Review
Anesthesiology
Hong-Mei Liu, Hong Yu, Yi-Ding Zuo, Peng Liang
Summary: In this systematic review and meta-analysis, sugammadex was found to be more effective than neostigmine in reducing the incidence of postoperative pulmonary complications, including pneumonia, atelectasis, noninvasive ventilation, and reintubation.
BMC ANESTHESIOLOGY
(2023)
Article
Clinical Neurology
Xia Sun, Jintao Yu, Jia Luo, Shan Xu, Ning Yang, Yan Wang
Summary: There is a significant association between obstructive sleep apnea (OSA) and postoperative adverse events. The severity of OSA increases the risk of complications, while preoperative diagnosis and continuous positive airway pressure (CPAP) therapy can reduce the risks. CPAP treatment can help reduce the incidence of postoperative complications.
Article
Anesthesiology
Paulo A. Germano-Filho, Ismar L. Cavalcanti, Angelo J. Q. R. Micuci, Luis G. C. Velarde, Hans D. de Boer, Nubia Vercosa
Summary: The objective of this study was to test the hypothesis that magnesium sulfate after reversal with sugammadex causes recurarization. The study was designed as a single-center, prospective, randomized, double-blind, controlled trial. The results showed that in the magnesium sulfate group, 64% of patients with deep blockade and 73% of patients with moderate blockade experienced recurarization, while in the placebo group, only 7% and 0% of patients experienced recurarization, respectively. This study demonstrated that a single dose of magnesium sulfate led to recurarization in patients who had recovered from rocuronium-induced deep and moderate neuromuscular blockade using sugammadex, and additional sugammadex could reverse prolonged recurarization.
JOURNAL OF CLINICAL ANESTHESIA
(2023)
Article
Medicine, General & Internal
Juan Fiorda Diaz, Marco Echeverria-Villalobos, Alan Esparza Gutierrez, Olufunke Dada, Nicoleta Stoicea, Wiebke Ackermann, Mahmoud Abdel-Rasoul, Jarrett Heard, Alberto Uribe, Sergio D. D. Bergese
Summary: This study compared the effectiveness and cost-effectiveness of sugammadex and neostigmine for moderate neuromuscular blockade reversal. The results showed that sugammadex achieved faster reversal without increasing perioperative costs.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Andrea Calef, Rashel Castelgrande, Kristin Crawley, Sara Dorris, Joanna Durham, Kaitlin Lee, Jen Paras, Kristen Piazza, Abigail Race, Laura Rider, Michael Shelley, Emily Stewart, Miranda Tamok, Jennifer Tate, Jeffrey M. Dodd-o
Summary: This study aimed to investigate the consequences of not using residual neuromuscular blockade (RNB) analysis to guide the administration of neuromuscular blockade reversal in the postsurgical ICU. The results showed that there may be a risk of residual neuromuscular blockade in patients who did not undergo RNB analysis before receiving neuromuscular blockade reversal agents. Therefore, careful assessment and monitoring of residual neuromuscular blockade in patients in the postsurgical ICU is necessary.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Anesthesiology
Ana B. Serrano, Oscar Diaz-Cambronero, Javier Melchor-Ripolles, Alfredo Abad-Gurumeta, Jose M. Ramirez-Rodriguez, Javier Martinez-Ubieto, Miriam Sanchez-Merchante, Rita Rodriguez, Laura Jorda, Silvia Gil-Trujillo, Mercedes Cabellos-Olivares, Daniel Bordonaba-Bosque, Cesar Aldecoa
Summary: The study found that optimal neuromuscular blockade management in colorectal surgery did not lead to reduced moderate-severe complications, length of hospital stay, or mortality postoperatively within an enhanced recovery program. Reversing neuromuscular blockade with neostigmine was associated with a higher mortality rate compared to using sugammadex.
MINERVA ANESTESIOLOGICA
(2021)
Article
Anesthesiology
Thomas Ledowski, Zoltan Szabo-Maak, Pui San Loh, Berwin A. Turlach, Hong Seuk Yang, Hans D. de Boer, Laszlo Asztalos, Ina Ismiarti Shariffuddin, Lucy Chan, Bela Fulesdi
Summary: In high-risk older patients, reversing rocuronium neuromuscular block with sugammadex may result in a reduced risk of postoperative pulmonary complications on Day 7.
