Article
Multidisciplinary Sciences
Hamid Riazi-Esfahani, Esmaeil Asadi Khameneh, Fariba Ghassemi, Mohammadreza Mehrabi Bahar, Ali Torkashvand, Alireza Mahmoudi, Ahmed Husein Ahmed, Shahin Faghihi, Masoud Rahimi, Ali Akbarzadeh, Hooshang Faghihi, Elias Khalili Pour
Summary: Using optical coherence tomography angiography, this study analyzed the choroidal neovascular features of individuals with pachychoroid neovasculopathy (PNV) and neovascular age-related macular degeneration (nAMD) with and without shallow irregular pigment epithelial detachment (SIPED). The results showed that PNV had higher values in several parameters compared to nAMD with SIPED and nAMD without SIPED, including vessel percentage area, junction density, average vessel length, and fractal dimension. Furthermore, nAMD with SIPED had higher values in vessel area, total number of junctions, total vessel length, and average vessel length compared to nAMD without SIPED. The study suggests that fractal dimension, as a biomarker of choroidal neovascular complexity, can be used to differentiate PNV from nAMD with or without SIPED.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Nazanin Ebrahimiadib, Mohammadreza Mehrabi Bahar, Hamid Riazi-esfahani, Elias Khalili Pour, Fariba Ghassemi, Hooshang Faghihi, Ahmad Mirshahi, Ramak Roohipourmoallai, Alireza Lashay, Alireza Mahmoudi, Kaveh Fadakar
Summary: This study investigates the long-term visual and structural outcomes of two types of flat irregular pigment epithelial detachment (FIPED) in eyes within pachychoroid spectrum. The study finds that aFIPED eyes show visual improvement and structural changes after photodynamic therapy (PDT), while vFIPED eyes do not exhibit visual improvement after PDT alone. Combination therapy of PDT and intravitreal bevacizumab (IVB) may be a better choice for vFIPED eyes.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Hooshang Faghihi, Alireza Mahmoudi, Elias Khalili Pour, Nazanin Ebrahimiadib, Kaveh Fadakar, Fariba Ghassemi, Ahmad Mirshahi, Alireza Khodabande, Hassan Khojasteh, Fatemeh Bazvand, Mohammadreza Mehrabi Bahar, Hamid Riazi-Esfahani
Summary: This study investigated differences in choroidal biomarkers between avascular (aFIPED) and vascularized (vFIPED) flat irregular pigment epithelial detachments in eyes with chronic CSC. The results showed that vFIPED patients had lower SFCT and higher CVI compared to aFIPED patients. Measurement of CVI along with SFCT may help differentiate aFIPED from vFIPED in CSC patients.
Article
Ophthalmology
Jingli Guo, Wenyi Tang, Sisi Xu, Wei Liu, Gezhi Xu
Summary: SS-OCTA was used to evaluate the features of treatment-naive FIPED-associated CNV in chronic CSC, showing quiescent characteristics. Half-dose PDT had favorable effects on chronic CSC complicated with FIPED-associated CNV, leading to improved visual acuity and decreased subfoveal choroidal thickness. Juxtaposed to baseline levels, the vessel density of CNV remained stable at 1-, 3-, and 6-month follow-ups, while the area of CNV significantly increased at the 6-month follow-up.
Article
Medicine, General & Internal
Sibel Demirel, Pinar Guran Begar, Ozge Yanik, Figen Batioglu, Emin Ozmert
Summary: This study compared OCTA and ICGA in detecting type-1 MNV in pachychoroid spectrum diseases. The results showed that OCTA had higher sensitivity and negative predictive value, making it a preferred imaging modality.
Article
Medicine, General & Internal
Paulina Szabelska, Justyna Medrzycka, Joanna Brydak-Godowska, Radoslaw Rozycki, Joanna Golebiewska
Summary: This study reviewed 5076 OCT scans in 2538 patients and confirmed that FCE is a rare ocular condition, which may be more common in the Caucasian population than previously known. OCT is a crucial method for diagnosing FCE.
