Article
Engineering, Environmental
Yu Long, Nannan Wei, Peizhe Yuan, Xiaoying Lv, Xiangming Song, Ziyang Zhu, Qingyao Liu, Dawei Jiang, Xiaoli Lan, Yongkang Gai
Summary: A non-invasive method of tracking γδ T cells through NIRF/PET imaging was developed using metabolic glycoengineering and bioorthogonal click chemistry. The study demonstrated that this method accurately maps the biodistribution, migration, and tumor-homing efficiency of adoptive γδ T cells in vivo, representing a new potential γδ T cell imaging technology.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Engineering, Biomedical
Yu Deng, Wenjun Zhan, Gaolin Liang
Summary: Intracellular self-assembly (ISA) is a powerful strategy for constructing complex nanostructures in cells, and has been widely applied in biomedicine and biomedical engineering. Using peptide conjugates for ISA in tumor imaging and treatment has made significant progress, with potential for other important imaging or therapeutic applications.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Chemistry, Inorganic & Nuclear
Xiayi Liang, Yan Zhang, Jing Zhou, Zhaoting Bu, Junjie Liu, Kun Zhang
Summary: This article reviews the recent progress and rationales of intratumoral stimuli-responsive in situ assembly of supramolecular self-assemblies based on artificial small molecule nanomaterials in tumors. It explores the tumor-related stimulatory response components and summarizes the intermolecular driving forces or interactions after TME-triggered precursor cleavage. The article sheds light on the design concepts and application innovation in the field of tumor diagnosis and treatment, while also discussing the challenges and potential solutions for intratumoral stimuli-responsive supramolecular self-assembly synthesis.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Pharmacology & Pharmacy
Dan Yan, Haili Zhang, Zhongrui Li
Summary: With the development of precision medicine, a self-assembly theranostic nanosystem (MWNs) was designed for enhanced cell apoptosis and guided cancer therapy. This intelligent nanosystem provides information on tumor location, instructs the appropriate treatment time, and enables precise cancer therapy.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Keigo Tashiro, Takuho Saito, Hironari Arima, Natsuki Suda, Balaraman Vedhanarayanan, Shiki Yagai
Summary: Chemists have constructed sophisticated artificial nanostructured systems through self-assembly, including scissor-shaped photochromic dyads that hierarchically self-assemble into discrete nanostructures with photoresponsive properties. These nanostructures, such as azobenzene dyads, can be dissociated and reorganized through the photoisomerization of azobenzene units, enabling controllable and adjustable structures.
Article
Chemistry, Multidisciplinary
Hao Chen, Kangquan Shou, Si Chen, Chunrong Qu, Zhiming Wang, Lei Jiang, Mark Zhu, Bingbing Ding, Kun Qian, Aiyan Ji, Hongyue Lou, Ling Tong, Alexander Hsu, Yuebing Wang, Dean W. Felsher, Zhenhua Hu, Jie Tian, Zhen Cheng
Summary: The development of novel nanomaterials for disease theranostics, such as the pH-sensitive self-assembling cyclopeptide-dye SIMM1000, offers promising opportunities for high-resolution and sensitive imaging in living animals. Its smart properties in responding to changes in tumor microenvironments make it a valuable tool for molecular imaging and drug development.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Ikuya Matsumoto, Ryo Sekiya, Takeharu Haino
Summary: By decorating nanographenes with alkyl chains and controlling concentration, solvent polarity, temperature, and sonication, it is possible to achieve self-assembly and formation of stacked structures. Optical measurements and AFM images confirm the presence of stacked structures, while molecular mechanics calculations model the interactions within the aggregates. The nanographenes exhibit concentration-dependent morphologies, forming stacked structures at low concentrations and polymer-like network structures at higher concentrations on mica.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Analytical
Longpeng Peng, Gangqiang Yuan, Haiyuan Ding, Libin Tan, Qiaomei Yang, Liyi Zhou
