Article
Engineering, Chemical
Yulian Wang, Jiayi Liu, Tianjiao Shi, Qihao Wang, Jun Zhang, Yibin Zhu, Chuang Li, Zhigang Yuan, Jin Yao, Wanzhong Yin
Summary: Mineralizing CO2 with magnesium salt is an effective and achievable method to reduce the greenhouse effect. This study successfully prepared hydrated magnesium carbonate as a functional material under the regulation of biosugars, which has significant economic benefits. The formation mechanism of porous spherical nesquehonite was also revealed.
ADVANCED POWDER TECHNOLOGY
(2022)
Article
Engineering, Biomedical
Justine Tanjaya, Pin Ha, Yulong Zhang, Chenchao Wang, Yash Shah, Emily Berthiaume, Hsin Chuan Pan, Jiayu Shi, Jinny Kwak, Benjamin Wu, Kang Ting, Xinli Zhang, Chia Soo
Summary: Recent investigations have shown that suppressing PPAR gamma-mediated adipogenesis can improve bone formation in osteoporosis. This study explores a co-treatment strategy using NELL-1 and PPAR gamma suppression, which significantly enhanced bone formation and increased cell proliferation while decreasing apoptosis in mice. This suggests that combining PPAR gamma suppression with NELL-1 therapy may be a promising method to reverse bone loss in osteoporosis.
Article
Agriculture, Dairy & Animal Science
Cezary Osiak-Wicha, Ewa Tomaszewska, Siemowit Muszynski, Marian Flis, Marcin B. B. Arciszewski
Summary: This study aimed to examine the mechanical properties, mineralization, and general geometric properties of hare femora during growth and maturation. The findings revealed age-related differences in bone properties, with adult males exhibiting increased bone mineral content and density compared to young males. The study contributes to our understanding of the relationship between bone mechanical properties, musculoskeletal system, and aging in the wild.
Article
Endocrinology & Metabolism
Ilari Kuitunen, Reijo Sund, Ulla Sankilampi
Summary: This study aimed to compare the occurrence of bone fractures in preterm and low birthweight children with full-term and normal birthweight children. The study found that very preterm newborns had a 23% lower incidence of fractures compared to term newborns, while preterm newborns had a similar fracture rate. Birthweight showed a linear increase in fracture rates, with lower birthweight associated with lower fracture incidence. Overall, children born very preterm or with extremely low birthweight have a lower incidence of fractures during childhood compared to those born full term and with normal birthweight.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Engineering, Biomedical
Xinchen Wu, Tengfei Zhang, Brianna Hoff, Sanika Suvarnapathaki, Darlin Lantigua, Colleen McCarthy, Bin Wu, Gulden Camci-Unal
Summary: Sequential mineralization allows integration of minerals into the 3D structure of hydrogels, with collagen-based hydrogels mineralized over 10 cycles. The compressive modulus of the gels increases significantly after mineralization for 30 minutes and 24 hours, with XRD and FTIR analyses indicating mainly hydroxyapatite minerals. In vitro experiments show increased gene expression and biocompatibility, with in vivo studies demonstrating successful bone regeneration. These results highlight the potential of sequentially mineralized hydrogel scaffolds for bone repair and regeneration.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Tianming Du, Xufeng Niu, Peng Cao, Yanping Zhang, Youjun Liu, Haisheng Yang, Aike Qiao
Summary: Bone mineralization is a fundamental process in skeletal growth, remodeling, and regeneration, involving the deposition of inorganic matter on organic matter and the regulation of non-collagenous proteins. Different metal elements can directly modify calcium phosphate formation and regulate bone mineralization through signaling pathways and gene expression. This review discusses the roles of metal elements in bone mineralization and offers future research directions for the development of advanced bone substitutes and orthopedic implants.
