Review
Biochemistry & Molecular Biology
Anthony V. Nguyen, Jose M. Soto, Sarah-Marie Gonzalez, Jennifer Murillo, Eric R. Trumble, Frank Y. Shan, Jason H. Huang
Summary: The 2021 World Health Organization Classification of Tumors of the Central Nervous System introduced the H3.3-G34R/V mutant glioma alongside the already recognized H3-K27M altered glioma, reflecting advances in understanding the roles of oncohistones in gliomagenesis. However, the prognosis remains poor for patients with these disease entities and the H3.3-G34R/V mutant gliomas are particularly understudied. Further research is needed to explore the molecular mechanisms underlying gliomagenesis and develop effective diagnosis, treatment, and future therapeutics.
Review
Biochemistry & Molecular Biology
Eric J. Lehrer, Brianna M. Jones, Kunal K. Sindhu, Daniel R. Dickstein, Mira Cohen, Stanislav Lazarev, Alfredo Quinones-Hinojosa, Sheryl Green, Daniel M. Trifiletti
Summary: Stereotactic radiosurgery (SRS) and immune checkpoint inhibitors (ICIs) are commonly used in the treatment of brain metastases. However, their use in primary brain tumors is still controversial. Meningiomas respond well to treatment, but higher grade meningiomas are resistant. Glioblastoma has a poor prognosis, but preoperative SRS may enhance the immune response to ICIs.
Review
Medicine, General & Internal
Victor Gabriel El-Hajj, Jenny Pettersson Segerlind, Gustav Burstrom, Erik Edstrom, Adrian Elmi-Terander
Summary: This article provides a systematic review of spinal meningiomas, summarizing studies on their epidemiology, diagnosis, treatment, and outcomes. By searching relevant databases and screening research, the current knowledge on spinal meningiomas is summarized, contributing to a better understanding and management of this disease.
Review
Surgery
Eric J. J. Lehrer, Roman O. O. Kowalchuk, Henry Ruiz-Garcia, Kenneth W. W. Merrell, Paul D. D. Brown, Joshua D. D. Palmer, Stuart H. H. Burri, Jason P. P. Sheehan, Alfredo Quninoes-Hinojosa, Daniel M. M. Trifiletti
Summary: Stereotactic radiosurgery (SRS) is an effective and safe treatment method for intracranial neoplasms and functional disorders. It has shown favorable rates of tumor control and cognitive preservation for brain metastases, but also carries risks of local failure and complications. Further research is needed to explore its potential benefits for high grade gliomas.
FRONTIERS IN SURGERY
(2022)
Article
Medicine, General & Internal
Jasper Kees Wim Gerritsen, Clemens Maria Franciscus Dirven, Steven De Vleeschouwer, Philippe Schucht, Christine Jungk, Sandro M. Krieg, Brian Vala Nahed, Mitchel Stuart Berger, Marike Lianne Daphne Broekman, Arnaud Jean Pierre Edouard Vincent
Summary: The study aims to evaluate the effectiveness of intraoperative stimulation mapping (ISM) in high-grade glioma (HGG) resections by comparing outcomes of patients operated with awake mapping, asleep mapping or no mapping. Primary endpoints include proportion of patients with National Institute of Health Stroke Scale deterioration and residual tumor volume on postoperative MRI scans, while secondary endpoints include overall survival and progression-free survival at 12 months.
Article
Clinical Neurology
Alexandre Roux, Oumaima Aboubakr, Angela Elia, Alessandro Moiraghi, Chiara Benevello, Houssem Fathallah, Eduardo Parraga, Catherine Oppenheim, Fabrice Chretien, Edouard Dezamis, Marc Zanello, Johan Pallud
Summary: We evaluated the feasibility of Carmustine wafer implantation in extreme conditions and in patients with a newly diagnosed supratentorial glioblastoma, IDH-wildtype. We conducted a retrospective cohort study and found that Carmustine wafer implantation did not increase postoperative complications and was beneficial for survival. The number of Carmustine wafers should be adjusted to the resection cavity to improve outcomes.
NEUROSURGICAL REVIEW
(2023)
Article
Neurosciences
Venkatesh S. Madhugiri, Aliasgar Moiyadi, Amrutha Bindu Nagella, Vikram Singh, Prakash Shetty
Summary: The survey revealed that although 37% of institutions had high surgical volumes, only about half of them performed a high volume of malignant brain tumor surgeries. There were wide variations in medical management, perioperative protocols, use of adjuncts and intraoperative technologies, and paradigms for specific clinical scenarios. Standardizing protocols in neuro-oncology is necessary, and this could be achieved through enhancing formal training in surgical neuro-oncology.