BRITISH JOURNAL OF ANAESTHESIA
(2021)
Article
Anesthesiology
Ruidong Zhang, Jie Hu, Shengde Li, Bin Xue, Lu Wang, Jie Bai, Jijian Zheng
Summary: This study compared the efficacy of using Sugammadex for reversing neuromuscular blockade in children of different age groups, showing that in Chinese children aged 1-12 years, a moderate rocuronium-induced neuromuscular blockade can be effectively reversed with 2 mg/kg Sugammadex.
BMC ANESTHESIOLOGY
(2021)
Article
Medicine, General & Internal
HaoTian Wu, ZengMao Lin, RuiHao Zhou, SuiSui Huang, LingJun Chen, Yang Su, LuoNa Cheng, Huan Zhang
Summary: Little is known about the recent use of neuromuscular blocking agents (NMBAs) and monitoring in China. A nationwide survey was conducted to obtain information on the current management of NMBAs in China. The results showed a low frequency of using reversal agents and monitors in China.
FRONTIERS IN MEDICINE
(2022)
Review
Biology
Cyrus Motamed
Summary: There is a global trend of recommending quantitative neuromuscular monitoring in the operating room, which can help in rational use of muscle relaxants and avoid complications. A specific culture is necessary to integrate this monitoring as part of anesthesia in patients, including understanding the physiology, pharmacology, concept of monitoring, and choice of reversal agents like sugammadex.
Article
Multidisciplinary Sciences
Cristian Aragon-Benedi, Ana Pascual-Bellosta, Sonia Ortega-Lucea, Sara Visiedo-Sanchez, Javier Martinez-Ubieto
Summary: This study aimed to assess the effects of spontaneous or pharmacological reversal of neuromuscular blockade on postoperative residual neuromuscular blockade and pulmonary complications. A prognostic model was also developed to predict the probability of postoperative residual neuromuscular blockade based on comorbidities and intraoperative management of neuromuscular blocking agents. The results showed that pharmacological reversal and neuromuscular monitoring during surgery were the most effective factors in reducing the risk of residual neuromuscular blockade and postoperative pulmonary complications.
SCIENTIFIC REPORTS
(2022)
Article
Anesthesiology
J. Martinez-Ubieto, C. Aragon-Benedi, J. de Pedro, L. Cea-Calvo, A. Morell, Y. Jiang, S. Cedillo, P. Ramirez-Boix, A. M. Pascual-Bellosta
Summary: This study evaluated the clinical and economic impact of introducing Sugammadex for reversing rocuronium-induced neuromuscular blockade in Spain and found that its introduction led to cost savings and reduced postoperative pulmonary complications.
BMC ANESTHESIOLOGY
(2021)
Article
Anesthesiology
J. Ross, D. P. Ramsay, L. J. Sutton-Smith, R. D. Willink, J. E. Moore
Summary: Residual neuromuscular blockade is a common problem in ICU patients, but neuromuscular function monitoring before tracheal extubation is rarely conducted in New Zealand ICUs.
Article
Anesthesiology
Marc Schmidt, Julian Rossler, Jack Brooker, Valentina Lara-Erazo, Elyad Ekrami, Xuan Pu, Alparslan Turan, Daniel I. Sessler, Kurt Ruetzler
Summary: This study aimed to compare the postoperative lung function of patients undergoing neuromuscular block reversal using sugammadex versus neostigmine. The results showed similar lung function with both methods, but patients given sugammadex had more minor pulmonary complications.
JOURNAL OF CLINICAL ANESTHESIA
(2023)
Article
Anesthesiology
Frances Chung, Rida Waseem, Chew Yin Wang, Edwin Seet, Colin Suen, Matthew T. Chan
Summary: The study aims to determine whether preoperative oximetry-derived hypoxemia can predict postoperative cardiovascular events in surgical patients with unrecognized obstructive sleep apnea.
