Article
Dentistry, Oral Surgery & Medicine
Dogukan Yilmaz, Mervi Gursoy, Ulvi Kahraman Gursoy
Summary: The aim of this study was to investigate the tissue levels and ratios of anti-apoptotic and pro-apoptotic Bcl-2 family proteins in peri-implant diseases. The results showed that the levels of anti-apoptotic proteins were significantly higher in controls compared with patients with peri-implant mucositis and peri-implantitis, while the levels of pro-apoptotic proteins were lower in the patient groups. Therefore, dysregulation of Bcl-2 family proteins may contribute to the pathogenesis of peri-implant diseases.
CLINICAL ORAL IMPLANTS RESEARCH
(2023)
Article
Engineering, Biomedical
Oyunchimeg Bayaraa, Khandmaa Dashnyam, Rajendra K. Singh, Nandin Mandakhbayar, Jun Hee Lee, Jong-Tae Park, Jung-Hwan Lee, Hae-Won Kim
Summary: Critical limb ischemia (CLI) is a severe peripheral arterial disease characterized by blocked blood flow, leading to foot necrosis and limb loss. The delivery of cells, such as HUVEC/MSC, with the use of nanoceria-decorated graphene oxide (CeGO) nanosheets enhances cell survival and promotes angiogenic events. This delivery system scavenges excessive ROS, stimulates angiogenesis, and helps in the revascularization and tissue recovery of critical ischemic limbs.
Article
Biochemistry & Molecular Biology
Mostafa A. Aboouf, Julia Armbruster, Markus Thiersch, Franco Guscetti, Glen Kristiansen, Peter Schraml, Anne Bicker, Ruben Petry, Thomas Hankeln, Max Gassmann, Thomas A. Gorr
Summary: The expression of myoglobin is associated with better prognosis in breast cancer patients, but its role in mammary tumorigenesis is unclear. Through CRISPR/Cas9 technology, we generated myoglobin-deficient breast cancer cell lines and found that loss of myoglobin increased cell survival and expression of cell cyclins, as well as enhanced cell migration and invasion under hypoxia. In human invasive mammary ductal carcinoma tissues, myoglobin levels were positively correlated with apoptotic markers, and myoglobin expression was associated with a positive prognostic value.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nanoscience & Nanotechnology
Jun Wan, Jie Yang, Wenrui Lei, Zezhou Xiao, Pengyu Zhou, Shaoyi Zheng, Peng Zhu
Summary: This study developed liposome nanoparticles (SE-LNPs) using Simvastatin (SIM) as a model drug, EGCG as an antioxidant, and distearyl phosphatidylcholine (DSPC) as carriers. The nanoparticles showed good therapeutic effects in vitro and in vivo by resisting oxidation, promoting M2 polarization, reducing blood lipids, and improving atherosclerotic lesions.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Review
Chemistry, Medicinal
Rosette Agena, Alejandro de Jesus Cortes-Sanchez, Humberto Hernandez-Sanchez, Maria Eugenia Jaramillo-Flores
Summary: The ability of cancer cells to evade or inhibit apoptosis is a characteristic of cancer and contributes to tumor proliferation and metastasis. Several studies have reported promising bioactive compounds extracted from macroalgae that have pro-apoptotic effects. This review provides a basis for further research and the development of new anticancer drugs.
Article
Biochemistry & Molecular Biology
Ravit Malishev, Shani Ben-Zichri, Ofek Oren, Nitzan Shauloff, Tal Peretz, Ran Taube, Niv Papo, Raz Jelinek
Summary: The BIM-BH3 motif is a key pro-apoptotic domain that forms toxic amyloid fibrils, leading to cell death and impacting mitochondrial functions.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Cell Biology
Natalia Respekta, Karolina Pich, Monika Dawid, Ewa Mlyczynska, Patrycja Kurowska, Agnieszka Rak
Summary: The apelinergic system, consisting of apelin, ELABELA, and the apelin receptor APJ, plays a multifaceted role in various biological functions. This review focuses on the role of the apelinergic system in cell apoptosis and highlights the signaling pathways involved, such as PI3K, ERK1/2, AKT, AMPK, and PKA. Dysregulation of apoptosis can lead to pathological conditions, and the apelinergic system shows potential as a therapeutic target in various diseases.
