A high throughput, functional screen of human Body Mass Index GWAS loci using tissue-specific RNAi Drosophila melanogaster crosses

Conditional eQTL analysis reveals allelic heterogeneity of gene expression

(2017) Rick Jansen et al.   HUMAN MOLECULAR GENETICS

Curcumin represses mouse 3T3-L1 cell adipogenic differentiation via inhibiting miR-17-5p and stimulating the Wnt signalling pathway effector Tcf7l2

(2017) Lili Tian et al.   Cell Death & Disease

Reduced intestinal lipid absorption and body weight-independent improvements in insulin sensitivity in high-fat diet-fed Park2 knockout mice

(2016) Diana K. Costa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Fat body remodeling and homeostasis control in Drosophila

(2016) Huimei Zheng et al.   LIFE SCIENCES

The Obesity-Linked GeneNudt3 DrosophilaHomologApsIs Associated With Insulin Signaling

(2015) Michael J. Williams et al.   MOLECULAR ENDOCRINOLOGY

Genetic studies of body mass index yield new insights for obesity biology

(2015) Adam E. Locke et al.   NATURE

FTO Obesity Variant Circuitry and Adipocyte Browning in Humans

(2015) Melina Claussnitzer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Drosophila glucome screening identifies Ck1alpha as a regulator of mammalian glucose metabolism

(2015) Rupali Ugrankar et al.   Nature Communications

A Genome-Wide mRNA Screen and Functional Analysis Reveal FOXO3 as a Candidate Gene for Chicken Growth

(2015) Biao Chen et al.   PLoS One

Obesity-associated variants within FTO form long-range functional connections with IRX3

(2014) Scott Smemo et al.   NATURE

A Drosophila functional evaluation of candidates from human genome-wide association studies of type 2 diabetes and related metabolic traits identifies tissue-specific roles for dHHEX

(2013) Jay Pendse et al.   BMC GENOMICS

Systematic identification of trans eQTLs as putative drivers of known disease associations

(2013) Harm-Jan Westra et al.   NATURE GENETICS

Reduction in Tcf7l2 Expression Decreases Diabetic Susceptibility in Mice

(2012) Hyekyung Yang et al.   International Journal of Biological Sciences

A VASP-Rac-Soluble Guanylyl Cyclase Pathway Controls cGMP Production in Adipocytes

(2012) K. Jennissen et al.   Science Signaling

PKA/CREB Signaling Triggers Initiation of Endothelial and Hematopoietic Cell Differentiation via Etv2 Induction

(2012) Kohei Yamamizu et al.   STEM CELLS

Functional Screening of Alzheimer Pathology Genome-wide Association Signals in Drosophila

(2011) Joshua M. Shulman et al.   AMERICAN JOURNAL OF HUMAN GENETICS

An integrative approach to ortholog prediction for disease-focused and other functional studies

(2011) Yanhui Hu et al.   BMC BIOINFORMATICS

Endothelial NO/cGMP/VASP Signaling Attenuates Kupffer Cell Activation and Hepatic Insulin Resistance Induced by High-Fat Feeding

(2011) Sanshiro Tateya et al.   DIABETES

A high-sugar diet produces obesity and insulin resistance in wild-type Drosophila

(2011) L. Palanker Musselman et al.   Disease Models & Mechanisms

Suppression of 5′-Nucleotidase Enzymes Promotes AMP-activated Protein Kinase (AMPK) Phosphorylation and Metabolism in Human and Mouse Skeletal Muscle

(2011) Sameer S. Kulkarni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Drosophila Genome-wide Obesity Screen Reveals Hedgehog as a Determinant of Brown versus White Adipose Cell Fate

(2010) J. Andrew Pospisilik et al.   CELL

Long Noncoding RNAs with Enhancer-like Function in Human Cells

(2010) Ulf Andersson Ørom et al.   CELL

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

(2010) Elizabeth K Speliotes et al.   NATURE GENETICS

Insect Fat Body: Energy, Metabolism, and Regulation

(2009) Estela L. Arrese et al.   Annual Review of Entomology

Regulation of Fat Cell Mass by Insulin in Drosophila melanogaster

(2009) J. R. DiAngelo et al.   MOLECULAR AND CELLULAR BIOLOGY

Genomic views of distant-acting enhancers

(2009) Axel Visel et al.   NATURE