Article
Ophthalmology
Pauline Eymard, Melvin Gerardy, Lucas Bouys, Chadi Mehanna, Jerome Bertherat, Francine Behar-Cohen, Elodie Bousquet
Summary: The study found a higher prevalence of pachychoroid spectrum disease in patients with Cushing syndrome, along with a higher occurrence of pachyvessels and specific abnormalities in the eyes of these patients.
ACTA OPHTHALMOLOGICA
(2021)
Article
Medicine, General & Internal
Rui Hua, Meixia Zhang
Summary: The study found similarities in imaging characteristics between neovascular and atrophic pachychoroid spectrum disease, both of which share features of late-stage lesions. Age, subfoveal choroidal thickness, patched hyper-reflective lesions in choriocapillaris layers, and double layer signs were identified as predictive factors for choroidal neovascularization progression in pachychoroid spectrum disease eyes.
FRONTIERS IN MEDICINE
(2022)
Article
Multidisciplinary Sciences
Hidetaka Matsumoto, Junki Hoshino, Ryo Mukai, Kosuke Nakamura, Shoji Kishi, Hideo Akiyama
Summary: In this study, choroidal congestion in PNV patients was assessed using multimodal imaging. The findings showed an overlap between areas of choriocapillaris filling delay, dilated outer choroidal vessels, CNV, and RPE atrophy. The results suggest that chronic choriocapillaris ischemia due to vortex vein congestion may lead to CNV development and RPE atrophy in eyes with PNV.
SCIENTIFIC REPORTS
(2021)
Review
Ophthalmology
Hamid Safi, Hamid Ahmadieh, Kiana Hassanpour, Sare Safi
Summary: The diagnostic investigation on pachychoroid spectrum disease (PSD) has been expanding with the advancement of imaging technology. Optical coherence tomography (OCT)-based studies have demonstrated various patterns in choroidal thickness profile, luminal and stromal choroidal ratio, and abnormalities in the neurosensory retina in different clinical entities related to PSD. OCT angiography (OCTA) has played a growing role in quantitative analysis of OCTA parameters and evaluation of choriocapillaris signal void and vessel density as indicators of choriocapillaris ischemia. Recent studies using indocyanine green angiography have focused on the evaluation of choroidal vascular hyperpermeability and its relationship with other pachychoroid related features. Ultra-widefield indocyanine green angiography allows observation and characterization of peripheral choroidal pathologies and their associations with macular abnormalities. Multicolor imaging is emerging as a modality to demonstrate early abnormalities in PSD. This article summarizes the new insights into the application of multimodal imaging for PSD and focuses on novel findings observed in different clinical entities with each imaging modality.
SURVEY OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Vinod Kumar, Shorya V. Azad, Saurabh Verma, Abhidnya Surve, Rajpal Vohra, Pradeep Venkatesh
Summary: This study aims to evaluate the features of peripapillary pachychoroid syndrome (PPS) using multimodal imaging and further understand this entity. The results show that PPS shares common findings with central serous chorioretinopathy and may be a subset within the pachychoroid disease spectrum.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
Rion Ozawa, Keiko Azuma, Yoko Nomura, Hiroshi Murata, Ryo Asaoka, Kohdai Kitamoto, Kohei Ueda, Tatsuya Inoue, Ryo Obata
Summary: This study found that the presence of nonexudative choroidal neovascularization (CNV) in eyes with pachychoroid diseases leads to a decrease in retinal sensitivity (RS).
Article
Oncology
Yongyue Su, Xiongze Zhang, Yuhong Gan, Yunkao Zeng, Feng Wen
Summary: This study found that OCTA has a superior detection rate and accuracy for identifying PNV compared to dye angiography. Patients with PNV eyes differed significantly from those without PNV eyes in terms of age, history of the disease, and visual acuity.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Ophthalmology
Gokhan Celik, Murat Gunay, Asli Vural, Osman Kizilay, Yasemin Kendir Demirkol, Muhammet Kazim Erol
Summary: This study evaluated the clinical characteristics of TM lesions in 17 infants under 1.5 years old and found no pathogenic or likely pathogenic variant of NEXMIF gene. The lesions commonly showed hypopigmentation with findings of ellipsoid zone disruption on OCT examination. Contrary to popular belief, a satellite lesion was observed in one case.
