Article
Endocrinology & Metabolism
Diana Hedevang Christensen, Sia K. Nicolaisen, Emma Ahlqvist, Jacob Stidsen, Jens Steen Nielsen, Kurt Hojlund, Michael H. Olsen, Sonia Garcia-Calzon, Charlotte Ling, Jorgen Rungby, Ivan Brandslund, Peter Vestergaard, Niels Jessen, Torben Hansen, Charlotte Brons, Henning Beck-Nielsen, Henrik T. Sorensen, Reimar W. Thomsen, Allan Vaag
Summary: Different HOMA2-based approaches did not classify patients with T2D in a consistent manner. The T2D classes characterized by high insulin resistance/hyperinsulinemia appeared most distinct.
BMJ OPEN DIABETES RESEARCH & CARE
(2022)
Article
Cardiac & Cardiovascular Systems
Frederik Pagh Bredahl Kristensen, Diana Hedevang Christensen, Martin Bodtker Mortensen, Michael Maeng, Johnny Kahlert, Henrik Toft Sorensen, Reimar Wernich Thomsen
Summary: Triglyceride levels are associated with cardiovascular risk in newly diagnosed type 2 diabetes patients who are already on statin therapy. High triglyceride levels may serve as a predictor of residual cardiovascular risk in early type 2 diabetes.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Medicine, General & Internal
Anders Gummesson, Elias Bjornson, Linn Fagerberg, Wen Zhong, Abdellah Tebani, Fredrik Edfors, Caroline Schmidt, Annika Lundqvist, Martin Adiels, Fredrik Baeckhed, Jochen M. Schwenk, Per-Anders Jansson, Mathias Uhlen, Goran Bergstrom
Summary: The study found distinct protein patterns in early-stage type 2 diabetes patients, reflecting key metabolic syndrome features. These patterns improved after treatment, indicating that comprehensive protein profiling can be a useful tool in elucidating the biological effects of diabetes treatments.
Article
Endocrinology & Metabolism
Alexander C. C. Falkentoft, Thomas Alexander Gerds, Bochra Zareini, Filip K. K. Knop, Lars Kober, Christian Torp-Pedersen, Morten Schou, Niels E. E. Bruun, Anne-Christine Ruwald
Summary: This study found that individuals with initial omission of glucose-lowering drug treatment (GLDT), including those who achieved initial remission of type 2 diabetes, had a higher risk of major adverse cardiovascular events (MACE) compared to well-controlled individuals on GLDT in real-world clinical practice. This higher risk may be related to lower initiation of statins and renin-angiotensin system inhibitors (RASi).
Article
Endocrinology & Metabolism
Jung-Chi Li, Po-Chung Cheng, Chien-Nin Huang, Li-Fen Jian, Ying-Syuan Wu, Chih-Li Lin
Summary: This study investigates the effect of adding the antihypertensive drug Amlodipine to standard diabetes therapy on glycemic control in patients with type 2 diabetes mellitus (T2DM). The results show that patients who received additional Amlodipine demonstrated significantly improved glycemic control compared to those who received standard diabetes therapy after 24 weeks.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
A. G. Unnikrishnan, R. K. Sahay, Uday Phadke, S. K. Sharma, Parag Shah, Rishi Shukla, Vijay Viswanathan, S. K. Wangnoo, Santosh Singhal, Mathew John, Ajay Kumar, Mala Dharmalingam, Subodh Jain, Shehla Shaikh, Willem J. Verberk
Summary: Through studying newly diagnosed T2DM patients in India, it is found that they have high cardiovascular disease risk. This indicates the need for further extension of ASCVD risk identification programs and prevention strategies to reduce the occurrence of cardiovascular diseases.
Article
Endocrinology & Metabolism
Anna Parkkola, Maaret Turtinen, Taina Harkonen, Jorma Ilonen, Mikael Knip
Summary: Family history of type 2 diabetes may impact the phenotype and genotype of children with type 1 diabetes, as children with a positive family history for type 2 diabetes tend to have features associated with type 2 diabetes at the time of type 1 diabetes diagnosis.
Article
Endocrinology & Metabolism
S. Bonetti, C. Zusi, E. Rinaldi, M. L. Boselli, A. Csermely, G. Malerba, E. Trabetti, E. Bonora, R. C. Bonadonna, M. Trombetta
Summary: This study found that common genetic variability of monogenic diabetes genes is significantly associated with impaired beta-cell function in patients with newly diagnosed type 2 diabetes mellitus (T2DM), suggesting that these genes may be targeted by specific treatments for T2DM.
