Immediate Early Genes, Memory and Psychiatric Disorders: Focus on c-Fos, Egr1 and Arc

The Neuronal Gene Arc Encodes a Repurposed Retrotransposon Gag Protein that Mediates Intercellular RNA Transfer

(2018) Elissa D. Pastuzyn et al.   CELL

Retrovirus-like Gag Protein Arc1 Binds RNA and Traffics across Synaptic Boutons

(2018) James Ashley et al.   CELL

Effects of stressor controllability on transcriptional levels of c-fos, Arc, and brain-derived neurotrophic factor in mouse amygdala and medial prefrontal cortex

(2018) Mayumi Machida et al.   NEUROREPORT

Plasticity Mechanisms of Memory Consolidation and Reconsolidation in the Perirhinal Cortex

(2018) Magdalena Miranda et al.   NEUROSCIENCE

Chronic vortioxetine treatment in rodents modulates gene expression of neurodevelopmental and plasticity markers

(2017) Jessica A. Waller et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Cognitive analysis of schizophrenia risk genes that function as epigenetic regulators of gene expression

(2016) Laura Whitton et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Waves of c-Fos and Arc Proteins Expression in Neuronal Populations of the Hippocampus in Response to a Single Episode of New Experience

(2016) O. I. Ivashkina et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Extracellular vesicles and intercellular communication within the nervous system

(2016) Valentina Zappulli et al.   JOURNAL OF CLINICAL INVESTIGATION

MMP-9 in translation: from molecule to brain physiology, pathology, and therapy

(2016) Behnam Vafadari et al.   JOURNAL OF NEUROCHEMISTRY

Extracellular vesicles round off communication in the nervous system

(2016) Vivian Budnik et al.   NATURE REVIEWS NEUROSCIENCE

The time course of systems consolidation of spatial memory from recent to remote retention: A comparison of the Immediate Early Genes Zif268, c-Fos and Arc

(2016) Daniel N. Barry et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Cognitive control and episodic memory in adolescents with autism spectrum disorders

(2016) Marjorie Solomon et al.   NEUROPSYCHOLOGIA

Fear Memory

(2016) Ivan Izquierdo et al.   PHYSIOLOGICAL REVIEWS

Stress-induced gene expression and behavior are controlled by DNA methylation and methyl donor availability in the dentate gyrus

(2016) Emily A. Saunderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Animal models of major depression and their clinical implications

(2016) Boldizsár Czéh et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Evidence for a differential contribution of early perceptual and late cognitive processes during encoding to episodic memory impairment in schizophrenia

(2016) Amity E. Green et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Genetic Feedback Regulation of Frontal Cortical Neuronal Ensembles Through Activity-Dependent Arc Expression and Dopaminergic Input

(2016) Surjeet Mastwal et al.   Frontiers in Neural Circuits

Genetic Disruption of Arc/Arg3.1 in Mice Causes Alterations in Dopamine and Neurobehavioral Phenotypes Related to Schizophrenia

(2016) Francesca Managò et al.   Cell Reports

Role of Immediate-Early Genes in Synaptic Plasticity and Neuronal Ensembles Underlying the Memory Trace

(2016) Keiichiro Minatohara et al.   Frontiers in Molecular Neuroscience

Aberrant prefrontal beta oscillations predict episodic memory encoding deficits in schizophrenia

(2016) Federica Meconi et al.   NeuroImage-Clinical

Medial prefrontal cortex role in recognition memory in rodents

(2015) Juan Facundo Morici et al.   BEHAVIOURAL BRAIN RESEARCH

Requirement of an Early Activation of BDNF/c-Fos Cascade in the Retrosplenial Cortex for the Persistence of a Long-Lasting Aversive Memory

(2015) Cynthia Katche et al.   CEREBRAL CORTEX

Update on the Mechanism of Action of Aripiprazole: Translational Insights into Antipsychotic Strategies Beyond Dopamine Receptor Antagonism

(2015) Andrea de Bartolomeis et al.   CNS DRUGS

∆FosB: A transcriptional regulator of stress and antidepressant responses

(2015) Eric J. Nestler   EUROPEAN JOURNAL OF PHARMACOLOGY

Verbal episodic memory along the course of schizophrenia and bipolar disorder: A new perspective

(2015) Letícia S. Czepielewski et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Progressive recruitment of cortical and striatal regions by inducible postsynaptic density transcripts after increasing doses of antipsychotics with different receptor profiles: Insights for psychosis treatment

