Article
Polymer Science
Yongji Wang, Xu Jia, Yuejun Zhang
Summary: This study investigated the hydrolysis stability and mechanism of PMAPTAC under different temperatures and pH values. The results showed that higher temperatures and lower pH values led to greater viscosity loss of PMAPTAC, and the intrinsic viscosity had little effect on its hydrolysis stability.
Article
Chemistry, Physical
Jialiang Chen, Lirong Fu, Yan Li, Xiaodeng Yang, Beibei Wang, Chunlin Xu, Tianduo Li
Summary: The study revealed that HTCC/CMC/glycerol (PVA and anthocyanin) film-forming solutions exhibited shear-thinning behavior, with a slower decrease in apparent viscosity due to the electrostatic and hydrogen bonding interactions among the biomacromolecules and glycerol, PVA, and anthocyanin, resulting in the formation of three-dimensional networks.
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yuan Gao, Xiaochen Gong, Shuang Yu, Zheng Jin, Qicheng Ruan, Chunjing Zhang, Kai Zhao
Summary: The study found that N-2-Hydroxypropyl trimethyl ammonium chloride chitosan/N, O-carboxymethyl chitosan nanoparticles (N-2-HACC/CMCS NPs) showed good immunogenicity and no toxicity as a universal vaccine adjuvant/delivery system. The prepared N-2-HACC/OVA/CMCS NPs induced higher levels of antibodies and immune responses in mice, suggesting their potential in enhancing humoral, cellular, and mucosal immune responses.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Ling Ding, Zhao Liu, Shen Song, Mohamed Aamer Abubaker, Lele Chen, Jipeng Shi, Zengjie Fan, Ji Zhang
Summary: HACC, synthesized by reacting chitosan with glycidyl trimethylammonium chloride, forms a non-Newtonian pseudoplastic fluid in solution, with thixotropy highly dependent on concentration changes. Dynamic viscoelasticity tests show that HACC exhibits both viscous behavior similar to a fluid and elastic properties of weak gel.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Polymer Science
Yongji Wang, Yuejun Zhang
Summary: The kinetics of PMAPTAC polymerization were studied experimentally, revealing that increasing monomer and initiator concentrations, as well as temperature, enhance the polymerization rate. Different initiators also have an impact on the polymerization rate.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2021)
Article
Pharmacology & Pharmacy
Csilla Bartos, Patricia Varga, Piroska Szabo-Revesz, Rita Ambrus
Summary: The study explores the absorption of NSAIDs through the nasal epithelium using chitosan-based microspheres prepared via spray-drying, with a focus on meloxicam delivery. The results demonstrate that non-cross-linked samples exhibit higher dissolution and permeation rates for meloxicam.
Article
Chemistry, Applied
Yong Li, Yan Li, Tao Chen, Xiaodeng Yang, Congde Qiao, Fei Hao, Mingxia Liu
Summary: This paper investigates the effect of crystallized calcium carbonate particles (cry-CaCO3) on the properties of HTCC/CMC films. The results show that cry-CaCO3 particles promote the homogeneous distribution of the HTCC/CMC matrix, significantly improving mechanical properties while having little effect on thermal stability, whiteness, and wettability of the films. The study further characterizes the cry-CaCO3 particles and reveals that the strong electrostatic, hydrogen bonding, and flexible interaction between CMC and cry-CaCO3 particles play a key role in improving the mechanical properties of HTCC/CMC films.
CARBOHYDRATE POLYMERS
(2022)
Article
Polymer Science
Cangheng Zhang, Yan Li, Shu Xing, Xiaodeng Yang, Jinrong Zhao, Qiaoyan Dong
Summary: The interaction between GTA-m-CS and DDEAC was studied using surface tension, viscosity, conductivity, and fluorescence methods. The GTA-m-CS/DDEAC aggregates could be used as curcumin carriers, achieving sustained release.
Article
Energy & Fuels
Weikun Li, Hongliang Wei, Yuhua Liu, Songmao Li, Gang Wang, Tao Guo, Huayun Han
Summary: Hydrogel microspheres were successfully prepared by in situ reactive spray drying, showing spherical structures with good swelling and adsorption performance. The study demonstrated that these microspheres exhibited pH and salt sensitivity, with maximum adsorption capacities for various substances and following Langmuir isotherm model and pseudo second-order model in adsorption process. The strategy presented in this research holds great application potential in wastewater treatment.
CHEMICAL ENGINEERING AND PROCESSING-PROCESS INTENSIFICATION
(2021)
Article
Biochemistry & Molecular Biology
Zhi Zhao, Jinyu Han, Shangen Xu, Zheng Jin, Tan Hui Yin, Kai Zhao
Summary: This report presents the encapsulation of amoxicillin in N-2-Hydroxypropyl trimethyl ammonium chloride chitosan and N,O-carboxymethyl chitosan nanoparticles for biomedical applications. The synthesized nanoparticles demonstrated sustained drug release, good cytocompatibility and broad-spectrum antimicrobial activity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Nanoscience & Nanotechnology
Priyanka Biswas, Debasis Sen, Meenu Prasher, Sudip Kumar Sarkar, Kinshuk Dasgupta
Summary: In this study, well-defined powder micro-granules with interstitial nanopores were achieved through one-step evaporative jamming of colloidal silica particles in contact-free spray droplets. The anomalous freezing behavior of confined water in these microspheres synthesized using spray drying was investigated, revealing a significant lowering of the freezing point to around -45 degrees C due to the confinement effect. The results from thermoporometry were supported by structural details obtained through gas adsorption measurements and small-angle x-ray scattering.
Article
Immunology
Kai Zhao, Yuan Gao, Gaowei Hu, Lei Wang, Shangjin Cui, Zheng Jin
Summary: The study developed a VP2 protein subunit vaccine against Porcine parvovirus (PPV) using N-2-Hydroxypropyl trimethyl ammonium chloride chitosan (N-2-HACC) as the adjuvant, showing that the vaccine induced higher antibody levels and long-term immune protection in immunized sows. However, the vaccine mainly stimulated humoral immunity rather than cellular immunity, and provided 100% protective efficacy against PPV infection in sows. This suggests that N-2-HACC could be a potential adjuvant for controlling PPV.
Article
Biotechnology & Applied Microbiology
Kai Zhao, Beini Sun, Ci Shi, Yanwei Sun, Zheng Jin, Gaowei Hu
Summary: The O-2'-HACC/pFDNA microparticles showed high encapsulation efficiency and loading capacity, promoting immune responses and generating more immune-related cells after intranasal vaccination in chickens, providing better protection compared to commercial live attenuated vaccines.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chaojie Xu, Ronge Xing, Song Liu, Yukun Qin, Kecheng Li, Huahua Yu, Pengcheng Li
Summary: This study generated chitosan nanoparticles and examined their effects on dendritic cells, finding that 200kDa NO-CMC-HACC nanoparticles showed strong potential as immunological adjuvants.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Engineering, Chemical
Jun Chen, Hao Yang, Chang-Ming Xu, Ji-Gui Cheng, Ying-Wei Lu
Summary: By using an optimized slurry with high solid content and low viscosity, zirconia microspheres with high sphericity and hardness were successfully produced through a cost-effective spray granulation method, showing potential for engineering applications.
Article
Biochemistry & Molecular Biology
Wenyu Wang, Huan Sheng, Daihong Cao, Fenglian Zhang, Weifen Zhang, Fang Yan, Dejun Ding, Ni Cheng
Summary: This study developed a multifunctional wound dressing by connecting endogenous NO donor to nanoparticles. The dressing achieved NO release and photothermal therapy through photothermal conversion, enhancing antimicrobial efficacy and wound healing activities. In addition, the dressing exhibited good biocompatibility.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Multidisciplinary
Jiao Liu, Xiao Zhang, Pengfei Zou, Jiahui Yao, Lingling Liu, Yun Cai, Tongyi Sun, Yuanyuan Gao, Li-Li Li
Summary: Antibiotic resistance is a serious threat to public health. Researchers have developed nano-antibiotic transformers that enhance the effectiveness of antibiotics and effectively clear bacterial infections.
