Article
Cell Biology
Ganghua Yang, Qinhong Xu, Yong Wan, Lei Zhang, Lin Wang, Fandi Meng
Summary: This study demonstrated the crucial role of circ-CSPP1 in hepatocellular carcinoma (HCC) by regulating the expression of miR-493-5p and HMGB1, thereby suppressing HCC development both in vitro and in vivo.
CELLULAR SIGNALLING
(2021)
Review
Oncology
Chenbin Liu, Han Wu, Yinqi Mao, Wei Chen, Shuying Chen
Summary: Exosomal microRNAs play a crucial role in hepatocellular carcinoma, holding significant value in the early diagnosis and treatment of this disease.
CANCER CELL INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Yihua Chen, Xuanqiu He, Fang Cheng, Mengqing Li, Xuan Wu, Chi Zhang, Jianfa Li, Bin Huang, Minghua Qi
Summary: This study identified E4F1 as a specific transcription factor induced by Ang-II to promote HMGB1 expression. E4F1 overexpression enhanced invasion and migration of HCC cells, while lack of E4F1 did not alter cell behavior. E4F1 was significantly elevated in all three HCC cell lines treated with Ang-II, suggesting its crucial role in mediating Ang-II-induced effects.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Enjiang Chen, Enliang Li, Hao Liu, Yue Zhou, Liang Wen, Jianxin Wang, Yi Wang, Longyun Ye, Tingbo Liang
Summary: The study demonstrates that miR-26b enhances the sensitivity of HCC cells to doxorubicin, providing a potential therapeutic pathway involving the modulation of de-ubiquitination of p53 and regulation of autophagy.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Plant Sciences
Elaine da Silva Siqueira, Virginia Marcia Concato, Fernanda Tomiotto-Pellissier, Taylon Felipe Silva, Bruna Taciane da Silva Bortoleti, Manoela Daiele Goncalves, Idessania Nazareth Costa, Waldiceu Aparecido Verri Junior, Wander Rogerio Pavanelli, Carolina Panis, Mario Sergio Mantovani, Milena Menegazzo Miranda-Sapla, Ivete Conchon-Costa
Summary: The study demonstrated that trans-chalcone exerts significant cytotoxic effects on human HCC HuH7.5 cells without toxicity to non-cancerous cells. It induces mitochondrial membrane damage, G0/G1 cell cycle arrest, decreases in beta-catenin levels, and promotes autophagic cell death, ultimately reducing the metastatic capacity of HuH7.5 cells.
Review
Biochemistry & Molecular Biology
Sharad Khare, Tripti Khare, Raghu Ramanathan, Jamal A. Ibdah
Summary: This review discusses the role and involvement of microRNAs (miRs) in the heterogeneity and metastasis of hepatocellular carcinoma, with a special emphasis on their potential as diagnostic and prognostic tools in the risk prediction, early detection, and treatment of hepatocellular carcinoma.
Review
Genetics & Heredity
Luis M. Ruiz-Manriquez, Oscar Carrasco-Morales, E. Adrian Sanchez, Sofia Madeline Osorio-Perez, Carolina Estrada-Meza, Surajit Pathak, Antara Banerjee, Anindya Bandyopadhyay, Asim K. Duttaroy, Sujay Paul
Summary: This article reviews the microRNA-mediated crucial signaling pathways in hepatocellular carcinoma (HCC), such as PI3K/Akt/mTOR, Hippo-YAP/TAZ, and Wnt/β-catenin, which are of great significance in the management of HCC.
FRONTIERS IN GENETICS
(2022)
Article
Cell Biology
Jun Li, Haozhen Ren, Jinglin Wang, Pengfei Zhang, Xiaolei Shi
Summary: In the progression of HCC, extracellular HMGB1 promotes invasion and EMT process by upregulating miR-21/CD44, and miR-21 activates CD44 expression via the OCT4/TGF-β1 signaling pathway. Moreover, the activation of the Rage/JNK signaling pathway caused by extracellular HMGB1 leads to miR-21 overexpression.
Article
Medicine, General & Internal
Rui Hao, He Lu, Yanan Guo, Qianqian Liu, Lu Wang, Yang Wang, Ailong Huang, Zeng Tu
Summary: Through bioinformatics analysis, key hub genes and miRNAs closely related to HCV-related HCC were identified and their regulatory network was constructed. These findings aim to provide potential therapeutic targets for HCV-related HCC.
Article
Oncology
Wei Zhu, Jun Li, Yuheng Zhang, Zhengyi Zhu, Hanyi Liu, Yunzhen Lin, Anyin Hu, Jingchao Zhou, Haozhen Ren, Xiaolei Shi
Summary: The research revealed that HMGB1 suppressed autophagic activity in a HIPK2-dependent way, leading to enhanced autophagic degradation of ZEB1 through reprogramming glucose metabolism/AMPK/mTOR axis. Selective degradation of ZEB1 was shown to inhibit HCC growth, and the combination therapy of HMGB1 inhibitor and rapamycin achieved a better anti-HCC effect.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Junhua Li, Wei Zhou, Qiang Mao, Dandan Gao, Lin Xiong, Xinyao Hu, Yongfa Zheng, Ximing Xu
Summary: The study revealed that HMGB1 enhances autophagy through the AMPK/mTOR pathway, promoting acquired drug resistance in HCC cells treated with doxorubicin (DOX). Inhibition of HMGB1 and autophagy increased sensitivity to DOX, suggesting HMGB1 inhibitors could be a promising targeted treatment strategy for HCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Qingan Jia, Yaoyao Zhang, Binghui Xu, Xia Liao, Yang Bu, Zihan Xu, Xianglong Duan, Qiangbo Zhang
Summary: The study confirmed the downregulation of WISP2 in HCC tissues and its role as a protective factor, especially in patients without alcohol intake. Upregulation of WISP2 was associated with inhibition of malignant phenotype in vitro, but not in vivo. Additionally, WISP2 negatively correlated with tumor purity, while fibroblast infiltration promoted malignant progression in HCC tissues.
Article
Biochemistry & Molecular Biology
Wing-Keung Chu, Li-Man Hung, Chun-Wei Hou, Jan-Kan Chen
Summary: This study found that MIR630 represses the expression of NANOG through transcriptional and post-transcriptional regulation, leading to the differentiation of NT2/D1 cells. MIR630 may have multiple binding sites in the 3'UTR of NANOG and may act together with other miRNAs to maximally suppress NANOG expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Ling Ji, Xinyi Li, Shushu He, Song Chen
Summary: This review introduces the pathways and related microRNAs involved in osteoclastogenesis, discusses the clinical potential of targeting microRNAs for the treatment of osteoclast-mediated bone resorption, and the challenges of avoiding potential side effects and producing efficient delivery methods.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Laura Gramantieri, Francesca Fornari, Catia Giovannini, Davide Trere
Summary: miRNAs in HCC play a bidirectional role in both immune-related pathways and oncogenic pathways. Understanding their function can help identify patient subgroups and design personalized treatment strategies.