JOURNAL OF CLINICAL ANESTHESIA
(2022)
Article
Clinical Neurology
Ilona Merikanto, Yves Dauvilliers, Frances Chung, Yun Kwok Wing, Luigi De Gennaro, Brigitte Holzinger, Bjorn Bjorvatn, Charles M. Morin, Thomas Penzel, Christian Benedict, Adrijana Koscec Bjelajac, Ngan Yin Chan, Colin A. Espie, Harald Hrubos-Strom, Yuichi Inoue, Maria Korman, Anne-Marie Landtblom, Damien Leger, Kentaro Matsui, Sergio Mota-Rolim, Michael R. Nadorff, Giuseppe Plazzi, Catia Reis, Juliana Yordanova, Markku Partinen
Summary: An international survey study reveals that post-acute sequelae of COVID-19 symptoms are more prevalent among severe cases and long-lasting sleep problems are at the core of these symptoms. Understanding the importance of sleep-related symptoms has clinical relevance in diagnosing and treating long-COVID.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Anesthesiology
Selena Gong, Dorothy Qian, Sheila Riazi, Frances Chung, Marina Englesakis, Qixuan Li, Ella Huszti, Jean Wong
Summary: This systematic review and meta-analysis examined the association between the FRAIL scale and mortality and postoperative outcomes in older surgical patients. The results showed that frailty was associated with 30-day mortality, 6-month mortality, postoperative complications, and postoperative delirium.
ANESTHESIA AND ANALGESIA
(2023)
Review
Anesthesiology
Emily Au, Gowtham Thangathurai, Aparna Saripella, Ellene Yan, Marina Englesakis, Mahesh Nagappa, Frances Chung
Summary: This systematic review and meta-analysis aimed to determine the association between preoperative cognitive impairment and dementia and postoperative outcomes in older surgical patients after cardiac surgery. The study found that preoperative cognitive impairment was associated with delirium, increased hospital length of stay, and intensive care unit length of stay in older patients undergoing cardiac surgery, but had no significant association with 30-day mortality.
ANESTHESIA AND ANALGESIA
(2023)
Article
Biology
Bjorn Bjorvatn, Ilona Merikanto, Catia Reis, Maria Korman, Adrijana Koscec Bjelajac, Brigitte Holzinger, Luigi De Gennaro, Yun Kwok Wing, Charles M. Morin, Colin A. Espie, Christian Benedict, Anne-Marie Landtblom, Kentaro Matsui, Harald Hrubos-Strom, Sergio Mota-Rolim, Michael R. Nadorff, Giuseppe Plazzi, Rachel Ngan Yin Chan, Markku Partinen, Yves Dauvilliers, Frances Chung, Ingeborg Forthun
Summary: The present study aimed to investigate the relationship between shift/night work and face-to-face work with the prevalence and severity of COVID-19. The results showed that shift/night work was not associated with an increased risk of COVID-19, but shift/night workers reported more severe disease when infected. Face-to-face work was associated with an increased risk of COVID-19, but not with higher disease severity.
CHRONOBIOLOGY INTERNATIONAL
(2023)
Review
Anesthesiology
Linor Berezin, Mahesh Nagappa, Khashayar Poorzargar, Aparna Saripella, Jennita Ariaratnam, Nina Butris, Marina Englesakis, Frances Chung
Summary: The study aimed to determine the effectiveness of positive airway pressure (PAP) therapy in reducing the risk of postoperative complications in patients with obstructive sleep apnea (OSA) undergoing surgery. The results showed that PAP therapy was associated with a decreased risk of postoperative respiratory complications and unplanned ICU admission in non-cardiac surgery patients with OSA. In patients undergoing cardiac surgery, PAP therapy decreased the risk of postoperative cardiac complications and atrial fibrillation.
