Article
Multidisciplinary Sciences
Hongxia Li, Emily B. Harrison, Huizhong Li, Koichi Hirabayashi, Jing Chen, Qi-Xiang Li, Jared Gunn, Jared Weiss, Barbara Savoldo, Joel S. Parker, Chad Pecot, Gianpietro Dotti, Hongwei Du
Summary: Therapeutic options for non-small cell lung cancer patients with brain metastases are limited. CAR-T cells targeting B7-H3 and expressing the chemokine receptor CCR2b show improved accumulation in the brain and enhanced anti-tumor activity. This strategy could improve the efficacy of adoptive T-cell therapies in patients with solid tumors presenting with brain metastases.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Anqi Lin, Hongman Zhang, Hui Meng, Ze Deng, Tianqi Gu, Peng Luo, Jian Zhang
Summary: This research indicates that TNFα-MT may serve as a potential clinical biomarker for predicting the efficacy and prognosis of NSCLC patients receiving ICIs. TNFα-MT is associated with high immunogenicity and infiltration of immune cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Pan Juncheng, Adrien Joseph, Antoine Lafarge, Isabelle Martins, Florine Obrist, Jonathan Pol, Ester Saavedra, Sijing Li, Allan Sauvat, Giulia Cerrato, Sarah Levesque, Marion Leduc, Oliver Kepp, Sylvere Durand, Fanny Aprahamian, Nitharsshini Nirmalathansan, Judith Michels, Guido Kroemer, Maria Castedo
Summary: This study found that high activity of PARP1 in non-small cell lung cancer cells affects the tumor microenvironment, leading to compromised immunosurveillance and reduced infiltration of cytotoxic T lymphocytes.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Medicine, General & Internal
Yi-Han Zuo, Wei-Na Gao, Ya-Jia Xie, Sheng-Yong Yang, Jin-Tai Zhou, Hai-Hai Liang, Xing-Xing Fan
Summary: PKC delta is identified as a critical factor in the non-inflamed tumor microenvironment (TME) of EGFR-mutated lung cancer. Inhibition of PKC delta enhances the infiltration of immune cells into tumors and increases the sensitivity of tumors to immune checkpoint blockade therapy.
Review
Immunology
Kexun Zhou, Shuo Li, Yi Zhao, Ke Cheng
Summary: Immune checkpoint inhibitors (ICIs) have shown great promise in prolonging the survival of patients with advanced non-small cell lung cancer (NSCLC). However, resistance to ICIs remains a challenge, with different mechanisms and tumor microenvironment playing a critical role.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Ding-Yu Rao, De-Fa Huang, Mao-Yan Si, Hua Lu, Zhi-Xian Tang, Zu-Xiong Zhang
Summary: As an important mediator of information transfer between cells, exosomes play a unique role in regulating tumor growth, supporting vascular proliferation, tumor invasion, and metastasis. Exosomes can be used as a potential tool for non-invasive liquid biopsy due to their presence in various body fluids. This study reviews the role of exosomes in liquid biopsy, tumor microenvironment formation, and epithelial-mesenchymal transition in non-small cell lung cancer (NSCLC). It also discusses the occurrence of EGFR+ exosomes and the role of exosomes and their contents in non-invasive detection and potential therapeutic targets in EGFR-mutated lung cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Sebastian Marwitz, Carmen Ballesteros-Merino, Shawn M. Jensen, Martin Reck, Christian Kugler, Sven Perner, Daniel Dromann, Torsten Goldmann, Bernard A. Fox
Summary: The activation of the TGFB pathway in lung cancer patients has been found to negatively impact survival, especially when it comes to the activation of local immune cells affecting disease progression. These findings may help in developing new approaches to treat early-stage lung cancer.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Joseph Seitlinger, Anasse Nounsi, Ysia Idoux-Gillet, Eloy Santos Pujol, Helene Le, Erwan Grandgirard, Anne Olland, Veronique Lindner, Cecile Zaupa, Jean-Marc Balloul, Eric Quemeneur, Gilbert Massard, Pierre-Emmanuel Falcoz, Guoqiang Hua, Nadia Benkirane-Jessel
Summary: Researchers have developed a vascularized patient-derived tumoroid model that preserves histopathological features of tumors and mimics the tumor microenvironment. This model shows promise for personalized medicine and can facilitate more accurate drug screening and treatment testing.
