Insight into small molecule binding to the neonatal Fc receptor by X-ray crystallography and 100 kHz magic-angle-spinning NMR

Partially-deuterated samples of HET-s(218–289) fibrils: assignment and deuterium isotope effect

(2017) Albert A. Smith et al.   JOURNAL OF BIOMOLECULAR NMR

Proton-Based Structural Analysis of a Heptahelical Transmembrane Protein in Lipid Bilayers

(2017) Daniela Lalli et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The FcRn inhibitor rozanolixizumab reduces human serum IgG concentration: A randomized phase 1 study

(2017) Peter Kiessling et al.   Science Translational Medicine

Expanding the horizons for structural analysis of fully protonated protein assemblies by NMR spectroscopy at MAS frequencies above 100 kHz

(2017) Jochem Struppe et al.   SOLID STATE NUCLEAR MAGNETIC RESONANCE

NMR Spectroscopic Assignment of Backbone and Side-Chain Protons in Fully Protonated Proteins: Microcrystals, Sedimented Assemblies, and Amyloid Fibrils

(2016) Jan Stanek et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

OrthoDB v9.1: cataloging evolutionary and functional annotations for animal, fungal, plant, archaeal, bacterial and viral orthologs

(2016) Evgeny M. Zdobnov et al.   NUCLEIC ACIDS RESEARCH

Structure of fully protonated proteins by proton-detected magic-angle spinning NMR

(2016) Loren B. Andreas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Progress in discovery of small-molecule modulators of protein–protein interactions via fragment screening

(2015) Thomas V. Magee   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Protein resonance assignment at MAS frequencies approaching 100 kHz: a quantitative comparison of J-coupling and dipolar-coupling-based transfer methods

(2015) Susanne Penzel et al.   JOURNAL OF BIOMOLECULAR NMR

The FTMap family of web servers for determining and characterizing ligand-binding hot spots of proteins

(2015) Dima Kozakov et al.   Nature Protocols

Detection of secondary binding sites in proteins using fragment screening

(2015) R. Frederick Ludlow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

De Novo 3D Structure Determination from Sub-milligram Protein Samples by Solid-State 100 kHz MAS NMR Spectroscopy

(2014) Vipin Agarwal et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Neonatal Fc receptor (FcRn): a novel target for therapeutic antibodies and antibody engineering

(2014) Yuan Wang et al.   JOURNAL OF DRUG TARGETING

Rapid Proton-Detected NMR Assignment for Proteins with Fast Magic Angle Spinning

(2014) Emeline Barbet-Massin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Discovery and structure–activity relationships of small molecules that block the human immunoglobulin G–human neonatal Fc receptor (hIgG–hFcRn) protein–protein interaction

(2013) Zhaolin Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Autoimmune myasthenia gravis

(2013) Rozen Le Panse et al.   CURRENT OPINION IN NEUROLOGY

NMR spectroscopy reveals unexpected structural variation at the protein–protein interface in MHC class I molecules

(2013) Monika Beerbaum et al.   JOURNAL OF BIOMOLECULAR NMR

Practical aspects of NMR signal assignment in larger and challenging proteins

(2013) Dominique P. Frueh   PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

A Sedimented Sample of a 59 kDa Dodecameric Helicase Yields High-Resolution Solid-State NMR Spectra

(2012) Carole Gardiennet et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Solid-state NMR analysis of membrane proteins and protein aggregates by proton detected spectroscopy

(2012) Donghua H. Zhou et al.   JOURNAL OF BIOMOLECULAR NMR

PEGylation enhances the therapeutic potential of peptide antagonists of the neonatal Fc receptor, FcRn

(2011) Adam R. Mezo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A software framework for analysing solid-state MAS NMR data

(2011) Tim J. Stevens et al.   JOURNAL OF BIOMOLECULAR NMR

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

MEDELLER: homology-based coordinate generation for membrane proteins

(2010) Sebastian Kelm et al.   BIOINFORMATICS

Guillain–Barré Syndrome—A Classical Autoimmune Disease Triggered by Infection or Vaccination

(2010) Eitan Israeli et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

X-ray Crystal Structures of Monomeric and Dimeric Peptide Inhibitors in Complex with the Human Neonatal Fc Receptor, FcRn

(2010) Adam R. Mezo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthesis and Structure−Activity Relationships of Dimeric Peptide Antagonists of the Human Immunoglobulin G−Human Neonatal Fc Receptor (IgG−FcRn) Interaction

(2010) Kevin A. McDonnell et al.   JOURNAL OF MEDICINAL CHEMISTRY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Gene Composer: database software for protein construct design, codon engineering, and gene synthesis

(2009) Don Lorimer et al.   BMC BIOTECHNOLOGY

Characterization of different water pools in solid-state NMR protein samples

(2009) Anja Böckmann et al.   JOURNAL OF BIOMOLECULAR NMR

Identifying and Characterizing Binding Sites and Assessing Druggability

(2009) Thomas A. Halgren   Journal of Chemical Information and Modeling

The titerless infected-cells preservation and scale-up (TIPS) method for large-scale production of NO-sensitive human soluble guanylate cyclase (sGC) from insect cells infected with recombinant baculovirus

(2009) David J. Wasilko et al.   PROTEIN EXPRESSION AND PURIFICATION

Predicting Protein Ligand Binding Sites by Combining Evolutionary Sequence Conservation and 3D Structure

(2009) John A. Capra et al.   PLoS Computational Biology

Structure–activity relationships of a peptide inhibitor of the human FcRn:human IgG interaction

(2008) Adam R. Mezo et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Proton-detected scalar coupling based assignment strategies in MAS solid-state NMR spectroscopy applied to perdeuterated proteins

(2008) Rasmus Linser et al.   JOURNAL OF MAGNETIC RESONANCE

Reduction of IgG in nonhuman primates by a peptide antagonist of the neonatal Fc receptor FcRn

(2008) A. R. Mezo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA