Article
Oncology
Haowen Jiang, Clifford Jiajun He, Albert Li, Bo He, Yang Li, Meng-Ning Zhou, Jiangbin Ye
Summary: This study demonstrates that mitochondrial uncoupling effectively inhibits the reductive carboxylation in cancer cells. By activating the electron transport chain and increasing the NAD(+)/NADH ratio, mitochondrial uncoupling accelerates the oxidative tricarboxylic acid cycle and blocks reductive carboxylation. Inhibiting reductive carboxylation could be a key mechanism by which mitochondrial uncouplers inhibit tumor growth.
MOLECULAR CANCER RESEARCH
(2023)
Review
Gastroenterology & Hepatology
Lorenza Rimassa, Richard S. Finn, Bruno Sangro
Summary: Single-agent immune checkpoint inhibitors (ICIs) have limited efficacy in advanced hepatocellular carcinoma (HCC) patients, and approximately 30% of patients show intrinsic resistance to ICIs. Therefore, researchers are exploring combination therapies, such as anti-angiogenic agents and other ICIs. Some trials have shown promising results and potential for clinical application. However, there are still many unanswered questions that require further research.
JOURNAL OF HEPATOLOGY
(2023)
Article
Microbiology
Wu Yang, Shiqi Dong, Junhuan Yang, Hassan Mohamed, Aabid Manzoor Shah, Yusuf Nazir, Xiuzhen Gao, Huirong Fan, Yuanda Song
Summary: This study investigated the citrate transport mechanism of the mitochondrial citrate transporter (MCT) in M. circinelloides, showing that citrate efflux is associated with high lipid accumulation. The study confirmed the efficiency of CT for [C-14] citrate/citrate exchange and the promoting effect of other molecules on citrate transport, providing mechanistic evidence of citrate efflux in oleaginous fungi.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Medicine, General & Internal
Chin-Ho Tsao, Rong-Hong Jhou, Chien-Chih Ke, Chun-Wei Chang, Chi-Wei Chang, Bang-Hung Yang, Wen-Sheng Huang, Bing-Fu Shih, Ren-Shyan Liu
Summary: Proposed a imaging probe that can assess the lipogenic activity of hepatocellular carcinoma (HCC) and predict the response to lipogenesis-targeted therapy.
FRONTIERS IN MEDICINE
(2022)
Article
Oncology
Tengfei Liu, Junming Yu, Chao Ge, Fangyu Zhao, Jing Chen, Chunxiao Miao, Wenjiao Jin, Qingqing Zhou, Qin Geng, Hechun Lin, Hua Tian, Taoyang Chen, Haiyang Xie, Ying Cui, Ming Yao, Xiuying Xiao, Jinjun Li, Hong Li
Summary: The study demonstrates that SPAG4 plays an oncogenic role in hepatocellular carcinoma (HCC) progression by affecting lipid metabolism. Combining orlistat with sorafenib reverses SPAG4-mediated oncogenesis in HCC cells and xenograft tumors, suggesting a potential therapeutic strategy for HCC treatment.
Article
Physiology
Chaitra Surugihalli, Linda S. Farley, Ronique C. Beckford, Boonyarit Kamkrathok, Hsiao-Ching Liu, Vaishna Muralidaran, Kruti Patel, Tom E. Porter, Nishanth E. Sunny
Summary: The developmental transition from embryonic liver relying on lipid oxidation to neonatal liver upregulating de novo lipogenesis is characterized by rapid remodeling of hepatic mitochondrial and cytoplasmic networks without symptoms of hepatocellular stress. This metabolic phenotype is preserved in isolated hepatocytes from embryos and neonates, with neonatal hepatocytes showing robust response to insulin and glucagon, impacting lipid oxidation and lipogenesis. Overall, primary hepatocytes from embryonic and neonatal chickens serve as a valuable tool to study mechanisms regulating hepatic mitochondrial metabolism and de novo lipogenesis.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Microbiology
Wei Cao, Licheng Zhang, Liu Wu, Mingyi Zhang, Jiao Liu, Zhoujie Xie, Hao Liu
Summary: "This study identified and characterized the mitochondrial citrate transporters (Ctps) in Aspergillus Niger, a major cell factory for citric acid production. The results showed that CtpA, CtpB, and CtpD play important roles in citric acid transport across the mitochondrial membrane and function redundantly. Enhancing the citric acid transport process could serve as a target for boosting citric acid accumulation in A. niger."
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Oncology
Qian Liu, Xifeng Dong
Summary: Hepatocellular carcinoma is a common and serious type of cancer with limited treatment options. Studies have shown that inhibiting de novo lipogenesis and cholesterol biosynthesis may be a novel therapeutic strategy for HCC.