Article
Oncology
Jiaqi Zhu, Jinjie Wang, Tianyi Wang, Hao Zhou, Mingming Xu, Jiliang Zha, Chen Feng, Zihao Shen, Yun Jiang, Jianle Chen
Summary: This study explores the impact of necroptosis on tumor development in non-small cell lung cancer (NSCLC) and identifies prognostic genes. The results show that the construction of prognostic risk models has stable validity in guiding immunotherapy and chemotherapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Xiaoyan Sun, Weiran Liu, Leina Sun, Huilan Mo, Yingnan Feng, Xinyi Wu, Chenguang Li, Chen Chen, Jingjing Li, Ying Xin, Zhenfa Zhang, Changli Wang, Bin Zhang, Dongsheng Yue
Summary: This study investigated the maturation and abundance of tertiary lymphoid structures (TLS) in resectable non-small cell lung cancer (NSCLC) patients receiving neoadjuvant treatments, and found that the maturation of TLS is associated with treatment response and patient prognosis. The neoadjuvant chemoimmunotherapy group showed the highest TLS maturation and abundance, as well as higher rates of major pathological response (MPR) and pathological complete response (pCR). The maturation and abundance of TLS were significantly correlated with MPR and disease-free survival (DFS), and were independent predictors for DFS.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Genetics & Heredity
Fumiaki Takatsu, Ken Suzawa, Shuta Tomida, Yin Min Thu, Masakiyo Sakaguchi, Tomohiro Toji, Masayoshi Ohki, Shimpei Tsudaka, Keiichi Date, Naoki Matsuda, Kazuma Iwata, Yidan Zhu, Kentaro Nakata, Kazuhiko Shien, Hiromasa Yamamoto, Akiko Nakayama, Mikio Okazaki, Seiichiro Sugimoto, Shinichi Toyooka
Summary: CAF-derived POSTN plays a crucial role in tumor growth, migration, EMT induction, and drug resistance in NSCLC. Targeting CAF-secreted POSTN could be a potential therapeutic strategy for NSCLC.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Immunology
Haoxin Peng, Xiangrong Wu, Ran Zhong, Tao Yu, Xiuyu Cai, Jun Liu, Yaokai Wen, Yiyuan Ao, Jiana Chen, Yutian Li, Miao He, Caichen Li, Hongbo Zheng, Yanhui Chen, Zhenkui Pan, Jianxing He, Wenhua Liang
Summary: This study analyzed the tumor immune microenvironment (TIME) in non-small cell lung cancer (NSCLC) using multiplex immunofluorescence, identifying three immune subtypes correlated with distinct characteristics and prognosis for patients. Various immune cells were found to play different roles in NSCLC, offering potential prognostic biomarkers and risk stratification methods.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Jia-Qi Xu, Yan-Li Fu, Jing Zhang, Kai-Yu Zhang, Jie Ma, Jing-Yi Tang, Zhi-Wei Zhang, Zhong-Yan Zhou
Summary: Metabolic disturbance, particularly of glucose metabolism, is a hallmark of tumors such as non-small cell lung cancer (NSCLC). This review focuses on research advances in glycolysis in NSCLC and systematically provides an overview of the key enzymes, biomarkers, non-coding RNAs, and signaling pathways that modulate the glycolysis process and, consequently, tumor growth and metastasis in NSCLC. Current medications, therapeutic approaches, and natural products that affect glycolysis in NSCLC are also summarized. The development of metabolic intervention that targets glycolysis, alone or in combination with current therapy, is a potential therapeutic approach in NSCLC treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Jie Deng, Xuejiao Ma, Yang Ni, Xiaomin Li, Wenjing Xi, Minqi Tian, Xing Zhang, Manyu Xiang, Wanglong Deng, Chao Song, Hao Wu
Summary: This study evaluated the immune microenvironment of NSCLC patients treated with PD-1 inhibitors and found that CXCL5 may serve as a potential biomarker for prognosis and responsiveness to immunotherapy, suggesting it as a novel preventive and therapeutic target for NSCLC.
