Article
Immunology
Briana G. Nixon, Chun Chou, Chirag Krishna, Saida Dadi, Adam O. Michel, Andrew E. Cornish, Emily R. Kansler, Mytrang H. Do, Xinxin Wang, Kristelle J. Capistrano, Alexander Y. Rudensky, Christina S. Leslie, Ming O. Li
Summary: Innate lymphocytes are important components of the cellular immune system. They can defend the host against various challenges and can lead to immunopathology when dysregulated. This study found that granzyme C, a cytolytic molecule, was expressed in a specific type of innate lymphoid cells (ILC1s) in the liver and salivary gland of mice. These granzyme C-expressing ILC1s were derived from ILC progenitors and did not convert into NK cells, ILC2s, or ILC3s. Granzyme C marked a maturation state of ILC1s, and its expression in ILC1s required specific transcription factors and support from transforming growth factor-beta signaling. Depleting ILC1s in a mouse breast cancer model resulted in accelerated tumor growth. IL-15 stimulation induced granzyme C expression in ILC1s, enabling them to exhibit perforin-mediated cytotoxicity. However, constitutive activation of STAT5 in granzyme C-expressing ILC1s led to lethal perforin-dependent autoimmunity in neonatal mice. This study broadens the understanding of the function of ILC1s beyond helper-like lymphocytes.
SCIENCE IMMUNOLOGY
(2022)
Letter
Oncology
Shoubao Ma, Michael A. Caligiuri, Jianhua Yu
Summary: This study identifies a four-stage developmental model for mouse NK cell development and defines two distinct populations of immature NK cells.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Article
Immunology
Yawen Chen, Xianwei Wang, Xiaolei Hao, Bin Li, Wanyin Tao, Shu Zhu, Kun Qu, Haiming Wei, Rui Sun, Hui Peng, Zhigang Tian
Summary: The study reveals the heterogeneity of liver ILC1s and demonstrates the dynamic changes that occur in ILC1 subsets from different origins during ontogeny. Ly49E(+) ILC1s originate from embryonic non-bone marrow hematopoietic progenitor cells and play a role in neonatal innate immunity, while Ly49E(-) ILC1s develop from bone marrow and extramedullary hematopoietic progenitor cells after birth and are involved in adult immune memory responses.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Immunology
Emily R. Kansler, Saida Dadi, Chirag Krishna, Briana G. Nixon, Efstathios G. Stamatiades, Ming Liu, Fengshen Kuo, Jing Zhang, Xian Zhang, Kristelle Capistrano, Kyle A. Blum, Kate Weiss, Ross M. Kedl, Guangwei Cui, Koichi Ikuta, Timothy A. Chan, Christina S. Leslie, A. Ari Hakimi, Ming O. Li
Summary: This study reveals an innate immune surveillance response mediated by cytotoxic ILC1 sensing of cancer cell-expressed IL-15, which is associated with patient survival and contributes to tumor suppression.
Article
Immunology
Christin Friedrich, Renske L. R. E. Taggenbrock, Remi Doucet-Ladeveze, Gosia Golda, Rebekka Moenius, Panagiota Arampatzi, Natasja A. M. Kragten, Katharina Kreymborg, Mercedes Gomez de Agueero, Wolfgang Kastenmueller, Antoine-Emmanuel Saliba, Dominic Gruen, Klaas P. J. M. van Gisbergen, Georg Gasteiger
Summary: ILC1 cells exhibit similar differentiation pathways in different organs, with a gradual loss of TCF-1 resulting in loss of proliferative potential and increased expression of effector molecules.
Article
Cell Biology
Antonio Arulanandam, Liang Lin, Hao-Ming Chang, Martine Cerutti, Sylvie Choblet, Peng Gao, Armin Rath, Armand Bensussan, Jean Kadouche, Daniel Teper, Ofer Mandelboim, Wei Li
Summary: GPC3 is highly expressed in multiple solid tumors and is barely expressed in adult normal tissues except the placenta. NKp46 activation receptor is expressed in all-natural killer cells, including tumor-infiltrating NK cells. CYT-303 is a multifunctional antibody that targets both GPC3 and NKp46 to mediate NK cell-redirected killing of HCC tumors.