Article
Oncology
Almog Nadir, Anna Shteinfer-Kuzmine, Swaroop Kumar Pandey, Juan Ortas, Daniel Kerekes, Varda Shoshan-Barmatz
Summary: This study identified three different plant extracts that can effectively induce cell death and focused on the most potent extract. The extract kills tumor cells through multiple mechanisms, including impairing cell energy and metabolism, generating reactive oxygen species, increasing intracellular calcium levels, and inducing mitochondria-mediated apoptosis. In a mouse model of glioblastoma, the extract inhibits tumor growth and induces massive tumor cell death, including cancer stem cells, by inhibiting blood supply and modulating the tumor microenvironment. These findings suggest that the plant extract has potential as a cancer therapeutic.
Article
Food Science & Technology
Suresh Sulekha Dhanisha, Sudarsanan Drishya, Chandrasekharan Guruvayoorappan
Summary: The present study demonstrates the efficacy of fruit extract of Pithecellobium dulce against Dalton's lymphoma ascites cell lines in vitro and in vivo. The extract induced apoptosis in the cancer cells and reduced tumor burden, increased survival time, and decreased proinflammatory cytokines.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Hae-Seul Choi, Kwang-Hyun Baek
Summary: Apoptosis is a structured cell death process involving cell morphology and biochemical changes, and the ubiquitin-proteasome system regulates the protein levels. Targeting UPS enzymes and controlling proteasomal degradation of apoptotic proteins could be a unique approach for cancer treatment.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
ElHusseiny M. M. Abdelwahab, Judit Bovari-Biri, Gabor Smuk, Janos Fillinger, Donald McPhail, Vera P. Krymskaya, Judit E. Pongracz
Summary: This study investigates the deregulation of cell death processes in TSC mutation, and identifies a potential treatment strategy involving the use of Proxison and rapamycin in combination to increase ROS production, modify miRNA expression pattern, and reduce cell viability.
Article
Biochemistry & Molecular Biology
Rafael Cardoso Maciel Costa Silva, Luis Tan, Danielle Aparecida Rodrigues, Elisa Beatriz Prestes, Caroline Pereira Gomes, Andreza Moreira Gama, Pedro Lagerblad de Oliveira, Claudia Neto Paiva, Benedicte Manoury, Marcelo Torres Bozza
Summary: The study indicates that chloroquine may be used as a supportive therapy to control heme-induced deleterious inflammation in different hemolytic diseases by inhibiting inflammatory effects induced by heme.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Immunology
Muttiah Barathan, Behnaz Riazalhosseini, Thevambiga Iyadorai, Kumutha Malar Vellasamy, Jamuna Vadivelu, Li-Yen Chang, Ahmad Khusairy Zulpa, Marie Larsson, Esaki M. Shankar, Rosmawati Mohamed
Summary: In chronic HBV patients, those with liver cirrhosis showed higher levels of oxidative stress and cell apoptosis, as well as alterations in inflammatory mediators.
MICROBIAL PATHOGENESIS
(2021)
Article
Biochemistry & Molecular Biology
Taewook Kang, Honggang Huang, Thomas Mandrup-Poulsen, Martin R. Larsen
Summary: Pro-inflammatory cytokines promote iron-import in pancreatic beta-cells through upregulation of divalent metal transporter-1 (DMT1), leading to cell death. Silencing of DMT1 protects against apoptosis in diabetes animal models by reversing IL-1 beta-induced phosphosites levels and inactivating autophagic flux, potentially improving beta-cell functions. This study sheds light on the signal transduction pathways involved in protecting beta-cells against inflammation-induced cell death after DMT1 silencing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Theresa H. Wirtz, Alena Saal, Irina Bergmann, Petra Fischer, Daniel Heinrichs, Elisa F. Brandt, Maria T. Koenen, Sonja Djudjaj, Kai M. Schneider, Peter Boor, Richard Bucala, Ralf Weiskirchen, Jurgen Bernhagen, Christian Trautwein, Marie-Luise Berres
Summary: The study identified a pro-tumorigenic role of MIF in the proliferation and therapy-induced apoptosis of HCC cells, mediated through the MIF cognate receptor CD74.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Arijita Basu, Priyanka Upadhyay, Avijit Ghosh, Aparajita Bose, Payal Gupta, Sreya Chattopadhyay, Dipankar Chattopadhyay, Arghya Adhikary
Summary: HA-GO-Met nanoparticles exhibit significant anti-cancer efficacy in triple negative breast cancer, inducing apoptosis and inhibiting cell migration by targeting the miR-10b/PTEN axis via NFkB-p65. They also reduce tumor load and overall toxicity, inhibit epithelial mesenchymal transition and stemness, addressing the issue of cancer recurrence.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2021)
Article
Materials Science, Multidisciplinary
Anil Chamuah, Koyel Bhattacharya, Mir Sahidul Ali, Chandan Kumar Ghosh, Dipankar Chattopadhyay, Sanjib Bhattacharya
Summary: The development of some Ag2S mixed chalcogenide glassy systems and their microstructure correlations with electrical transport properties have been discussed, with various nanophases and defects identified through XRD studies. The enhancement of structural vibrations due to optical phonon frequency and the explanation of increased density of states near the Fermi level at different temperatures were highlighted. The glassy structure is expected to expand to reduce scattering cross-section and achieve higher N(E-F) values at elevated temperatures.