(2015) Andrea de Bartolomeis et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Memory integration in the autobiographical narratives of individuals with autism

(2015) Rachel S. Brezis   Frontiers in Human Neuroscience

Long-Delayed Expression of the Immediate Early Gene Arc/Arg3.1 Refines Neuronal Circuits to Perpetuate Fear Memory

(2015) D. Nakayama et al.   JOURNAL OF NEUROSCIENCE

Inhibition of phosphodiesterase 2 reverses impaired cognition and neuronal remodeling caused by chronic stress

(2015) Ying Xu et al.   NEUROBIOLOGY OF AGING

Nuclear factor kappa B-dependent Zif268 expression in hippocampus is required for recognition memory in mice

(2015) Gisela Zalcman et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Modulatory effects of an NMDAR partial agonist in MK-801-induced memory impairment

(2015) S. Vishnoi et al.   NEUROSCIENCE

A critical appraisal of the what-where-when episodic-like memory test in rodents: Achievements, caveats and future directions

(2015) Sonja Binder et al.   PROGRESS IN NEUROBIOLOGY

Functional connectivity pattern during rest within the episodic memory network in association with episodic memory performance in bipolar disorder

(2015) Viola Oertel-Knöchel et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

PCP-based mice models of schizophrenia: differential behavioral, neurochemical and cellular effects of acute and subchronic treatments

(2015) Anna Castañé et al.   PSYCHOPHARMACOLOGY

Matrix Metalloproteinase-9 as a Novel Player in Synaptic Plasticity and Schizophrenia: Table 1.

(2015) Katarzyna Lepeta et al.   SCHIZOPHRENIA BULLETIN

Conscious and Unconscious Memory Systems

(2015) Larry R. Squire et al.   Cold Spring Harbor Perspectives in Biology

Cognitive impairment in manic bipolar patients: important, understated, significant aspects

(2015) Mădălina Vrabie et al.   Annals of General Psychiatry

Persistent active avoidance correlates with activity in prelimbic cortex and ventral striatum

(2015) Christian Bravo-Rivera et al.   Frontiers in Behavioral Neuroscience

Functional and Neuroanatomic Specificity of Episodic Memory Dysfunction in Schizophrenia

(2015) J. Daniel Ragland et al.   JAMA Psychiatry

Localization and local translation of Arc/Arg3.1 mRNA at synapses: some observations and paradoxes

(2015) Oswald Steward et al.   Frontiers in Molecular Neuroscience

A critical evaluation of the activity-regulated cytoskeleton-associated protein (Arc/Arg3.1)'s putative role in regulating dendritic plasticity, cognitive processes, and mood in animal models of depression

(2015) Yan Li et al.   Frontiers in Neuroscience

Neuropsychology, autobiographical memory, and hippocampal volume in “younger” and “older” patients with chronic schizophrenia

(2015) Christina Herold   Frontiers in Psychiatry

Altered Gene Expression in Schizophrenia: Findings from Transcriptional Signatures in Fibroblasts and Blood

(2015) Nadia Cattane et al.   PLoS One

Lower Expression of Glutamic Acid Decarboxylase 67 in the Prefrontal Cortex in Schizophrenia: Contribution of Altered Regulation by Zif268

(2014) Sohei Kimoto et al.   AMERICAN JOURNAL OF PSYCHIATRY

Effects of Striatal ΔFosB Overexpression and Ketamine on Social Defeat Stress–Induced Anhedonia in Mice

(2014) Rachel J. Donahue et al.   BIOLOGICAL PSYCHIATRY

The Molecular and Systems Biology of Memory

(2014) Eric R. Kandel et al.   CELL

Effects of social context on endocrine function and Zif268 expression in response to an acute stressor in adolescent and adult rats

(2014) Travis E. Hodges et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Changes in brain functional connectivity after chronic haloperidol in rats: a network analysis

(2014) Anne L Wheeler et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Prefrontal Cortical Circuit for Depression- and Anxiety-Related Behaviors Mediated by Cholecystokinin: Role of  FosB

(2014) V. Vialou et al.   JOURNAL OF NEUROSCIENCE

Altered hippocampal function before emotional trauma in rats susceptible to PTSD-like behaviors

(2014) Rebecca Nalloor et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Social Isolation Stress-Induced Fear Memory Deficit is Mediated by Down-Regulated Neuro-Signaling System and Egr-1 Expression in the Brain