APPLIED MATERIALS TODAY
(2023)
Article
Endocrinology & Metabolism
Konica Porwal, Shivani Sharma, Saroj Kumar, Manendra Singh Tomar, Sreyanko Sadhukhan, Swati Rajput, Chirag Kulkarni, Ashutosh Shrivastava, Navin Kumar, Naibedya Chattopadhyay
Summary: We investigated the effects of hormonal and non-hormonal oral contraceptives on bone mass, mineralization, composition, mechanical properties, and metabolites in pubertal female rats. Both types of contraceptives had adverse effects on various skeletal parameters, with the hormonal contraceptive having a greater negative impact on bone strength. Overall, the study highlights the importance of considering the effects of oral contraceptives on bone health.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Grace Felciya Sekar Jeyakumar, Poornima Velswamy, Deebasuganya Gunasekaran, Nivethitha Panneerselvam Manimegalai, Kiran Manikantan Syamala, Uma Tiruchirappalli Sivagnanam
Summary: The irregular expression of bone matrix proteins during bone regeneration can result in deformities. In this study, a metal-organic composite [TQ-Sr-Fe] was developed to enhance bone mineralization. The composite showed a sheet-like structure and exhibited biocompatibility with cells. It promoted cell adhesion, proliferation, and osteoblastic differentiation, leading to increased calcium deposition and mineralization. Overall, the TQ-Sr-Fe composite has the potential to accelerate bone regeneration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Tierong Bian, Hongyun Xing
Summary: This study successfully prepared a biomineralized bone scaffold with bionic bone composition and double multi-level interface reinforcement, and explored its multi-scale structure and mechanisms for enhancing mechanical properties through characterization and theoretical analysis.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Cell Biology
Xiaofang Zhu, Xiangfen Li, Xiaoxuan Wang, Ting Chen, Fengjuan Tao, Chuanju Liu, Qisheng Tu, Guofang Shen, Jake J. Chen
Summary: Research indicates that irisin plays a crucial role in bone metabolism and in the cross-talk between bone and adipose tissue. Absence of irisin results in decreased bone density, delayed bone development and mineralization, as well as weakening of positive effects of exercise on bone strength and weight loss. Supplementation with recombinant irisin during exercise can rescue these effects.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Annalisa Frattini, Simona Bolamperti, Roberto Valli, Marco Cipolli, Rita Maria Pinto, Elena Bergami, Maria Rita Frau, Simone Cesaro, Michela Signo, Valentino Bezzerri, Giovanni Porta, Abdul Waheed Khan, Alessandro Rubinacci, Isabella Villa
Summary: Analysis of osteoblasts from Shwachman-Diamond syndrome (SDS) patients revealed reduced SBDS gene expression and protein levels, leading to lower mineralization capacity compared to healthy subjects. Furthermore, SDS osteoblasts exhibited decreased expression of genes involved in osteoblastogenesis and elevated levels of p53, inhibiting osteogenesis. Silencing of Tp53 resulted in increased collagen type I and alkaline phosphatase protein levels, enhancing mineralization capacity of SDS osteoblasts.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Orthopedics
Julian Stuerznickel, Nico Hinz, Maximilian M. Delsmann, Tim Hoenig, Tim Rolvien
Summary: This cross-sectional study characterized the bone microarchitecture in athletes with bone stress injuries and found reduced bone mineral density and impaired cortical bone microarchitecture in many athletes. However, neither bone mineral density nor bone microarchitecture was related to the injury site, highlighting the multifactorial etiology of bone stress injuries.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2022)
Article
Anatomy & Morphology
Piero Antonio Zecca, Marcella Reguzzoni, Marina Protasoni, Mario Raspanti
Summary: In the synovial joints, the transition between the soft articular cartilage and the subchondral bone is mediated by a calcified cartilage layer with similar characteristics to bone. This layer is not directly accessible and is visualized through histological sections of decalcified tissue. This study used conventional histology and scanning electron microscopy to discriminate between the calcified and uncalcified cartilage, revealing a high heterogeneity of the calcified layer and a different mineralization process compared to other hard tissues. Selective removal of the soft matrix allowed for a 3D view of the mineralization front.
Article
Biochemistry & Molecular Biology
Gonggong Lu, Xiang Li, Peilei Wang, Xing Li, Yuxiang Wang, Jiayi Zhu, Alfredo Ronca, Ugo D'Amora, Wenke Liu, Xuhui Hui
Summary: In this study, a hybrid cross-linked hierarchical microporous hydrogel scaffold (PHCLS) was developed for the treatment of critical-size skull defects. The scaffold showed promising results in promoting bone cell proliferation and angiogenesis in vitro, and achieved significant skull reconstruction in a rabbit cranial defect model.
Article
Pediatrics
Tanju Celik, Ozlem Sangun, Sule Unal, Ali Balci, Sedat Motor
Summary: The study suggests that serum OPG concentration can be used as a biochemical marker for screening the development of osteoporosis in patients with beta-thalassemia major.
ITALIAN JOURNAL OF PEDIATRICS
(2022)