Review
Clinical Neurology
Isobel Wright, Fahim Mughal, Gemma Bowers, Richard Meiser-Stedman
Summary: The study found that dropout rates for depression treatment in children and youth were similar across different types of interventions and control conditions. Providing more sessions and longer duration of interventions may help reduce dropout rates, while interventions using Interpersonal Psychotherapy (IPT) had lower dropout rates.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Psychology, Multidisciplinary
James Knox, Philip Morgan, Frances Kay-Lambkin, Jessica Wilson, Kimberley Wallis, Carly Mallise, Briana Barclay, Myles Young
Summary: Men are significantly underrepresented in research trials targeting depression, and they are less likely to seek help for mental health concerns. Existing treatments may not be engaging or accessible to men.
CURRENT PSYCHOLOGY
(2022)
Article
Clinical Neurology
Po-Han Chou, Ping-Tao Tseng, Yi-Cheng Wu, Jane Pei-Chen Chang, Yu-Kang Tu, Brendon Stubbs, Andre F. Carvalho, Pao-Yen Lin, Yen-Wen Chen, Kuan-Pin Su
Summary: A network meta-analysis investigated the efficacy of different interventions for acrophobia, finding that VR coach-delivered psychotherapy and other specific interventions were significantly superior in improving patient symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Clinical Neurology
Jacqueline Lee, Madelaine Gierc, Fidel Vila-Rodriguez, Eli Puterman, Guy Faulkner
Summary: Exercise combined with standard treatments leads to significantly greater antidepressant effects compared to standard treatment alone, especially for more severe patients. Sensitivity analyses confirmed the significant benefits, indicating that using exercise alongside standard treatments can enhance therapeutic efficacy for depression.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Geriatrics & Gerontology
Chien-Tai Hong, Shennie Tan, Tsai-Wei Huang
Summary: Psychotherapeutic interventions, especially cognitive-behavioral therapy, are effective in managing anxiety and depression in patients with Parkinson's disease, significantly reducing symptoms. CBT has a significant alleviating effect on anxiety and depression, while non-CBT interventions are also effective in reducing depressive symptoms.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2021)
Article
Psychiatry
Fei-Wan Ngai, Ling-Ling Gao
Summary: This study demonstrates significant and sustained reduction in depressive symptoms for Chinese couples at 6 weeks and 6 months postpartum, highlighting the importance of incorporating couple-based IPT into perinatal services.
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Psychology, Clinical
Milena Gandy, Andreea I. I. Heriseanu, Tanya Balakumar, Eyal Karin, Jennie Walker, Taylor Hathway, Madelyne A. A. Bisby, Amelia J. J. Scott, Joanne Dudeney, Alana Fisher, Nickolai Titov, Blake F. F. Dear
Summary: This randomized controlled trial assessed the effectiveness of a novel transdiagnostic internet-delivered psychological intervention for adults with neurological disorders. The intervention showed significant improvements in depression, anxiety, and disability compared to the treatment-as-usual waitlist control group, and these effects were maintained at 3-month follow-up.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Nutrition & Dietetics
Simone O'Neill, Michelle Minehan, Catherine R. Knight-Agarwal, Murray Turner
Summary: This systematic literature review examines the effectiveness of whole food or whole diet interventions in treating depression. The reviewed studies found that dietary interventions can lead to a decrease in depression levels, with varying effect sizes. Further improvements in study design and measurement outcomes are recommended.
Article
Medicine, General & Internal
Maria K. Sobczyk, Jie Zheng, George Davey Smith, Tom R. Gaunt
Summary: We conclude that careful triangulation of MR with RCT evidence should involve consideration of similarity of phenotypes across study designs, intervention intensity and duration, study population demography and health status, comparator group, intervention goal and quality of evidence.
Review
Medicine, General & Internal
Benignus Logan, Dev Jegatheesan, Andrea Viecelli, Elaine Pascoe, Ruth Hubbard
Summary: A scoping review found that goal attainment scaling (GAS) has been widely used as an outcome measure in various healthcare settings and trial environments. However, there are inadequacies and inconsistencies in how GAS has been applied and implemented, highlighting the need for a interdisciplinary practical guide to improve the reliability and comparability of trial results.
Article
Critical Care Medicine
Jean Baptiste Lascarrou, Cyrielle Ermel, Alain Cariou, Timo Laitio, Hans Kirkegaard, Eldar Soreide, Anders M. Grejs, Matti Reinikainen, Gwenhael Colin, Fabio Silvio Taccone, Amelie Le Gouge, Markus B. Skrifvars
Summary: The study evaluated the potential association between early dysnatremia and 6-month functional outcome after cardiac arrest. The results showed that early hyponatremia was common in patients with cardiac arrest and was associated with poorer functional outcome at 6 months.
