期刊
CHEMPLUSCHEM
卷 83, 期 7, 页码 612-619出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cplu.201800194
关键词
2-pyridinecarbothiamide ligands; antitumor agents; bioorganometallic compounds; organoruthenium compounds; sulfonamides
资金
- University of Auckland (University of Auckland Doctoral Scholarship)
- Higher Education Commission of Pakistan (IRSIP Scholarship)
- Royal Society of New Zealand
Anticancer-active Ru-II-eta(6)-p-cymene complexes of bioactive 2-pyridinecarbothioamide ligands have been shown to have high selectivity for plectin and can be administered orally. Reported herein is the functionalization of a 2-pyridinecarbothioamide with a sulfonamide group and its conversion into M-eta(6)-p-cymene complexes (M = Ru, Os). The presence of a sulfonamide moiety in many organic drugs and metal complexes endows these agents with interesting biological properties and can transform the latter into multi-targeted agents. The compounds were characterized with standard methods and the in vitro anticancer activity data was compared with studies on the hydrolytic stability of the complexes and their reactivity to small biomolecules. A molecular modeling study revealed plausible modes of binding of the complexes in the catalytic pocket of carbonic anhydrase II.
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