期刊
BIOMATERIALS SCIENCE
卷 6, 期 7, 页码 1834-1845出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8bm00343b
关键词
-
资金
- National Natural Science Foundation of China [81671813, 81601538, U1505221, 61727823, 61575044]
- Joint Research Projects of Health and Education Commission of Fujian Province [WKJ2016-2-15]
- Joint Funds for the Innovation of Science and Technology, Fujian Province [2016Y9062, 2016Y9061]
- Natural Science Foundation of Fujian Province [2018J01144]
- Scientific Foundation of the Fujian provincial Health and Family Planning Commission [2017-ZQN-75]
Theranostic nanoprobes integrated with dual-modal imaging and therapeutic functions, such as photodynamic therapy (PDT), have exhibited significant potency in cancer treatments due to their high imaging accuracy and non-invasive advantages for cancer elimination. However, biocompatibility and highly efficient accumulation of these nanoprobes in tumor are still unsatisfactory for clinical application. In this study, a photosensitizer -loaded magnetic nanobead with surface further coated with a layer of cancer cell membrane (SSAP-Ce6@CCM) was designed to improve the biocompatibility and cellular uptake and ultimately achieve enhanced MR/NIR fluorescence imaging and PDT efficacy. Compared with similar nanobeads without CCM coating, SSAP-Ce6@CCM showed significantly enhanced cellular uptake, as evidenced by Prussian blue staining, confocal laser scanning microscopy (CLSM) and flow cytometric analysis. Consequently, SSAP-Ce6@CCM displayed a more distinct MR/NIR imaging ability and more obvious photo-cytotoxicity towards cancer cells under 670 nm laser irradiation. Furthermore, the enhanced PDT effect benefited from the surface coating of cancer cell membrane was demonstrated in SMMC-7721 tumor-bearing mice through tumor growth observation and tumor tissue pathological examination. Therefore, this CCM-disguised nanobead that integrated the abilities of MR/NIR fluorescence dual-modal imaging and photodynamic therapy might be a promising theranostic platform for tumor treatment.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据