Article
Genetics & Heredity
Sven Geurts, Michelle M. J. Mens, Maxime M. Bos, M. Arfan Ikram, Mohsen Ghanbari, Maryam Kavousi
Summary: The study revealed a significant association between miR-4798-3p and prevalent AF in men, suggesting its potential role in regulating target genes related to AF pathophysiology. Further experimental studies are warranted to investigate the mechanisms underlying this association.
Article
Cardiac & Cardiovascular Systems
Sven Geurts, Martijn J. Tilly, Jan A. Kors, Jaap W. Deckers, Bruno H. C. Stricker, Natasja M. S. de Groot, M. Arfan Ikram, Maryam Kavousi
Summary: The study aims to assess the association and sex differences in electrocardiographic parameters with new-onset atrial fibrillation (AF). A total of 12,212 participants from the Rotterdam Study were included. The findings showed that the associations between electrocardiographic parameters and new-onset AF were mostly U- and N-shaped, with significant sex differences observed. Longitudinal measures of PR and QTc interval were significantly associated with new-onset AF, especially in men.
Article
Cardiac & Cardiovascular Systems
Shaan Khurshid, Lu-Chen Weng, Mostafa A. Al-Alusi, Jennifer L. Halford, Julian S. Haimovich, Emelia J. Benjamin, Ludovic Trinquart, Patrick T. Ellinor, David D. McManus, Steven A. Lubitz
Summary: The study indicated that adherence to guideline-adherent physical activity was associated with lower risks of AF and stroke, while there was weak correlation between accelerometer-derived and self-reported activity.
EUROPEAN HEART JOURNAL
(2021)
Article
Gastroenterology & Hepatology
Laurens A. van Kleef, Zuolin Lu, M. Arfan Ikram, Natasja M. S. de Groot, Maryam Kavousi, Robert J. de Knegt
Summary: Liver stiffness is significantly associated with atrial fibrillation, especially in individuals without fatty liver disease. Conversely, there is no clear association between fatty liver disease and atrial fibrillation.
JOURNAL OF HEPATOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Sven Geurts, Cathrine Brunborg, Grigorios Papageorgiou, M. Arfan Ikram, Maryam Kavousi
Summary: This study found a significant association between baseline and longitudinal subclinical measures of peripheral atherosclerosis and new-onset atrial fibrillation, particularly in women.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Endocrinology & Metabolism
Chan Soon Park, Eue-Keun Choi, Kyung-Do Han, Juhwan Yoo, Hyo-Jeong Ahn, Soonil Kwon, So-Ryoung Lee, Seil Oh, Gregory Y. H. Lip
Summary: This study investigated the association between changes in regular physical activity and the risk of developing atrial fibrillation (AF) in patients with type 2 diabetes mellitus (T2DM), as well as the optimal range of physical activity based on energy expenditure. The results showed that starting and maintaining regular physical activity were both associated with a lower risk of incident AF. Based on energy expenditure, new exercisers who engaged in regular physical activity for at least 1,500 MET-min/week and exercise maintainers who engaged in at least 1,000 MET-min/week had a lower risk of developing AF compared to non-exercisers.
Article
Clinical Neurology
Elena Herber, Stefanie Aeschbacher, Michael Coslovsky, Fabian Schwendinger, Elisa Hennings, Andreas Gasser, Marcello Di Valentino, Elia Rigamonti, Tobias Reichlin, Nicolas Rodondi, Seraina Netzer, Juerg H. Beer, Annina Stauber, Andreas Mueller, Peter Ammann, Tim Sinnecker, Marco Duering, Jens Wuerfel, David Conen, Michael Kuhne, Stefan Osswald, Leo H. Bonati
Summary: This study found that regular exercise in patients with atrial fibrillation can reduce the prevalence of ischemic infarcts and white matter lesions, increase brain volume, and improve cognitive performance. Therefore, it is recommended that patients with atrial fibrillation actively participate in physical exercise.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Health Care Sciences & Services
Ayelet Shapira-Daniels, Jelena Kornej, Nicole L. Spartano, Xuzhi Wang, Yuankai Zhang, Chathurangi H. Pathiravasan, Chunyu Liu, Ludovic Trinquart, Belinda Borrelli, David McManus, Joanne M. Murabito, Emelia J. Benjamin, Honghuang Lin
Summary: This study investigated the association between daily step count and the predicted 5-year risk of atrial fibrillation (AF). It found that every 1000 steps were associated with a 0.08% lower AF risk. The association was stronger in men and individuals with obesity. The use of a wearable daily step counter for reducing AF risk deserves further investigation.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Mathias Pinto Bonnesen, Diana My Frodi, Ketil Jorgen Haugan, Christian Kronborg, Claus Graff, Soren Hojberg, Lars Kober, Derk Krieger, Axel Brandes, Jesper Hastrup Svendsen, Soren Zoga Diederichsen
Summary: This study found that within-individual changes in physical activity are associated with the onset of atrial fibrillation (AF) episodes in individuals at high risk. A 1-hour decrease in daily physical activity was associated with a 25% increase in the odds of AF onset the next day, with the strongest association seen in individuals with the lowest overall activity level.
