Article
Immunology
Ronan Thibaut, Lucie Orliaguet, Tina Ejlalmanesh, Nicolas Venteclef, Fawaz Alzaid
Summary: Macrophages are innate immune cells with high phenotypic plasticity that can polarize on a spectrum from pro- to anti-inflammatory. Cellular metabolism is recognized as a key factor influencing macrophage function, but the directionality between metabolism and phenotype is still under investigation. By modulating metabolic pathways in macrophages, it has been shown that disruption of cellular metabolism does influence macrophage phenotype and function.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Egan L. Choi, Negar Taheri, Abhishek Chandra, Yujiro Hayashi
Summary: Due to modern medical advancements, more people are living longer lives. However, this increased lifespan does not always correspond to improved health, and can lead to a rise in aging-related diseases. These diseases are often attributed to cellular senescence, which creates a proinflammatory environment suitable for tumor progression. This review focuses on the effects of cellular senescence on gastrointestinal aging, inflammation, and cancers, aiming to enhance our understanding of these processes for future therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Teresa Rubio-Tomas, Ascension Rueda-Robles, Julio Plaza-Diaz, Ana I. alvarez-Mercado
Summary: Adequate nutrition is crucial for immune homeostasis, but the rising incidence of obesity worldwide is linked to chronic inflammation and cellular senescence. Targeting senescence processes may provide a beneficial approach to combating obesity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Neurosciences
Yujiao Lu, Abbas Jarrahi, Nicholas Moore, Manuela Bartoli, Darrell W. Brann, Babak Baban, Krishnan M. Dhandapani
Summary: Traumatic brain injury (TBI) is a leading cause of progressive neurodegeneration and is associated with mortality and morbidity worldwide. Inflammation plays a crucial role in neurodegenerative changes and cognitive dysfunction after TBI, suggesting a potential link between immune activation and age- or TBI-induced cognitive decline. This mini-review explores the association between cellular senescence and poor TBI outcomes, as well as the potential use of senotherapeutics as therapeutics for TBI.
NEUROBIOLOGY OF DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Cong Xie, Mai Maititusun Ya Likun, Qing-li Luo, Jing-cheng Dong
Summary: Cellular senescence, characterized by permanent cell proliferation arrest, plays a crucial role in the development of cancer and age-related illnesses. This study reviews the recent progress on cellular senescence and its impact on lung inflammation, providing insights into the underlying mechanisms and clinical relevance. The study also proposes the importance of controlling cellular senescence and pro-inflammatory response activation in order to attenuate inflammatory lung conditions and improve disease outcomes.
CYTOKINE & GROWTH FACTOR REVIEWS
(2023)
Article
Nutrition & Dietetics
Pedro L. Valenzuela, Adrian Castillo-Garcia, Javier S. Morales, Alejandro Lucia
Summary: Despite the theoretical potential benefits of oral ketone supplements on exercise performance and cognition, current research evidence does not support their effectiveness in sports, and there is limited evidence on their long-term use.
ADVANCES IN NUTRITION
(2021)
Review
Cell Biology
Gregory Livshits, Alexander Kalinkovich
Summary: The increase in lifespan and proportion of older adults has resulted in a rise in age-associated chronic diseases, such as sarcopenia and obesity. Sestrins, a family of proteins, play a crucial role in cellular adaption to stress and have shown potential in treating sarcopenia and obesity in pre-clinical models. Activation of sestrins can eliminate senescent cells and resolve inflammation. Therefore, sestrin activation, inflammation resolution, and senescent cell elimination may be a novel treatment strategy for age-associated sarcopenia and obesity.
AGEING RESEARCH REVIEWS
(2023)
Article
Nutrition & Dietetics
Raci Karayigit, Mitat Koz, Angela Sanchez-Gomez, Alireza Naderi, Ulas Can Yildirim, Raul Dominguez, Fatih Gur
Summary: This study found that high dosage of caffeine mouth rinsing significantly increased muscular endurance performance and decreased ratings of perceived exertion, suggesting a dose-dependent response to CMR on muscular endurance.