Article
Clinical Neurology
Domenique M. J. Muller, Pierre A. Robe, Hilko Ardon, Frederik Barkhof, Lorenzo Bello, Mitchel S. Berger, Wim Bouwknegt, Wimar A. Van den Brink, Marco Conti Nibali, Roelant S. Eijgelaar, Julia Furtner, Seunggu J. Han, Shawn L. Hervey-Jumper, Albert J. S. Idema, Barbara Kiesel, Alfred Kloet, Jan C. De Munck, Marco Rossi, Tommaso Sciortino, W. Peter Vandertop, Martin Visser, Michiel Wagemakers, Georg Widhalm, Marnix G. Witte, Aeilko H. Zwinderman, Philip C. De Witt Hamer
Summary: The study introduces eRV and eRI, which can better predict biopsy decisions, resectability, and survival rates. Expected residual tumor volume and expected resectability index can support surgical decisions.
JOURNAL OF NEUROSURGERY
(2021)
Article
Medicine, General & Internal
Abdurrahman I. Islim, Christopher P. Millward, Rory J. Piper, Daniel M. Fountain, Shaveta Mehta, Ruwanthi Kolamunnage-Dona, Usama Ali, Shelli Diane Koszdin, Theo Georgious, Samantha J. Mills, Andrew R. Brodbelt, Ryan K. Mathew, Thomas Santarius, Michael D. Jenkinson
Summary: Due to the increased use of CT and MRI, the prevalence of incidental findings on brain scans is increasing. Meningioma is the most common primary brain tumor and often encountered as an incidental finding. The management methods for incidental meningioma vary, and there is a lack of defined duration of monitoring and time intervals for assessment. A statistical model called IMPACT has been developed to categorize patients with incidental meningioma into risk groups and propose an active monitoring strategy based on the risk and progression trajectory. The aim of this study is to assess the external validity of this model.
Review
Medicine, General & Internal
Pengtao Li, Jialing Wang, Aximujiang Axier, Kai Zhou, Jingwei Yun, Huayi Wang, Tingrong Zhang, Shaoshan Li
Summary: Craniopharyngioma is a challenging brain tumor with high recurrence rates, and proton therapy (PT) with its physical properties of heavy ion beam has been used more frequently in adults with this condition. PT has advantages in reducing normal tissue damage and increasing tumor damage compared to conventional X-ray beam radiotherapy. However, the optimal management of craniopharyngioma remains controversial. This study aims to evaluate the efficacy and safety of PT for craniopharyngioma in adults.
Article
Medicine, General & Internal
Christian Carrwik, Claes Olerud, Yohan Robinson
Summary: A retrospective longitudinal multiregistry nationwide cohort study was conducted in 19 public hospitals in Sweden to evaluate survival after surgery and indications for surgery due to spinal metastatic disease. The study included 1820 patients aged 18 years or older, with results showing a median estimated survival time of 6.2 months and a mean estimated survival time of 12.2 months after surgery, indicating significant effectiveness of surgical treatment for survival in patients with spinal metastases.
Review
Medicine, General & Internal
Xinlong Li, Juncheng Wang, Guoqiang Yuan, Yawen Pan
Summary: Despite the recent FDA approval, the benefit of using TTFields for the treatment of high-grade gliomas is still unclear. Therefore, a systematic review and meta-analysis are conducted to evaluate the effectiveness of TTFields.
Article
Medicine, General & Internal
Michael Amoo, Jack Horan, Brian Gilmartin, Deirdre Nolan, Paula Corr, Stephen MacNally, Mohammed Ben Husien, Mohsen Javadpour
Summary: The study found that there were 127 and 139 admissions for neuro-oncological surgery during the 3-month periods in 2020 and 2019, respectively, with lower postoperative morbidity and mortality rates in 2020. There was one COVID-19-related death. The results suggest that neuro-oncological surgery can be safely continued during a respiratory illness epidemic or pandemic with the implementation of a rigorous testing and staffing framework.
IRISH JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Clinical Neurology
Adham M. Khalafallah, Adrian E. Jimenez, Carlos G. Romo, David Olayinka Kamson, Lawrence Kleinberg, Jon Weingart, Henry Brem, Stuart A. Grossman, Debraj Mukherjee
Summary: The study shows that multidisciplinary tumor boards (MDTBs) can provide alternative diagnostic interpretations and treatment plans for patients with nervous system tumors, leading to significant changes in patient management and shortened referral times.