JOURNAL OF HEPATOCELLULAR CARCINOMA
(2021)
Article
Cell Biology
Qingfang Zhao, Chenguang Zhang, Xialu Zhang, Shanshan Wang, Ting Guo, Yuzhe Yin, Hui Zhang, Zhuo Li, Yang Si, Yabin Lu, Shan Cheng, Wei Ding
Summary: This study reveals a novel suppressive function of ZNF281 on mitochondrial biogenesis through inhibition of the NRF1/PGC-1α-TFAM axis, which promotes epithelial mesenchymal transition, invasion, and metastasis of HCC cells.
CELL DEATH DISCOVERY
(2023)
Article
Multidisciplinary Sciences
Qiang Chen, Jianlong Du, Kun Cui, Wei Fang, Zengqi Zhao, Qiuchi Chen, Kangsen Mai, Qinghui Ai
Summary: Acetylation plays a key role in regulating inflammation induced by lipid surplus, with studies showing that high-fat diet can enhance mitochondrial fatty acid beta-oxidation and increase acetyl-CoA levels in the liver. Activation of ACLY and CEP leads to heightened p65 acetylation, exacerbating inflammation, while inactivation of SIRT1 further intensifies the inflammatory response.
Article
Oncology
Seon Yoo Kim, Dongwoo Kim, Jisu Kim, Hae Young Ko, Won Jin Kim, Youngjoo Park, Hye Won Lee, Dai Hoon Han, Kyung Sik Kim, Sunghyouk Park, Misu Lee, Mijin Yun
Summary: Patients with low-glycolytic hepatocellular carcinoma (HCC) have better clinical outcomes compared to those with hypoxic and high-glycolytic HCC. The study found that SLC13A5/NaCT is an important solute carrier (SLC) in low-glycolytic HCCs. Extracellular citrate treatment in HCCs with high SLC13A5/NaCT expression led to reduced glucose uptake and tumor growth inhibition. This research suggests that extracellular nutrient administration related to SLCs can prevent hypoxic tumor progression in low-glycolytic HCC.
Article
Biochemistry & Molecular Biology
Raquel Alves, Ana Cristina Goncalves, Joana Jorge, Antonio M. Almeida, Ana Bela Sarmento-Ribeiro
Summary: This study evaluated the therapeutic potential of elacridar, a P-glycoprotein and BCRP inhibitor, in CML cell lines. The results showed that elacridar as monotherapy was not effective, but when combined with imatinib, it could overcome resistance. This provides a new treatment option for overcoming TKI resistance.
Article
Multidisciplinary Sciences
J. Noe Garcia-Chavez, Veronica R. Vasquez-Garzon, Mercedes G. Lopez, Saul Villa-Trevino, Rafael Montiel
Summary: The study analyzed samples chronologically obtained from induced hepatocellular carcinoma (HCC) in rats, finding specific modifications in mitochondria during HCC development. They proposed an omics integration pipeline to identify potential key regulators, biomarkers or therapeutic targets.
Article
Biochemistry & Molecular Biology
Phuriwat Khiewkamrop, Damratsamon Surangkul, Metawee Srikummool, Lysiane Richert, Dumrongsak Pekthong, Supawadee Parhira, Julintorn Somran, Piyarat Srisawang
Summary: Our study found that EGCG promotes apoptosis by inhibiting de novo lipogenesis pathway in cancer cells. In vitro and in vivo experiments confirmed that EGCG can decrease the viability of colorectal cancer cells and induce apoptosis through mitochondrial damage. Furthermore, EGCG treatment resulted in a decrease in intracellular fatty acid levels in tumors, suppressed ATP synthesis, and inhibited the expression of certain signaling proteins.
Article
Pharmacology & Pharmacy
Zhanxu Liu, Nanya Wang, Zhaoli Meng, Shiying Lu, Gong Peng
Summary: Pseudolaric acid B (PAB), isolated from Pseudolarix kaempferi, has been shown to inhibit various cancers. This study investigated the mechanism of PAB in hepatocellular carcinoma (HCC). PAB inhibited cell viability and induced apoptosis in a dose-dependent manner. It disrupted mitochondrial membrane potential and impaired ATP production.
Article
Biochemistry & Molecular Biology
Phornpun Phokrai, Wan-angkan Poolsri, Somrudee Suwankulanan, Narinthorn Phakdeeto, Worasak Kaewkong, Dumrongsak Pekthong, Lysiane Richert, Piyarat Srisawang
Article
Medicine, Research & Experimental
Wanangkan Poolsri, Rattikarn Noitem, Promsuk Jutabha, Manasanan Raveesunthornkiat, Ade Danova, Warinthorn Chavasiri, Chatchai Muanprasat
Summary: This study identified a novel anti-fibrotic agent, AD-021, which effectively reduced collagen accumulation in renal proximal tubule epithelial cells (RPTEC) by inhibiting the TGF-beta 1 pathway. AD-021 suppressed TGF-beta 1-induced collagen production and activation of pro-fibrotic proteins, and ameliorated mitochondrial fission in RPTEC cells. In a mouse model of renal fibrosis, AD-021 reduced plasma TGF-beta 1, improved renal fibrosis, and enhanced renal function.
BIOMEDICINE & PHARMACOTHERAPY
(2023)