期刊
CELL REPORTS
卷 22, 期 6, 页码 1392-1400出版社
CELL PRESS
DOI: 10.1016/j.celrep.2018.01.035
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资金
- NIH [AI116420, AI125770, AI127704]
- National Cancer Institute (NCI) [P01-CA97132, 4]
Cryptococcus neoformans (C. neoformans) is estimated to cause about 220,000 new cases every year in patients with AIDS, despite advances in antifungal treatments. C. neoformans possesses a remarkable ability to disseminate through an immunocompromised host, making treatment difficult. Here, we examine the mechanism of survival of C. neoformans under varying host conditions and find a role for ceramide synthase in C. neoformans virulence. This study also provides a detailed lipidomics resource for the fungal lipid research community in addition to discovering a potential target for antifungal therapy.
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