Article
Pharmacology & Pharmacy
Eder Lilia Romero, Maria Jose Morilla
Summary: Archaea are microorganisms that are more closely related to eukaryotes than bacteria. They have been defined as a new domain of life on Earth for almost 50 years, and new species continue to be discovered and studied. The study of their genetics, metabolism, and extreme habitats has led to them being seen as potential models for extraterrestrial life forms. However, archaea also play a significant role on Earth, from their presence in diverse environments to their involvement in global organic material cycles and their association with our microbiota.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Anne Huppertsberg, Leonard Kaps, Zifu Zhong, Sascha Schmitt, Judith Stickdorn, Kim Deswarte, Francis Combes, Christian Czysch, Jana De Vrieze, Sabah Kasmi, Niklas Choteschovsky, Adrian Klefenz, Carolina Medina-Montano, Pia Winterwerber, Chaojian Chen, Matthias Bros, Stefan Lienenklaus, Niek N. Sanders, Kaloian Koynov, Detlef Schuppan, Bart N. Lambrecht, Sunil A. David, Bruno G. De Geest, Lutz Nuhn
Summary: pH-responsive nanogels were fabricated for safe delivery of TLR7/8-stimulating imidazoquinolines, showing a spatially controlled immunostimulatory activity in the spleen after intravenous injection, without causing systemic off-target inflammatory responses. This approach highlights the potential of pH-degradable nanogels as a promising platform for intravenous administration of small-molecular TLR7/8 agonists in immune therapeutic applications.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Review
Pharmacology & Pharmacy
Parismita Kalita, Timir Tripathi
Summary: This review examines contemporary methods for identifying and optimizing epitopes, engineering their immunogenic properties, and developing safe and efficient delivery into the host.
DRUG DISCOVERY TODAY
(2022)
Article
Pharmacology & Pharmacy
Yimei Jia, Gerard Agbayani, Vandana Chandan, Umar Iqbal, Renu Dudani, Hui Qian, Zygmunt Jakubek, Kenneth Chan, Blair Harrison, Lise Deschatelets, Bassel Akache, Michael J. McCluskie
Summary: This study successfully generated SLA archaeosomes at different sizes using microfluidic mixing technology and evaluated their characteristics, activity, and biodistribution in mice. The results showed that archaeosomes prepared by microfluidic mixing had similar properties and activity compared to the conventional method, indicating the potential of microfluidics for generating consistently sized archaeosomes as vaccine adjuvants.
Article
Pharmacology & Pharmacy
Myriam Lamrayah, Capucine Phelip, Celine Coiffier, Celine Lacroix, Thibaut Willemin, Thomas Trimaille, Bernard Verrier
Summary: This study investigates the potential of micelles composed of polylactide-block-poly(N-acryloxysuccinimide-co-N-vinylpyrrolidone) as a delivery system for vaccines. The micelles were non-toxic and efficiently taken up by immune cells. Coupling of antigenic protein p24 on the micelles improved its antigenicity. In mouse immunization, the micelles showed comparable immune response intensity to gold standards and higher avidity index over time.
Article
Immunology
Tyler M. Renner, Bassel Akache, Matthew Stuible, Nazanin Rohani, Yuneivy Cepero-Donates, Lise Deschatelets, Renu Dudani, Blair A. Harrison, Jason Baardsnes, Izel Koyuturk, Jennifer J. Hill, Usha D. Hemraz, Sophie Regnier, Anne E. G. Lenferink, Yves Durocher, Michael J. McCluskie
Summary: Liposomes composed of sulfated lactosyl archaeol (SLA) have been shown to be a safe and effective vaccine adjuvant, especially in the case of SLA-adjuvanted SARS-CoV-2 subunit vaccines based on trimeric spike protein antigens. An updated version of the resistin-trimerized SmT1 antigen corresponding to the Omicron variant was successfully generated and evaluated for its immunogenicity and immune response generation when paired with SLA liposomes or AddaS03 adjuvant. The SLA-adjuvanted formulations showed better performance in inducing neutralizing antibody responses and cell-mediated responses compared to the AddaS03-adjuvanted formulations.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Coralie Backlund, Sasan Jalili-Firoozinezhad, Byungji Kim, Darrell J. Irvine
Summary: Modulation of the immune system is crucial in therapeutic strategies and vaccine development. Biomaterials are being developed to accurately deliver stimulatory cues to specific cells at the right time and place, ensuring safe and effective immunotherapy. This article discusses the uses of biomaterials in enhancing immune modulation and presents evidence from clinical and preclinical studies on how biomaterials can impact the development of new therapeutics. The focus is on understanding immunological mechanisms and in vivo immune system modulation, as well as overcoming challenges in translating these technologies to clinical practice.