Review
Genetics & Heredity
Kaixian Wang, Yuanyuan Gao, Chen Wang, Meng Liang, Yaping Liao, Ke Hu
Summary: According to WHO statistics, millions of couples and individuals suffer from infertility, with varicocele identified as a leading cause of male infertility. This review examines the role of oxidative stress and reactive oxygen species (ROS) in the pathophysiology of varicocele and its impact on fertility. High levels of ROS can lead to infertility by damaging DNA, affecting lipid peroxidation, and inactivating enzymes and proteins involved in spermatogenesis.
FRONTIERS IN GENETICS
(2022)
Article
Neurosciences
Yuanyuan Gao, Hanqing Chao, Lora Cavuoto, Pingkun Yan, Uwe Kruger, Jack E. Norfleet, Basiel A. Makled, Steven Schwaitzberg, Suvranu De, Xavier Intes
Summary: This study presents a motion artifact removal method for fNIRS data using a deep learning approach. The developed deep learning model, with a specific loss function and generated training data, outperforms conventional methods in removing motion artifacts.
Article
Biochemistry & Molecular Biology
Yirong Wang, Li Guo, Jiao Liu, Xiaofei Huang, Xinxin Wang, Xiaolong Guo, Xinguo You, Wenhui Li, Lili Li, Tongyi Sun, Yuanyuan Gao
Summary: Wound treatment is a common healthcare issue, and Tylotoin, a peptide derived from salamander, has shown skin wound healing properties. However, its degradation and administration limitations hinder its use. In this study, Chitosan-PLGA-Tylotoin nanoparticles were developed to deliver Tylotoin for wound healing. The nanoparticles demonstrated good antibacterial properties, biocompatibility, and sustained release of Tylotoin, leading to improved wound healing in vitro and in vivo.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Pharmacology & Pharmacy
Wen Tian, Shao-Yuan Liu, Meng Zhang, Jing-Ru Meng, Na Tang, Ying-Da Feng, Yang Sun, Yuan-Yuan Gao, Lei Zhou, Wei Cao, Xiao-Qiang Li
Summary: TRPC1 plays a crucial role in endotoxemia-induced cardiac dysfunction by mediating myocardial apoptosis and autophagy.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Clinical Neurology
Cunsheng Wei, Tingwen Shen, Xuelian Tang, Yuanyuan Gao, Xiaorong Yu, Xuemei Chen
Summary: This study examined the impact of cerebral small vessel disease (SVD) and its interaction with cerebral collaterals on the prognosis of patients with large artery atherosclerotic (LAA) stroke. The study found that the combination of cerebral collaterals and total SVD burden was better at predicting the prognosis of acute LAA stroke patients compared to cerebral collaterals or SVD alone.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Antonio Ortega-Martinez, De'Ja Rogers, Jessica Anderson, Parya Farzam, Yuanyuan Gao, Bernhard Zimmermann, Meryem A. Yucel, David A. Boas
Summary: This research proposes a TD GLM method based on temporal moment analysis, which improves the recovery of HRF by incorporating TD moment data and auxiliary physiological measurements. The results show that properly covariance-scaled TD moment techniques outperform their CW equivalents in both RMSE and correlation, and the proposed TD GLM outperforms regular TD moment analysis while allowing the incorporation of auxiliary measurements.
Article
Chemistry, Multidisciplinary
Pengfei Zou, Jiao Liu, Xinyu Li, Muhammad Yaseen, Jiahui Yao, Lingling Liu, Lujun Luo, Hui Wang, Xinghua Shi, Zhiping Li, Tongyi Sun, Yuanyuan Gao, Chunsheng Gao, Li-Li Li
Summary: A lipopeptide nanomicelle (LP 20) with the ability to modulate membrane curvature was developed, resulting in accelerated and enhanced antibacterial activity against multidrug-resistant (MDR) Gram-negative pathogens. LP-20 effectively targeted multiple components on the bacterial membrane, causing efficient damage to both inner and outer membrane. In addition, LP-20 showed prolonged lifetime in mice infected with MDR pathogens.