Article
Immunology
Xiangqian Guan, Yuyan Lu, Yi Zhang, Ping Zhan, Zhigao Chen, Chuanzheng Wang, Zhenyu Yin
Summary: This study showed that early removal of NK cells can significantly inhibit tumor growth in a CD8+T cell-dependent manner in a murine hepatocellular carcinoma model. The presence of abundant NKp46+ NK cells in the tumor microenvironment was positively correlated with tumor growth and these cells exhibited dysfunction. Blockade of NKp46 effectively attenuated HCC growth. This work revealed a regulatory role of tumor-associated NK cells in HCC and suggested NKp46 as a potential target for HCC treatment.
IMMUNOLOGY LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Johannes Hoefle, Timo Trenkner, Nadja Kleist, Vera Schwane, Sarah Vollmers, Bryan Barcelona, Annika Niehrs, Pia Fittje, Van Hung Huynh-Tran, Juergen Sauter, Alexander H. Schmidt, Sven Peine, Angelique Hoelzemer, Laura Richert, Marcus Altfeld, Christian Koerner
Summary: TRAIL is identified to be involved in the recognition and activation of NK cells against HIV-1-infected cells. It induces degranulation and IFN-γ production, and its activation is not limited to its cognate death receptors but also involves decoy receptor I.
Article
Immunology
Ryu Takeyama, Atsushi Fukui, Chuxian Mai, Mayu Yamamoto, Shinichiro Saeki, Ayano Yamaya, Hiroaki Shibahara
Summary: This study found that in the high-risk group, there was a decrease in NKp46 expression and an increase in TNF-alpha production, indicating a lower expression of activating receptors on NK cells in high-risk women.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Review
Immunology
Nurul Izza Ismail
Summary: As the placenta is semi-allogenic, it is expected that maternal immune cells would attack the invading trophoblast, but studies have shown that they cooperate with the trophoblast to disrupt the arterial wall. uNK cells, unique immune cells, play a role in pregnancy. The interaction between HLA class 1b genes and maternal uNK cells in humans is described in this review.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Hans Bergman, Elinda Hermanson, Christer Lindqvist
Summary: This study established two different NK-92 cell clones with distinct NK target cell properties. A significant difference was observed in the cytotoxic capacity against K562 cells between these two NK-92 clones, with NK-92 clone 2 displaying a higher ability to kill K562 cells. Prolonged incubation of PBMCs also enhanced their NK activity against NK-92 clone 1.
ANTICANCER RESEARCH
(2022)
Article
Obstetrics & Gynecology
Isabel Cuadrado-Torroglosa, Alberto Pacheco, Ana Barrio, Nicolas Garrido, Pilar Aparicio, Nuria Pellicer, Juan Antonio Garcia-Velasco, Diana Alecsandru
Summary: This study aims to investigate the distribution and gene expression of endometrial immune cell populations, especially natural killer (NK) subsets, in assisted reproductive technology patients and healthy donors. The results showed a higher percentage of CD56dimCD16 thorn NK cells in patients compared to healthy donors. However, there was no statistically significant difference in endometrial gene expression or immune cell populations when categorizing patients by KIR genotype. Furthermore, there were no differences in binding between KIR and HLA-C molecules among these patient groups.
FERTILITY AND STERILITY
(2023)
Article
Multidisciplinary Sciences
Minseon Lee, Dongjoo Kim, Soonjo Kwon
Summary: In this study, a hypergravity exposure system was used to enhance breast cancer cell responsiveness to natural killer cells for immunotherapy. The hypergravity treatment led to cytoskeletal changes and increased cytotoxicity of breast cancer cells, potentially improving efficiency of cell-based immunotherapies.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Alexandre de Nonneville, Pascal Finetti, Maelle Picard, Audrey Monneur, Maria Abbondanza Pantaleo, Annalisa Astolfi, Jerzy Ostrowski, Daniel Birnbaum, Emilie Mamessier, Francois Bertucci
Summary: Gastrointestinal stromal tumors (GIST) are the most frequent sarcomas of the gastrointestinal tract. This study found that high expression of cell surface proteoglycan CSPG4 in GIST is associated with better disease-free survival and an immune environment favorable to cytotoxic immune response. These findings suggest the potential value of CSPG4-specific chimeric antigen receptor-redirected cytokine-induced killer lymphocytes treatment in GIST, especially in CSPG4-high tumors, and calls for further validation and clinical trials.