ANNUAL REVIEW OF IMMUNOLOGY
(2023)
Review
Immunology
Pooja Choudhary, Donaldson Magloire, Glenn Hamonic, Heather L. Wilson
Summary: The immune system in the upper reproductive tract provides protection against pathogens and immune tolerance against sperm and fetus. The timing of exposure to pathogens is most likely during estrus and breeding when the cervix is semi-permissive. The goal of intrauterine immunization is to induce local or systemic immunity and/or promote passive protection for suckling offspring.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Bahareh Vakili, Mahboubeh Karami-Darehnaranji, Esmaeil Mirzaei, Farnaz Hosseini, Navid Nezafat
Summary: Graphene, as a new type of vaccine adjuvant, has been found to enhance antigen immunogenicity and stimulate immune responses. However, its injection may lead to oxidative stress and inflammation, thereby requiring modifications to reduce adverse effects.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Jennifer Cable, Barney S. Graham, Richard A. Koup, Robert A. Seder, Katalin Kariko, Norbert Pardi, Dan H. Barouch, Bhawna Sharma, Susanne Rauch, Raffael Nachbagauer, Mattias N. E. Forsell, Michael Schotsaert, Ali H. Ellebedy, Karin Lore, Darrell J. Irvine, Emily Pilkington, Siri Tahtinen, Elizabeth A. Thompson, Yanis Feraoun, Neil P. King, Kevin Saunders, Galit Alter, Syed M. Moin, Kwinten Sliepen, Gunilla B. Karlsson Hedestam, Hedda Wardemann, Bali Pulendran, Nicole A. Doria-Rose, Wan-Ting He, Jennifer A. Juno, Sila Ataca, Adam K. Wheatley, Jason S. McLellan, Laura M. Walker, Julia Lederhofer, Lisa C. Lindesmith, Holger Wille, Peter J. Hotez, Linda-Gail Bekker
Summary: The COVID-19 pandemic has highlighted the importance of vaccines in public health and advancements in vaccine technology are vital for preventing infectious diseases. While many diseases still lack effective vaccines, recent developments in fields like immunology and structural biology may lead to breakthroughs in vaccination and enhance preparedness for future pandemics.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Seung Mo Jin, Sang Nam Lee, Jung Eun Kim, Yeon Jeong Yoo, Chanyoung Song, Hong Sik Shin, Hathaichanok Phuengkham, Chang Hoon Lee, Soong Ho Um, Yong Taik Lim
Summary: A novel immune modulating suspension containing inducers of cell death and supra-adjuvants can effectively increase cytotoxic T lymphocytes and alleviate immune suppression in the tumor microenvironment, leading to enhanced T cell infiltration and inhibition of tumor metastasis. This approach shows promise in increasing the response rate of immune checkpoint blockade therapy, presenting a new nanotheranostic strategy in cancer immunotherapy.
Review
Biotechnology & Applied Microbiology
Jim P. Buttery, Hazel Clothier
Summary: Immunization implementation in the community depends on post-licensure vaccine safety surveillance, which utilizes various electronic sources (such as electronic health records and internet-based media) to detect rare adverse events following immunization. These surveillance methods, including electronic spontaneous reporting and natural language processing techniques, have advantages and disadvantages, but together they provide a comprehensive approach to vaccine safety monitoring.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Review
Chemistry, Physical
Adelina-Gabriela Niculescu, Alexandru Mihai Grumezescu
Summary: Polymer-based nanoparticles customized for size, morphology, and surface properties are gaining attention for drug, biomolecule, and gene delivery. They protect payloads from degradation and sustain controlled drug release, reducing clearance and increasing stability, solubility, and optimal concentration at target sites, especially in vaccine development.
Article
Multidisciplinary Sciences
Fernanda Raya-Tonetti, Melisa Muller, Jacinto Sacur, Haruki Kitazawa, Julio Villena, Maria Guadalupe Vizoso-Pinto
Summary: Two LysM domains of Limosilactobacillus fermentum were characterized, showing potential as an antigen display platform. Nasal immunization with a complex Venus-Acglu-BLPs027 significantly increased specific immunoglobulin levels and induced cytokine secretion in spleen cells. A Gateway compatible destination vector was constructed for easy fusion of LysM domains to develop mucosal subunit vaccines.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Viktor Sedlmayr, Christina Horn, David Johannes Wurm, Oliver Spadiut, Julian Quehenberger
Summary: This study compared lecithin-derived liposomes with archaeosomes as an oral delivery system for CBD. The results showed that archaeosomes had higher drug load, better stability, higher CBD recovery in a simulated GI tract, and enhanced particle uptake in Caco-2 cells compared to conventional liposomes.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Immunology
Felicity C. Stark, Bassel Akache, Amalia Ponce, Renu Dudani, Lise Deschatelets, Yimei Jia, Janelle Sauvageau, Dean Williams, Mohammad P. Jamshidi, Gerard Agbayani, Kristina Wachholz, Blair A. Harrison, Xuguang Li, Lakshmi Krishnan, Wangxue Chen, Michael J. McCluskie
Article
Immunology
Bassel Akache, Lise Deschatelets, Blair A. Harrison, Renu Dudani, Felicity C. Stark, Yimei Jia, Amir Landi, John L. M. Law, Michael Logan, Darren Hockman, Juthika Kundu, D. Lorne Tyrrell, Lakshmi Krishnan, Michael Houghton, Michael J. McCluskie
Article
Biochemistry & Molecular Biology
Yimei Jia, Vandana Chandan, Bassel Akache, Hui Qian, Zygmunt J. Jakubek, Evguenii Vinogradov, Renu Dudani, Blair A. Harrison, Mohammad P. Jamshidi, Felicity C. Stark, Lise Deschatelets, Janelle Sauvageau, Dean Williams, Lakshmi Krishnan, Michael J. McCluskie
Summary: The study evaluated the long-term stability of SLA archaeosomes at different temperatures, demonstrating that their components did not degrade, and their adjuvant function and vesicle characteristics remained consistent during storage.
