Dekker, William W. Schairer, W. Jeffrey Grantham, Nicholas N. DePhillipo, Zachary S. Aman, Robert F. LaPrade
Summary: This study compared varus knee stability and clinical outcomes in patients undergoing FCLR or LCL reconstruction with autografts or allografts during ACLR. Results showed no significant differences in varus stress laxity or clinical outcome scores between autograft and allograft groups at short-term and ≥2-year follow-up. Both autografts and allografts for FCL reconstructions demonstrated reliable and similar radiographic and clinical results.
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2021)
Article
Orthopedics
E. P. Wellings, M. T. Houdek, A. R. Owen, K. Bakri, M. J. Yaszemski, F. H. Sim, S. L. Moran, P. S. Rose
Summary: This study compared the use of free vascularized fibular flaps (FVF) and allograft fibular struts (AFS) for spinopelvic reconstruction after sacral tumor resection. The results showed that reconstruction with FVF had shorter time to union and higher Musculoskeletal Tumor Society Score compared to reconstruction with AFS.
BONE & JOINT JOURNAL
(2021)
Article
Orthopedics
Ahmed Fathy Sadek, Ezzat Hassan Fouly, Ahmad Fouad Abdelbaki Allam, Alaa Zenhom Mahmoud
Summary: The combination of locked compression plating with non-vascularized fibular autograft appears to be an effective treatment option for resistant humeral diaphyseal nonunion, resulting in reliable bony union and improved functional outcomes. Despite some complications such as infection or nonunion, the overall success rate of achieving union and better postoperative outcomes is significant.
ORTHOPAEDICS & TRAUMATOLOGY-SURGERY & RESEARCH
(2021)
Article
Medicine, General & Internal
Zhaohui Li, Zhen Pan, Hua Guo, Xiang Fei, Dongdong Cheng, Qingcheng Yang
Summary: This study retrospectively evaluated the clinical outcomes and complications of reconstruction with a composite free fibula inside other biological grafts. The results showed that this method is a reasonable and durable option with a high union rate. The administration of vascularized or non-vascularized grafts did not significantly affect the surgical outcomes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Orthopedics
Jan Lesensky, Andreas F. Mavrogenis
Summary: The study found that permanent cement spacer intercalary reconstruction can be a viable surgical option after intercalary tumor resection in patients with humerus and femur bone tumors, demonstrating low complication rates and good survival and functional recovery outcomes.
Article
Oncology
Yajie Lu, Xin Xiao, Minghui Li, Guojing Chen, Mengquan Huang, Chuanlei Ji, Zhen Wang, Jing Li
Summary: The combination of vascularized fibula epiphyseal transfer with massive allograft bone provides a reliable oncologic reconstruction of proximal humerus in children, offering longitudinal growth, hypertrophy, and osseous union while decreasing reconstructive complications and improving shoulder function. The study retrospectively investigated five pediatric patients who underwent this composite approach, finding positive outcomes with improved growth and shoulder function postoperatively.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Orthopedics
Ki Bum Kwon, Chin Youb Chung, Moon Seok Park, Kyoung Min Lee, Ki Hyuk Sung
Summary: A pediatric patient with Ewing's sarcoma of the tibia was successfully treated with vascularized fibular autograft to correct limb deformity and leg length discrepancy. Despite good progress in bone union, further osteosynthesis with iliac bone allograft was needed to address nonunion.
JOURNAL OF ORTHOPAEDIC SURGERY
(2021)
Article
Orthopedics
Xianhao Shao, Mengmeng Dou, Qiang Yang, Jianmin Li, Ailin Zhang, Yuan Yao, Qing Chu, Ka Li, Zhenfeng Li
Summary: Two novel 3D-printed customized intercalary femoral prostheses were used to reconstruct massive bone defects in oncologic patients, achieving satisfactory postoperative outcomes and increasing the opportunities for joint-preserving tumor resection.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Orthopedics
Amanda N. Goldin, Samuel R. Johnson, Katherine S. Hajdu, Brooke L. Kowalski, Alexander J. Volkmar, Cullen P. Moran, Akhil Rekulapelli, Joshua M. Lawrenz, Jennifer L. Halpern, Herbert S. Schwartz, Ginger E. Holt
Summary: This study compared fixation methods in intercalary allograft reconstruction in the lower extremity and found that intramedullary fixation with nails had higher rates of nonunion, but lower fracture rates and revision surgery rates. Additionally, allograft survival was longer in the intramedullary group.
JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
(2023)
Article
Orthopedics
Xin Hu, Minxun Lu, Xuanhong He, Longqing Li, Jingqi Lin, Yong Zhou, Yi Luo, Li Min, Chongqi Tu
Summary: Background: Hip-preserved reconstruction for patients with ultrashort proximal femur segments following extensive femoral diaphyseal tumor resection is a challenging procedure. Methods: This study aimed to analyze and compare the biomechanical behavior and clinical outcomes of a customized intercalary prosthesis with a rhino horn-designed uncemented stem for the reconstruction of these extensive skeletal defects. Results: The biomechanical results showed that the rhino horn-designed uncemented stem had better stress and displacement distribution patterns compared to the straight stem. Stem A performed better in terms of biomechanical performance, while the fixation system with Stem B was relatively unstable. The clinical results were consistent with the finite element analysis (FEA) results. Conclusion: The rhino horn-designed uncemented stem offers precise shape matching and osseointegration. This novel prosthesis design may reduce the risk of mechanical failure and aseptic loosening, particularly when using Stem A. Therefore, the customized intercalary prosthesis with this rhino horn-designed uncemented stem may be a suitable option for the reconstruction of ultrashort proximal femur segments following extensive tumor resection.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Surgery
Kou Fujisawa, Shimpei Miyamoto, Hiroshi Kobayashi, Mutsumi Okazaki
Summary: With advances in chemotherapy and surgical techniques, limb salvage and biological reconstruction, including autologous bone grafting, have become the preferred treatment options for primary malignant bone tumors of the extremities. However, fracture is a frequent major complication of autografts. This report describes successful salvage of refractory autograft fractures using free vascularized fibular grafts.
PLASTIC AND RECONSTRUCTIVE SURGERY-GLOBAL OPEN
(2023)
Review
Pediatrics
M. Florio, S. Careri, C. Zoccali, A. G. Aulisa, F. Falciglia, R. M. Toniolo, M. Giordano
Summary: This article presents a case of the use of a non-vascularized fibular graft for metatarsal bone reconstruction after Giant Cell Tumor resection in a 9-year-old patient, and reviews the literature on metatarsal bone reconstruction in skeletally immature patients.
FRONTIERS IN PEDIATRICS
(2022)
Article
Orthopedics
Bulent Erol, Omer Sofulu, Evrim Sirin, Fevzi Saglam, Ozgur Baysal, Cihangir Tetik
Summary: Pelvic ring reconstruction using double-barreled free vascularized fibular graft (FVFG) and internal fixation following iliosacral resections in children can achieve a high rate of bone union and good functional outcomes. Complications, such as deep infection, hematoma, wound dehiscence, and disease relapse, are usually manageable without the need for revision surgical procedures.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2021)
Article
Orthopedics
Matteo Innocenti, Francesco Muratori, Lorenzo Foschi, Saverio Bartolini, Maurizio Scorianz, Guido Scoccianti, Domenico Andrea Campanacci
Summary: Megaprosthesis is commonly used for limb salvage after tumor resection, but it is associated with high complication rates and potential limb amputation. This study found that multiple revision surgeries increase the incidence of complications, particularly after infection, leading to a higher amputation rate.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2023)
Review
Surgery
Stefano Bastoni, Elena Lucattelli, Federico Cipriani, Giacomo Cannamela, Marco Innocenti, Giulio Menichini
Summary: Pelvic ring reconstruction using a double-barreled fibular free flap (DBF) provides a good functional outcome. Our analysis did not find any statistical evidence of correlation between fixation technique and complications or ambulation status, but did find a statistical correlation between age and fixation technique.
Article
Dentistry, Oral Surgery & Medicine
F. Arcuri, M. Innocenti, G. Menichini, C. Pantani, M. Raffaini
Summary: This study describes the first cases of using the medial femoral condyle (MFC) flap for the treatment of mandibular non-union. The technique showed satisfactory results during one-year follow-up.
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2022)
Letter
Surgery
Marco Innocenti, Sara Calabrese
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Adriano Pasqui, Anna Boddi, Domenico Andrea Campanacci, Guido Scoccianti, Andrea Bernini, Daniela Grasso, Elisabetta Gambale, Federico Scolari, Ilaria Palchetti, Annarita Palomba, Sara Fancelli, Enrico Caliman, Lorenzo Antonuzzo, Serena Pillozzi
Summary: In this study, we observed a severe deregulation of the nucleotide excision repair (NER) pathway in soft tissue sarcoma (STS) patients and described the effect of SNP rs1047768 in the ERCC5 structure for the first time. These findings revealed the correlation between specific genotypes of ERCC genes and the proficiency of the NER pathway in STS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Roberto Scanferla, Giuliana Roselli, Guido Scoccianti, Marco Bartolini, Francesco Muratori, Domenico Andrea Campanacci
Summary: This study reviewed 73 cases of chronic osteomyelitis treated in their department between 1995 and 2019, and found an incidence rate of 8.2% of malignant degeneration to squamous cell carcinoma. MRI was found to be crucial in differential diagnosis and follow-up.
