Article
Cell Biology
Prameet Kaur, Ellora Hui Zhen Chua, Wen Kin Lim, Jiarui Liu, Nathan Harmston, Nicholas S. Tolwinski
Summary: In this study, the researchers used an optogenetic model to investigate the effect of Wnt signaling on amyloid-beta in patients with Alzheimer's disease. They found that Wnt activation can rescue the detrimental effects of amyloid expression and oligomerization, and identified changes in gene expression related to aging, protein misfolding, metabolism, and inflammation. They proposed that Wnt expression reduces inflammation through repression of Toll activating factors.
Article
Biochemistry & Molecular Biology
Priyanka Nagu, Vivek Sharma, Tapan Behl, Amjad Khan A. Pathan, Vineet Mehta
Summary: Wnt signaling is essential for neurogenesis and plays a crucial role in the development and differentiation of neurons in the adult brain. Impaired Wnt signaling pathways are directly associated with the pathogenesis of Alzheimer's disorder (AD). Activation of Wnt signaling improves cognitive functions and restores neurogenesis in animal models. Various natural and synthetic molecules have been identified to modulate Wnt signaling and promote neurogenesis, which could be beneficial in managing AD. However, more research is needed on the role of Wnt signaling in AD patients to further understand the pathogenesis and identify novel therapeutic targets.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Yuri Lee, Hai-long Piao, Jongchan Kim
Summary: The Wnt signaling pathway is crucial for regulating various cellular processes, and dysregulation of this pathway has been linked to human diseases, including cancer. In this study, researchers aimed to identify the deubiquitinases (DUBs) that regulate the pathway through the essential component LEF1. They discovered that OTUD7B interacts with LEF1 and activates Wnt signaling. Furthermore, OTUD7B promotes the nuclear localization of LEF1, leading to increased interaction with beta-catenin. This study suggests that OTUD7B may serve as a potential therapeutic target in diseases where Wnt signaling is dysregulated, such as cancer.
Article
Biochemistry & Molecular Biology
Marlyn D. Laksitorini, Vinith Yathindranath, Wei Xiong, Fiona E. Parkinson, James A. Thliveris, Donald W. Miller
Summary: Chronic exposure to ethanol can enhance blood-brain barrier permeability, but this effect can be reversed by activating the Wnt signaling pathway.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Min Gyu Lee, Hwamok Oh, Jong Woo Park, Jueng Soo You, Jeung-Whan Han
Summary: Nuclear S6K1 functions in the regulation of Wnt target gene expression and has an impact on cell proliferation and invasion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Matthieu Drouyer, Marc F. Bolliger, Evy Lobbestael, Chris Van den Haute, Marco Emanuele, Reginald Lefebvre, William Sibran, Tina De Wit, Coline Leghay, Eugenie Mutez, Nicolas Dzamko, Glenda M. Halliday, Shigeo Murayama, Alain Martoriati, Katia Cailliau, Jean-Francois Bodart, Marie-Christine Chartier-Harlin, Veerle Baekelandt, R. Jeremy Nichols, Jean-Marc Taymans
Summary: Through a comprehensive screening and testing of phosphatases involved in dephosphorylation of LRRK2, we found that regulators linked to PP1 and PP2A holoenzyme complexes as well as CDC25 phosphatases can modulate LRRK2 phosphorylation. Pharmacological inhibition-induced dephosphorylation leads to relocalization of PP1 and PP2A in LRRK2 subcellular compartments, and we identified PPP2CA:PPP2R2 as a potent phosphoregulator of pS935-LRRK2.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Medicine, Research & Experimental
Zheng Qin, Yupei Li, Jiameng Li, Luojia Jiang, Zhuyun Zhang, Kaixi Chang, Qinbo Yang, Shanshan Chen, Ruoxi Liao, Baihai Su
Summary: This study found that exosomal STAT1 derived from HP-treated HUVECs can promote VSMC calcification. Activation of the Wnt/beta-catenin pathway may be a potential mechanism of exosome-promoted VSMC calcification.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Zeliha Guney, Sivge Kurgan, Canan Onder, Mahmure Ayse Tayman, Oemer Gunhan, Alpdogan Kantarci, Muhittin Abdulkadir Serdar, Meral Gunhan
Summary: This study aimed to evaluate the activity of the Wnt/beta-catenin signaling pathway in gingival samples obtained from patients with periodontitis. The results showed that periodontal inflammation disrupts the Wnt/beta-catenin signaling pathway, leading to tissue inflammation and changes in morphology. This finding may shed light on the pathogenesis of periodontal disease.
