期刊
WORLD NEUROSURGERY
卷 112, 期 -, 页码 E876-E880出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.wneu.2018.01.196
关键词
Arterial tortuosity; Intracranial aneurysm; Pathomechanism
资金
- Korea Health Technology R&D Project, Ministry for Health & Welfare, Republic of Korea [HI12C1847]
BACKGROUND: Although intracranial aneurysms (IAs) are focal bulges of arterial walls, an uncharacterized predisposing factor that affects cerebral arteries may increase tortuosity of intracranial arteries in patients with IAs. METHODS: Subjects who underwent routine health examinations and magnetic resonance angiography at a university hospital health promotion center were enrolled. Age- and sex-matched control subjects were selected from among individuals who did not have IAs. Tortuosity of right and left middle cerebral arteries and basilar artery (BA) was measured. Distant factor [(arc/chord ratio x 100) - 100] was used to estimate tortuosity. Vascular risk factors and intracranial arterial tortuosities were compared between subjects with IAs and control subjects. Independent factors associated with intracranial artery tortuosity were also investigated. RESULTS: Of 18,954 (1.9%) subjects, 367 exhibited IAs. The prevalence of hypertension (P = 0.01) and current smoking (P = 0.01) were higher in subjects with IAs than in control subjects. The BA tortuosity was greater in subjects with IAs compared with control subjects (9.0 +/- 8.1 vs. 5.5 +/- 7.2; P< 0.001). In addition to hypertension, smoking, and absence of coronary artery disease, BA tortuosity (P< 0.001) was independently associated with presence of lAs. The presence of IAs (P < 0.001) and absence of coronary artery disease (P = 0.002) were independently associated with high BA tortuosity. CONCLUSIONS: Patients with IAs exhibit a more tortuous BA. A predisposing factor weakening the cerebrovasculature in patients with IAs may exist and may manifest as high tortuosity of intracranial arteries.
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