DIABETES & METABOLISM
(2022)
Article
Cardiac & Cardiovascular Systems
Christine Gyldenkerne, Martin Bodtker Mortensen, Johnny Kahlert, Pernille Gro Thrane, Kevin Kris Warnakula Olesen, Henrik Toft Sorensen, Reimar Wernich Thomsen, Michael Maeng
Summary: Newly diagnosed type 2 diabetes mellitus significantly increases the risk of cardiovascular disease in patients, especially among younger individuals. Compared to the general population, individuals with type 2 diabetes have a significantly higher 10-year risk of developing cardiovascular events, occurring at least 12 years earlier.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Environmental Sciences
Laura Deen, Alice Clark, Karin Sorig Hougaard, Kajsa Ugelvig Petersen, Marie Frederiksen, Lauren A. Wise, Amelia K. Wesselink, Harald William Meyer, Jens Peter Bonde, Sandra Sogaard Tottenborg
Summary: This study found an association between indoor air exposure to PCBs and T2D incidence, but there was no clear dose-response relationship between exposure and risk.
ENVIRONMENTAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Chiara Zusi, Alessandro Csermely, Elisabetta Rinaldi, Kezia Bertoldo, Sara Bonetti, Maria Linda Boselli, Daniela Travia, Enzo Bonora, Riccardo C. Bonadonna, Maddalena Trombetta
Summary: The aim of this study is to evaluate the relationship between genetic variability of ADIPOQ, LEP, and LEPR genes with the glucose-insulin system and markers of subclinical atherosclerosis (ATS) in patients with newly diagnosed type 2 diabetes. The results showed that two SNPs within the ADIPOQ gene were associated with adiponectin levels. Haplotypes of ADIPOQ, LEP, and LEPR genes were associated with circulating levels of adiponectin, leptin, and markers of ATS, providing insight into the role of adipokines in glucose metabolism and atherosclerosis.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Anette P. Gjesing, Line Engelbrechtsen, Anne Cathrine B. Thuesen, Christian T. Have, Mette Hollensted, Niels Grarup, Allan Linneberg, Jens Steen Nielsen, Lotte B. Christensen, Reimar W. Thomsen, Kristoffer E. Johansson, Matteo Cagiada, Sarah Gersing, Rasmus Hartmann-Petersen, Kresten Lindorff-Larsen, Allan Vaag, Henrik T. Sorensen, Ivan Brandslund, Henning Beck-Nielsen, Oluf Pedersen, Jorgen Rungby, Torben Hansen
Summary: This study investigated the prevalence and phenotypic characteristics of GCK gene variants in patients with and without diabetes. The results showed that patients with type 2 diabetes carrying GCK variants had lower waist circumference, hip circumference, and BMI compared to non-carriers. Some GCK variant carriers also experienced microvascular complications during follow-up. This subset of diabetes patients may benefit from treatment cessation.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Medicine, General & Internal
Hon-Ke Sia, Chew-Teng Kor, Shih-Te Tu, Pei-Yung Liao, Jiun-Yi Wang
Summary: This study found that smoking was independently associated with unfavorable glycemic control among men with newly diagnosed type 2 diabetes, especially in those with a lower BMI.
ANNALS OF MEDICINE
(2022)
Article
Endocrinology & Metabolism
Enzo Bonora, Maddalena Trombetta, Marco Dauriz, Corinna Brangani, Vittorio Cacciatori, Carlo Negri, Isabella Pichiri, Vincenzo Stoico, Elisabetta Rinaldi, Giuliana Da Prato, Maria Linda Boselli, Lorenza Santi, Federica Moschetta, Monica Zardini, Riccardo C. Bonadonna
Summary: In newly diagnosed type 2 diabetes, insulin resistance and beta-cell dysfunction are very common with a wide range of expression but no specific pattern of aggregation.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2022)
Article
Endocrinology & Metabolism
Michael Fang, Elizabeth Selvin
Summary: Over the past three decades, there have been encouraging reductions in albuminuria and risk factor control in adults with newly diagnosed diabetes, but the overall burden of complications around the time of the diagnosis remains high.
Article
Psychiatry
Else Foverskov, Justin S. White, Marie Norredam, Trine Froslev, Min Hee Kim, M. Maria Glymour, Lars Pedersen, Henrik T. Sorensen, Rita Hamad
Summary: This study based on refugees in Denmark found that resettling in socioeconomically disadvantaged neighborhoods increased the risk of psychiatric disorders among refugees. The results suggest that targeted placement of newly arrived refugees could help improve their mental health.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Cecilia Hvitfeldt Fuglsang, Istvan Bakos, Kristina Laugesen, Frederikke Schonfeldt Troelsen, Erzsebet Horvath-Puho, Henrik Toft Sorensen
Summary: This population-based cohort study in Denmark investigated the association between smoking during pregnancy and the risk of appendicitis in offspring. The results showed a slightly higher hazard rate for children of smoking mothers compared to nonsmokers. The association may be mediated by later-life exposures.
Article
Cardiac & Cardiovascular Systems
Maria A. de Winter, Harry R. Buller, Marc Carrier, Alexander T. Cohen, John-Bjarne Hansen, Karin A. H. Kaasjager, Ajay K. Kakkar, Saskia Middeldorp, Gary E. Raskob, Henrik T. Sorensen, Frank L. J. Visseren, Philip S. Wells, Jannick A. N. Dorresteijn, Mathilde Nijkeuter, VTE PREDICT study Grp
Summary: This study aimed to develop and validate models for predicting 5-year risks of recurrence and bleeding in VTE patients without cancer. The models were derived from patient data and validated externally, showing good agreement between predicted and observed risks for up to 5 years.
EUROPEAN HEART JOURNAL
(2023)
Article
Endocrinology & Metabolism
Tina Wullum Gundersen, Andreas Ebbehoj, Sine Knorr, Dorte Moller Jensen, Peter Damm, Ellen Christine Leth Lokkegaard, Elisabeth R. Mathiesen, Reimar W. Thomsen, Tine Dalsgaard Clausen
Summary: The aim of this study was to validate the accuracy of the Danish national registries in identifying type 1 diabetes in women giving live birth. The study found that the registries can accurately identify women with type 1 diabetes, providing valuable data for future research and monitoring.
ENDOCRINOLOGY DIABETES & METABOLISM
(2023)
Article
Cell Biology
Anders Jorgensen, Ivan Brandslund, Christina Ellervik, Trine Henriksen, Allan Weimann, Per Kragh Andersen, Henrik E. E. Poulsen
Summary: Modifications of nucleic acids (DNA and RNA) from oxidative stress are potential drivers of aging and mortality in age-associated medical disorders such as type 2 diabetes (T2D). A marker of RNA oxidation was found to strongly predict all-cause mortality in T2D patients and nondiabetic control subjects, even after adjusting for established modifiers of oxidative stress. On the other hand, DNA damage from oxidation, which has traditionally been linked to T2D and aging, failed to predict mortality. These findings were subsequently replicated in an independent general population study, highlighting the specific importance of RNA damage from oxidation in T2D and general aging.
Article
Endocrinology & Metabolism
Anne Gedebjerg, Mette Bjerre, Alisa Devedzic Kjaergaard, Jens Steen Nielsen, Jorgen Rungby, Ivan Brandslund, Michael Maeng, Henning Beck-Nielsen, Allan Vaag, Henrik Toft Sorensen, Troels Krarup Hansen, Reimar Wernich Thomsen
Summary: We investigated the relationship between hs-CRP and C-peptide in patients with recently diagnosed T2D and found that high levels of hs-CRP were associated with increased risk of CVEs and all-cause mortality. Patients with high levels of both biomarkers had the highest risk. These findings have important implications for early detection and prevention of deadly diseases beyond CVEs.
Article
Endocrinology & Metabolism
Frederik Pagh Bredahl Kristensen, Diana Hedevang Christensen, Brian Christopher Callaghan, Jacob Volmer Stidsen, Jens Steen Nielsen, Kurt Hojlund, Henning Beck-Nielsen, Troels Staehelin Jensen, Henning Andersen, Peter Vestergaard, Niels Jessen, Michael Hecht Olsen, Torben Hansen, Charlotte Brons, Allan Vaag, Henrik Toft Sorensen, Reimar Wernich Thomsen
Summary: This study investigated the prevalence of diabetic polyneuropathy (DPN) in three subgroups of type 2 diabetes mellitus (T2DM) patients based on β-cell function and insulin sensitivity. The results showed that patients with hyperinsulinemia had the highest prevalence of DPN (23%), while patients with low insulin sensitivity had the lowest prevalence (14%). Therefore, hyperinsulinemia may be an important risk factor for DPN.
