Article
Chemistry, Medicinal
Wen Xu, Jiaying Li, Dongli Li, Junfeng Tan, Hang Ma, Yu Mu, Yan Wen, Lishe Gan, Xueshi Huang, Liya Li
Summary: Clinacanthus nutans, a medicinal herb consumed traditionally in Asia, has been found to contain compounds with potential anticancer and antifungal activities. The cycloartane triterpenoids and megastigmanes isolated from C. nutans showed moderate anti-proliferative effects and induced apoptosis in HepG2 cells, as well as enhanced the anti-Candida albicans activity of amphotericin B. These findings provide insight into the relationship between the chemical constituents of C. nutans and its health beneficial effects, supporting further pharmaceutical applications of this medicinal plant.
Review
Biochemistry & Molecular Biology
Wei-Yi Ong, Deron R. Herr, Grace Y. Sun, Teng-Nan Lin
Summary: Recent studies on Clinacanthus nutans have shown its potential anti-inflammatory, anti-tumorigenic, and antiviral properties. The extraction of its leaves has yielded various C-glycosyl flavones, which have been studied for their anti-inflammatory effects. This review focuses on the effects of C. nutans extracts and its phytochemical components on inflammatory signaling pathways in the nervous system. The study highlights their role in targeting the TLR4-NF-kB pathway, antioxidant defense pathway, and PLA2-COX-2 pathway.
Article
Food Science & Technology
Sriyana Abdullah, Yus Aniza Yusof, Ibni Hajar Rukunudin, Nor Nadiah Abdul Karim Shah, Norawanis Abdul Razak
Summary: The drying rate of Clinacanthus nutans leaves can be increased using infrared radiation, which reduces drying time and optimizes energy usage. Five selected models provided the best fit for specific drying treatments, and the moisture diffusivity and activation energy values were within certain ranges.
JOURNAL OF FOOD PROCESSING AND PRESERVATION
(2022)
Article
Biochemistry & Molecular Biology
Hock Ing Chiu, Che Nurul Azieyan Che Mood, Nur Nadhirah Mohamad Zain, Muggundha Raoov Ramachandran, Noorfatimah Yahaya, Nik Nur Syazni Nik Mohamed Kamal, Wai Hau Tung, Yoke Keong Yong, Chee Keong Lee, Vuanghao Lim
Summary: The biosynthesized silver nanoparticles using extracts from Clinacanthus nutans demonstrated promising potential in antioxidant, antimicrobial, and cytotoxic activities, showing high inhibition against Staphylococcus aureus, good antioxidant activities, and cytotoxic effects on cancer cells.
BIOINORGANIC CHEMISTRY AND APPLICATIONS
(2021)
Article
Environmental Sciences
Noor Zafirah Ismail, Salwani Md Saad, Ismail Abiola Adebayo, Zaleha Md Toha, Rafedah Abas, Nur Nadhirah Mohamad Zain, Hasni Arsad
Summary: This study found that Clinacanthus nutans dichloromethane fraction (SF2) extract can induce apoptosis in MCF7 cells through both intrinsic and extrinsic pathways. SF2 extract significantly inhibited MCF7 cell proliferation and upregulated the expression of P53, BAX, BID, caspase-8, caspase-9, and caspase-3, while downregulating the expression of BCL2. This suggests that SF2 extract has the potential to be effective against breast cancer.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Lalana Kongkaneramit, Worapan Sitthithaworn, Wattanaporn Phattanaphakdee, Narong Sarisuta
Summary: The development of nanoemulsions containing Clinacanthus nutans leaf extract was studied for its physicochemical properties, stability, and permeability. The results showed that 4%w/w CNE nanoemulsion was stable and exhibited potential as a herbal topical dosage form for postherpetic neuralgia.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Crystallography
Dharshini Perumal, Emmellie Laura Albert, Norazalina Saad, Taufiq Yap Yun Hin, Ruzniza Mohd Zawawi, Huey Fang Teh, Che Azurahanim Che Abdullah
Summary: In this study, clinacanthus nutans leaf extract was used to synthesize reduced graphene oxide (rGO) using a simple reflux method. The synthesized rGO was characterized using various spectroscopic and microscopic techniques. The results showed that the oxygen groups in rGO were reduced, resulting in a changed structure and lower toxicity compared to conventional carbon-based materials. These findings support the potential of clinacanthus nutans as an eco-friendly substitute for carbon-based fabrication.