(2014) Ryo Okada et al.   NEUROCHEMICAL RESEARCH

Direct Reactivation of a Coherent Neocortical Memory of Context

(2014) Kiriana K. Cowansage et al.   NEURON

Chronic Corticosterone Exposure Persistently Elevates the Expression of Memory-Related Genes in the Lateral Amygdala and Enhances the Consolidation of a Pavlovian Fear Memory

(2014) Melissa S. Monsey et al.   PLoS One

Coming to terms with fear

(2014) J. E. LeDoux   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prefrontal Cortical Dendritic Spine Pathology in Schizophrenia and Bipolar Disorder

(2014) Glenn T. Konopaske et al.   JAMA Psychiatry

Conditioned Fear Associated Phenotypes as Robust, Translational Indices of Trauma-, Stressor-, and Anxiety-Related Behaviors

(2014) Maria Anne Briscione et al.   Frontiers in Psychiatry

Learning-facilitated long-term depression requires activation of the immediate early gene, c-fos, and is transcription dependent

(2013) Anne Kemp et al.   BEHAVIOURAL BRAIN RESEARCH

COGNITIVE DEFICITS AND FUNCTIONAL OUTCOMES IN MAJOR DEPRESSIVE DISORDER: DETERMINANTS, SUBSTRATES, AND TREATMENT INTERVENTIONS

(2013) Roger S. McIntyre et al.   DEPRESSION AND ANXIETY

On the role of retrosplenial cortex in long-lasting memory storage

(2013) Cynthia Katche et al.   HIPPOCAMPUS

Implications of memory modulation for post-traumatic stress and fear disorders

(2013) Ryan G Parsons et al.   NATURE NEUROSCIENCE

BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases

(2013) Bai Lu et al.   NATURE REVIEWS NEUROSCIENCE

Genome-wide approaches reveal EGR1-controlled regulatory networks associated with neurodegeneration

(2013) Radosveta Koldamova et al.   NEUROBIOLOGY OF DISEASE

BDNF-induced local protein synthesis and synaptic plasticity

(2013) Graciano Leal et al.   NEUROPHARMACOLOGY

BDNF mechanisms in late LTP formation: A synthesis and breakdown

(2013) Debabrata Panja et al.   NEUROPHARMACOLOGY

Changes in Neural Circuitry Regulating Response-Reversal Learning and Arc-Mediated Consolidation of Learning in Rats with Methamphetamine-Induced Partial Monoamine Loss

(2013) Elissa D Pastuzyn et al.   NEUROPSYCHOPHARMACOLOGY

Zif268/Egr1 gain of function facilitates hippocampal synaptic plasticity and long-term spatial recognition memory

(2013) Z. Penke et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Recall and Reconsolidation of Contextual Fear Memory: Differential Control by ERK and Zif268 Expression Dosage

(2013) Antoine Besnard et al.   PLoS One

5-HTT Deficiency Affects Neuroplasticity and Increases Stress Sensitivity Resulting in Altered Spatial Learning Performance in the Morris Water Maze but Not in the Barnes Maze

(2013) Margherita M. Karabeg et al.   PLoS One

Evolution of working memory

(2013) P. Carruthers   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arc mRNA docks precisely at the base of individual dendritic spines indicating the existence of a specialized microdomain for synapse-specific mRNA translation

(2012) Joseph L. Dynes et al.   JOURNAL OF COMPARATIVE NEUROLOGY

A combined analysis of microarray gene expression studies of the human prefrontal cortex identifies genes implicated in schizophrenia

(2012) Josué Pérez-Santiago et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Brain region-specific activity patterns after recent or remote memory retrieval of auditory conditioned fear

(2012) J.-T. Kwon et al.   LEARNING & MEMORY

Opposite effects of fear conditioning and extinction on dendritic spine remodelling

(2012) Cora Sau Wan Lai et al.   NATURE

Optogenetic stimulation of a hippocampal engram activates fear memory recall

(2012) Xu Liu et al.   NATURE

Synaptic circuit remodelling by matrix metalloproteinases in health and disease

(2012) George W. Huntley   NATURE REVIEWS NEUROSCIENCE

Memory traces compete under regimes of limited Arc protein synthesis: Implications for memory interference

(2012) María Cecilia Martínez et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Maintenance of long-term memory storage is dependent on late posttraining Egr-1 expression

(2012) Cynthia Katche et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Animal models of working memory: A review of tasks that might be used in screening drug treatments for the memory impairments found in schizophrenia

