期刊
ADVANCED HEALTHCARE MATERIALS
卷 7, 期 14, 页码 -出版社
WILEY
DOI: 10.1002/adhm.201800252
关键词
biosensing; Forster resonance energy transfer (FRET); molecular imaging; photodynamic therapy (PDT); quantum dots
资金
- KRIBB Research Initiative Program (Korean Biomedical Scientist Fellowship Program)
- Korea Research Institute of Bioscience and Biotechnology, Republic of Korea
- Intramural Research Program (IRP), the National Institute of Biomedical Imaging and Bioengineering (NIBIB), the National Institutes of Health (NIH)
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [ZIAEB000073] Funding Source: NIH RePORTER
Adding value to the intrinsic properties of quantum dots (QDs), a strategy to conjugate dyes on the surface of QDs offers new opportunities, since the coupling between QD and dyes can be designed to allow Forster resonance energy transfer (FRET) and/or electron transfer (eT). These processes are accompanied by the change of QD and/or dye fluorescence and subsequent photochemical reactions (e.g., generation of O-1(2)). Based on the change of fluorescence signals by the interaction with biomolecules, QD-dye conjugates are exploited as biosensors for the detection of pH, O-2, nicotinamide adenine dinucleotide (phosphate), ions, proteases, glutathione, and microRNA. QD-dye conjugates also can be modulated by the irradiation of external light; this concept is demonstrated for fluorescence super-resolution imaging as photoactivatable or photoswitchable probes. When QDs are conjugated with photosensitizing dyes, the QD-dye conjugates can generate O-1(2) in a repetitive manner for better cancer treatment, and can also be available for approaches using two-photon excitation or bioluminescence resonance energy transfer mechanisms for deep tissue imaging. Here, the recent advances in QD-dye conjugates, where FRET or eT produces fluorescence readouts or photochemical reactions, are reviewed. Various QD-dye conjugate systems and their biosensing/imaging and photodynamic therapeutics are summarized.
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