期刊
CELL REPORTS
卷 23, 期 9, 页码 2541-2549出版社
CELL PRESS
DOI: 10.1016/j.celrep.2018.04.095
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资金
- Deutsche Forschungsgemeinschaft (DFG) [SFB 958, Exc 257]
- Bundesministerium fur Bildung und Forschung (BMBF) (Bernstein Center for Computational Neuroscience [BCCN] Berlin grant) [01GQ1001A]
- Bundesministerium fur Bildung und Forschung (BMBF) (Bernstein Focus Learning grant
- SMARTAGE) [01GQ0972]
The role of mossy cells (MCs) of the hippocampal dentate area has long remained mysterious. Recent research has begun to unveil their significance in spatial computation of the hippocampus. Here, we used an in vitro model of sharp wave-ripple complexes (SWRs), which contribute to hippocampal memory formation, to investigate MC involvement in this fundamental population activity. We find that a significant fraction of MCs (similar to 47%) is recruited into the active neuronal network during SWRs in the CA3 area. Moreover, MCs receive pronounced, ripple-coherent, excitatory and inhibitory synaptic input. Finally, we find evidence for SWR-related synaptic activity in granule cells that is mediated by MCs. Given the widespread connectivity of MCs within and between hippocampi, our data suggest a role for MCs as a hub functionally coupling the CA3 and the DG during ripple-associated computations.
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