Article
Immunology
Yong Du, Yi Ding, Tianyun Shi, Wei He, Zhoufang Mei, Xintong Feng, Xiaohua Zhang, Zhijun Jie
Summary: This study reveals that circXPO1 plays a role in the pathogenesis of COPD by modulating TAB3 through sponging miR-23b-3p. Suppression of circXPO1 can inhibit cigarette smoke-induced inflammatory cytokine production and cellular senescence. CircXPO1 knockdown has a potential therapeutic effect on attenuating CS-induced inflammation and senescence in the mouse lungs.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Yixiu Tao, Yingxin Sun, Bo Wu, Donghui Xu, Jun Yang, Liang Gu, Chunling Du
Summary: FOXA2 is underexpressed in CS-exposed mouse lungs, associated with cell senescence and inflammation. Overexpression of FOXA2 delays senescence and inflammation, potentially through regulation of the p38 and Erk1/2 MAPK signaling pathways.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Alessandra Maria Lodrini, Marie-Jose Goumans
Summary: Despite the advancement in interventional coronary reperfusion strategies, mortality from acute myocardial infarction remains high. MI leads to adverse remodelling in the affected myocardium, with cellular phenotypes like senescence, inflammation, and dedifferentiation playing key roles in the pathophysiology of the infarcted heart. Enhancing electric coupling between cardiomyocytes, eliminating senescent cells, and upregulating cellular processes like autophagy could potentially improve cardiac contractility post-MI.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Oishani Chaterjee, Debjeet Sur
Summary: Macrophages are mature form of monocytes that can shift from one phenotype to another through the process of macrophage polarization. Different phenotypes of macrophages have different functions with M1 macrophages being responsible for immune responses and M2 macrophages having healing properties. Maintaining macrophage homeostasis is important to avoid tissue damage and ensure proper wound healing and angiogenesis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Szymon Turkiewicz, Marta Ditmer, Marcin Sochal, Piotr Bialasiewicz, Dominik Strzelecki, Agata Gabryelska
Summary: OSA patients have a higher prevalence of age-related disorders and telomere shortening has been linked to oxidative stress, hypoxia, and inflammation, suggesting a potential positive feedback loop causing cellular senescence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ji-Won Noh, Min-Soo Jun, Hee-Kwon Yang, Byung-Cheol Lee
Summary: Berberine has anti-obesity and anti-inflammatory effects by modulating ATM recruitment and activation.
Article
Biochemistry & Molecular Biology
Andrea Ribeiro, Feiyue Liu, Matthias Srebrzynski, Simone Rother, Karina Adamowicz, Marta Wadowska, Stefanie Steiger, Hans-Joachim Anders, Christoph Schmaderer, Joanna Koziel, Maciej Lech
Summary: In this study, the impact of uremic toxin indoxyl sulfate on macrophages and tubular epithelial cells and its role in modulating the response to lipopolysaccharide (LPS) were investigated. Indoxyl sulfate, which accumulates in the blood of patients with chronic kidney disease (CKD), was found to induce low-grade inflammation and modulate macrophage function. Additionally, it was shown to enhance the inflammatory response associated with LPS and contribute to the senescence of tubular epithelial cells during injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Li-Kung Wu, Surbhi Agarwal, Chia-Hua Kuo, Yen-Lun Kung, Cecilia Hsuan Day, Pi-Yu Lin, Shinn-Zong Lin, Dennis Jine-Yuan Hsieh, Chih-Yang Huang, Chien-Yi Chiang
Summary: The study demonstrates that Artemisia argyi has neuroprotective effects by stimulating TRPML1 and promoting autophagy/mitophagy, as well as activating a cell survival pathway.
Review
Sport Sciences
Luthfia Dewi, Yin-Chou Lin, Andrew Nicholls, Giancarlo Condello, Chih-Yang Huang, Chia-Hua Kuo
Summary: This study provides a quantitative estimate of the changes in Pax7(+) muscle stem cells and circulating CD34(+) bone marrow stem cells in humans following acute exercise. The results show that Pax7(+) cells in skeletal muscle increase significantly after resistance exercise, while circulating CD34(+) cells also increase after both resistance exercise and aerobic exercise but quickly return to baseline levels.
