Article
Immunology
Lisa E. Manhart, Gina Leipertz, Olusegun O. Soge, Stephen J. Jordan, Candice McNeil, Preeti Pathela, Hilary Reno, Karen Wendel, Anika Parker, William M. Geisler, Damon Getman, Matthew R. Golden
Summary: The prevalence of Mycoplasma genitalium (MG) infection is high in individuals at high risk of sexually transmitted infections, and there is a high level of macrolide resistance. Testing for MG and resistance mutations is necessary for appropriate therapy.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Microbiology
Alexey Y. Kuzmenkov, Ivan V. Trushin, Alina G. Vinogradova, Andrey A. Avramenko, Marina V. Sukhorukova, Surbhi Malhotra-Kumar, Andrey V. Dekhnich, Mikhail V. Edelstein, Roman S. Kozlov
Summary: Surveillance of antimicrobial resistance is crucial for identifying resistance trends and developing infection prevention and treatment strategies. Implementation of a new-generation web platform, AMRmap, in Russia aims to improve the availability and accessibility of comprehensive AMR surveillance data, including susceptibility information and resistance determinants.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Infectious Diseases
Yuichi Muraki, Masayuki Maeda, Ryo Inose, Koki Yoshimura, Naoki Onizuka, Masao Takahashi, Eiji Kawakami, Yoshiaki Shikamura, Naotaka Son, Makoto Iwashita, Manabu Suzuki, Masayuki Yokoi, Hirokazu Horikoshi, Yasuaki Aoki, Michiyo Kawana, Miwako Kamei, Hajime Hashiba, Choichiro Miyazaki
Summary: This study evaluated the use of antimicrobial drugs in Japanese pharmacies using a new indicator and found differences in usage patterns among different medical departments. The study highlights the need for targeted interventions, particularly in the otolaryngology department.
Review
Microbiology
Marina Radovanovic, Dusan Kekic, Milos Jovicevic, Jovana Kabic, Ina Gajic, Natasa Opavski, Lazar Ranin
Summary: N. gonorrhoeae is becoming resistant to all major classes of antibiotics, posing a global threat to the treatment of gonorrhoea. Slow updates of treatment guidelines and the bacterium's high capacity to develop and retain antimicrobial resistance may lead to worsening global antimicrobial resistance in gonococci.
Article
Agriculture, Dairy & Animal Science
Barbara Martin-Maldonado, Pablo Rodriguez-Alcazar, Aitor Fernandez-Novo, Fernando Gonzalez, Natalia Pastor, Irene Lopez, Laura Suarez, Virginia Moraleda, Alicia Aranaz
Summary: Antimicrobial resistance (AMR) is a major health challenge of the 21st century. Wildlife can serve as sentinels for pathogen surveillance, and the presence of AMR bacteria in wildlife indicates the level of human impact on the ecosystem. This study compared the level of AMR in three bird species and found that both seagulls and white storks carried antimicrobial-resistant Escherichia coli, with a significant percentage considered multi-drug resistant. Beta-lactams, quinolones, and tetracyclines were the antibiotic classes with the highest rate of AMR.
Review
Infectious Diseases
Maria Diletta Pezzani, Barbara Tornimbene, Carmem Pessoa-Silva, Marlieke de Kraker, Sebastiano Rizzardo, Nicola Duccio Salerno, Stephan Harbarth, Evelina Tacconelli
Summary: This study assessed the clinical impact of infections caused by priority antibiotic resistant pathogens monitored by the WHO. The results show the need for improved data harmonization, representativeness, and quality in surveillance to accurately estimate the burden of AMR. Policy makers require accurate burden estimates to prioritize resource allocation and intervention strategies for combating the AMR crisis.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Infectious Diseases
Alona Kuraieva, Guillermo Cabezas-Camarero, Pattarachai Kiratisin, Eric Utt
Summary: The objective of this study was to assess the in vitro activity of ceftaroline and a panel of comparator agents against isolates causing skin and soft tissue infections (SSTIs). Ceftaroline demonstrated potent activity against methicillin-resistant S. aureus (MRSA) isolates across all regions. It also showed very potent activity against fi-hemolytic streptococci isolates and high susceptibility to ceftaroline was observed in ESBL-negative Enterobacterales.
Article
Public, Environmental & Occupational Health
D. Ashiru-Oredope, E. L. Budd, A. Doble, E. Cramp, A. Hendrick, S. Hopkins
Summary: Public Health England developed an antimicrobial stewardship surveillance system and conducted a national pilot to test the feasibility of centrally collecting data from NHS hospital trusts. Results showed that most trusts participating in the pilot performed well in documenting indications, with fewer collecting data on review decisions within 48-72 hours. Approximately 88% of trusts submitted AMR CQUIN data, with an increase in the percentage of antibiotic prescriptions with evidence of review within 72 hours.