Article
Oncology
Yanan Cui, Xinyin Liu, Yuemin Wu, Xiao Liang, Jiali Dai, Zhihong Zhang, Renhua Guo
Summary: Immune checkpoint inhibitors have limited efficacy in non-small cell lung cancer patients, and there is a need for reliable predictive markers. This study identified AHNAK2 mutation as a potential biomarker for predicting favorable response to ICI treatment in NSCLC patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Construction & Building Technology
Chenchen Zhang, Xinchun Guan, Rongwei Lu, Jinglu Li, Yazhao Li
Summary: This paper explores the effect of CCCW on the various transport properties of cracked cementitious composites. The results show that CCCW can promote the rapid reduction of water absorption of cracked specimens, especially in Ca(OH)2 solution. CCCW improves the durability recovery of cracked specimens and accelerates the formation of calcium carbonate, thus reducing the transport properties of cracked specimens.
CONSTRUCTION AND BUILDING MATERIALS
(2023)
Article
Energy & Fuels
Yongping Ma, Xianwen Zhang, Guodong Wang, Duonian Xu, Xin Guan, Shuxin Pan, Yongqiang Qu
Summary: This study analyzes the sedimentary facies, petrologic features, and physical property regularities of the Permian Xiazijie Formation in order to develop a pore evolution model of coarse-grained deposition. The results provide a theoretical reference for predicting tight glutenite reservoirs.
ENERGY EXPLORATION & EXPLOITATION
(2023)
Article
Chemistry, Multidisciplinary
Zihan Yang, Zhihang Zhou, Tongxu Si, Zhengdong Zhou, Li Zhou, Y. Rebecca Chin, Liang Zhang, Xinyuan Guan, Mengsu Yang
Summary: Cancer metastasis is a major cause of cancer-related death, and it is characterized by excessive extracellular matrix deposition and increased stiffness in solid tumors. The confined migration of tumor cells in these conditions plays a crucial role in metastasis, but inhibitors specifically targeting this type of migration are rare. In this study, a microfluidic chip was designed to screen for drugs that can effectively inhibit confined migration of cancer cells. By applying this chip, three novel inhibitors of confined migration, MA-5, SB-705498, and diphenyleneiodonium chloride, were discovered in multiple cancer types. The mechanisms of action of these inhibitors were found to be targeting mitochondria, actin polymerization, and cell viability, respectively. Overall, a high-throughput microfluidic platform for screening drugs targeting confined migration was established, and three effective inhibitors were identified.
Article
Green & Sustainable Science & Technology
Bin Zou, Xin Guan, Yinghua Shao, Peng Chen
Summary: This research investigates the impact of social network-based interaction on students' English speaking practice with the assistance of AI speaking apps in China. The results indicate that students generally held positive attitudes towards interactive activities when using AI apps to practice their spoken English. The finding also showed that social network-based interaction can effectively improve learners' speaking skills in the AI context.
Article
Pharmacology & Pharmacy
Hongyu Zhou, Licheng Tan, Beilei Liu, Xin-Yuan Guan
Summary: Tumors consist of malignant components that generate abnormal tissues through self-renewal and differentiation. Cancer stem cells (CSCs) play a fundamental role in maintaining tumor heterogeneity and remodeling the tumor microenvironment. Recent advances in technology have allowed for better understanding of CSC characteristics, markers, mechanisms, and their interactions with other cells in the tumor microenvironment.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Oncology
Shuyue Zheng, Xin-Yuan Guan
Summary: Ferroptosis is a cell death that occurs due to the accumulation of ferrous ions and lipid peroxidation in tumor cells. Targeting ferroptosis as a novel strategy for anti-tumor therapy involves regulating various metabolic and immune elements. This review highlights the mechanism of ferroptosis, its interaction with cancer and tumor immune microenvironment, particularly the relationship between immune cells and ferroptosis. Additionally, it discusses the latest preclinical progress in combining ferroptosis-targeted drugs with immunotherapy, and the optimal conditions for their combined use, providing insight into the potential value of ferroptosis in cancer immunotherapy.