Summary: A novel supramolecular near-infrared (NIR) fluorescent nanosensor (NIRCD-Ca) has been developed for detecting and imaging analysis of Ca2+ both in vitro and in vivo. The nanosensor exhibits excellent water solubility, low background fluorescence, high fluorescence intensity enhancement in the presence of Ca2+, superb resolution for mice imaging by NIR-emission, and extremely low detection line. It is a promising tool for detecting and imaging analysis of Ca2+ in complex biological samples and in mouse models.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Polymer Science
Yunfeng Shi, Mengyue Wang, Linzhu Zhou, Xueqi Shen, Jinhao Wang, Nannan Mo, Guo Zhao, Su Yang, Xinyuan Zhu, Andrew M. Smith
Summary: A new strategy based on supramolecular self-assembly has been described for constructing fluorescent quantum dots (QDs) responsive to triethylamine. The encapsulation of QDs in a supramolecular self-assembly system shows promising prospects in bioimaging applications.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Angela Sin-Yee Law, Lawrence Cho-Cheung Lee, Kenneth Kam-Wing Lo, Vivian Wing-Wah Yam
Summary: In this study, a novel luminescence assay based on platinum(II) complexes was introduced to detect RNA and achieve nucleolus imaging. The noncovalent interactions between platinum(II) complexes and RNA were induced by introducing a guanidinium group, resulting in strong RNA affinity and remarkable luminescence turnon. The unique properties of platinum(II) complexes, including low-energy red luminescence and large Stokes shifts, make them promising for nucleolus imaging with high signal-to-background ratios and potential biological applications.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Jian-Cai Liu, Jie-Fei Wang, Qing Han, Ping Shangguan, Lu-Lu Liu, Li-Juan Chen, Jun-Wei Zhao, Carsten Streb, Yu-Fei Song
Summary: The study demonstrates how the aggregation of giant molecular metal oxide superstructures can be driven using organotin and lanthanide cations, with detailed structural analysis. Initial biomedical tests show inhibitory effects of the compound on cancer cell proliferation, indicating potential applications in cancer treatment.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Biochemistry & Molecular Biology
Raquel Teixeira, Vanda Vaz Serra, David Botequim, Pedro M. R. Paulo, Suzana M. Andrade, Silvia M. B. Costa
Summary: The article reviews the molecular interactions of TPPS with PAMAM dendrimers and albumin proteins, as well as the self-assembly molecular complementarity. It also discusses the spectroscopic studies of AlPCS4 with PAMAM G4 dendrimers, and the impact of TPPS functionalization on morphology.
Review
Chemistry, Multidisciplinary
Jingjing Han, Haoning Gong, Xiaokang Ren, Xuehai Yan
Summary: This article introduces the research field of peptide-based supramolecular nanozymes, emphasizing the importance and versatility of peptides as building blocks, as well as the potential for regulating catalytic performance.
Article
Chemistry, Multidisciplinary
Zongshang Li, Ke Xiao, Qingyun Wan, Rui Tang, Kam-Hung Low, Xiaodong Cui, Chi-Ming Che
Summary: The introduction of multiple kinetic aggregation states (Aggs) into the self-assembly pathway can increase the complexity and flexibility of the self-assemblies. This was achieved by using a series of chiral and achiral d(10) Au-I bis(N-heterocyclic carbene, NHC) complexes, where the achiral complex could undergo self-assembly with multiple kinetic Aggs. The chiral Au-I self-assemblies exhibited nonlinear optical response of second harmonic generation (SHG) and could function as optical waveguides with strong emission polarization, while these properties were absent in the achiral analogue.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Sylvain Sudan, Farzaneh Fadaei-Tirani, Rosario Scopelliti, Kristina E. Ebbert, Guido H. Clever, Kay Severin
Summary: Thirteen palladium-ligand assemblies with different structures and topologies were studied for their ability to bind lithium ions. It was found that the addition of LiBF4 caused a significant structural rearrangement in one case, converting a dinuclear [Pd2L4](4+) complex into a low-symmetry [Pd4L8](8+) assembly with two binding pockets for solvated LiBF4 ion pairs. This rearrangement was only induced by Li+, indicating highly specific host-guest interactions. Structural analysis revealed that the [Pd4L8](8+) receptor had a compact structure with multiple intramolecular interactions, similar to natural and synthetic foldamers.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Xin-yu Wang, Yan Wang, Qiong Wu, Jing-jing Liu, Yu Liu, Dong-hui Pan, Wei Qi, Li-zhen Wang, Jun-jie Yan, Yu-ping Xu, Guang-ji Wang, Li-yan Miao, Lei Yu, Min Yang