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
(2021)
Article
Biophysics
Soumya Ganguly, Saikat Dewanjee, Ramkrishna Sen, Dipankar Chattopadhyay, Shantanu Ganguly, Raghuvir Gaonkar, Mita Chatterjee Debnath
Summary: The study developed galactose-tailored PLGA nanoparticles loaded with apigenin for active liver targeting in hepatocellular carcinoma treatment. In vitro and in vivo experiments showed that these nanoparticles exhibit improved cellular internalization and cytotoxic potential, leading to better therapeutic efficacy against HCC compared to free apigenin and apigenin-loaded nanoparticles.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Subrata Ghorai, Braja Gopal Bag
Summary: Uvaol, a pentacyclic triterpenoid isolated from various plants, exhibits self-assembly properties in different organic liquids and binary liquid mixtures, forming intricate nano- to micrometer-scale superstructures. These self-assemblies have been utilized in the synthesis of anticancer drug conjugates and the removal of harmful chemicals.
Article
Polymer Science
Madhumita Mukherjee, Piyali Mandal, Diptendu Patra, Dwaipayan Pal, Raja Shunmugam, Dipankar Chattopadhyay
Summary: By adding 1-pyrenemethanol (PM) to the polynorbornene (PNORCNF), a significant change in the polarity of the PNORCNF/PM microenvironment was observed, leading to morphological changes in the system. The mechanism of this change may be attributed to the pi-pi interaction between PM and the cinnamoyl moiety of PNORCNF.
JOURNAL OF POLYMER SCIENCE
(2021)
Article
Materials Science, Biomaterials
Koushik Dutta, Sriparna De, Beauty Das, Suman Bera, Biswanath Guria, Mir Sahidul Ali, Dipankar Chattopadhyay
Summary: A novel electrochemical immunosensor based on N-GQD and SWCNHs was developed for detecting the cancer biomarker AFP. The nanocomposite architecture N-GQD@SWCNHs served as an excellent base for antibody immobilization, showing broad dynamic range and low detection limit with high selectivity, stability, and reproducibility. AFP measurements in human serum demonstrated outstanding recovery, highlighting the potential role of the sensor for early clinical screening of cancer biomarkers.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2021)
Review
Biotechnology & Applied Microbiology
Jit Sarkar, Deepanjan Mridha, Joy Sarkar, Jonathan Tersur Orasugh, Bhuman Gangopadhyay, Dipankar Chattopadhyay, Tarit Roychowdhury, Krishnendu Acharya
Summary: Agricultural waste management is a significant challenge in the 21st century, but converting agricultural wastes into value-added products like nanosilica can help reduce pollution. Silica nanoparticles (SiNPs) synthesized from agricultural wastes, particularly cereal crops, have proven to be versatile with advantages like biocompatibility and adjustable functionalization, making them attractive for use in various fields.
BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY
(2021)
Review
Engineering, Environmental
Adrija Ghosh, Jonathan Tersur Orasugh, Dipankar Chattopadhyay, Sayanti Ghosh
Summary: Researchers are increasingly concerned about the presence of endocrine-disrupting chemicals in the environment, with electrospun nanofibres playing a significant role in adsorption, filtration, detection, and degradation of these harmful chemicals. These nanofibres have the potential to help address the challenges in treating EDCs.