Article
Biotechnology & Applied Microbiology
Jing-Ying Lin, Bruce Chi-Kang Tsai, Hui-Chuan Kao, Chien-Yi Chiang, Yun-An Chen, William Shao-Tsu Chen, Tsung-Jung Ho, Chun-Hsu Yao, Wei-Wen Kuo, Chih-Yang Huang
Summary: This study investigated the neuroprotective mechanisms of Lactobacillus reuteri GMNL-263 in streptozotocin-induced diabetic rats. The results showed that GMNL-263 attenuated diabetes-induced hippocampal damage by enhancing cell survival pathways and repressing inflammatory and apoptotic pathways. Histopathological analysis revealed that GMNL-263 prevented structural changes and reduced inflammation and apoptosis in the hippocampus. These findings suggest that GMNL-263 may have potential clinical application for the brain of diabetic individuals.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Toxicology
Indra Putra Taufani, Jiro Hasegawa Situmorang, Rifki Febriansah, Sri Tasminatun, Sunarno Sunarno, Liang-Yo Yang, Yi-Ting Chiang, Chih-Yang Huang
Summary: Ferroptosis is a form of cell death characterized by the accumulation of iron and lipid ROS. In this study, we investigated the role of GPX4 and Nrf2 in regulating ferroptosis. Our findings showed that inhibition of Nrf2 with ML385 enhanced the toxicity of RSL3 by increasing mitochondrial ROS levels and disrupting mitochondrial function. Additionally, the application of Mito TEMPOL prevented the upregulation of ROS and reduced the toxicity of RSL3, restoring the antioxidant capacity and mitochondrial function of the cells.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2023)
Article
Cell Biology
Pei-Rung Wu, Shang-Yin Chiang, Robert Midence, Wen-Chao Kao, Chun-Lun Lai, I-Cheng Cheng, Shen-Ju Chou, Chih-Cheng Chen, Chih-Yang Huang, Ruey-Hwa Chen
Summary: Patients with mutations in the WDR4 gene exhibit cerebellar atrophy and gait phenotypes, but the underlying mechanisms have not been explored. This study reveals a crucial role of Wdr4 in cerebellar development. Deficiency of Wdr4 in granule neuron progenitors (GNPs) leads to reduced foliation, smaller external and internal granular layers, compromised Purkinje neuron organization, and smaller molecular layer, resulting in locomotion defects.
CELL DEATH & DISEASE
(2023)
Article
Environmental Sciences
Cheng-You Lu, Chia-Hua Kuo, Wei-Wen Kuo, Dennis Jine-Yuan Hsieh, Tso-Fu Wang, Cheng-Yen Shih, Pi-Yu Lin, Shinn-Zong Lin, Tsung-Jung Ho, Chih-Yang Huang
Summary: The study found that Ohwia caudata extract (OCE) inhibits inflammatory response and reduces proliferation and activation of fibroblast-like synoviocytes in rheumatoid arthritis (RA) through regulation of suppressors of cytokine signaling 3 (SOCS3) and the JAK2/STAT3 pathway. This suggests that OCE may be further investigated as a candidate anti-inflammatory and anti-arthritic agent.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mei-Chih Chen, Bing-Ze Yang, Wei-Wen Kuo, Shih-Hsin Wu, Tso-Fu Wang, Yu-Lan Yeh, Ming-Cheng Chen, Chih-Yang Huang
Summary: Resistance to chemotherapy is a major obstacle in cancer treatment. This study investigated the molecular mechanisms underlying drug resistance in colon cancer using oxaliplatin-resistant LOVOOR cells. The findings suggest that Aurora-A, a kinase involved in the G2/M phase, may contribute to the resistance of LOVOOR cells to oxaliplatin treatment by depressing p53 signaling. Targeting Aurora-A could be a potential solution for patients who have failed oxaliplatin treatment.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2023)
Article
Cell Biology
Chih-Ming Su, Tung-Wei Hsu, Hsin-An Chen, Wan-Yu Wang, Chih-Yang Huang, Chih-Chiang Hung, Ming-Hsin Yeh, Yen-Hao Su, Ming-Te Huang, Po-Hsiang Liao
Summary: Metastasis in breast cancer is the main cause of death in clinical patients. Lower levels of Dicer protein in highly invasive breast cancer cells are usually associated with poor clinical outcomes. Our study reveals the regulatory mechanism of Dicer protein degradation through a process called chaperone-mediated autophagy (CMA), which promotes cancer metastasis.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Nutrition & Dietetics
Chen-Chan Wei, Giancarlo Condello, Ai-Lun Yang, Szu-Hsien Yu, Yi-Hung Liao, Chung-Yu Chen, Chi-Chieh Hsu, Chi-Yang Huang, Chia-Hua Kuo
Summary: This study aimed to determine the effect of rectal defecation on endurance performance and blood supply to the prefrontal brain and sub-navel regions of elite triathletes. The results showed that defecation improved performance in cycling and increased blood availability to compensate for cerebral deoxygenation during exercise.