Article
Engineering, Mechanical
Ming-jie Hu, Xin-long Liu, Chao-wei Zhou, Dong-yun Wang, Qian Xiao, Xin Guan, Song Zhang, Zhi-biao Xu
Summary: This study investigates the impact of sliding speed and electrical current on the current-carrying friction performance of carbon brushes with different hardnesses. Two carbon-graphite materials with different hardnesses were prepared using powder metallurgy, and a pin-disc current-carrying friction tester was utilized for testing. The results demonstrate that the difference in hardness significantly affects the sliding contact resistance and interface temperature rise. Moreover, the low hardness material exhibits good adaptability to changes in electric current, while adhesive wear occurs for all materials with different hardnesses and transitions to abrasive wear with increasing electrical current. The wear rate of low-hardness material decreases with increasing sliding speed, whereas the opposite trend is observed for high-hardness material, which is not notably damaged by increased sliding speed, indicating good resistance to mechanical shocks.
INTERNATIONAL JOURNAL OF MECHANICAL SCIENCES
(2023)
Letter
Rheumatology
Xin Guan, Zerui Zhao, Guangtao Xia, Miaomiao Xin, Qingrui Yang, Hongling Sun, Min Fu
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Forestry
Kai Liu, Hang Sun, Hong S. S. He, Xin Guan
Summary: Seed harvesting has a significant negative impact on the natural regeneration of Pinus koraiensis, reducing its ability to regenerate and exacerbating the effects of climate change. To protect and restore the primary mixed Pinus koraiensis forests, it is recommended to reduce the intensity of seed harvesting and implement silvicultural treatments.
Article
Engineering, Mechanical
Yanzhao Wu, Xin Guan, Ran Tao, Ruofu Xiao
Summary: In this study, the phenomenon of unusual peak of critical cavitation under small flowrate conditions is analyzed by the combination of experiment, numerical simulation and neural network. It is found that the unusual peak of critical cavitation mainly occurs under the flowrate range of 0.081-0.108. The application of artificial intelligence can intuitively and accurately reflect the flowrate change of pump and the influence from inception to development of cavitation on pump performance, providing new ideas for improving pump performance and reducing cavitation.
IRANIAN JOURNAL OF SCIENCE AND TECHNOLOGY-TRANSACTIONS OF MECHANICAL ENGINEERING
(2023)
Article
Computer Science, Information Systems
Xuefei Sun, Mohammed Jajere Adamu, Ruifeng Zhang, Xin Guan, Qiang Li
Summary: In order to accurately estimate human pose, we propose a novel method that directly incorporates pixel coordinates for pose estimation and uses coordinate attention to capture position- and structure-sensitive features. By using small-scale convolution kernels and smooth activation functions, we further reduce network parameters and computational cost. Through evaluation on the MPII Human Pose and COCO Keypoint Detection datasets, we demonstrate improved accuracy, highlighting the importance of directly incorporating coordinate location information in position-sensitive tasks.
Article
Materials Science, Multidisciplinary
Zhonghua Chen, Xin Guan, Ningxuan Wen, Lujun Pan, Zeng Fan
Summary: In this study, highly conductive PEDOT:PSS fibers were produced via wet-spinning, and flexible and self-supporting PEDOT:PSS thick films with evident thermoelectric property anisotropy were further developed using a wet-winding approach. The anisotropic films exhibited a power factor that was 2.4 times higher than that of the isotropic counterpart prepared via drop-casting and outperformed many previously reported binary inorganic-organic thermoelectric composite films.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Physics, Multidisciplinary
Guan Xin, Chen Gang
Summary: In this paper, we demonstrate the existence of topological nonmediocre nodes in a two-leg SSH model implemented in superconducting circuits. Two distinct topological insulating phases characterized by winding number ±1 are identified, with corresponding edge states exhibiting distinct characteristics. By representing the Bloch states as a vector field in k space, we demonstrate the existence of two kinks of nonmediocre nodes with first-type phase boundaries.