JOURNAL OF HOSPITAL INFECTION
(2021)
Article
Public, Environmental & Occupational Health
Sara Petrin, Massimiliano Orsini, Andrea Massaro, John E. Olsen, Lisa Barco, Carmen Losasso
Summary: The antimicrobial resistance among zoonotic pathogens, such as Salmonella, is a serious health threat. This study investigated the phenotypic antimicrobial resistance and identified the antimicrobial resistance genes (ARGs) and plasmid replicons associated with the resistances. The results showed a high level of variability in ARGs and plasmid replicons content among different serovars of Salmonella enterica.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Infectious Diseases
Rujipas Sirijatuphat, Sunee Chayangsu, Jintana Srisompong, Darat Ruangkriengsin, Visanu Thamlikitkul, Surapee Tiengrim, Walaiporn Wangchinda, Pornpan Koomanachai, Pinyo Rattanaumpawan
Summary: The Global Antimicrobial Resistance Surveillance System (GLASS) is an important tool in combating antimicrobial resistance. This study examined the feasibility and benefits of implementing GLASS in three provincial hospitals in Thailand. The results showed high antibiotic resistance in community-acquired infections (CAIs) and potential misclassification of bacteria. The study also highlighted the need for additional training on specimen collection and data management to improve the validity of GLASS-based surveillance.
Article
Veterinary Sciences
Nurul Asyiqin Haulisah, Latiffah Hassan, Siti Khairani Bejo, Saleh Mohammed Jajere, Nur Indah Ahmad
Summary: The overuse of antimicrobials in livestock has been recognized as a major risk factor for the acceleration of antimicrobial resistance. A study found high levels of resistance in clinical isolates from both ruminant and non-ruminant animals, with a significant portion of isolates being multi-drug resistant.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Immunology
Tim Du, Kelly B. Choi, Anada Silva, George R. Golding, Linda Pelude, Romeo Hizon, Ghada N. Al-Rawahi, James Brooks, Blanda Chow, Jun C. Collet, Jeannette L. Comeau, Ian Davis, Gerald A. Evans, Charles Frenette, Guanghong Han, Jennie Johnstone, Pamela Kibsey, Kevin C. Katz, Joanne M. Langley, Bonita E. Lee, Yves Longtin, Dominik Mertz, Jessica Minion, Michelle Science, Jocelyn A. Srigley, Paula Stagg, Kathryn N. Suh, Nisha Thampi, Alice Wong, Susy S. Hota
Summary: We investigated the epidemiology and molecular characteristics of healthcare-associated and community-associated Clostridioides difficile infection (CDI) in adult patients in Canadian hospitals. Our study found higher mortality rate associated with healthcare-associated CDI, and a decrease in both healthcare-associated and community-associated CDI rates from 2015 to 2019. Certain ribotypes were more commonly associated with CDI-related deaths.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Genetics & Heredity
Maaike van den Beld, Roan Pijnacker, Alje van Dam, Lian Bovee, David Kwa, Ineke Linde, Roxanne Wolthuis, Daan Notermans, Thijs Bosch, Eelco Franz
Summary: More than half of the domestic shigellosis cases in the Netherlands are among men who have sex with men, especially in the Amsterdam region. The circulating Shigella strains in the Netherlands are not well understood. Whole-genome sequencing (WGS)-based surveillance for Shigella was found to be valuable in providing insight into the clustering of shigellosis cases, the affected population, and antimicrobial resistance, leading to targeted control measures.
MICROBIAL GENOMICS
(2023)
Article
Public, Environmental & Occupational Health
Scott J. C. Pallett, Esmita Charani, Lois Hawkins, Andrea Mazzella, Vanesa Anton-Vazquez, Rishi Banerjee, Terry J. Evans, Benjamin Patterson, Sathyavani Subbarao, Saleh Alqahtani, Marina Basarab, Aodhan S. Breathnach, Nabeela Mughal, Luke S. P. Moore
Summary: This study aimed to assess the differences in national antimicrobial susceptibility data used to inform national action plans across different surveillance platforms. The results showed significant heterogeneity between platforms, which compromises the effectiveness of local and global antimicrobial resistance strategies.
BULLETIN OF THE WORLD HEALTH ORGANIZATION
(2023)
Article
Engineering, Environmental
Maria Virginia Prieto Riquelme, Emily Garner, Suraj Gupta, Jake Metch, Ni Zhu, Matthew F. Blair, Gustavo Arango-Argoty, Ayella Maile-Moskowitz, An-dong Li, Carl-Fredrik Flach, Diana S. Aga, Indumathi M. Nambi, D. G. Joakim Larsson, Helmut Buergmann, Tong Zhang, Amy Pruden, Peter J. Vikesland
Summary: This study presents a comprehensive metagenomics-based approach for global surveillance of antibiotic resistance in sewage. The results show that there are shared antibiotic resistance genes (ARGs) across different regions/communities, and certain ARGs can be used as discriminatory markers to differentiate Asian and European/US resistomes. The study also reveals discrepancies between measured antibiotic concentrations and public sales data, suggesting that wastewater-based surveillance (WBS) can capture additional antibiotic uses that are not accounted for. The WBS approach demonstrated in this study is sensitive to local/regional factors and can provide comparable results across different sites.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