JOURNAL OF THE INTERNATIONAL SOCIETY OF SPORTS NUTRITION
(2023)
Article
Environmental Sciences
Dennis jine Yuan Hsieh, Md. Nazmul Islam, Wei-Wen Kuo, Marthandam Asokan Shibu, Chin-Hu Lai, Pi-Yu Lin, Shinn-Zong Lin, Michael Yu-Chih Chen, Chih-Yang Huang
Summary: This study aimed to investigate the effect of a combination of Artemisia argyi and Ohwia caudata leaf extracts with Isoliquiritigenin on the side effects of chemotherapy drugs. The results showed that this combination could improve cardiac damage and function, making it a potential herbal treatment for cardiac hypertrophy and inflammatory diseases.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Environmental Sciences
Pei-Ying Lee, Bruce Chi-Kang Tsai, Maria Angelina Sitorus, Pi-Yu Lin, Shinn-Zong Lin, Cheng-Yen Shih, Shang-Yeh Lu, Yueh-Min Lin, Tsung-Jung Ho, Chih-Yang Huang
Summary: This study found that Ohwia caudata aqueous extract can effectively suppress doxorubicin-induced mitochondrial dysfunction, maintain the stability of stem cells, and reduce apoptosis rate. The findings provide new directions for the medical application of Ohwia caudata.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Food Science & Technology
Yu-Jung Lin, Chih-Yang Huang, Kannan Ashok Kumar, Bruce Chi-Kang Tsai, Dennis Jine-Yuan Hsieh, Ping-Ling Chiu, Yung-Ming Chang, Tsung-Jung Ho, Wei-Wen Kuo, Da-Tong Ju
Summary: Hericium erinaceus mycelia extract can prevent the accumulation of Aβ and alpha-syn in A53T transgenic mice by regulating SIRT-1/ERK-1/2 mediated autophagy.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Review
Oncology
Farheen Badrealam Khan, Parul Singh, Yahya F. Jamous, Syed Azmal Ali, Abdullah, Shahab Uddin, Qamar Zia, Manoj Kumar Jena, Mohsina Khan, Mohammad Owais, Chih Yang Huang, Venkatesh Chanukuppa, Chrismawan Ardianto, Long Chiau Ming, Waqas Alam, Haroon Khan, Mohammad Akli Ayoub
Summary: This article reviews the use of proteomics to study the molecular details of phytochemicals such as curcumin, genistein, and tanshinone IIA. These phytochemicals have various pharmacological properties that are extensively studied to understand their mechanisms of action. Proteomics technology has proved to be a reliable approach to unravel the molecular intricacies of phytochemicals.
Article
Medicine, Research & Experimental
Chikondi Jassi, Wei-Wen Kuo, Yu-Chun Chang, Tso-Fu Wang, Chi-Cheng Li, Tsung-Jung Ho, Dennis Jine-Yuan Hsieh, Chia-Hua Kuo, Ming-Cheng Chen, Chih-Yang Huang
Summary: The combination of Aloin and CPT-11 has been found to have an enhanced anti-tumor effect in colorectal cancer. This combination reduces cell viability and induces apoptosis, while regulating the expression of miRNA-133b, IGF1R, and their downstream pathways. CPT-11 and Aloin show potential as combination treatment partners against colorectal cancer, with miRNA-133b possibly serving as a co-therapeutic target with IGF1R.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Yu-Jung Lin, Navaneethan Sundhar, Hema Sri Devi, Hsueh-Fa Pien, Shina Fong-Mei Wen, Jenn-Line Sheu, Bruce Chi-Kang Tsai, Chih-Yang Huang
Summary: A novel compound based on chromium (III) was synthesized and evaluated for its antiviral effectiveness against multiple variants of COVID-19. It demonstrated interference with the interaction between the spike protein and ACE2, reduced the expression of ACE2 and TMPRSS2, and inhibited the activity of 3CL and RdRp. This compound effectively inhibited viral infection in vitro and in vivo.