EUROPEAN HEART JOURNAL
(2021)
Article
Medicine, General & Internal
Joonatan Palmu, Christin S. Boerschel, Alfredo Ortega-Alonso, Lajos Marko, Michael Inouye, Pekka Jousilahti, Rodolfo A. Salido, Karenina Sanders, Caitriona Brennan, Gregory C. Humphrey, Jon G. Sanders, Friederike Gutmann, Dominik Linz, Veikko Salomaa, Aki S. Havulinna, Sofia K. Forslund, Rob Knight, Leo Lahti, Teemu Niiranen, Renate B. Schnabel
Summary: This study found that the gut microbiome composition is associated with the risk of atrial fibrillation (AF). Certain microbial genera were found to be related to the occurrence and prediction of AF. These findings establish the basis for using microbiome profiling in predicting AF risk, but further research is needed before microbiome sequencing can be used in prevention and targeted treatment of AF.
Article
Cardiac & Cardiovascular Systems
Martijn J. Tilly, Sven Geurts, Samantha J. Donkel, M. Arfan Ikram, Natasja M. S. de Groot, Moniek P. M. de Maat, Maryam Kavousi
Summary: The study did not find significant associations between markers of immunothrombosis and new-onset AF, suggesting that inflammation and immunothrombosis may be linked to AF through other cardiovascular risk factors or predisposing conditions. This challenges the added value of biomarkers in predicting AF risk.
CLINICAL RESEARCH IN CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Ole-Christian Walter Rutherford, Christian Jonasson, Waleed Ghanima, Fabian Soderdahl, Sigrun Halvorsen
Summary: A study on elderly atrial fibrillation patients aged 65 and above using oral anticoagulants found that NOACs compared to warfarin had similar risks of stroke/SE but lower or similar risks of bleeding. The findings suggest that NOACs are a safe option for elderly patients.
Article
Cardiac & Cardiovascular Systems
Mathias Pinto Bonnesen, Soren Zoga Diederichsen, Jonas L. Isaksen, Kristian Steen Frederiksen, Steen Gregers Hasselbalch, Ketil Jorgen Haugan, Christian Kronborg, Claus Graff, Soren Hojberg, Lars Kober, Derk W. Krieger, Axel Brandes, Jesper Hastrup Svendsen
Summary: The study revealed that in a large cohort of individuals with stroke risk factors, subclinical atrial fibrillation detected and subsequently treated with oral anticoagulation did not significantly impact cognitive function over a 3-year period.
AMERICAN HEART JOURNAL
(2021)
Article
Multidisciplinary Sciences
Yordi J. van de Vegte, Joylene E. Siland, Michiel Rienstra, Pim van der Harst
Summary: The study found a causal association between atrial fibrillation and left atrial size and function. Atrial fibrillation was found to increase left atrial size and decrease left atrial ejection fraction, with strong influence from the AF risk allele near the PITX2 gene.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Becker M. Al-Khayatt, Justin D. Salciccioli, Dominic C. Marshall, Andrew D. Krahn, Joseph Shalhoub, Markus B. Sikkel
Summary: The incidence and mortality of atrial fibrillation across Europe did not show a general trend from 1990 to 2017, with unique patterns observed for some nations. Higher mortality rates were observed in wealthier countries, with women experiencing worse outcomes and increasing disparities over time.
EUROPEAN HEART JOURNAL
(2021)
Review
Cardiac & Cardiovascular Systems
Martijn J. Tilly, Sven Geurts, Angelo M. Pezzullo, Wichor M. Bramer, Natasja M. S. de Groot, Maryam Kavousi, Moniek P. M. de Maat
Summary: This study aims to summarize and analyze the evidence on the associations between coagulation factors and atrial fibrillation (AF) in both longitudinal and cross-sectional studies. The findings suggest that higher levels of coagulation factors are associated with both prevalent and incident AF, with the associations being more pronounced in cross-sectional studies. Limited evidence from longitudinal studies suggests a prothrombotic state underlying AF development.