GROUNDWATER FOR SUSTAINABLE DEVELOPMENT
(2022)
Article
Materials Science, Multidisciplinary
Arpita Adhikari, Jyotishka Nath, Dipak Rana, Sriparna De, Mukut Chakraborty, Pradip Kar, Amit K. Chakraborty, Dipankar Chattopadhyay
Summary: A polypyrrole (PPY) nanoribbon based nanocomposite decorated with Ag metal (PPY-Ag) was successfully fabricated as a working electrode for electrochemical sensing of serotonin. The electrode showed fast, precise, selective, and sensitive determination of serotonin with a limit of detection as low as 0.01 nM.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Jhimli Banerjee, Sk Nurul Hasan, Sovan Samanta, Biplab Giri, Braja Gopal Bag, Sandeep Kumar Dash
Summary: This experimental study investigated the potential of maslinic acid (MA) to mitigate cytotoxicity induced by Doxorubicin (DOX) in human healthy peripheral blood mononuclear cells (hPBMCs). The results showed that pre-treatment with MA significantly reduced intracellular oxidative stress and protected cell morphology. Furthermore, it was found that MA protected cells by inhibiting inflammatory pathways generated by DOX treatment.
CELL BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Biochemistry & Molecular Biology
Mir Sahidul Ali, Pritha Bhunia, Arpita Priyadarshini Samanta, Jonathan Tersur Orasugh, Dipankar Chattopadhyay
Summary: In recent years, there has been increasing focus on the fabrication and application of bio-based non-cytotoxic drug carriers. Cellulose nanocrystals (CNCs) have been extensively studied as a promising bioderived material in the biomedical field. This study aimed to develop a transdermal patch using CNCs as nanofillers and carriers for sustained delivery of ketorolac tromethamine (KT). The results showed that BNCs containing 1 wt% CNCs exhibited the best-sustained drug release profile.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Pharmacology & Pharmacy
Surya Kanta Dey, Ananya Pradhan, Tamanna Roy, Subhasis Das, Dipankar Chattopadhyay, Sujata Maiti Choudhury
Summary: This study reported the preparation of poly lactide-co-glycolide encapsulated diosgenin nanoparticles (PLGA-DGN NPs) and explored their potential in anticancer therapy. The results showed that PLGA-DGN NPs had appropriate size and morphology, high encapsulation efficacy and drug release. They exhibited significant antineoplastic activities both in vitro and in vivo. Furthermore, PLGA-DGN NPs demonstrated excellent pharmacokinetic profile, enhanced drug accumulation in tumor tissue, and good safety profile.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Physical
Arpita Adhikari, Somali Mukherjee, K. Amit Chakraborty, Suman Biswas, Arijita Basu, Mukut Chakraborty, Sanatan Chattopadhyay, Debasis Das, Dipankar Chattopadhyay
Summary: This study demonstrates the development of a low-cost polymer by doping polyaniline nanoribbons with lac-extract, which shows excellent fluorescence sensing properties against aqueous AsO43- and Fe3+ ions. The sensor exhibits high specificity and reversibility, making it a potential candidate for next-generation fluorescence sensors for water quality monitoring.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2022)
Article
Chemistry, Applied
Arpita Priyadarshini Samanta, Mir Sahidul Ali, Jonathan Tersur Orasugh, Swapan Kumar Ghosh, Dipankar Chattopadhyay
Summary: Engaging potent drug delivery systems have profound effects on managing drug outcome and pharmacokinetic profile, including drug release rate, target site, bioavailability, and side effects. This research investigates the impact of reinforcing nanofillers on drug release and other properties of nanofiber-drug loaded systems. The experimental results demonstrate that the nanofiber structures with reinforced nanofillers exhibit excellent sustained drug release performance, making them suitable for transdermal drug delivery systems.
CARBOHYDRATE POLYMER TECHNOLOGIES AND APPLICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Saikat Kumar Panja, Soumen Patra, Braja Gopal Bag
Summary: Lupeol is a medicinally important triterpenoid that can self-assemble into supramolecular gels in various organic and aqueous-organic liquid mixtures. These gels exhibit capabilities in removing pollutants from water and releasing drugs, showcasing potential applications in environmental and pharmaceutical fields.