Article
Pharmacology & Pharmacy
Danli Zhao, Yuanyuan Gao, Ying Su, Yuanyuan Zhou, Ting Yang, Yang Li, Yingqian Wang, Ying Sun, Li Chen, Feng Zhang, Zili Zhang, Feixia Wang, Jiangjuan Shao, Shizhong Zheng
Summary: Relevant studies have shown that Oroxylin A promotes senescence in hepatic stellate cells (HSC) by activating the cGAS-STING pathway. The activation of this pathway is dependent on the downregulation of DNMT3A, which suppresses cGAS gene DNA methylation. Oroxylin A prevents the production of methionine metabolites, leading to a decrease in SAM levels and consequently a reduction in DNMT activity. In vivo experiments also confirmed the induction of HSC senescence by Oroxylin A, with partially offset by DNMT3A overexpression.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Engineering, Biomedical
Xinxin Wang, Yiting Wang, Mengteng Tang, Xiaoyi Wang, Wei Xue, Xiao Zhang, Yuxia Wang, Wen-Hui Lee, Yingshuai Wang, Tong-Yi Sun, Yuanyuan Gao, Li-Li Li
Summary: This paper proposes a drug delivery strategy for the treatment of aerobic vaginitis by utilizing the changing dynamics of the bacterial flora. The strategy involves the use of a core-shell nanogel to encapsulate prebiotic inulin and antimicrobial peptide Cath 30, allowing for sequential drug release and selective killing of pathogenic bacteria, followed by the promotion of beneficial bacteria proliferation in the vagina.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Man Zhang, Zunqing Fan, Jie Zhang, Yilei Yang, Changbao Huang, Weifen Zhang, Dejun Ding, Guoyan Liu, Ni Cheng
Summary: Developing novel multifunctional wound dressing materials capable of delivering active molecules for resolving bacterial infections and promoting wound healing is highly desirable. In this study, a multifunctional chitosan/alginate hydrogel decorated with beta-cyclodextrin modified polydopamine-bioactive glass nanoparticles was developed. It demonstrated photothermal performance, nitric-oxide release activities, and potential for treating bacterially infected wounds. The results showed that this nanocomposite hydrogel has multiple functions in preventing bacterial infections, accelerating angiogenesis, and wound regeneration, indicating promising application in wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Endocrinology & Metabolism
Ping Chen, Min Mao, Chendan Wang, Xu Zhang, Xiaoyu Zhao, Yuanyuan Gao, Yankun Luo, Yun Zhou
Summary: This study investigated the efficacy of rituximab in the treatment of idiopathic membranous nephropathy (IMN). The results showed that rituximab treatment significantly improved the clinical and biochemical indexes of patients with IMN, regardless of whether it was used as an initial therapy or for refractory/relapsed nephropathy.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Zhengchao Zhang, Dejun Ding, Jinxiang Liu, Changbao Huang, Wentong Li, Keliang Lu, Ni Cheng
Summary: The study successfully developed a supramolecular cascade catalytic nanozyme system for photothermal-enhanced multienzyme cascade catalytic and glutathione (GSH) depletion activities, triggering apoptosis-ferroptosis synergistic tumor therapy. The system was fabricated using β-cyclodextrin-functionalized polydopamine (PDA) as the substrate, entangled with polyoxometalate (POM), and assembled with adamantane-grafted hyaluronic acid and glucose oxidase (GOx) for tumor targeting and GOx loading. The catalytic function of GOx facilitates the conversion of glucose to H2O2 and gluconic acid, generating hydroxyl radical ((OH)-O-& BULL;) through POM-mediated cascade catalysis. Additionally, the PDA-POM-mediated photothermal hyperthermia boosted the cascade catalytic effect and increased ROS production, promising potential for photothermal therapy/nanocatalytic cancer therapy.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Multidisciplinary Sciences
Anil Kamat, Condell Eastmond, Yuanyuan Gao, Arun Nemani, Erim Yanik, Lora Cavuoto, Matthew Hackett, Jack Norfleet, Steven Schwaitzberg, Suvranu De, Xavier Intes
Summary: This study presents a fNIRS dataset acquired on mobile subjects performing FLS tasks in a laboratory environment. Relevant information and FLS scores are provided to facilitate the use of this open-access dataset.