Article
Ophthalmology
Hyun Goo Kang, Jae Yong Han, Min Kim, Suk Ho Byeon, Sung Soo Kim, Hyoung Jun Koh, Christopher Seungkyu Lee
Summary: The study discovered an association between pachydrusen and PHS in patients with PCV or PNV, with frequent localization of new drusen to these choroidal lesions observed over long-term follow-up. PHS may be a form of late-staining forme fruste drusen, possibly associated with micro-ischemic changes to the choriocapillaris.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Ophthalmology
David Xu, Elisha Garg, Kook Lee, Yoichi Sakurada, Atchara Amphornphruet, Nopasak Phasukkijwatana, Sandra Liakopoulos, Scott Eugene Pautler, Allan E. Kreiger, Suzanne Yzer, Won Ki Lee, SriniVas Sadda, K. Bailey Freund, David Sarraf
Summary: The long-term anatomic and visual outcomes of patients with peripapillary pachychoroid syndrome (PPS) were analyzed in this study. The study found that patients with PPS experienced decreased retinal oedema and choroidal thickening throughout the course of the disease. While some patients may experience visual decline, the overall visual outcome was relatively favorable and independent of trends in retinal or choroidal thickening.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Editorial Material
Ophthalmology
Andreas Berlin, Ling Chen, Jeffrey Messinger, Daniela Ferrara, K. Bailey Freund, Christine A. Curcio
ACTA OPHTHALMOLOGICA
(2022)
Article
Ophthalmology
Claudio Iovino, Adrian Au, Prithvi Ramtohul, Tommaso Bacci, Abdullah AlBahlal, Abdullah M. Khan, Abdulelah A. Al-Abdullah, Robert Wendel, Jay Chhablani, SriniVas Sadda, K. Bailey Freund, David Sarraf
Summary: This study analyzed the imaging characteristics and clinical course of patients with coincident lesions of PAMM and AMN in the same eye, and found that this phenomenon may be associated with retinal vein impairment and hypoperfusion in the deep retinal capillary plexus.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Xiaofei Wang, Stanley Chang, Jack Grinband, Lawrence A. Yannuzzi, K. Bailey Freund, Quan Hoang, Michael J. A. Girard
Summary: The axial length is longer in highly myopic eyes and the adjusted tortuosity of the optic nerve is lower, suggesting higher traction forces during eye movements. Optic nerve displacements differ significantly between adduction and abduction, with smaller displacements in highly myopic eyes. Additionally, posterior segment displacements are smaller in highly myopic eyes in both gaze directions, with larger displacements in the anterior-most segment during adduction.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Max Brinkmann, Tommaso Bacci, Deepayan Kar, Jeffrey D. Messinger, Kenneth R. Sloan, Ling Chen, Timothy Hamann, Maximilian Wiest, K. Bailey Freund, Sandrine Zweifel, Christine A. Curcio
Summary: This study evaluated the role of acquired vitelliform lesion (AVL) in age-related macular degeneration pathophysiology and analyzed the histological and clinical features of AVL. The results showed that AVL deposits have low levels of retinal pigment epithelium (RPE) organelles and outer segments. The growth rates of collapsing and non-collapsing AVLs were different, suggesting dysregulation of lipid transfer pathways specific to cone photoreceptors and supporting cells in the formation of AVL deposits.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Ling Chen, Dongfeng Cao, Jeffrey D. Messinger, Thomas Ach, Daniela Ferrara, K. Bailey Freund, Christine A. Curcio
Summary: Melanotic cells with large spherical melanosomes, possibly originating from retinal pigment epithelium, were found in eyes with neovascular age-related macular degeneration. These cells exhibit molecular differences from RPE, suggesting a process of transdifferentiation. Studying detailed histology of eyes affected by nvAMD may lead to the development of new therapies for fibrosis.
