期刊
CELL REPORTS
卷 22, 期 6, 页码 1484-1495出版社
CELL PRESS
DOI: 10.1016/j.celrep.2018.01.021
关键词
-
类别
资金
- NIH Tetramer Core Facility [HHSN272201300006C]
- CNIC
- Spanish Ministry of Economy, Industry and Competitiveness (MINECO) [SAF2016-79040-R]
- Agencia Estatal de Investigacion
- FEDER (European fund for Regional Development)
- Foundation Acteria
- European Commission [635122-PROCROP H2020]
- European Research Council (ERC-Consolidator Grant) [725091]
- Dutch Cancer Society [VU2009-4504, VU2013-5940]
- VUmc CCA [2015-5-22]
- [SAF2015-74561-JIN]
Splenic CD169(+) macrophages are located in the marginal zone to efficiently capture blood-borne pathogens. Here, we investigate the requirements for the induction of CD8(+) T cell responses by antigens (Ags) bound by CD169(+) macrophages. Upon Ag targeting to CD169(+) macrophages, we show that BATF3-dependent CD8 alpha(+) dendritic cells (DCs) are crucial for DNGR-1-mediated cross-priming of CD8(+) T cell responses. In addition, we demonstrate that CD169, a sialic acid binding lectin involved in cell-cell contact, preferentially binds to CD8 alpha(+) DCs and that Ag transfer to CD8 alpha(+) DCs and subsequent T cell activation is dependent on the sialic acid-binding capacity of CD169. Finally, functional CD169 mediates optimal CD8(+) T cell responses to modified vaccinia Ankara virus infection. Together, these data indicate that the collaboration of CD169(+) macrophages and CD8 alpha(+) DCs for the initiation of effective CD8(+) T cell responses is facilitated by binding of CD169 to sialic acid containing ligands on CD8 alpha(+) DCs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据