期刊
POLYMERS
卷 10, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/polym10060650
关键词
polypyridyl; octahedral; ruthenium complex; antimicrobial activities
资金
- National Natural Science Foundation of China [21601146]
- Fundamental Research Funds for the Central Universities [XDJK2018C086, XDJK2017B011]
- National Experimental Teaching Demonstration Center of Pharmaceutical Sciences [YX2017-CXYB09]
Recent developments of therapeutic agents based on transition metals have attracted a great deal of attention. Metal drugs have advantages over other small molecule drugs, and it was demonstrated that, in a number of studies, they played an important role in pharmaceutical chemical research and clinical chemotherapy of cancers. It is worthwhile mentioning that octahedral polypyridyl ruthenium(II) complexes have shown remarkable applications in chemical biology and medicinal chemistry over the last decade. However, only very recently has there been comprehensive interest in their antimicrobial properties due to metal-related toxic concerns or neglected potential roles in microbiological systems. Our review will highlight the recent developments in octahedral polypyridyl ruthenium(III) complexes that have exhibited significant antimicrobial activities and will discuss the relationship between the chemical structure and biological process of ruthenium complexes, in both bacterial and fungal cells.
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