JOURNAL OF LIPOSOME RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Gerard Agbayani, Yimei Jia, Bassel Akache, Vandana Chandan, Umar Iqbal, Felicity C. Stark, Lise Deschatelets, Edmond Lam, Usha D. Hemraz, Sophie Regnier, Lakshmi Krishnan, Michael J. McCluskie
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2020)
Article
Pharmacology & Pharmacy
Bassel Akache, Gerard Agbayani, Felicity C. Stark, Yimei Jia, Renu Dudani, Blair A. Harrison, Lise Deschatelets, Vandana Chandan, Edmond Lam, Usha D. Hemraz, Sophie Regnier, Lakshmi Krishnan, Michael J. McCluskie
Summary: Cancer vaccines use the immune system to generate targeted immune responses. Archaeosomes composed of SLA enhance immunogenicity. In a mouse melanoma tumor model, SLA archaeosomes in combination with Poly(I:C) can suppress tumor growth and extend survival.
Article
Pharmacology & Pharmacy
Yimei Jia, Bassel Akache, Gerard Agbayani, Vandana Chandan, Renu Dudani, Blair A. Harrison, Lise Deschatelets, Usha D. Hemraz, Edmond Lam, Sophie Regnier, Felicity C. Stark, Lakshmi Krishnan, Michael J. McCluskie
Summary: Archaeosomes containing SLA glycolipids have been shown to be an effective vaccine adjuvant, capable of enhancing both humoral and cellular immune responses. Combining SLA archaeosomes with specific Toll-like receptor agonists can further boost immune responses, indicating potential for adjuvant combinations in future research.
Article
Microbiology
Qing Yan Liu, Sonia Leclerc, Youlian Pan, Ziying Liu, Felicity Stark, Joseph Wayne Conlan
Summary: Francisella tularensis subspecies tularensis (Ftt) is a highly virulent bacterium that poses a significant threat to humans. Previous vaccines have shown limited efficacy, prompting the search for better candidates. Deleting the clpB gene from virulent Ftt strain has resulted in a mutant that provides better protection in mice. Transcriptomics analysis has identified potential molecular correlates of protection induced by this mutant.
Article
Chemistry, Medicinal
Sophie Regnier, Edmond Lam, Vinicio Vasquez, Camilo F. Martinez-Farina, Felicity C. Stark, Gerard Agbayani, Lise Deschatelets, Renu Dudani, Blair A. Harrison, Bassel Akache, Michael J. McCluskie, Usha D. Hemraz
Summary: This study reports a new synthesis method for archaeol and investigates the effect of stereochemistry on the adjuvanticity of archaeosomes. The results show that all SLA archaeosomes can induce strong immune responses regardless of their chiral purities.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Sophie Regnier, Edmond Lam, Vinicio Vasquez, Camilo F. Martinez-Farina, Felicity C. Stark, Gerard Agbayani, Lise Deschatelets, Renu Dudani, Blair A. Harrison, Bassel Akache, Michael J. McCluskie, Usha D. Hemraz
Summary: Archaeosomes composed of sulfated lactosyl archaeol (SLA) glycolipids from stereoisomerically pure archaeol (1) are vaccine adjuvants that can boost immunogenicity and vaccine efficacy in preclinical models. The synthesis of a new compound (3) and the preparation of SLA archaeosomes from different chiral purities were reported in this study. The adjuvanticity of SLA archaeosomes towards ovalbumin was investigated and found to induce strong immune responses. The results suggest that SLA archaeosomes could be a promising, safe, scalable, and economically viable vaccine adjuvant system.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Editorial Material
Biochemical Research Methods
Scott McComb, Aude Thiriot, Bassel Akache, Lakshmi Krishnan, Felicity Stark
IMMUNOPROTEOMICS: METHODS AND PROTOCOLS, 2ND EDITION
(2019)
Article
Biochemistry & Molecular Biology
Felicity C. Stark, Gerard Agbayani, Jagdeep K. Sandhu, Bassel Akache, Charis McPherson, Lise Deschatelets, Renu Dudani, Melissa Hewitt, Yimei Jia, Lakshmi Krishnan, Michael J. McCluskie