(2012) Paul A. Dudchenko et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Social isolation stress down-regulates cortical early growth response 1 (Egr-1) expression in mice

(2012) Kinzo Matsumoto et al.   NEUROSCIENCE RESEARCH

Generation of a Synthetic Memory Trace

(2012) A. R. Garner et al.   SCIENCE

Intermediate phenotypes in psychiatric disorders

(2011) Roberta Rasetti et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Magnetic resonance imaging studies in unipolar depression: Systematic review and meta-regression analyses

(2011) D. Arnone et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Context-dependent modulation of hippocampal and cortical recruitment during remote spatial memory retrieval

(2011) Joëlle Lopez et al.   HIPPOCAMPUS

A meta-analysis of cognitive deficits in first-episode Major Depressive Disorder

(2011) Rico S.C. Lee et al.   JOURNAL OF AFFECTIVE DISORDERS

Learning-related feedforward inhibitory connectivity growth required for memory precision

(2011) Sarah Ruediger et al.   NATURE

Post-training disruption of Arc protein expression in the anterior cingulate cortex impairs long-term memory for inhibitory avoidance training

(2011) Crystal M. Holloway et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Loss of activity-dependent Arc gene expression in the retrosplenial cortex after hippocampal inactivation: Interaction in a higher-order memory circuit

(2011) Stepan Kubik et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Identification of transmitter systems and learning tag molecules involved in behavioral tagging during memory formation

(2011) D. Moncada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arc in synaptic plasticity: from gene to behavior

(2011) Erica Korb et al.   TRENDS IN NEUROSCIENCES

Prospective memory in schizophrenia and schizotypy

(2011) Julie D. Henry et al.   Cognitive Neuropsychiatry

Swim stress increases hippocampal Zif268 expression in the spontaneously hypertensive rat

(2010) K.M. Clements et al.   BRAIN RESEARCH BULLETIN

Immediate-early gene response to repeated immobilization: Fos protein and arc mRNA levels appear to be less sensitive than c-fos mRNA to adaptation

(2010) Sheila Ons et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Homer 1a Gates the Induction Mechanism for Endocannabinoid-Mediated Synaptic Plasticity

(2010) A. M. Roloff et al.   JOURNAL OF NEUROSCIENCE

Erasing Fear Memories with Extinction Training

(2010) G. J. Quirk et al.   JOURNAL OF NEUROSCIENCE

Antidepressant Effect of Optogenetic Stimulation of the Medial Prefrontal Cortex

(2010) H. E. Covington et al.   JOURNAL OF NEUROSCIENCE

Continuing the search for the engram: examining the mechanism of fear memories

(2010) Sheena Josselyn   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

Effects of recent exposure to a conditioned stimulus on extinction of Pavlovian fear conditioning

(2010) W. Y. M. Chan et al.   LEARNING & MEMORY

Early growth response gene 1 (Egr-1) is required for new and reactivated fear memories in the lateral amygdala

(2010) S. A. Maddox et al.   LEARNING & MEMORY

The enhancement of stress-related memory by glucocorticoids depends on synapsin-Ia/Ib

(2010) J-M Revest et al.   MOLECULAR PSYCHIATRY

Neuroscience: Editing out fear

(2010) Gregory J. Quirk et al.   NATURE

ΔFosB in brain reward circuits mediates resilience to stress and antidepressant responses

(2010) Vincent Vialou et al.   NATURE NEUROSCIENCE

Narp regulates homeostatic scaling of excitatory synapses on parvalbumin-expressing interneurons

(2010) Michael C Chang et al.   NATURE NEUROSCIENCE

Animal models of neuropsychiatric disorders

(2010) Eric J Nestler et al.   NATURE NEUROSCIENCE

Persistence of Long-Term Memory Storage: New Insights into its Molecular Signatures in the Hippocampus and Related Structures

(2010) Pedro Bekinschtein et al.   NEUROTOXICITY RESEARCH

Morphine Use after Combat Injury in Iraq and Post-Traumatic Stress Disorder

(2010) Troy Lisa Holbrook et al.   NEW ENGLAND JOURNAL OF MEDICINE

Arc regulates spine morphology and maintains network stability in vivo

(2010) C. L. Peebles et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Relevance of synaptic tagging and capture to the persistence of long-term potentiation and everyday spatial memory

(2010) S.-H. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Formation and Stability of Recognition Memory: What Happens Upon Recall?