ACTA PHYSICA SINICA
(2023)
Article
Computer Science, Information Systems
Xin Guan, Zhenghui Xue, Wu Ren, Weiming Li
Summary: This paper presents a multi-polarization series-fed antenna operating at 10 GHz. Patch elements built by eccentric rings enable circular polarization performance. The dual-port feeding enables polarization switching. The antenna can achieve right-hand circular polarization (RHCP), left-hand circular polarization (LHCP), and linear polarization (LP) by proper feeding. The antenna polarization can be changed without switch controlling. The antenna features a compact structure due to the circular array arrangement. The measured axial ratios are lower than 3dB and |S-21| is lower than -14 dB within the specified bandwidth. A compact 4 x 4 MIMO array is designed and simulated, and the circular array is processed and measured, showing good agreement between experimental and simulation results.
Article
Chemistry, Multidisciplinary
Junai Lv, Qi Li, Xin Guan, Na Lin, Jian Zhang, Zhitai Jia, Xutang Tao
Summary: In this study, three new transition metal selenite and tellurite compounds have been successfully synthesized and characterized. The crystallographic structures, thermal analysis, optical spectra, birefringence, and theoretical calculations of the compounds were investigated. The results show that ZrSe2O6 and HfSe2O6 exhibit birefringence and short UV cut-off edges, while HfTe3O8 has high thermal stability and a short UV cut-off edge.
Article
Oncology
Masashi Nishimura, Yoshifumi Kimizuka, Takunori Ogawa, Motohiro Tsuchiya, Yoshiki Kato, Akira Matsukida, Shunya Igarashi, Koki Ito, Yusuke Serizawa, Tomomi Tanigaki, Yuji Fujikura, Yuka Katsurada, Sho Ogata, Akihiko Kawana
Summary: This study reports a case of IgG4-related retroperitoneal fibrosis occurring after chemotherapy. The patient showed improvement after discontinuing immunotherapy and receiving steroid treatment.
Article
Oncology
Yuta Ohishi, Yoko Nakanishi, Yukari Hirotani, Atsuko Suzuki, Tomoyuki Tanino, Haruna Nishimaki-Watanabe, Hiroko Kobayashi, Fumi Nozaki, Sumie Ohni, Xiaoyan Tang, Kentaro Hayashi, Yoshiko Nakagawa, Tetsuo Shimizu, Ichiro Tsujino, Noriaki Takahashi, Yasuhiro Gon, Shinobu Masuda
Summary: This study aimed to investigate the clinicopathological differences and therapeutic response of NSCLC patients with SDC4::ROS1 fusion to crizotinib. The study found that different ROS1 fusion partners may affect the efficacy of crizotinib and patient prognosis. In addition, higher expression levels of ROS1 and pERK1/2 in tumor cells of case 2 may be related to the therapeutic response and prognosis.
Review
Oncology
Zitong Zheng, Juanjuan Liu, Junling Ma, Runting Kang, Zhen Liu, Jiangyong Yu
Summary: Small cell lung cancer (SCLC) is a highly aggressive malignancy with limited treatment options. Over the past decade, immunotherapy has made progress in the treatment of SCLC, but current immune checkpoint inhibitors have limited benefits for patient survival. Therefore, it is important to explore new targets and develop drugs with novel mechanisms for immunotherapy in SCLC.
Article
Oncology
Kazuto Sugai, Kojiro Nakaoka, Rika Tobita, Shinji Kikuchi, Kei Inoue, Midori Enokido, Moriyuki Kiyoshima
Summary: This article presents a case of multilocular mediastinal cyst leading to the development of thymic cancer. Resection of multilocular anterior mediastinal cysts should be considered due to the challenges in preoperative diagnosis, the potential for coexisting tumors with cysts, and the risk of malignant tumor development.