Article
Cardiac & Cardiovascular Systems
Martijn J. Tilly, Sven Geurts, Fang Zhu, Maxime M. Bos, M. Arfan Ikram, Moniek P. M. de Maat, Natasja M. S. de Groot, Maryam Kavousi
Summary: This study aims to investigate the association between autoimmune diseases and atrial fibrillation (AF). The findings suggest that rheumatic fever, gastrointestinal autoimmune diseases, and rheumatoid arthritis, among others, are associated with an increased risk of AF, especially in women.
Article
Public, Environmental & Occupational Health
Silvan Licher, Frank J. Wolters, Jelena Pavlovic, Maryam Kavousi, Maarten J. G. Leening, M. Kamran Ikram, M. Arfan Ikram
Summary: Multidomain dementia prevention trials fail to prioritize high-risk dementia patients, and mostly include individuals who already meet cardiovascular prevention guidelines. Better targeting of recruitment for individuals whose trial results can improve clinical decision making is needed.
Editorial Material
Cardiac & Cardiovascular Systems
Maryam Kavousi, Patrick T. T. Ellinor
NETHERLANDS HEART JOURNAL
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Juliana Alexandra Hernandez Vargas, Silvia Juliana Trujillo-Caceres, Julieth Pilar Uriza-Pinzon, Oscar H. Franco
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Banafsheh Arshi, Hamid A. Aliahmad, M. Arfan Ikram, Daniel Bos, Maryam Kavousi
Summary: A larger epicardial fat volume (EFV) is associated with increased risks of cardiovascular disease and atrial fibrillation. This study found that EFV is also associated with impaired cardiac function and an increased risk of heart failure (HF).
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Letter
Cardiac & Cardiovascular Systems
Martijn J. Tilly, Natasja M. S. de Groot, Maryam Kavousi
Article
Endocrinology & Metabolism
Kan Wang, Fariba Ahmadizar, Sven Geurts, Banafsheh Arshi, Jan A. Kors, Dimitris Rizopoulos, Eric J. G. Sijbrands, M. Arfan Ikram, Maryam Kavousi
Summary: This study examined the association between the longitudinal evolution of heart rate variability (HRV) and the development of type 2 diabetes (T2D). The results showed that an increase in heart rate and a decrease in HRV were independently associated with the incidence of T2D, especially among younger individuals.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Sunny S. Singh, Janine E. van der Toorn, Eric J. G. Sijbrands, Yolanda B. de Rijke, Maryam Kavousi, Daniel Bos
Summary: This study aimed to investigate the association between Lp(a) and arteriosclerosis. The results showed that higher levels of Lp(a) were consistently associated with increased calcification volumes in multiple arteries, including coronary arteries, aortic arch, and carotid arteries. The findings suggest that Lp(a) is a systemic risk factor for arteriosclerosis, highlighting its potential as a target for treatment.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Jasmijn A. M. Sleutjes, C. Janneke van der Woude, P. J. Pepijn Verploegh, Elif Aribas, Maryam Kavousi, Jeanine E. Roeters van Lennep, Annemarie C. de Vries
Summary: This study compared the cardiovascular disease (CVD) risk factors and 10-year risk in inflammatory bowel disease (IBD) patients to the general population. The results showed that IBD patients had a higher likelihood of experiencing ASCVD events compared to controls, but the 10-year CVD risk estimate was lower, potentially due to differences in CVD risk profiles between IBD patients and the general population.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Rachel Cahalane, Ali Akyildiz, Maryam Kavousi, Meike W. Vernooij, M. Kamran Ikram, Frank Gijsen, Daniel Bos
Summary: This study validated a technique for measuring carotid calcium density and investigated its associations with cardiovascular risk factors. The density technique showed good agreement with clinical software measurements, supporting its validity. Only total calcium volume and hypercholesterolemia were significantly associated with mean calcium density, while other participant demographics and cardiovascular risk factors showed no significant association. These findings provide a basis for future longitudinal studies on the association between carotid calcium density and the risk of cerebrovascular events.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Genetics & Heredity