CLINICAL ORAL INVESTIGATIONS
(2023)
Review
Biochemistry & Molecular Biology
Michael Latour, Nam-Gu Her, Santosh Kesari, Elmar Nurmemmedov
Summary: The WNT signaling pathway plays a crucial role in glioblastoma genesis and therapy resistance, presenting a therapeutic challenge. Current targeted therapies under clinical investigation may offer new treatment options.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Hong-He Xiao, Ji-Cong Chen, He Li, Rui-Hai Li, Hai-Bo Wang, Hui-Peng Song, Hong-Yan Li, Guo-Shun Shan, Yu Tian, Yu-Meng Zhao, Jin-Ming Tian, Jing-Xian Yang
Summary: The study demonstrated that ICS II could improve neurogenesis dysfunction and inhibit mitochondrial fission by activating the Wnt/beta-catenin signaling pathway, thereby promoting the restoration of cognitive function in APP/PS1 mice.
PHYTOTHERAPY RESEARCH
(2022)
Article
Oncology
Yang Zhou, Jiang Xu, Haichang Luo, Xiangjing Meng, Ming Chen, Di Zhu
Summary: Abnormal activation of the Wnt/beta-catenin signaling pathway is closely related to tumorigenesis and immune surveillance, leading to increased resistance to immunotherapy.
Article
Biochemistry & Molecular Biology
Mingliang He, Xiaoyang Lv, Xiukai Cao, Zehu Yuan, Tesfaye Getachew, Yutao Li, Shanhe Wang, Wei Sun
Summary: SRY-box transcription factor 18 (SOX18) is expressed in dermal papilla cells (DPCs) of sheep hair follicles and plays a crucial role in promoting DPC proliferation through activating the Wnt/β-Catenin signaling pathway. Inhibition of the Wnt/β-Catenin signaling pathway can be rescued by SOX18, suggesting the essential role of SOX18 in governing DPC proliferation and hair growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Jung Ki Min, Hwee-Seon Park, Yoon-Beom Lee, Jae-Gyu Kim, Jong-Il Kim, Jae-Bong Park
Summary: Src, a non-receptor tyrosine kinase, plays a critical role in cancer progression for various tissues. It regulates Wnt signaling through multiple signaling molecules, and aberrant regulation of this interaction can lead to the development of various diseases, particularly cancer.
Review
Biochemistry & Molecular Biology
Nives Pecina-Slaus, Sara Anicic, Anja Bukovac, Anja Kafka
Summary: In the search for improved antitumor therapies, inhibition of the Wnt signaling pathway has emerged as a promising target due to its altered functioning in human tumors. The pathway's frequent mutations and epigenetic changes in tumors have promoted the investigation of Wnt signaling inhibitors. Studies have shown that knocking down specific components of the pathway inhibits tumor growth. This review discusses the inhibitors of the canonical Wnt pathway, evaluates their effectiveness as therapeutics, and examines their potential side effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell & Tissue Engineering
Gozal Bahlakeh, Reza Rahbarghazi, Ali Abedelahi, Saeed Sadigh-Eteghad, Mohammad Karimipour
Summary: This study investigates the impact of NTF-SCs on hippocampal neurogenesis mediated by the Wnt/β-catenin signaling cascade in AD-like mouse brain. The results suggest that activating the Wnt/β-catenin pathway through NTF-SCs may be a potential therapeutic approach to restore neurogenesis in AD.
STEM CELL RESEARCH & THERAPY
(2022)