Article
Endocrinology & Metabolism
Aleksander L. Hansen, Reimar W. Thomsen, Charlotte Brons, Helene M. L. Svane, Rasmus T. Jensen, Mette K. Andersen, Torben Hansen, Jens S. Nielsen, Peter Vestergaard, Kurt Hojlund, Niels Jessen, Michael H. Olsen, Henrik T. Sorensen, Allan A. Vaag
Summary: Low birthweight is associated with earlier onset of type 2 diabetes and lower BMI and waist circumference. Individuals with low birthweight have more comorbidities and require more medication for glucose-lowering and hypertension control.
Article
Public, Environmental & Occupational Health
Jeppe Klok Due, Marianne Giortz Pedersen, Sussie Antonsen, Joen Rommedahl, Esben Agerbo, Preben Bo Mortensen, Henrik Toft Sorensen, Jonas Faerch Lotz, Laura Cabello Piqueras, Constanza Fierro, Antonia Karamolegkou, Christian Igel, Phillip Rust, Anders Sogaard, Carsten Bocker Pedersen
Summary: Linking information in the Danish Civil Registration System (CRS) with national registers provides unique research opportunities. The introduction of the "lite MGR" and future "Danish MGR" allows for more complete familial linkages. The lite MGR offers more comprehensive familial information than the current CRS, and the lite and full MGR will enhance research value.
SCANDINAVIAN JOURNAL OF PUBLIC HEALTH
(2023)
Article
Genetics & Heredity
Anne Cathrine Baun Thuesen, Rasmus Tanderup Jensen, Henrik Maagensen, Maja Refshauge Kristiansen, Henrik Toft Sorensen, Allan Vaag, Henning Beck-Nielsen, Oluf B. Pedersen, Niels Grarup, Jens Steen Nielsen, Jorgen Rungby, Anette Prior Gjesing, Heidi Storgaard, Tina Vilsboll, Torben Hansen
Summary: This study investigated the glycemic phenotype and treatment response of patients with type 2 diabetes carrying rare GCK variants consistent with GCK-diabetes. Carriers of pathogenic and likely pathogenic variants had lower fasting glucose and C-peptide levels. Stopping medication did not lead to worsening of HbA1c or fasting glucose. Variants of uncertain significance should be interpreted carefully.
MOLECULAR GENETICS AND METABOLISM REPORTS
(2023)
Article
Medicine, General & Internal
Malene Risager Lykke, Henrik Toft Sorensen, Joy Elisabeth Lawn, Erzsebet Horvath-Puho
Summary: This population-based cohort study in Denmark examined the association between neonatal invasive Group B Streptococcus (iGBS) disease and long-term risk of epilepsy. The study found that children with iGBS disease had a higher incidence of epilepsy, particularly after meningitis. Factors such as premature birth, sex, and low maternal socioeconomic position were associated with an increased risk of epilepsy in later childhood.
Article
Endocrinology & Metabolism
Alma B. Pedersen, Sven E. Norholt, Lars Rejnmark, Bente Langdahl, Thomas Starch-Jensen, Henrik T. Sorensen
Summary: This study investigates the relationship between pharmacogenomics and osteonecrosis of the jaw (ONJ), and found no evidence for any genetic predisposition to ONJ.
Article
Endocrinology & Metabolism
Frederik Pagh Bredahl Kristensen, Miguel Adriano Sanchez-Lastra, Knut Eirik Dalene, Borja del Pozo Cruz, Mathias Ried-Larsen, Reimar Wernich Thomsen, Ding Ding, Ulf Ekelund, Jakob Tarp
Summary: This study found that engaging in any level of leisure-time physical activity can reduce the risk of neuropathy and nephropathy in individuals with type 2 diabetes, but not retinopathy. The minimal effective level of physical activity may correspond to less than 1.5 hours of walking per week.
Article
Endocrinology & Metabolism
Rikke Hjortebjerg, Maja R. Kristiansen, Ivan Brandslund, Dorte Aa. Olsen, Jacob V. Stidsen, Jens S. Nielsen, Jan Frystyk
Summary: In individuals with type 2 diabetes, high levels of IGFBP-2 are associated with low glucose and insulin secretion, are unaffected by metformin treatment, and are associated with the risk of prior comorbidity and mortality.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Holly Elser, Erzsebet Horvath-Puho, Jaimie L. Gradus, Meghan L. Smith, Timothy L. Lash, M. Maria Glymour, Henrik Toft Sorensen, Victor W. Henderson
Summary: Late-life depressive symptoms are associated with subsequent dementia diagnosis and may be an early symptom or response to preclinical disease. Evaluating associations with early- and middle-life depression will help clarify whether depression influences dementia risk.