Maryam Kavousi, Maxime M. Bos, Hanna J. Barnes, Christian L. Lino Cardenas, Doris Wong, Haojie Lu, Chani J. Hodonsky, Lennart P. L. Landsmeer, Adam W. Turner, Minjung Kho, Natalie R. Hasbani, Paul S. de Vries, Donald W. Bowden, Sandesh Chopade, Joris Deelen, Ernest Diez Benavente, Xiuqing Guo, Edith Hofer, Shih-Jen Hwang, Sharon M. Lutz, Leo-Pekka Lyytikaeinen, Lotte Slenders, Albert V. Smith, Maggie A. Stanislawski, Jessica van Setten, Quenna Wong, Lisa R. Yanek, Diane M. Becker, Marian Beekman, Matthew J. Budoff, Mary F. Feitosa, Chris Finan, Austin T. Hilliard, Sharon L. R. Kardia, Jason C. Kovacic, Brian G. Kral, Carl D. Langefeld, Lenore J. Launer, Shaista Malik, Firdaus A. A. Mohamed Hoesein, Michal Mokry, Reinhold Schmidt, Jennifer A. Smith, Kent D. Taylor, James G. Terry, Jeroen van der Grond, Joyce van Meurs, Rozemarijn Vliegenthart, Jianzhao Xu, Kendra A. Young, Nuno R. Zilhao, Robert Zweiker, Themistocles L. Assimes, Lewis C. Becker, Daniel Bos, J. Jeffrey Carr, L. Adrienne Cupples, Dominique P. v. de Kleijn, Menno de Winther, Hester M. den Ruijter, Myriam Fornage, Barry I. Freedman, Vilmundur Gudnason, Aroon D. Hingorani, John E. Hokanson, M. Arfan Ikram, Ivana Isgum, David R. Jacobs, Mika Kaehoenen, Leslie A. Lange, Terho Lehtimaeki, Gerard Pasterkamp, Olli T. Raitakari, Helena Schmidt, P. Eline Slagboom, Andre G. Uitterlinden, Meike W. Vernooij, Joshua C. Bis, Nora Franceschini, Bruce M. Psaty, Wendy S. Post, Jerome I. Rotter, Johan L. M. Bjoerkegren, Christopher J. O'Donnell, Lawrence F. Bielak, Patricia A. Peyser, Rajeev Malhotra, Sander W. van der Laan, Clint L. Miller
Summary: This study conducted a large-scale analysis and identified eleven new risk loci for coronary artery calcification (CAC), a measure of subclinical atherosclerosis. These new loci are related to bone mineralization, phosphate catabolism, and hormone metabolic pathways. The findings contribute to a better understanding of the genetic architecture of CAC and provide potential targets for therapeutic interventions.
Editorial Material
Cardiac & Cardiovascular Systems
Vicente Artola Arita, Juliana Alexandra Hernandez Vargas, Oscar H. Franco
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Fang Zhu, Danielle Noordermeer, Elif Aribas, Maxime Bos, Eric Boersma, Maryam Kavousi
Summary: Hypertension, diabetes, and lipoprotein metabolism disorders mediate the association between miscarriage and various cardiovascular outcomes. Hypertension plays the largest role in mediating the relationship between miscarriage and atherosclerotic cardiovascular events. Women who have experienced miscarriage should be regularly monitored for blood pressure, blood lipids, and glucose to reduce their long-term cardiovascular risk.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jeanine E. Roeters van Lennep, Lale S. Tokgozoglu, Lina Badimon, Sandra M. Dumanski, Martha Gulati, Connie N. Hess, Kirsten B. Holven, Maryam Kavousi, Meral Kayikcioglu, Esther Lutgens, Erin D. Michos, Eva Prescott, Jane K. Stock, Anne Tybjaerg-Hansen, Marieke J. H. Wermer, Marianne Benn
Summary: Cardiovascular disease is the leading cause of death globally, with women experiencing the fastest relative increase in middle-aged mortality. In addition to missed or delayed diagnosis and undertreatment, sex-specific factors contribute to increased cardiovascular risk in women. The European Atherosclerosis Society's position statement focuses on the impact of gender-specific factors and the effects of these factors on women's lifelong lipid profiles, including lipoprotein(a). Sociocultural components further compound these effects. Early identification and treatment of modifiable cardiovascular risk factors in women, especially those related to sex-specific conditions, are necessary to reduce the high burden of cardiovascular disease in women.
EUROPEAN HEART JOURNAL
(2023)