EXPERIMENTAL EYE RESEARCH
(2022)
Review
Ophthalmology
Meira Fogel-Levin, SriniVas R. Sadda, Philip J. Rosenfeld, Nadia Waheed, Giuseppe Querques, Bailey K. Freund, David Sarraf
Summary: Imaging is crucial in the evaluation and management of retinal disorders, and different imaging modalities have unique capabilities to show different aspects of the disease. Multimodal retinal imaging provides abundant and insightful information, but integrating the complex data can be overwhelming. This article discusses the applications, strengths, and limitations of various retinal imaging tools, including color fundus photography, widefield imaging, fundus autofluorescence, near infrared reflectance, optical coherence tomography angiography, and en face optical coherence tomography, as well as the advantages and disadvantages of a multimodal approach.
SURVEY OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Marc J. Sirks, Elon H. C. van Dijk, Noa Rosenberg, Carla E. M. Hollak, Stamatios Aslanis, Chui Ming Gemmy Cheung, Itay Chowers, Chiara M. Eandi, K. Bailey Freund, Frank G. Holz, Peter K. Kaiser, Andrew J. Lotery, Kyoko Ohno-Matsui, Giuseppe Querques, Yousif Subhi, Ramin Tadayoni, Charles C. Wykoff, Dinah Zur, Roselie M. H. Diederen, Camiel J. F. Boon, Reinier O. Schlingemann
Summary: Since July 2021, there has been a worldwide shortage of verteporfin (Visudyne (R)), which has had a significant impact on the care of ophthalmic patients worldwide and may result in serious and irreversible vision loss.
ACTA OPHTHALMOLOGICA
(2022)
Editorial Material
Ophthalmology
Prithvi Ramtohul, Diogo Cabral, K. Bailey Freund
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2023)
Letter
Ophthalmology
Prithvi Ramtohul, Maria Vittoria Cicinelli, K. Bailey Freund
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2023)
Article
Ophthalmology
Riccardo Sacconi, David Sarraf, SriniVas R. Sadda, K. Bailey Freund, Andrea Servillo, Meira Miri Fogel Levin, Eliana Costanzo, Giulia Corradetti, Diogo Cabral, Dinah Zur, Omer Trivizki, Mariacristina Parravano, Francesco Bandello, Anat Loewenstein, Giuseppe Querques
Summary: This study investigated the association between nascent geographic atrophy (GA) and the development of exudative type 3 macular neovascularization (MNV) in patients with age-related macular degeneration (AMD). The results showed that 22.7% of the patients had nascent GA preceding exudative type 3 MNV. Therefore, the detection of nascent GA in AMD patients may require closer surveillance to identify early exudative type 3 MNV warranting treatment.
OPHTHALMOLOGY RETINA
(2023)
Article
Ophthalmology
Prithvi Ramtohul, Diogo Cabral, Daniel Oh, Daniel Galhoz, K. Bailey Freund
Summary: The purpose of this study was to investigate whether noninvasive en face ultrawidefield (UWF) OCT can demonstrate distinctive features of choroidal vasculature in eyes with central serous chorioretinopathy (CSC). Patients diagnosed with CSC underwent UWF indocyanine green angiography (ICGA) and widefield OCT imaging. The results showed that en face UWF OCT imaging can show distinctive features of choroidal venous insufficiency previously identified with UWF ICGA in eyes with CSC.
OPHTHALMOLOGY RETINA
(2023)
Letter
Ophthalmology
Meira Fogel-Levin, Alice Wong, SriniVas R. Sadda, K. Bailey Freund, David Sarraf
CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE
(2022)
Article
Ophthalmology
Prithvi Ramtohul, Ariane Malcles, Edward Gigon, K. Bailey Freund, Ugo Introini, Francesco Bandello, Maria Vittoria Cicinelli
Summary: The study evaluated the clinical characteristics, multimodal imaging features, and long-term treatment outcomes of eyes with neovascular age-related macular degeneration (nAMD) and bacillary layer detachment (BALAD) treated with intravitreal anti-VEGF therapy. The findings showed that BALAD was associated with all types of MNV in nAMD patients, and there was a high risk of subretinal fibrosis leading to poor functional outcomes.