JOURNAL OF NEUROSURGERY
(2021)
Review
Clinical Neurology
Nathan A. Shlobin, Eric Y. Montgomery, Laila M. Mohammad, Viswajit Kandula, Molly Beestrum, Michael DeCuypere, Sandi K. Lam
Summary: The objective of this study was to summarize the effects of treatment strategies on visual outcomes in pediatric patients with sporadic OPG. The results showed that vision in most patients remained stable to poor after observation, chemotherapy, radiotherapy, or surgery. Chemotherapy may be associated with the most favorable visual outcomes.
WORLD NEUROSURGERY
(2022)
Article
Clinical Neurology
Aaron P. Kamer, Jose M. Bonnin, Robert J. Spinner, Aaron A. Cohen-Gadol
JOURNAL OF NEUROSURGERY
(2020)
Article
Clinical Neurology
Clint M. Alfaro, Valentina Pirro, Michael F. Keating, Eyas M. Hattab, R. Graham Cooks, Aaron A. Cohen-Gadol
JOURNAL OF NEUROSURGERY
(2020)
Article
Clinical Neurology
Aaron A. Cohen-Gadol
OPERATIVE NEUROSURGERY
(2020)
Article
Clinical Neurology
Robert A. Scranton, Kushal Shah, Aaron A. Cohen-Gadol
JOURNAL OF NEUROSURGERY
(2020)
Article
Clinical Neurology
Benjamin K. Hendricks, Aaron A. Cohen-Gadol
OPERATIVE NEUROSURGERY
(2020)
Article
Clinical Neurology
Robert A. Scranton, Aaron A. Cohen-Gadol
OPERATIVE NEUROSURGERY
(2020)
Article
Clinical Neurology
Aaron Cohen-Gadol
OPERATIVE NEUROSURGERY
(2020)
Article
Clinical Neurology
Umit Eroglu, Burak Bahadir, Samuel B. Tomlinson, Hasan Caglar Ugur, Emre Yagiz Sayaci, Ayhan Attar, Yusuf Sukru Caglar, Aaron A. Cohen Gadol
WORLD NEUROSURGERY
(2020)
Review
Engineering, Biomedical
Vitaliy L. Rayz, Aaron A. Cohen-Gadol
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 22
(2020)
Editorial Material
Clinical Neurology
Samuel B. Tomlinson, Benjamin K. Hendricks, Aaron A. Cohen-Gadol
JOURNAL OF NEUROSURGERY
(2020)
Letter
Clinical Neurology
Samuel B. Tomlinson, Benjamin K. Hendricks, Aaron Cohen-Gadol
WORLD NEUROSURGERY
(2020)
Review
Clinical Neurology
Chung Liang Chai, Jin Pyeong Jeon, Yi-Hsin Tsai, Paula Whittaker, R. Loch Macdonald, Antti E. Lindgren, Oliver G. S. Ayling, Marcus Andre Acioly, Aaron Cohen-Gadol, Yu-Hua Huang
Review
Oncology
Paolo Palmisciano, Ali S. Haider, Mohammadmahdi Sabahi, Chibueze D. Nwagwu, Othman Bin Alamer, Gianluca Scalia, Giuseppe E. Umana, Aaron A. Cohen-Gadol, Tarek Y. El Ahmadieh, Kenny Yu, Omar N. Pathmanaban
Summary: Primary skull base chondrosarcomas (SBCs) can result in significant tumor burden leading to severe cranial nerve neuropathies. Current treatment strategies mainly focus on surgical resection and radiotherapy, with a range of efficacy and safety outcomes. Surgical resection favors maximal tumor removal with acceptable complication rates, while radiotherapy protocols offer safe and effective local tumor control. Overall, prognosis for primary SBCs is favorable and comparable to benign skull base neoplasms, making them a challenging but manageable entity in clinical practice.
Review
Medicine, General & Internal
Hailey C. Budnick, Samuel Tomlinson, Jesse Savage, Aaron Cohen-Gadol
CUREUS JOURNAL OF MEDICAL SCIENCE
(2020)
Article
Medicine, General & Internal
Charles Kulwin, Aaron Cohen-Gadol
CUREUS JOURNAL OF MEDICAL SCIENCE
(2020)
Article
Clinical Neurology
Guilu He, Jianhao Lin, Jing Ye, Fobao Huang, Changzhi Yan, Zesi Liu, Xiuming Zhou, Qiao Li, Liang Zhang
Summary: This article introduces long tunneled external ventricular drain (LTEVD), which effectively avoids multiple surgeries by connecting an external shunt valve. It allows visual control of drainage flow, prolongs catheter indwelling time, and eliminates the need for multiple surgeries.
