Hepatitis C virus NS4B induces the degradation of TRIF to inhibit TLR3-mediated interferon signaling pathway

Laboratory of genetics and physiology 2 (LGP2) plays an essential role in hepatitis C virus infection-induced interferon responses

(2017) Lei Hei et al.   HEPATOLOGY

STING Requires the Adaptor TRIF to Trigger Innate Immune Responses to Microbial Infection

(2016) Xin Wang et al.   Cell Host & Microbe

Innate immunity against hepatitis C virus

(2016) Yongfen Xu et al.   CURRENT OPINION IN IMMUNOLOGY

Innate immune evasion by hepatitis B virus-mediated downregulation of TRIF

(2015) Yun Hong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MDA5 plays a critical role in interferon response during hepatitis C virus infection

(2015) Xuezhi Cao et al.   JOURNAL OF HEPATOLOGY

Hepatitis C Virus NS4B Can Suppress STING Accumulation To Evade Innate Immune Responses

(2015) Guanghui Yi et al.   JOURNAL OF VIROLOGY

Hepatitis C virus vaccine development: old challenges and new opportunities

(2015) Dapeng Li et al.   National Science Review

The Roles of Endoplasmic Reticulum Overload Response Induced by HCV and NS4B Protein in Human Hepatocyte Viability and Virus Replication

(2015) Lingbao Kong et al.   PLoS One

MITA/STING: A central and multifaceted mediator in innate immune response

(2014) Yong Ran et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Hepatitis C virus NS4B blocks the interaction of STING and TBK1 to evade host innate immunity

(2013) Qiang Ding et al.   JOURNAL OF HEPATOLOGY

Regulation of hepatic innate immunity by hepatitis C virus

(2013) Stacy M Horner et al.   NATURE MEDICINE

Epidemiology and natural history of HCV infection

(2013) Behzad Hajarizadeh et al.   Nature Reviews Gastroenterology & Hepatology

Hepatitis C virus NS3/4A protease blocks IL-28 production

(2012) Qiang Ding et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Hepatitis C virus NS4B protein targets STING and abrogates RIG-I-mediated type I interferon-dependent innate immunity

(2012) Sayuri Nitta et al.   HEPATOLOGY

Innate immune responses in hepatitis C virus infection

(2012) Kui Li et al.   Seminars in Immunopathology

Uridine Composition of the Poly-U/UC Tract of HCV RNA Defines Non-Self Recognition by RIG-I

(2012) Gretja Schnell et al.   PLoS Pathogens

Kaposi Sarcoma-associated Herpesvirus Degrades Cellular Toll-Interleukin-1 Receptor Domain-containing Adaptor-inducing β-Interferon (TRIF)

(2011) Humera Ahmad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disruption of TLR3 Signaling Due to Cleavage of TRIF by the Hepatitis A Virus Protease-Polymerase Processing Intermediate, 3CD

(2011) Lin Qu et al.   PLoS Pathogens

The Coxsackievirus B 3Cpro Protease Cleaves MAVS and TRIF to Attenuate Host Type I Interferon and Apoptotic Signaling

(2011) Amitava Mukherjee et al.   PLoS Pathogens

Double-stranded RNA-induced interferon-beta and inflammatory cytokine production modulated by hepatitis C virus serine proteases derived from patients with hepatic diseases

(2009) Hiromichi Dansako et al.   ARCHIVES OF VIROLOGY

Toll-like receptor 3 signaling attenuates liver regeneration

(2009) Elina Zorde-Khvalevsky et al.   HEPATOLOGY

Distinct antiviral signaling pathways in primary human hepatocytes and their differential disruption by HCV NS3 protease

(2009) Loubna Jouan et al.   JOURNAL OF HEPATOLOGY

Nucleotide Sequences and Modifications That Determine RIG-I/RNA Binding and Signaling Activities

(2009) D. Uzri et al.   JOURNAL OF VIROLOGY

Hepatitis C virus NS4B induces unfolded protein response and endoplasmic reticulum overload response-dependent NF-κB activation

(2009) Shanshan Li et al.   VIROLOGY

The antiviral adaptor proteins Cardif and Trif are processed and inactivated by caspases

(2008) M Rebsamen et al.   CELL DEATH AND DIFFERENTIATION

Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA

(2008) Takeshi Saito et al.   NATURE