Summary: Tracking of CAR T cells in vivo using Ga-68 as a PET tracer shows promising results with low absorbed dose and potential for clinical translation. The distribution and homing behavior of CAR T cells in the early stage correlates with their long-term fate in vivo.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Cell Biology
Qiong Wu, Yan Wang, Xinyu Wang, Ningxia Liang, Jingjing Liu, Donghui Pan, Yuping Xu, Lizhen Wang, Junjie Yan, Guangji Wang, Liyan Miao, Min Yang
Summary: In recent years, CAR T-cell therapy has shown potential in treating haematologic diseases, but has not yet made breakthroughs in solid tumours. Study on the pharmacokinetic and pharmacodynamic of CD19 CAR T cells in solid tumours revealed higher tumour-specific uptake in the CD19-positive model and consistent PD results.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Engineering, Biomedical
Xinxin Li, Xinyu Wang, Qingfeng Liu, Junjie Yan, Donghui Pan, Lizhen Wang, Yuping Xu, Fang Wang, Yuhang Liu, Xiaotian Li, Min Yang
Summary: The boronate-stabilized polyphenol-poloxamer assembled dexamethasone nanodrug demonstrates the ability to efficiently inhibit ROS and nitric oxide production in macrophages, as well as modulate macrophage polarization. In OA mice treated with this nanodrug, body weight and evaluation scores showed similarities to normal mice with reduced inflammation-associated angiogenesis. The nanodrug also inhibits cartilage degradation, bone erosion, and proinflammatory cytokines, showcasing potential for treating various inflammatory diseases.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Urban Studies
Terence Y. M. Lam, Junjie Yan
Summary: This study found that the main supply barriers for CCRC development in Shanghai are operation management experience, financial risks, and government support policy. On the other hand, the main demand barriers are poor quality of services and living environment, rather than traditional family-oriented culture and affordability. Therefore, successful CCRC investment strategy should focus on partnering with experienced professional eldercare management companies and providing high-quality medical professionals and trained care personnel, along with intensive capital flows for land, construction, and operating costs.
INTERNATIONAL JOURNAL OF HOUSING MARKETS AND ANALYSIS
(2022)
Article
Engineering, Environmental
Junjie Yan, Xinyu Wang, Jianjun Xiong, Lizhen Wang, Donghui Pan, Yuping Xu, Min Yang
Summary: By constructing a library of aliphatic polyamides using thiolactone chemistry, the structure-NTILs relationship of aliphatic fluorescent polyamides was revealed. Aliphatic polyamides exhibit dual Polymerization-induced emissions (PIEs) and introducing a piperazine unit enables lysosome-specific anchoring for the resultant fluorescent polyamide.
CHEMICAL ENGINEERING JOURNAL
(2022)
Review
Engineering, Environmental
Xinyu Wang, Yeli Fan, Junjie Yan, Min Yang
Summary: Polyphenols, compounds found in natural plants, have various beneficial effects such as anti-tumor, anti-inflammatory, and antibacterial capacities. Polyphenol-based polymeric nanoparticles have emerged as promising drug carriers in biomedical engineering.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Donghui Pan, Yan Wang, Nan Xu, Yuping Xu, Xinyu Wang, Lizhen Wang, Junjie Yan, Lei Yu, Liyan Miao, Guangji Wang, Min Yang
Summary: In this study, a novel reporter system for PET imaging the behaviors of CAR T cells was constructed and evaluated. The system was able to effectively monitor the proliferation profiles of CAR T cells in solid tumor models. The pharmacodynamics and pharmacokinetics of CAR T cells in whole-body hematologic neoplasms were also evaluated using bioluminescence imaging and PET imaging.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Oceanography
Xingchuan Liu, Fangguo Zhai, Junjie Yan, Yanzhen Gu, Yucheng Wang, Peiliang Li, Kejian Wu
Summary: The study found that typhoons can cause significant changes in three-dimensional circulation in the Yellow Sea, resulting in temperature changes below the surface layer and the fast southward movement of the Yellow Sea Cold Water Mass. The Yellow Sea is one of the most important large marine ecosystems in the world, and this study enriches our understanding of its response to typhoons.
JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS
(2022)
Article
Psychology, Multidisciplinary
Junjie Yan, Jingwen Zeng, Peiduo Liu
Summary: The study conducted three experiments to investigate the effects of phasic alertness on representational momentum, finding that it enhances forward displacement and sensitivity regardless of motion speed. The results suggest that phasic alertness may influence representational momentum by modulating the process of executive control in the retention interval.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Engineering, Environmental
Junjie Yan, Chen Su, Kequan Lou, Min Gu, Xinyu Wang, Donghui Pan, Lizhen Wang, Yuping Xu, Chongyang Chen, Yu Chen, Daozhen Chen, Min Yang
Summary: With endogenous redox systems and multiple enzymes, living cells can store and utilize external energy through photo/ultrasonic synthesis/catalysis. In artificial systems, however, sonochemical energy is rapidly dissipated due to electron-hole pairs recombination and ROS termination. In this study, a nanohybrid (LMND@ZIF-90) is synthesized by integrating zeolitic imidazolate framework-90 (ZIF-90) and liquid metal (LM), which efficiently captures sonogenerated holes and electrons, suppressing electron-hole pairs recombination and storing ultrasonic energy for over ten days. The nanohybrid also exhibits acid-responsive release and faster dye degradation rate.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Review
Environmental Sciences
Yeli Fan, Donghui Pan, Min Yang, Xinyu Wang
Summary: Emerging pollutants (EPs) have become a global concern due to their serious threats to human and animal health. The radiolabelling and in vivo radionuclide imaging tracking of various EPs have provided valuable insights into their behavior and potential toxicity in organs and tissues.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Medicine, Research & Experimental
Chongyang Chen, Jing Wang, Donghui Pan, Xinyu Wang, Yuping Xu, Junjie Yan, Lizhen Wang, Xifei Yang, Min Yang, Gong-Ping Liu
Summary: Multi-omics refers to the application of multiple high-throughput screening technologies in the study of human diseases, such as genomics, transcriptomics, single-cell transcriptomics, proteomics, and metabolomics. This review provides a comprehensive introduction to the various technical categories, experimental design considerations, integrated analysis methods, machine learning and deep learning approaches, and application in medical research and precision medicine. It also discusses the challenges, future directions, and emerging fields of single-cell multi-omics and spatial multi-omics. This review is important for researchers entering the field of multi-omics medical research.
Article
Materials Science, Biomaterials
Yeli Fan, Xinyu Wang, Ge Yan, Hongfang Gao, Min Yang
Summary: Inflammatory bowel diseases (IBDs) are chronic gastrointestinal inflammation, and the pro-inflammatory cytokine TNF-α plays a key role in its pathogenesis. We developed polyphenol-poloxamer nanoparticles loaded with anti-inflammatory INF as a novel IBD therapy, which can be administered rectally for localized drug delivery, prolonging drug activity and minimizing systemic exposure, showing high therapeutic potential.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Optics
Chen Peng, Qi Chao, Liu Renwei, Wang Zhenzhen, Luo Han, Yan Junjie, Liu Jiping, Deguchi Yoshihiro
Summary: Laser induced breakdown spectroscopy (LIBS) is used to analyze fly ash samples, and support vector machine regression (SVR) model is used to predict the carbon content. The study shows that the SVR model with radial basis function (RBF) kernel function achieves good accuracy and avoids underfitting. The SVR model based on the internal standard element characteristic spectrum has similar accuracy to the internal standard method, while the model based on the full spectrum shows overfitting. The SVR model based on the main element characteristic spectrum has high regression coefficient and low root mean square error, effectively avoiding underfitting and overfitting.
ACTA OPTICA SINICA
(2022)
