Organic cation transporter 1 (OCT1) modulates multiple cardiometabolic traits through effects on hepatic thiamine content

A genome-wide association meta-analysis on lipoprotein (a) concentrations adjusted for apolipoprotein (a) isoforms

(2017) Salome Mack et al.   JOURNAL OF LIPID RESEARCH

Genetic effects on gene expression across human tissues

(2017) François Aguet et al.   NATURE

Dissecting the genetics of complex traits using summary association statistics

(2016) Bogdan Pasaniuc et al.   NATURE REVIEWS GENETICS

Distribution and clinical impact of functional variants in 50,726 whole-exome sequences from the DiscovEHR study

(2016) Frederick E. Dewey et al.   SCIENCE

An exome array study of the plasma metabolome

(2016) Eugene P. Rhee et al.   Nature Communications

Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA

(2016) Johannes Kettunen et al.   Nature Communications

Genetic studies of plasma analytes identify novel potential biomarkers for several complex traits

(2016) Yuetiva Deming et al.   Scientific Reports

Are There Genetic Paths Common to Obesity, Cardiovascular Disease Outcomes, and Cardiovascular Risk Factors?

(2015) T. Rankinen et al.   CIRCULATION RESEARCH

Genome- and exome-wide association study of serum lipoprotein (a) in the Jackson Heart Study

(2015) Jin Li et al.   JOURNAL OF HUMAN GENETICS

The impact of low-frequency and rare variants on lipid levels

(2015) Ida Surakka et al.   NATURE GENETICS

Role of SLC22A1 polymorphic variants in drug disposition, therapeutic responses and drug–drug interactions

(2015) C Arimany-Nardi et al.   PHARMACOGENOMICS JOURNAL

Thiamin Deficiency in People with Obesity

(2015) Jennifer C Kerns et al.   Advances in Nutrition

Global genetic analyses reveal strong inter-ethnic variability in the loss of activity of the organic cation transporter OCT1

(2015) Tina Seitz et al.   Genome Medicine

LDL, HDL, VLDL, and CVD Prevention: Lessons from Genetics?

(2015) Bernd Hewing et al.   Current Cardiology Reports

All Low-Density Lipoprotein Particles Are Not Created Equal

(2014) Ronald M. Krauss   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Metabolic Inflexibility: When Mitochondrial Indecision Leads to Metabolic Gridlock

(2014) Deborah M. Muoio   CELL

Thiamine deficiency induces anorexia by inhibiting hypothalamic AMPK

(2014) M. Liu et al.   NEUROSCIENCE

GRASP v2.0: an update on the Genome-Wide Repository of Associations between SNPs and phenotypes

(2014) John D. Eicher et al.   NUCLEIC ACIDS RESEARCH

The pivotal role of pyruvate dehydrogenase kinases in metabolic flexibility

(2014) Shuai Zhang et al.   Nutrition & Metabolism

Thiamine Deficiency Secondary to Anorexia Nervosa: An Uncommon Cause of Peripheral Neuropathy and Wernicke Encephalopathy in Adolescence

(2014) William Renthal et al.   PEDIATRIC NEUROLOGY

Genetic, anatomic, and clinical determinants of human serum sterol and vitamin D levels

(2014) A. R. Stiles et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic activation of pyruvate dehydrogenase alters oxidative substrate selection to induce skeletal muscle insulin resistance

(2014) Yasmeen Rahimi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin

(2014) Ligong Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Morphine is a substrate of the organic cation transporter OCT1 and polymorphisms in OCT1 gene affect morphine pharmacokinetics after codeine administration

(2013) Mladen V. Tzvetkov et al.   BIOCHEMICAL PHARMACOLOGY

VASP Increases Hepatic Fatty Acid Oxidation by Activating AMPK in Mice

(2013) S. Tateya et al.   DIABETES

Glucose-6-Phosphate-Mediated Activation of Liver Glycogen Synthase Plays a Key Role in Hepatic Glycogen Synthesis

(2013) A. von Wilamowitz-Moellendorff et al.   DIABETES

High-dose thiamine supplementation improves glucose tolerance in hyperglycemic individuals: a randomized, double-blind cross-over trial

(2013) F. Alaei Shahmiri et al.   EUROPEAN JOURNAL OF NUTRITION

The relationship between lactate and thiamine levels in patients with diabetic ketoacidosis

(2013) Ari Moskowitz et al.   JOURNAL OF CRITICAL CARE

Discovery and refinement of loci associated with lipid levels

(2013) Cristen J Willer et al.   NATURE GENETICS

OCT1 genetic variants influence the pharmacokinetics of morphine in children

(2013) Tsuyoshi Fukuda et al.   PHARMACOGENOMICS

Adipose Weight Gain during Chronic Insulin Treatment of Mice Results from Changes in Lipid Storage without Affecting De Novo Synthesis of Palmitate

(2013) Henriette Frikke-Schmidt et al.   PLoS One

Muscle-Specific Deletion of Carnitine Acetyltransferase Compromises Glucose Tolerance and Metabolic Flexibility

(2012) Deborah M. Muoio et al.   Cell Metabolism

Acetyl-CoA Carboxylase 2−/−Mutant Mice are Protected against Fatty Liver under High-fat, High-carbohydrate Dietary andde NovoLipogenic Conditions

(2012) Lutfi Abu-Elheiga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucose-Induced Down Regulation of Thiamine Transporters in the Kidney Proximal Tubular Epithelium Produces Thiamine Insufficiency in Diabetes

(2012) James R. Larkin et al.   PLoS One

Fatty Acids, Obesity, and Insulin Resistance: Time for a Reevaluation

(2011) F. Karpe et al.   DIABETES

Genetic variants, plasma lipoprotein(a) levels, and risk of cardiovascular morbidity and mortality among two prospective cohorts of type 2 diabetes

(2011) Qibin Qi et al.   EUROPEAN HEART JOURNAL

The interaction of hepatic lipid and glucose metabolism in liver diseases

(2011) Lars P. Bechmann et al.   JOURNAL OF HEPATOLOGY

A guide to analysis of mouse energy metabolism

(2011) Matthias H Tschöp et al.   NATURE METHODS

Identification, Replication, and Functional Fine-Mapping of Expression Quantitative Trait Loci in Primary Human Liver Tissue

(2011) Federico Innocenti et al.   PLoS Genetics

Iron Overload and Diabetes Risk: A Shift From Glucose to Fatty Acid Oxidation and Increased Hepatic Glucose Production in a Mouse Model of Hereditary Hemochromatosis

(2010) J. Huang et al.   DIABETES

A Recurring Problem With the Analysis of Energy Expenditure in Genetic Models Expressing Lean and Obese Phenotypes

(2010) A. A. Butler et al.   DIABETES

Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice

(2010) J. E. Ayala et al.   Disease Models & Mechanisms

Biological, clinical and population relevance of 95 loci for blood lipids

(2010) Tanya M. Teslovich et al.   NATURE

The Randle cycle revisited: a new head for an old hat

(2009) Louis Hue et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Monitoring phosphorylation of the pyruvate dehydrogenase complex

(2009) Matthew J. Rardin et al.   ANALYTICAL BIOCHEMISTRY

Nutritional Deficiencies in Obesity and After Bariatric Surgery

(2009) Stavra A. Xanthakos   PEDIATRIC CLINICS OF NORTH AMERICA

Cellular cholesterol trafficking and compartmentalization

(2008) Elina Ikonen   NATURE REVIEWS MOLECULAR CELL BIOLOGY