Article
Biochemistry & Molecular Biology
Kai Song Ng, Sheri-Ann Tan, Chui Yin Bok, Khye Er Loh, Intan Safinar Ismail, Chen Son Yue, Chui Fung Loke
Summary: Antioxidants, particularly from Clinacanthus nutans leaves, show potential in preventing liver cancer in NAFLD patients. The study identified strong radical scavenging and reducing power properties in CNL compared to CNS, with the presence of specific metabolites contributing to antioxidant and hepatoprotective abilities. HepG2 cell model further supported the effectiveness of CNL in reducing ROS levels and protecting liver cells from oxidative stress.
Article
Plant Sciences
Audrey Siew Foong Kow, Leng Wei Khoo, Ji Wei Tan, Faridah Abas, Ming-Tatt Lee, Daud Ahmad Israf, Khozirah Shaari, Chau Ling Tham
Summary: C. nutans, a herbal plant used traditionally to treat skin rash, was found to exert anti-allergic effects by suppressing the IgG pathway and the release of mediators.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Infectious Diseases
Saruda Thongyim, Salinee Chiangchin, Hataichanok Pandith, Yingmanee Tragoolpua, Siriphorn Jangsutthivorawat, Aussara Panya
Summary: Clinacanthus nutans is widely used as a traditional medicine in Southeast Asia, mainly as an anti-viral agent. This study demonstrates the therapeutic activity of C. nutans extracts in reducing inflammation in bovine mastitis caused by bacterial infection, indicating its potential as an alternative treatment option for this disease.
Article
Multidisciplinary Sciences
Dharshini Perumal, Che Azurahanim Che Abdullah, Emmellie Laura Albert, Ruzniza Mohd Zawawi
Summary: A method using Clinacanthus nutans leaf extract to anchor silver nanoparticles onto graphene oxide has been successfully demonstrated. The nanocomposite was characterized and showed promising properties for potential biomedical device applications with enhanced electrochemical performance and excellent antibacterial activity. The use of green reductants in the synthesis of nanocomposites offers a guide for future research in this area.
Article
Multidisciplinary Sciences
Fariza Juliana Nordin, Lishantini Pearanpan, Kok Meng Chan, Endang Kumolosasi, Yoke Keong Yong, Khozirah Shaari, Nor Fadilah Rajab
Summary: Clinacanthus nutans (CN) extracts did not show cytotoxic effects on MDA-MB-231 and THP-1 cells, but exhibited potential in ameliorating chronic inflammation in the tumor microenvironment of breast cancer. Further studies are needed to fully understand the underlying mechanisms of CN in cooling the inflamed TME in breast cancer.
Article
Engineering, Chemical
Siti N. S. Othman, Ana N. Mustapa, Ku Halim Ku Hamid
Summary: In this study, solvent-free microwave extraction (SFME) was used to extract polyphenols from Clinacanthus nutans Lindau, showing that extraction under vacuum pressure resulted in higher polyphenol content compared to ambient pressure extraction. This study demonstrates that vacuum conditions are beneficial for polyphenol extraction from C. nutans.
CHEMICAL ENGINEERING COMMUNICATIONS
(2021)
Review
Integrative & Complementary Medicine
Chung-Ming Lin, Hsin-Han Chen, Chi-Wen Lung, Hui-Jye Chen
Summary: Clinacanthus nutans is a traditional medicinal herb used for treating various diseases, including cancer. The underlying mechanisms of its anticancer activity are still unclear. Researchers hope that by collecting recent relevant studies, updating people's understanding of this herb, and speeding up its clinical application in the future.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Agricultural Engineering
Kogilavanee Devasvaran, Batoul Alallam, Vuanghao Lim
Summary: This study aimed to evaluate the optimal method for extracting crude polysaccharides from Clinacanthus nutans leaves (CNP) as natural antioxidants. Five different extraction methods were compared, and the alkaline and ultrasound-assisted methods were found to be the most effective, with the highest extraction yield and antioxidant properties. The total phenolic content (TPC) was directly related to antioxidant activity, with the freeze-thaw method showing the highest TPC. The extraction method played a significant role in determining the antioxidant properties of CNP extracts. These findings have implications for the food industry, which has a high demand for natural antioxidants for food preservation and enhancement.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Integrative & Complementary Medicine
Nurul 'Ain Abu Bakar, Muhammad Nazrul Hakim Abdullah, Vuanghao Lim, Yoke Keong Yong
Summary: This study demonstrated the gastroprotective effect of polypeptide K (PPK) on gastric ulcers. Results showed that PPK effectively reduced the ulcer area, preserved the architecture of gastric tissues, and enhanced gastric wall mucus secretion. This may contribute to the decreased total acidity in the stomach.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Chemistry, Applied
Vasagee Elencovan, Julia Joseph, Noorfatimah Yahaya, Nozlena Abdul Samad, Muggundha Raoov, Vuanghao Lim, Nur Nadhirah Mohamad Zain
Summary: A novel DES was successfully applied in VALLME for the determination of organophosphorus pesticides in honey and fruit samples, providing new opportunities for safe delivery and application. Thorough optimization of parameters resulted in efficient extraction, with the method proving to be simple, cost-effective, rapid, and non-toxic.
Article
Chemistry, Analytical
Tan Lei Lu, Mohamad Shariff Shahriman, Kavirajaa Pandian Sambasevam, Nur Nadhirah Mohamad Zain, Noorfatimah Yahaya, Vuanghao Lim, Muggundha Raoov
Summary: This study developed an in-pipette tip solid-phase microextraction (SPME) method using activated charcoal as an adsorbent for simultaneous determination of three sulphonamide antibiotic residues in environmental water. The method demonstrated good linearity, sensitivity, and recoveries, while offering a simple and reusable setup and a significant reduction in chemical consumption.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY
(2022)
Review
Integrative & Complementary Medicine
Nur Aqilah Kamaruddin, Muhammad Nazrul Hakim Abdullah, Jun Jie Tan, Vuanghao Lim, Lai Yen Fong, Siti Aisyah Abd Ghafar, Yoke Keong Yong
Summary: Vascular endothelial dysfunction is a key factor in the development of cardiovascular diseases, and modulation of the vascular endothelium using phytochemical compounds is considered an important therapeutic strategy. Regular consumption of medicinal plants, fruits, and vegetables can lower the risk of cardiovascular diseases. Numerous studies have demonstrated the vascular protective effects of phytochemical compounds, with curcumin, resveratrol, cyanidin-3-glucoside, berberine, epigallocatechin-3-gallate, and quercetin being discussed in this review for their potential mechanisms of action. Phytochemical compounds show promise as therapeutic agents for vascular dysfunction due to their antioxidative mechanisms, but further human studies are needed to confirm their clinical effects.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Polymer Science
Muhammad Shahid Latif, Asif Nawaz, Sheikh Abdur Rashid, Muhammad Akhlaq, Asif Iqbal, Muhammad Jamil Khan, Muhammad Shuaib Khan, Vuanghao Lim, Mulham Alfatama
Summary: This study aimed to prepare methotrexate-loaded transdermal patches with different blends of hydrophobic and hydrophilic polymers, and investigate their drug release and permeation profiles. The formulated patches, especially F5, showed good drug release, permeation, and retention, indicating their potential for psoriasis management.
Article
Integrative & Complementary Medicine
Nur Mazidah Haji Noor Mohamed, Vuanghao Lim, Rafeezul Mohamed, Ida Shazrina Ismail
Summary: C. nutans extracts have immunomodulatory effects on macrophage cellular response, downregulating pro-inflammatory cytokine production and stimulating phagocytic function.
JOURNAL OF HERBAL MEDICINE
(2022)
Article
Microbiology
Wen-Nee Tan, Kashvintha Nagarajan, Vuanghao Lim, Juzaili Azizi, Kooi-Yeong Khaw, Woei-Yenn Tong, Chean-Ring Leong, Nelson Jeng-Yeou Chear
Summary: Endophytic fungi Diaporthe fraxini can produce bioactive metabolites with potential pharmacological activities. This study used metabolomics to investigate the variations in metabolomes of D. fraxini grown in different culture media. The supplemented culture medium stimulated the production of metabolites not found in the normal culture medium, and the fungal extract showed antioxidant activity.
Article
Polymer Science
Faiqa Falak Naz, Kifayat Ullah Shah, Zahid Rasul Niazi, Mansoor Zaman, Vuanghao Lim, Mulham Alfatama
Summary: This study designed inhalable spray-dried, rifampicin-loaded microparticles using aloe vera powder as an immune modulator, with varying concentrations of alginate and L-leucine. The physicochemical properties, in vitro drug release, and aerodynamic behavior of the microparticles were evaluated. The results showed that the microparticles had appropriate size and shape, and the drug release rate was influenced by the concentration of L-leucine. The slow release of the microparticles allows sufficient time for phagocytosis by alveolar macrophages, leading to the eradication of M. tuberculosis.