Article
Medicine, General & Internal
Barnaby D. Dunn, Emily Widnall, Laura Warbrick, Faith Warner, Nigel Reed, Alice Price, Merle Kock, Clara Courboin, Rosie Stevens, Kim Wright, Nicholas J. Moberly, Nicole Geschwind, Christabel Owens, Anne Spencer, John Campbell, Willem Kuyken
Summary: A pilot randomised controlled trial showed that Augmented Depression Therapy (ADepT) has significant advantages in treating anhedonia and wellbeing. It also has a high probability of cost-effectiveness.
Article
Public, Environmental & Occupational Health
Helen Crocker, Michele Peters, Charlie Foster, Nick Black, Ray Fitzpatrick
Summary: This study aimed to develop a core outcome set for public health trials evaluating interventions to promote physical activity. The study utilized literature review and Delphi surveys to decide the content of the outcome set and find the best measurement methods. However, there were challenges in achieving consensus on the inclusion of other outcome domains.
Article
Multidisciplinary Sciences
Guy William Fincham, Clara Strauss, Jesus Montero-Marin, Kate Cavanagh
Summary: Breathwork, a deliberate control of the breath, has gained significant attention and shows therapeutic potential for improving mental health. A meta-analysis of 12 randomized-controlled trials and a total of 785 adult participants revealed that breathwork interventions were associated with lower levels of self-reported/subjective stress, anxiety, and depressive symptoms. The results suggest that breathwork may be effective for reducing stress and improving mental well-being, but caution is advised to avoid exaggeration without sufficient evidence.
SCIENTIFIC REPORTS
(2023)
Review
Clinical Neurology
Anjan Nibber, Helen Singh, Phil Burnet, Belinda Lennox, Amedeo Minichino
Summary: Through a systematic review and meta-analysis of randomised controlled trials, the study found that metformin is significantly better than placebo in improving cognitive function in patients with clinical conditions associated with cognitive impairment. However, the effect of metformin on depressive symptoms did not reach statistical significance. Nevertheless, one study found an association between improved cognition and depressive symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Psychology, Clinical
Darin Pauley, Pim Cuijpers, Davide Papola, Clara Miguel, Eirini Karyotaki
Summary: This systematic review and meta-analysis found that digital interventions are effective for anxiety disorders. Digital interventions showed a larger effect size compared to wait-list and care-as-usual controls, supporting their application in the treatment of anxiety disorders.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Psychology, Developmental
Pim Cuijpers, Eirini Karyotaki, Marketa Ciharova, Clara Miguel, Hisashi Noma, Yvonne Stikkelbroek, John R. Weisz, Toshi A. Furukawa
Summary: Meta-analyses demonstrate the effectiveness of psychotherapies in treating depression in children and adolescents. However, more than 60% of youth receiving therapy do not respond, highlighting the need for more effective treatments and strategies.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Review
Psychology, Clinical
Ruiying Zhao, Arpana Amarnath, Eirini Karyotaki, Sascha Y. Struijs, Pim Cuijpers
Summary: Although many individuals with depression do not actively seek help, psychological treatments have been found to be effective. A meta-analysis of 52 randomized trials showed that psychological treatments have a moderate to high effect on reducing depressive symptoms. Additionally, only 13% of patients who completed a screening questionnaire met the inclusion criteria and participated in the clinical trial.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Behavioral Sciences
Pim Cuijpers, Clara Miguel, Marketa Ciharova, Soledad Quero, Constantin Yves Plessen, David Ebert, Mathias Harrer, Annemieke van Straten, Eirini Karyotaki
Summary: Most people with a mental disorder have multiple disorders. This study reviewed randomized trials and found that psychotherapies, particularly cognitive-behavioral therapy (CBT), were effective in treating depression with comorbid anxiety, insomnia, and substance use problems. However, the effects were less significant after adjusting for publication bias and limited to studies with low risk of bias.
COGNITIVE BEHAVIOUR THERAPY
(2023)
Article
Mathematical & Computational Biology
Michael Seo, Toshi A. Furukawa, Eirini Karyotaki, Orestis Efthimiou
Summary: Clinical prediction models are widely used in modern clinical practice. This study compares different approaches for developing prediction models when there are different sets of predictors available from multiple studies. The results show that multiple imputation methods and a new approach that synthesizes all predictions outperform a restrict predictors approach.
RESEARCH SYNTHESIS METHODS
(2023)
Article
Health Care Sciences & Services
Michaela Augustin, Maria Licata-Dandel, Linda D. Breeman, Mathias Harrer, Ayten Bilgin, Dieter Wolke, Volker Mall, Margret Ziegler, David Daniel Ebert, Anna Friedmann
Summary: This study investigated the effects of a psychoeducational app on parents' stress levels, knowledge about child problems, and perceived self-efficacy and social support in dealing with crying, sleeping, and feeding problems. The results showed that parents using the app reported lower parenting stress and higher knowledge levels compared to those who did not use the app. However, there were no significant changes in self-efficacy, perceived social support, and child symptoms between the two groups.