(2010) Sabrina Davis et al.   Frontiers in Behavioral Neuroscience

Time-Dependent Expression of Arc and Zif268 after Acquisition of Fear Conditioning

(2010) Mary E. Lonergan et al.   NEURAL PLASTICITY

The functional neuroanatomy of depression: Distinct roles for ventromedial and dorsolateral prefrontal cortex

(2009) Michael Koenigs et al.   BEHAVIOURAL BRAIN RESEARCH

Granular and dysgranular retrosplenial cortices provide qualitatively different contributions to spatial working memory: evidence from immediate-early gene imaging in rats

(2009) Helen H. J. Pothuizen et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

F15063, a potential antipsychotic with dopamine D2/D3 receptor antagonist and 5-HT1A receptor agonist properties: Influence on immediate-early gene expression in rat prefrontal cortex and striatum

(2009) Liesbeth A. Bruins Slot et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Identification of blood biomarkers for psychosis using convergent functional genomics

(2009) S M Kurian et al.   MOLECULAR PSYCHIATRY

Preventing the return of fear in humans using reconsolidation update mechanisms

(2009) Daniela Schiller et al.   NATURE

The Episodic Memory System: Neurocircuitry and Disorders

(2009) Bradford C Dickerson et al.   NEUROPSYCHOPHARMACOLOGY

Transcription Factors in Long-Term Memory and Synaptic Plasticity

(2009) Cristina M. Alberini   PHYSIOLOGICAL REVIEWS

Behavioral tagging is a general mechanism of long-term memory formation

(2009) F. Ballarini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Delayed wave of c-Fos expression in the dorsal hippocampus involved specifically in persistence of long-term memory storage

(2009) C. Katche et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of protein kinase C signaling protects prefrontal cortex dendritic spines and cognition from the effects of chronic stress

(2009) A. B. Hains et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extinction-Reconsolidation Boundaries: Key to Persistent Attenuation of Fear Memories

(2009) M.-H. Monfils et al.   SCIENCE

Neural activity changes underlying the working memory deficit in alpha-CaMKII heterozygous knockout mice

(2009) Naoki Matsuo   Frontiers in Behavioral Neuroscience

The Use of Animal Models in Psychiatric Research and Treatment

(2008) Vaishnav Krishnan et al.   AMERICAN JOURNAL OF PSYCHIATRY

The Descriptive Epidemiology of Commonly Occurring Mental Disorders in the United States

(2008) Ronald C. Kessler et al.   Annual Review of Public Health

The Activity-Regulated Cytoskeletal-Associated Protein (Arc/Arg3.1) Is Required for Memory Consolidation of Pavlovian Fear Conditioning in the Lateral Amygdala

(2008) J. E. Ploski et al.   JOURNAL OF NEUROSCIENCE

Differential expression of IEG mRNA in rat brain following acute treatment with clozapine or haloperidol: a semi-quantitative RT—PCR study

(2008) MJ Robbins et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Depression-prone mice with reduced glucocorticoid receptor expression display an altered stress-dependent regulation of brain-derived neurotrophic factor and activity-regulated cytoskeleton-associated protein

(2008) R. Molteni et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Immediate extinction causes a less durable loss of performance than delayed extinction following either fear or appetitive conditioning

(2008) A. M. Woods et al.   LEARNING & MEMORY

The molecular neurobiology of depression

(2008) Vaishnav Krishnan et al.   NATURE

Control of the establishment of aversive memory by calcineurin and Zif268

(2008) Karsten Baumgärtel et al.   NATURE NEUROSCIENCE

Memory reconsolidation mediates the strengthening of memories by additional learning

(2008) Jonathan L C Lee   NATURE NEUROSCIENCE

Sustained CPEB-Dependent Local Protein Synthesis Is Required to Stabilize Synaptic Growth for Persistence of Long-Term Facilitation in Aplysia

(2008) Maria Concetta Miniaci et al.   NEURON

Transcriptional mechanisms of addiction: role of  FosB

(2008) E. J Nestler   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Basal and stress-induced modulation of activity-regulated cytoskeletal associated protein (Arc) in the rat brain following duloxetine treatment

(2008) Raffaella Molteni et al.   PSYCHOPHARMACOLOGY

Neurocognitive deficits and prefrontal cortical atrophy in patients with schizophrenia

(2008) Leonardo Bonilha et al.   SCHIZOPHRENIA RESEARCH