JOURNAL OF CLINICAL ANESTHESIA
(2023)
Article
Clinical Neurology
Serena Scarpelli, Alessandra De Santis, Valentina Alfonsi, Maurizio Gorgoni, Charles M. Morin, Colin Espie, Ilona Merikanto, Frances Chung, Thomas Penzel, Bjorn Bjorvatn, Yves Dauvilliers, Brigitte Holzinger, Yun K. Wing, Markku Partinen, Giuseppe Plazzi, Luigi De Gennaro
Summary: Recent investigations have found that COVID-19 patients may continue to experience symptoms for 2-3 months after the onset of the infection. This study examined sleep and dream alterations in patients with long-COVID and identified the factors that contribute to these alterations. The results showed that long-COVID patients had more severe sleep problems compared to short-COVID patients. Additionally, the number of post-acute symptoms and psychological factors were found to be important determinants of sleep and dream alterations in long-COVID individuals.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Psychiatry
Pei Xue, Ilona Merikanto, Frances Chung, Charles M. Morin, Colin Espie, Bjorn Bjorvatn, Jonathan Cedernaes, Anne-Marie Landtblom, Thomas Penzel, Luigi De Gennaro, Brigitte Holzinger, Kentaro Matsui, Harald Hrubos-Strom, Maria Korman, Damien Leger, Sergio Mota-Rolim, Courtney J. Bolstad, Michael Nadorff, Giuseppe Plazzi, Catia Reis, Rachel Ngan Yin Chan, Yun Kwok Wing, Juliana Yordanova, Adrijana Koscec Bjelajac, Yuichi Inoue, Markku Partinen, Yves Dauvilliers, Christian Benedict
Summary: Short and long sleep duration after receiving mRNA vaccines is associated with a higher risk of post-COVID symptoms. The study suggests that short and long sleepers are more likely to experience prolonged COVID-19 symptoms compared to normal sleepers. Further research is needed to validate these findings in cohorts with confirmed SARS-CoV-2 infection.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Anesthesiology
Ellene Yan, David He, Tarek K. Rajji, Frances Chung
INTERNATIONAL ANESTHESIOLOGY CLINICS
(2023)
Review
Clinical Neurology
Nina Butris, Evan Tang, Bianca Pivetta, David He, Aparna Saripella, Ellene Yan, Marina Englesakis, Mark I. Boulos, Mahesh Nagappa, Frances Chung
Summary: Determining the prevalence and risk factors of sleep disturbances in surgical patients is crucial for risk stratification and perioperative care planning. A systematic review and meta-analysis showed that the overall prevalence of sleep disturbances in these patients was 60%, with high preoperative PSQI scores and anxiety being significant risk factors. Patients with postoperative delirium also had higher rates of pre- and postoperative sleep disturbances. The high prevalence of preoperative sleep disturbances negatively impacts postoperative outcomes and well-being, calling for further research.
SLEEP MEDICINE REVIEWS
(2023)
Review
Anesthesiology
Brandon Ruan, Mahesh Nagappa, Matin Rashid-Kolvear, Kevin Zhang, Rida Waseem, Marina Englesakis, Frances Chung
Summary: The study aimed to evaluate the effectiveness of supplemental oxygen therapy and high-flow nasal cannula (HFNC) therapy in patients with obstructive sleep apnea (OSA) in different clinical settings. The results showed that oxygen therapy significantly reduced AHI and increased SpO2, but CPAP was more effective in reducing AHI compared to oxygen therapy. HFNC therapy effectively reduced AHI, but did not substantially increase SpO2.
JOURNAL OF CLINICAL ANESTHESIA
(2023)
Article
Obstetrics & Gynecology
Jennifer E. Dominguez, Sarah Cantrell, Ashraf S. Habib, Bilgay Izci-Balserak, Ellen Lockhart, Judette M. Louis, Alice Miskovic, Jacob W. Nadler, Mahesh Nagappa, Louise M. O'Brien, Christine Won, Ghada Bourjeily
Summary: The Society of Anesthesia and Sleep Medicine and the Society for Obstetric Anesthesia and Perinatology have collaborated to provide recommendations on the management of obstructive sleep apnea during pregnancy. These recommendations are based on a review of scientific evidence and expert opinions. It is important for physicians to assess whether these recommendations are suitable for their individual patients, as the guideline may not be applicable to all clinical situations.
OBSTETRICS AND GYNECOLOGY
(2023)
Article
Anesthesiology
Chi Pham, Khashayar Poorzargar, Darshan Panesar, Kang Lee, Jean Wong, Matteo Parotto, Frances Chung
Summary: The study aimed to evaluate the feasibility and accuracy of remote Video Plethysmography (VPPG) for contactless measurements of blood pressure (BP) and heart rate (HR) in adult surgical patients in a hospital setting. An iPad Pro was used to record a 1.5-minute facial video of the participant's face and VPPG was used to extract vital signs measurements. The VPPG BP algorithm showed limitations in capturing individual variations in blood pressure, highlighting the need for further improvements.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2023)
Article
Anesthesiology
Khashayar Poorzargar, Chi Pham, Darshan Panesar, Sheila Riazi, Kang Lee, Matteo Parotto, Frances Chung
Summary: The accurate and contactless measurement of respiratory rate (RR) is crucial for patient care. Video Plethysmography (VPPG) is a novel technology that uses facial video to measure RR without contact. This study showed that VPPG can accurately predict RR in surgical patients, with a success rate of 99.1%.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2023)