JMIR MHEALTH AND UHEALTH
(2023)
Article
Psychology, Clinical
Pim Cuijpers, Eirini Karyotaki, Mathias Harrer, Yvonne Stikkelbroek
Summary: Behavioral activation (BA) is a simple and effective therapy for depression that aims to increase positive interactions between individuals and their environment. Previous meta-analyses have focused on BA in groups and guided self-help, but this study examines BA in individual psychotherapy. The results show that individual BA has a large effect on distal treatment outcomes, making it a valuable and versatile therapy option.
PSYCHOTHERAPY RESEARCH
(2023)
Article
Behavioral Sciences
Asala Halaj, Asher Y. Strauss, Dina Zalaznik, Isaac Fradkin, Elad Zlotnick, Gerhard Andersson, David Daniel Ebert, Jonathan D. Huppert
Summary: Individuals with Panic Disorder often have impaired insight, which can hinder their willingness to seek treatment. Cognitive processes, such as metacognition, cognitive flexibility, and jumping to conclusions may influence the level of insight. Understanding the relationship between insight and these cognitive factors can help identify individuals with vulnerabilities and improve their insight.
COGNITIVE BEHAVIOUR THERAPY
(2023)
Article
Medicine, General & Internal
Davide Papola, Eirini Karyotaki, Marianna Purgato, Marit Sijbrandij, Federico Tedeschi, Pim Cuijpers, Efthimiou Orestis, Toshi A. Furukawa, Vikram Patel, Corrado Barbui
Summary: Common mental disorders, such as depression and anxiety, are leading causes of disability worldwide. In low-resource settings, psychosocial interventions delivered through task-sharing modalities have been proven effective in expanding access to mental healthcare. However, the specific components of these interventions that are most efficacious in reducing symptoms of common mental disorders, and for whom, have yet to be substantiated by evidence.
Review
Psychiatry
Pim Cuijpers, Clara Miguel, Mathias Harrer, Marketa Ciharova, Eirini Karyotaki
Summary: This study investigated the interaction between psychotherapy and pharmacotherapy for adult depression and found no significant interaction. Patients can start with psychotherapy without fearing that it will reduce the effects of the treatment.
EUROPEAN PSYCHIATRY
(2023)
Review
Psychiatry
Constantin Yves Plessen, Eirini Karyotaki, Clara Miguel, Marketa Ciharova, Pim Cuijpers
Summary: Through a multiverse meta-analysis, the study found that psychotherapies for depression have overall robustness in terms of effectiveness. Meta-analyses that included studies with a high risk of bias, compared the intervention with wait-list control groups, and did not correct for publication bias produced larger effect sizes.
Review
Psychiatry
Eirini Karyotaki, Marit Sijbrandij, Marianna Purgato, Ceren Acarturk, Daniel Lakin, Della Bailey, Emily Peckham, Ersin Uygun, Federico Tedeschi, Johannes Wancata, Jura Augustinavicius, Kenneth Carswell, Maritta Valimaki, Mark van Ommeren, Markus Koesters, Mariana Popa, Marx Ronald Leku, Minna Anttila, Rachel Churchill, Ross G. White, Sarah Al-Hashimi, Tella Lantta, Teresa Au, Thomas Klein, Wietse A. Tol, Pim Cuijpers, Corrado Barbui
Summary: The study compared the effects of Self-Help Plus (SH+) and Enhanced Care as Usual (ECAU) on reducing depressive symptoms among refugees and asylum seekers. Results showed no significant difference between SH+ and ECAU post-intervention, but SH+ was more effective for unemployed and lower mental well-being participants, and improvements were observed at midterm follow-up.
Correction
Psychiatry
Yaara Sadeh, Anna Denejkina, Eirini Karyotaki, Lonneke I. M. Lenferink, Nancy Kassam-Adams
CAMBRIDGE PRISMS-GLOBAL MENTAL HEALTH
(2023)
Review
Psychiatry
Yaara Sadeh, Anna Denejkina, Eirini Karyotaki, Lonneke I. M. Lenferink, Nancy Kassam-Adams
Summary: Optimizing global mental health research is crucial in addressing the high burden of mental health challenges and mental illness. Data sharing and reuse have proven valuable in advancing science and knowledge development. The FAIR Guiding Principles provide a framework to improve research transparency and impact. This review explores ethical and equity considerations in data sharing and reuse, discusses the application of FAIR principles in mental health research, and examines the current state of FAIR data practices, identifying challenges and opportunities.
CAMBRIDGE PRISMS-GLOBAL MENTAL HEALTH
(2023)
Review
Psychiatry
Eirini Karyotaki, Clara Miguel, Olga M. Panagiotopoulou, Mathias Harrer, Nadine Seward, Marit Sijbrandij, Ricardo Araya, Vikram Patel, Pim Cuijpers
Summary: Digital interventions can effectively reduce symptoms of common mental disorders, improve quality of life, and have a lasting impact in low- and middle-income countries. However, further research is needed to determine the specific magnitude of the effects of digital interventions.
CAMBRIDGE PRISMS-GLOBAL MENTAL HEALTH
(2023)