OPHTHALMOLOGY RETINA
(2022)
Letter
Ophthalmology
Yu Qiang Soh, Quan V. Hoang, K. Bailey Freund, Jesse J. Jung
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2022)
Editorial Material
Ophthalmology
David Cui, Ian J. Saldanha, Gavin Li, Priya M. Mathews, Michael X. Lin, Esen K. Akpek
Summary: This article reports on the heterogeneity in methodology of clinical trials submitted to the US Food and Drug Administration for approval of topical dry eye treatments. Multiple outcome measures were used in these trials, highlighting the need for standardized assessment tools to optimize the evaluation and comparison of therapeutic benefits.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Adanna Udeh, Dana Huh, Terri Young, O'rese Knight, Fasika Woreta
Summary: This study examines the rates and trends of faculty promotions within the field of ophthalmology, with a focus on the rates of promotion among underrepresented in medicine (URiM) faculty. The results show that Black faculty had lower promotion rates and were more likely to leave academic medicine, highlighting the need for strategies and policies to address equity in promotion rates and retention of URiM faculty in academic ophthalmology.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Ursula Greferath, Erica Fletcher, Judy Savige, Heather G. Mack
Summary: Retinal drusen are uncommon in IgA nephropathy, but they resemble drusen found in age-related macular degeneration. The IgA-staining deposits in the drusen are likely related to systemic deposition of IgA. The nature of cystic spaces in the drusen is still unknown. Further research on the retinas of people with glomerulonephritis is recommended.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Andrew Mihalache, Ryan S. Huang, Nikhil S. Patil, Marko M. Popovic, Ashwin Mallipatna, Peter J. Kertes, Rajeev H. Muni, Radha P. Kohly
Summary: This study examines sociodemographic predictors of poor vision in children and adolescents in the US. The findings suggest that factors such as affordability of medical care, public health insurance, age, and parental education level are associated with vision difficulty. Addressing these disparities through public health policies is crucial for achieving equity in vision health.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Johannes Birtel, Richard Caswell, Samantha R. De Silva, Philipp Herrmann, Salwah Rehman, Andrew J. Lotery, Omar A. Mahroo, Michel Michaelides, Andrew R. Webster, Robert E. Maclaren, Peter Charbel Issa
Summary: The study investigated the phenotype, variability, and penetrance of IMPG2-related maculopathy. The results showed that mono-allelic IMPG2 variants could result in haploinsufficiency manifesting as a maculopathy with variable penetrance and expressivity. Family members of patients with IMPG2-related retinitis pigmentosa may also present with vitelliform lesions. The maculopathy is usually limited to the fovea and is associated with moderate visual impairment.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Colas Nils Authie, Mylene Poujade, Alireza Talebi, Alexis Defer, Ariel Zenouda, Cecilia Coen, Saddek Mohand-Said, Philippe Chaumet-Riffaud, Isabelle Audo, Jose-Alain Sahel
Summary: MOST has been validated as a reliable mobility test for measuring the movement ability of patients with vision impairments in both real and virtual environments.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Maria Krisch, Jordan Ueberroth, Neha Gupta, Stephen Merriam, Mark p. Breazzano
Summary: Orbeez-related ocular trauma can lead to severe visual morbidity and various intraocular sequelae. Adolescents may be at higher risk for posterior segment complications. Elevated IOP and hyphema at initial presentation may indicate a need for more aggressive interventions.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Jaron Pruett, Kelly Ruland, Sean Donahue
Summary: The study aimed to validate or refute the hypothesis that infants with birthweight over 750 g and gestational age over 27 weeks, who did not have retinopathy of prematurity (ROP) at 37 weeks, would not develop treatable ROP. The findings of the study supported the termination of examination at 37 weeks in infants meeting these criteria, as the value of continued screening was minimal.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Emily Sun, Jing Tian, Loaah Eltemsah, Divya Srikumaran, Grace Sun, Jessica Chow, Fasika Woreta
Summary: This study aims to evaluate the research productivity of ophthalmology residency applicants and identify differences in productivity based on gender and race. The findings reveal that women have similar or higher research outputs compared to men, while self-identified underrepresented in medicine (URiM) students have lower research outputs in ophthalmology. Therefore, greater mentorship and support for URiM students are needed to promote the recruitment of diverse trainees in ophthalmology programs.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Isaac A. Bernstein, Ann Caroline Fisher, Kuldev Singh, Sophia Y. Wang
Summary: This study aims to investigate the association between visual field loss and frailty in a nationally representative cohort of US adults.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