Review
Immunology
Matthias Peipp, Katja Klausz, Ammelie Svea Boje, Tobias Zeller, Stefan Zielonka, Christian Kellner
Summary: NK cells play a crucial role in cancer immune surveillance by recognizing malignant cells and controlling their activation through the expression of activating and inhibitory receptors. The recruitment and activation of NK cells have great potential in cancer treatment. Targeting the ligands expressed on tumors is also a promising approach to unleash the cytotoxicity of NK cells.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2022)
Article
Genetics & Heredity
Nicola Ferreira, Christopher E. Andoniou, Kara L. Perks, Judith A. Ermer, Danielle L. Rudler, Giulia Rossetti, Ambika Periyakaruppiah, Jamie K. Y. Wong, Oliver Rackham, Peter G. Noakes, Mariapia A. Degli-Esposti, Aleksandra Filipovska
Article
Biochemistry & Molecular Biology
Vivien R. Sutton, Christopher Andoniou, Michael G. Leeming, Colin M. House, Sally Watt, Sandra Verschoor, Annette Ciccone, Ilia Voskoboinik, Mariapia Degli-Esposti, Joseph A. Trapani
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
(2020)
Article
Oncology
Melody Cheong, Kate H. Gartlan, Jason S. Lee, Siok-Keen Tey, Ping Zhang, Rachel D. Kuns, Christopher E. Andoniou, Jose Paulo Martins, Karshing Chang, Vivien R. Sutton, Greg Kelly, Antiopi Varelias, Slavica Vuckovic, Kate A. Markey, Glen M. Boyle, Mark J. Smyth, Christian R. Engwerda, Kelli P. A. MacDonald, Joseph A. Trapani, Mariapia A. Degli-Esposti, Motoko Koyama, Geoffrey R. Hill
CANCER IMMUNOLOGY RESEARCH
(2020)
Article
Immunology
Susanna S. Ng, Fabian De Labastida Rivera, Juming Yan, Dillon Corvino, Indrajit Das, Ping Zhang, Rachel Kuns, Shashi Bhushan Chauhan, Jiajie Hou, Xian-Yang Li, Teija C. M. Frame, Benjamin A. McEnroe, Eilish Moore, Jinrui Na, Jessica A. Engel, Megan S. F. Soon, Bhawana Singh, Andrew J. Kueh, Marco J. Herold, Marcela Montes de Oca, Siddharth Sankar Singh, Patrick T. Bunn, Amy Roman Aguilera, Mika Casey, Matthias Braun, Nazanin Ghazanfari, Shivangi Wani, Yulin Wang, Fiona H. Amante, Chelsea L. Edwards, Ashraful Haque, William C. Dougall, Om Prakash Singh, Alan G. Baxter, Michele W. L. Teng, Alex Loukas, Norelle L. Daly, Nicole Cloonan, Mariapia A. Degli-Esposti, Jude Uzonna, William R. Heath, Tobias Bald, Siok-Keen Tey, Kyohei Nakamura, Geoffrey R. Hill, Rajiv Kumar, Shyam Sundar, Mark J. Smyth, Christian R. Engwerda
Article
Hematology
Andrea S. Henden, Motoko Koyama, Renee J. Robb, Adriana Forero, Rachel D. Kuns, Karshing Chang, Kathleen S. Ensbey, Antiopi Varelias, Stephen H. Kazakoff, Nicole Waddell, Andrew D. Clouston, Rabina Giri, Jakob Begun, Bruce R. Blazar, Mariapia A. Degli-Esposti, Sergei V. Kotenko, Steven W. Lane, Kate L. Bowerman, Ram Savan, Philip Hugenholtz, Kate H. Gartlan, Geoffrey R. Hill
Summary: The text discusses the importance of immunopathology and intestinal stem cell loss in graft-versus-host disease, as well as interferon-lambda as a key protective factor. Research shows that intervention with interferon-lambda can prevent the loss of intestinal stem cells and improve the condition of GVHD.