Review
Chemistry, Medicinal
Mansab Ali Saleemi, Noorfatimah Yahaya, Nur Nadhirah Mohamad Zain, Muggundha Raoov, Yoke Keong Yong, Nurul Shahfiza Noor, Vuanghao Lim
Summary: The development of new antibiotics is urgently needed to combat bacterial resistance. Cannabis extracts containing cannabinoids have potential antimicrobial properties, and combination therapy with different antibiotics may result in synergistic effects and broad-spectrum activity.
Article
Anatomy & Morphology
Soo Teng Chew, Zolkapli Eshak, Afaf Al-Haddad
Summary: The interfacial adaptation and penetration depth of three different bioceramic-based sealers (CeraSeal, EndoSeal MTA, Nishika Canal Sealer BG) were compared to an epoxy resin-based sealer (AH Plus) in oval root canals. Nishika Canal Sealer BG showed significantly higher sealer adaptation than EndoSeal MTA at apical and middle thirds, while AH Plus showed significantly higher sealer adaptation than EndoSeal MTA at middle third. Nishika Canal Sealer BG showed the longest sealer penetration, which was significant compared to AH Plus and EndoSeal MTA.
MICROSCOPY RESEARCH AND TECHNIQUE
(2023)
Article
Food Science & Technology
Ain Nabila Syahira Shamsol Azman, Jun Jie Tan, Muhammad Nazrul Hakim Abdullah, Hasnah Bahari, Vuanghao Lim, Yoke Keong Yong
Summary: This study utilized network pharmacology to assess the potential pharmacological effects of bioactive compounds in Tualang honey on atherosclerosis. The results showed that 6 compounds in Tualang honey had potential therapeutic effects on atherosclerosis, supporting its use as a promising treatment for the disease.
Article
Chemistry, Medicinal
Batoul Alallam, Abd Almonem Doolaanea, Mulham Alfatama, Vuanghao Lim
Summary: Zinc oxide nanoparticles (Green-ZnO-NPs) were prepared using pure curcumin and showed additive antimicrobial and anticancer effects with curcumin. The physicochemical properties of Green-ZnO-NPs were characterised, and their inhibitory effect on bacterial strains and cancer cells was evaluated. The results demonstrated that Green-ZnO-NPs have potential as an alternative therapeutic agent for cancer treatment.
Review
Polymer Science
Batoul Alallam, Hazem Choukaife, Salma Seyam, Vuanghao Lim, Mulham Alfatama
Summary: Kidney disease is a significant global burden, and drug delivery to the kidneys is challenging. Nanotechnology offers potential solutions, as nanomaterials with unique properties have shown promising potential in renal therapy. Various types of nanosystems have been developed to improve drug delivery to the kidneys, and this review discusses their features and strategies.
Article
Polymer Science
Ghufran Ullah, Asif Nawaz, Muhammad Shahid Latif, Kifayat Ullah Shah, Saeed Ahmad, Fatima Javed, Mulham Alfatama, Siti Aisyah Abd Ghafar, Vuanghao Lim
Summary: Bilayer/multilayer tablets are commonly used to tailor drug release, and this research aimed to formulate a novel gastro-retentive tablet to eliminate H. pylori in the gastrointestinal tract. Bilayer tablets were prepared using the direct compression technique, and the controlled-release bilayer tablets were prepared using hydrophilic swellable polymers (sodium alginate, chitosan, and HPMC-K15M). The study concluded that the combination of sodium alginate, chitosan, and HPMC polymers resulted in a gastro-retentive and controlled-release drug delivery system.
Article
Polymer Science
Asif Nawaz, Muhammad Shahid Latif, Maha Abdallah Alnuwaiser, Shafi Ullah, Muhammad Iqbal, Mulham Alfatama, Vuanghao Lim
Summary: The results suggest that chitosan-coated nanoemulsion gel is safe and can potentially be used to promote 5-FU skin retention, which is ideal for skin diseases such as melanoma. Incorporating nanoemulsion into gel has resulted in higher T-max, longer half-life, and greater skin drug retention.