Article
Biochemistry & Molecular Biology
Mauro Loi, Giulia Salvatore, Michele Aquilano, Daniela Greto, Cinzia Talamonti, Viola Salvestrini, Maria Elena Melica, Marianna Valzano, Giulio Francolini, Mariangela Sottili, Costanza Santini, Carlotta Becherini, Domenico Andrea Campanacci, Monica Mangoni, Lorenzo Livi
Summary: Trabectedin sensitizes STS cells to radiation therapy by reducing cell survival rate, inhibiting invasiveness, altering cell cycle distribution, and increasing γ-H2AX foci formation. However, it does not have a synergistic effect on DNA damage repair, neoangiogenesis, and the immune system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Surgery
Said C. Azoury, Ronnie L. Shammas, Sammy Othman, Amanda Sergesketter, Brian E. Brigman, Jie C. Nguyen, Alexandre Arkader, Kristy L. Weber, Detlev Erdmann, L. Scott Levin, Stephen J. Kovach, Marco Innocenti
Summary: This study reviewed the long-term outcomes of vascularized fibula epiphyseal transfer for proximal humeral reconstruction in children. The results showed that this surgery preserves future growth potential and articular surface motion, but often leads to peroneal nerve palsy. Future efforts should focus on reducing postoperative complications.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Editorial Material
Surgery
Marco Innocenti, Gerardo Malzone, Giulio Menichini
Summary: Microsurgery has become standard care for complex techniques, and robotic assistance has potential for extreme motion scaling and tremor reduction. The Symani Surgical System was used to successfully complete a robot-assisted microsurgical free flap reconstruction, demonstrating feasibility for anastomosis of small vessels. The system has the potential to open up new opportunities in microsurgery.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Article
Surgery
Sara Calabrese, Marco Innocenti
Summary: The aim of this study is to demonstrate the versatility of adipofascial flaps harvested around selected perforators, which allows for the safe expansion of the usage of superthin ALT perforator (ALTP) flaps.
ARCHIVES OF PLASTIC SURGERY-APS
(2022)
Article
Medicine, Research & Experimental
Emily Pettersen, Paolo Sassu, Carina Reinholdt, Peter Dahm, Ola Rolfson, Anders Bjoerkman, Marco Innocenti, Francesca Alice Pedrini, Juan Manuel Breyer, Aidan Roche, Andrew Hart, Lorraine Harrington, Adil Ladak, Hollie Power, Jacqueline Hebert, Max Ortiz-Catalan
Summary: This study protocol presents an international, double-blind, randomized controlled trial to evaluate the effectiveness of surgical interventions such as targeted muscle reinnervation (TMR), regenerative peripheral nerve interface (RPNI), and neuroma transposition in alleviating residual limb pain (RLP), neuroma pain, and phantom limb pain (PLP) in amputees. The study aims to establish evidence-based procedures and address the challenges of subjective pain experience and lack of objective evaluation methods.
Article
Oncology
Marco Innocenti, Francesco Mori, Francesca Alice Pedrini, Luca Salmaso, Andrea Gennaro, Paolo Sassu
Summary: Reconstruction of soft tissue defects in the posterior trunk following tumor excision has been challenging in the past due to limited local donor sites. The advent of perforator flaps has revolutionized this field and provided a new approach to the problem. This article aims to summarize the current trends in this area of reconstruction.
Article
Biochemistry & Molecular Biology
Cecilia Romagnoli, Roberto Zonefrati, Elena Lucattelli, Marco Innocenti, Roberto Civinini, Teresa Iantomasi, Maria Luisa Brandi
Summary: This study evaluated the effects of PTH on the proliferation and differentiation of skeletal muscle satellite cells isolated from human biopsies. Results showed no significant changes in cAMP and proliferation in the isolated cells treated with PTH, but differentiated myotubes treated with PTH exhibited increased cAMP, expression of myogenic differentiation genes, and MHC protein. This study provides new insights into the effects of PTH on human skeletal muscle cells and opens new avenues for research in muscle pathophysiology.
Article
Medicine, General & Internal
Michele Fiore, Andrea Sambri, Lorenzo Morante, Marta Bortoli, Stefania Claudia Parisi, Francesco Panzavolta, Domenico Alesi, Elisabetta Neri, Maria Pia Neri, Sara Tedeschi, Eleonora Zamparini, Luca Cevolani, Davide Maria Donati, Pierluigi Viale, Domenico Andrea Campanacci, Stefano Zaffagnini, Massimiliano De Paolis
Summary: Articulated silver-coated megaprosthesis in a two-stage protocol is a safe and effective treatment for chronic knee infection with severe bone loss. The recurrence-free survival rate is high, although there is a risk of complications.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Orthopedics
Marco Innocenti, Luca Delcroix, Elena Lucattelli, Stefano Bastoni, Primo Andrea Daolio