Review
Immunology
Sam Sheppard, Joseph C. Sun
Summary: NK cells express a limited number of germline-encoded receptors that identify infected or transformed cells, eliciting cytotoxicity, effector cytokine production, and in some circumstances clonal proliferation and memory. Cytomegalovirus infection in both species can expand a population of NK cells expressing receptors critical to the clearance of infected cells and generate a long-lived memory pool capable of targeting future infection with greater efficacy.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Review
Hematology
Mariapia A. Degli-Esposti, Geoffrey R. Hill
Summary: The reactivation of viruses after stem cell transplantation is a clinical challenge. Monitoring strategies and expensive antiviral drugs are needed. T cells, natural killer cells, and dendritic cells play important roles in protecting against viral reactivation. Graft-versus-host disease and new antiviral drugs may affect immune functionality and relevance.
Article
Hematology
Albert C. Yeh, Antiopi Varelias, Anupama Reddy, Sierra M. Barone, Stuart D. Olver, Kate Chilson, Lynn E. Onstad, Kathleen S. Ensbey, Andrea S. Henden, Luke Samson, Carla A. Jaeger, Timothy Bi, Kimberly B. Dahlman, Tae Kon Kim, Ping Zhang, Mariapia A. Degli-Esposti, Evan W. Newell, Madan H. Jagasia, Jonathan M. Irish, Stephanie J. Lee, Geoffrey R. Hill
Summary: Studies show that the CMV serostatus of donors and recipients is associated with transplant-related mortality following allogeneic stem cell transplant (SCT). Previous research has indicated that CMV-seronegative recipients receiving a CMV-seropositive graft may have inferior outcomes compared to other serostatus combinations, even without viral reactivation. This suggests that prior CMV exposure can have lasting effects on immune function after SCT.
Review
Ophthalmology
Jelena Marie Kezic, Steven Wiffen, Mariapia Degli-Esposti
Summary: Ocular graft versus host disease (GVHD) is a common complication in patients undergoing allo-HSCT, characterized by dry eye symptoms and inflammatory changes in the eye. Regular ocular assessments and additional screenings are crucial for the early detection and treatment of ocular complications associated with GVHD.
CLINICAL AND EXPERIMENTAL OPTOMETRY
(2022)
Review
Immunology
A. J. Highton, I. S. Schuster, M. A. Degli-Esposti, M. Altfeld
Summary: NK cells are a major immune subset within the liver, playing important roles in the immune responses against hepatotropic viral infections, autoimmune liver diseases, and fatty liver disease. Understanding the involvement of NK cells in liver inflammation is crucial for effective treatment and future immunotherapeutic targeting in these disease settings.
SEMINARS IN IMMUNOPATHOLOGY
(2021)
Article
Virology
Melkamu B. Tessema, Rubaiyea Farrukee, Christopher E. Andoniou, Mariapia A. Degli-Esposti, Clare Oates, James B. Barnes, Linda M. Wakim, Andrew G. Brooks, Sarah L. Londrigan, Patrick C. Reading
Summary: This study is the first to report the antiviral activity of mouse Mx1 against alphaherpesviruses, demonstrating that mMx1 can effectively inhibit the growth of HSV-1 by blocking viral genome replication and late gene expression. Additionally, the functional endogenous mMx1 is shown to limit the pathogenesis of HSV-1 in a mouse infection model.
JOURNAL OF VIROLOGY
(2022)
Article
Immunology
Iona S. Schuster, Xavier Y. X. Sng, Colleen M. Lau, David R. Powell, Orr-El Weizman, Joseph C. Sun, Peter Fleming, Georgia E. G. Neate, Valentina Voigt, Sam Sheppard, Andreas I. Maraskovsky, Sheridan Daly, Motoko Koyama, Geoffrey R. Hill, Stephen J. Turner, Timothy E. O'Sullivan, Christopher E. Andoniou, Mariapia A. Degli-Esposti
Summary: Tissue health relies on the ability to respond to disturbances and restore homeostasis. This study identifies a population of innate lymphocytes, called tissue-resident memory-like natural killer (NKRM) cells, that develop adaptive-like features including long-term residency in non-lymphoid tissues. These NKRM cells prevent autoimmunity by eliminating CD4+ T cells, and modulating their functions could offer new strategies for treating inflammatory and autoimmune diseases.
Review
Immunology
Richard Berry, Gabrielle M. Watson, Stipan Jonjic, Mariapia A. Degli-Esposti, Jamie Rossjohn
NATURE REVIEWS IMMUNOLOGY
(2020)