WORLD NEUROSURGERY
(2024)
Article
Clinical Neurology
Vinay Suresh, H. S. Suresh, Bharath Raju, Himanshu Jindal, Ahmad Ozair
Summary: This study investigated the outcomes of postoperative discitis treated with debridement and a novel technique focused on reducing outpatient antibiotic requirement in a low- and middle-income country (LMIC) setting. The results showed that patients with medically refractory postoperative discitis potentially have good outcomes after debridement plus 2-week local antibiotic instillation in LMICs.
WORLD NEUROSURGERY
(2024)
Editorial Material
Clinical Neurology
Beatrice C. Bono, Davide Milani, Fabio Ferreli, Simone Olei, Luca Raspagliesi, Maria Pia Tropeano, Giovanni B. Lasio, Federico Pessina
WORLD NEUROSURGERY
(2024)
Article
Clinical Neurology
Avi A. Gajjar, Shrey Patel, Raj Swaroop Lavadi, Rida Mitha, Rohit Prem Kumar, Tavis Taylor, Galal A. Elsayed, D. Kojo Hamilton, Nitin Agarwal
Summary: Art in neurosurgery has played a crucial role in the discipline for centuries. Medical illustrations help visualize anatomy and surgical procedures, contributing to education, surgical planning, and navigation.
WORLD NEUROSURGERY
(2024)
Article
Clinical Neurology
Joaquin Perez Zabala, Yamila Basilotta Marquez, Romina Arganaraz, Beatriz Mantese
Summary: We present a low-cost and easily accessible adaptation system for stereotactic procedures in infants. By using a headband cast technique, a stereotactic biopsy was successfully performed in a 5-month-old patient, achieving precise targeting, histopathological diagnosis, and no associated complications.
WORLD NEUROSURGERY
(2024)
Editorial Material
Clinical Neurology
Muhammad Kusdiansah, Arnau Benet, Yosuke Suzuki, Kenichi Haraguchi, Nakao Ota, Kosumo Noda, Rokuya Tanikawa
Summary: Fusiform vertebral artery aneurysms are difficult to treat, and endovascular and open microsurgical treatments are used for different situations. This report presents a case with complex anatomy and branch involvement and describes the treatment strategy used.
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Victor M. Lu
Summary: This review emphasizes four essential domains that should be considered when interpreting pediatric neurosurgical SRMAs and provides examples to ensure accurate and effective interpretation of findings in this niche.
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Lapo Bonosi, Angelo Torrente, Filippo Brighina, Cateno Concetto Tito Petralia, Pietro Merlino, Chiara Avallone, Vincenzo Gulino, Roberta Costanzo, Lara Brunasso, Domenico Gerardo Iacopino, Rosario Maugeri
Summary: Corticocortical evoked potentials (CCEPs) have emerged as a valuable intraoperative monitoring technique in eloquent brain tumor surgery, aiding in preserving critical functional areas. Current research shows the potential of CCEPs in guiding surgical decision making, reducing the risk of postoperative neurological deficits, and mapping functional connectivity, but further research and standardization are needed.
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Yuchen Duan, Dagang Feng, Min Zhu, Heng Qiu, Tong Li, Zhen Chen, Leiming Jiang, Yong Huang
Summary: This study aimed to compare the effect of different Modic changes (MC) grades on the cage subsidence rate after spinal interbody fusion surgery. A meta-analysis was conducted on relevant randomized controlled trials and cohort studies. The results showed that MC may be associated with a higher cage subsidence rate. With the increase in MC grades, the incidence of subsidence decreased gradually, but it was always higher than that in the non-Modic changes (NMC). Oblique lumbar interbody fusion may be a better treatment choice for lumbar degenerative disease with MC.
WORLD NEUROSURGERY
(2024)
Editorial Material
Clinical Neurology
Brian F. Saway, Conor M. Cunningham, Mustafa Ismail, Alejandro M. Spiotta
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Joanna M. Roy, Michael M. Covell, Carmelo Venero Jr, Christian A. Bowers
Summary: Early exposure to neurosurgery during medical school is critical for improving recruitment into the specialty. However, about 30% of medical schools in the U.S. lack a neurosurgery program, limiting students' exposure to the field. Virtual education, facilitated by webinars during the pandemic, has advantages such as global outreach and accessibility for international medical students. This review identifies and describes 16 educational resources, serving as a guide for medical students interested in neurosurgery.
WORLD NEUROSURGERY
(2024)